Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lymphocyte function-associated antigen 3

Gene

CD58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

GO - Molecular functioni

  • receptor binding Source: UniProtKB

GO - Biological processi

  • blood coagulation Source: Reactome
  • cell adhesion Source: ProtInc
  • cellular response to interferon-gamma Source: UniProtKB
  • cellular response to tumor necrosis factor Source: UniProtKB
  • heterotypic cell-cell adhesion Source: UniProtKB
  • leukocyte migration Source: Reactome
  • positive regulation of interleukin-8 secretion Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte function-associated antigen 3
Short name:
Ag3
Alternative name(s):
Surface glycoprotein LFA-3
CD_antigen: CD58
Gene namesi
Name:CD58
Synonyms:LFA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1688. CD58.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 215187ExtracellularSequence analysisAdd
BLAST
Transmembranei216 – 23823HelicalSequence analysisAdd
BLAST
Topological domaini239 – 25012CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi29 – 291F → S: No effect on CD2-binding. 1 Publication
Mutagenesisi37 – 371V → K: No effect on CD2-binding. 1 Publication
Mutagenesisi49 – 491V → Q: No effect on CD2-binding. 1 Publication
Mutagenesisi86 – 861V → K: No effect on CD2-binding. 1 Publication
Mutagenesisi113 – 1131T → S: No effect on CD2-binding. 1 Publication
Mutagenesisi121 – 1211L → G: No effect on CD2-binding. 1 Publication

Organism-specific databases

PharmGKBiPA26227.

Chemistry

ChEMBLiCHEMBL3790.

Polymorphism and mutation databases

BioMutaiCD58.
DMDMi126225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Chaini29 – 250222Lymphocyte function-associated antigen 3PRO_0000014814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)
Glycosylationi94 – 941N-linked (GlcNAc...)
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi142 ↔ 187By similarity
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP19256.
MaxQBiP19256.
PaxDbiP19256.
PRIDEiP19256.
TopDownProteomicsiP19256-1. [P19256-1]
P19256-2. [P19256-2]

PTM databases

SwissPalmiP19256.

Expressioni

Gene expression databases

BgeeiP19256.
CleanExiHS_CD58.
ExpressionAtlasiP19256. baseline and differential.
GenevisibleiP19256. HS.

Interactioni

Subunit structurei

Interacts with CD2.2 Publications

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107403. 11 interactions.
IntActiP19256. 4 interactions.
MINTiMINT-8201779.
STRINGi9606.ENSP00000358501.

Structurei

Secondary structure

1
250
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 367Combined sources
Beta strandi41 – 433Combined sources
Beta strandi54 – 585Combined sources
Beta strandi61 – 677Combined sources
Beta strandi70 – 734Combined sources
Helixi75 – 773Combined sources
Beta strandi80 – 834Combined sources
Turni85 – 873Combined sources
Beta strandi90 – 923Combined sources
Helixi97 – 993Combined sources
Beta strandi101 – 1066Combined sources
Beta strandi114 – 1218Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CCZX-ray1.80A29-122[»]
1CI5NMR-A29-123[»]
1QA9X-ray3.20B/D30-123[»]
ProteinModelPortaliP19256.
SMRiP19256. Positions 29-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19256.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12192Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1AA. Eukaryota.
ENOG410Z508. LUCA.
GeneTreeiENSGT00510000049596.
HOGENOMiHOG000013140.
HOVERGENiHBG003226.
InParanoidiP19256.
KOiK06492.
OMAiCFGFISC.
OrthoDBiEOG7VHT02.
PhylomeDBiP19256.
TreeFamiTF341787.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR015714. Lymphocyte_func-assoc_Ag_3.
[Graphical view]
PANTHERiPTHR21063. PTHR21063. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19256-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP
60 70 80 90 100
LKEVLWKKQK DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE
110 120 130 140 150
DEYEMESPNI TDTMKFFLYV LESLPSPTLT CALTNGSIEV QCMIPEHYNS
160 170 180 190 200
HRGLIMYSWD CPMEQCKRNS TSIYFKMEND LPQKIQCTLS NPLFNTTSSI
210 220 230 240 250
ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC DRKPDRTNSN
Length:250
Mass (Da):28,147
Last modified:November 1, 1990 - v1
Checksum:i34D635DF1D14FE2E
GO
Isoform 2 (identifier: P19256-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     236-237: GI → VL
     238-250: Missing.

Note: GPI-anchor amidated asparagine on Asn-235. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:237
Mass (Da):26,661
Checksum:i9FF77F81A224D8DC
GO
Isoform 3 (identifier: P19256-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-250: NSN → K

Show »
Length:248
Mass (Da):27,960
Checksum:iF2AF1D14FE2E6D57
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151S → G.
Corresponds to variant rs17426456 [ dbSNP | Ensembl ].
VAR_049885

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei236 – 2372GI → VL in isoform 2. 2 PublicationsVSP_002522
Alternative sequencei238 – 25013Missing in isoform 2. 2 PublicationsVSP_002523Add
BLAST
Alternative sequencei248 – 2503NSN → K in isoform 3. 1 PublicationVSP_038693

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00636 mRNA. Translation: CAA68668.1.
X06296 mRNA. Translation: CAA29622.1.
Y14780
, Y14781, Y14782, Y14783, Y14784 Genomic DNA. Translation: CAA75083.1.
Y14780
, Y14781, Y14782, Y14783, Y14784, Y14785 Genomic DNA. Translation: CAA75084.1.
AK291980 mRNA. Translation: BAF84669.1.
CR456939 mRNA. Translation: CAG33220.1.
BT019816 mRNA. Translation: AAV38619.1.
BT019817 mRNA. Translation: AAV38620.1.
AL390066, AL355794 Genomic DNA. Translation: CAI19099.1.
AL355794, AL390066 Genomic DNA. Translation: CAI22762.1.
CH471122 Genomic DNA. Translation: EAW56652.1.
CH471122 Genomic DNA. Translation: EAW56653.1.
CCDSiCCDS44199.1. [P19256-3]
CCDS888.1. [P19256-1]
PIRiA28564.
RefSeqiNP_001138294.1. NM_001144822.1. [P19256-3]
NP_001770.1. NM_001779.2. [P19256-1]
UniGeneiHs.34341.

