P19265 (EUTC_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ethanolamine ammonia-lyase light chain
EC=4.3.1.7

Alternative name(s):
Ethanolamine ammonia-lyase small subunit

Gene names

Name:	eutC
Ordered Locus Names:	STM2457

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. HAMAP-Rule MF_00601
Catalytic activity	Ethanolamine = acetaldehyde + NH3. HAMAP-Rule MF_00601
Cofactor	Adenosylcobalamin.
Pathway	Amine and polyamine degradation; ethanolamine degradation. HAMAP-Rule MF_00601
Subunit structure	Heterodimer of a small and a large subunit.
Sequence similarities	Belongs to the EutC family.

Ontologies

Keywords
Ligand	Cobalamin Cobalt
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro ethanolamine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	cobalamin binding Inferred from electronic annotation. Source: UniProtKB-KW ethanolamine ammonia-lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Ethanolamine ammonia-lyase light chain HAMAP-Rule MF_00601		PRO_0000206003
Experimental info
	Sequence conflict	45	1	S → T in AAA27062. Ref.1
	Sequence conflict	82 – 97	16	CTGRA…QALLR → LYGACRAASAHPGAVA in AAA27062. Ref.1
	Sequence conflict	129	1	E → EEWVKAQGLLEVRSE Ref.1
	Sequence conflict	253 – 298	46	TTVEA…INMTR → PPSRPTEPVFQTFIRGGRRQ Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P19265 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: C681A995C6A1671A	FASTA	298	32,137
	10 20 30 40 50 60 MDQKQIEEIV RSVMASMGQD VPQPAAPSTQ EGAKPQCAAP TVTESCALDL GSAEAKAWIG 70 80 90 100 110 120 VENPHRADVL TELRRSTAAR VCTGRAGPRP RTQALLRFLA DHSRSKDTVL KEVPEEWVKA 130 140 150 160 170 180 QGLLEVRSEI SDKNLYLTRP DMGRRLSPEA IDALKSQCVM NPDVQVVVSD GLSTDAITAN 190 200 210 220 230 240 YEEILPPLLA GLKQAGLNVG TPFFVRYGRV KIEDQIGEIL GAKVVILLVG ERPGLGQSES 250 260 270 280 290 LSCYAVYSPR VATTVEADRT CISNIHQGGT PPVEAAAVIV DLAKRMLEQK ASGINMTR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of Salmonella typhimurium." Faust L.R.P., Connor J.A., Roof D.M., Hoch J.A., Babior B.M. J. Biol. Chem. 265:12462-12466(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins." Kofoid E.C., Rappleye C.A., Stojiljkovic I., Roth J.R. J. Bacteriol. 181:5317-5329(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[3]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J05518 Genomic DNA. Translation: AAA27062.1. AF093749 Genomic DNA. Translation: AAC78124.1. AE006468 Genomic DNA. Translation: AAL21351.1.
PIR	B36570.
RefSeq	NP_461392.1. NC_003197.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM2457.
Proteomic databases
PaxDb	P19265.
PRIDE	P19265.
Protocols and materials databases
DNASU	1253979.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL21351; AAL21351; STM2457.
GeneID	1253979.
KEGG	stm:STM2457.
PATRIC	32383545. VBISalEnt20916_2595.
Phylogenomic databases
eggNOG	COG4302.
HOGENOM	HOG000253991.
KO	K03736.
OMA	IHKGGTP.
ProtClustDB	PRK05465.
Enzyme and pathway databases
UniPathway	UPA00560.
Family and domain databases
HAMAP	MF_00601. EutC.
InterPro	IPR009246. EutC. [Graphical view]
Pfam	PF05985. EutC. 1 hit. [Graphical view]
PIRSF	PIRSF018982. EutC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EUTC_SALTY

Accession

Primary (citable) accession number: P19265
Secondary accession number(s): Q9ZFV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program