Genome annotation databases

EnsembliENST00000369489; ENSP00000358501; ENSG00000116815. [P19256-1]
ENST00000457047; ENSP00000409080; ENSG00000116815. [P19256-3]
ENST00000464088; ENSP00000432773; ENSG00000116815. [P19256-2]
GeneIDi965.
KEGGihsa:965.
UCSCiuc001egm.4. human. [P19256-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00636 mRNA. Translation: CAA68668.1.
X06296 mRNA. Translation: CAA29622.1.
Y14780
, Y14781, Y14782, Y14783, Y14784 Genomic DNA. Translation: CAA75083.1.
Y14780
, Y14781, Y14782, Y14783, Y14784, Y14785 Genomic DNA. Translation: CAA75084.1.
AK291980 mRNA. Translation: BAF84669.1.
CR456939 mRNA. Translation: CAG33220.1.
BT019816 mRNA. Translation: AAV38619.1.
BT019817 mRNA. Translation: AAV38620.1.
AL390066, AL355794 Genomic DNA. Translation: CAI19099.1.
AL355794, AL390066 Genomic DNA. Translation: CAI22762.1.
CH471122 Genomic DNA. Translation: EAW56652.1.
CH471122 Genomic DNA. Translation: EAW56653.1.
CCDSiCCDS44199.1. [P19256-3]
CCDS888.1. [P19256-1]
PIRiA28564.
RefSeqiNP_001138294.1. NM_001144822.1. [P19256-3]
NP_001770.1. NM_001779.2. [P19256-1]
UniGeneiHs.34341.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CCZX-ray1.80A29-122[»]
1CI5NMR-A29-123[»]
1QA9X-ray3.20B/D30-123[»]
ProteinModelPortaliP19256.
SMRiP19256. Positions 29-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107403. 11 interactions.
IntActiP19256. 4 interactions.
MINTiMINT-8201779.
STRINGi9606.ENSP00000358501.

Chemistry

ChEMBLiCHEMBL3790.

PTM databases

SwissPalmiP19256.

Polymorphism and mutation databases

BioMutaiCD58.
DMDMi126225.

Proteomic databases

EPDiP19256.
MaxQBiP19256.
PaxDbiP19256.
PRIDEiP19256.
TopDownProteomicsiP19256-1. [P19256-1]
P19256-2. [P19256-2]

Protocols and materials databases

DNASUi965.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369489; ENSP00000358501; ENSG00000116815. [P19256-1]
ENST00000457047; ENSP00000409080; ENSG00000116815. [P19256-3]
ENST00000464088; ENSP00000432773; ENSG00000116815. [P19256-2]
GeneIDi965.
KEGGihsa:965.
UCSCiuc001egm.4. human. [P19256-1]

Organism-specific databases

CTDi965.
GeneCardsiCD58.
HGNCiHGNC:1688. CD58.
MIMi153420. gene.
neXtProtiNX_P19256.
PharmGKBiPA26227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1AA. Eukaryota.
ENOG410Z508. LUCA.
GeneTreeiENSGT00510000049596.
HOGENOMiHOG000013140.
HOVERGENiHBG003226.
InParanoidiP19256.
KOiK06492.
OMAiCFGFISC.
OrthoDBiEOG7VHT02.
PhylomeDBiP19256.
TreeFamiTF341787.

Enzyme and pathway databases

ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSiCD58. human.
EvolutionaryTraceiP19256.
GenomeRNAii965.
NextBioi4030.
PROiP19256.
SOURCEiSearch...

Gene expression databases

BgeeiP19256.
CleanExiHS_CD58.
ExpressionAtlasiP19256. baseline and differential.
GenevisibleiP19256. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR015714. Lymphocyte_func-assoc_Ag_3.
[Graphical view]
PANTHERiPTHR21063. PTHR21063. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein."
    Wallner B.P., Frey A.Z., Tizard R., Mattaliano R.J., Hession C., Sanders M.E., Dustin M.L., Springer T.A.
    J. Exp. Med. 166:923-932(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, INTERACTION WITH CD2.
    Tissue: Erythrocyte.
  2. "An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2."
    Seed B.
    Nature 329:840-842(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene."
    Wallich R., Brenner C., Brand Y., Roux M., Reister M., Meuer S.
    J. Immunol. 160:2862-2871(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Small intestine.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  10. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
    Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N.
    J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS] (ISOFORM 2).
    Tissue: Cervix carcinoma.
  11. "Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors."
    Wang J.H., Smolyar A., Tan K., Liu J.H., Kim M., Sun Z.Y., Wagner G., Reinherz E.L.
    Cell 97:791-803(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 29-123 IN COMPLEX WITH CD2, MUTAGENESIS OF PHE-29; VAL-37; VAL-49; VAL-86; THR-113 AND LEU-121.
  12. "Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution."
    Ikemizu S., Sparks L.M., van der Merwe P.A., Harlos K., Stuart D.I., Jones E.Y., Davis S.J.
    Proc. Natl. Acad. Sci. U.S.A. 96:4289-4294(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 29-122.

Entry informationi

Entry nameiLFA3_HUMAN
AccessioniPrimary (citable) accession number: P19256
Secondary accession number(s): A8K7G5
, Q5U053, Q6IB65, Q96KI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 11, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.