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Protein

Cytolysin

Gene

vvhA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis
LigandLectin

Enzyme and pathway databases

BioCyciVVUL216895:G1GJ4-3620-MONOMER

Protein family/group databases

CAZyiCBM13 Carbohydrate-Binding Module Family 13
TCDBi1.C.14.1.3 the cytohemolysin (chl) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cytolysin
Gene namesi
Name:vvhA
Ordered Locus Names:VV2_0404
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001336521 – 471CytolysinAdd BLAST451

Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi339 – 347Combined sources9
Beta strandi351 – 357Combined sources7
Beta strandi360 – 363Combined sources4
Beta strandi367 – 371Combined sources5
Helixi377 – 379Combined sources3
Beta strandi380 – 383Combined sources4
Beta strandi389 – 391Combined sources3
Beta strandi394 – 396Combined sources3
Beta strandi398 – 401Combined sources4
Beta strandi407 – 410Combined sources4
Helixi416 – 418Combined sources3
Beta strandi420 – 423Combined sources4
Beta strandi426 – 429Combined sources4
Beta strandi439 – 445Combined sources7
Beta strandi448 – 453Combined sources6
Helixi454 – 456Combined sources3
Beta strandi462 – 466Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OWJX-ray2.00A/B/C/D/E/F/G338-471[»]
4OWKX-ray2.00A/B/C/D/E/F/G338-471[»]
4OWLX-ray2.10A/B/C/D/E/F/G338-471[»]
ProteinModelPortaliP19247
SMRiP19247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini338 – 465Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the HlyA hemolysin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000144471
KOiK10948
OMAiHVAFYLN
OrthoDBiPOG091H05ZS

Family and domain databases

CDDicd00161 RICIN, 1 hit
InterProiView protein in InterPro
IPR016183 Leukocidin/Hemolysin_toxin
IPR036435 Leukocidin/porin_MspA_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF07968 Leukocidin, 1 hit
PF00652 Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56959 SSF56959, 1 hit
PROSITEiView protein in PROSITE
PS50231 RICIN_B_LECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKMTLFTLS LLATAVQVGA QEYVPIVEKP IYITSSKIKC VLHTSGDFNA
60 70 80 90 100
TRDWCNAGAS IDVRVNVAQM RSVQSATSDG FTPDAKIVRF TVDADKPGTG
110 120 130 140 150
IHLVNELQQD HSWFQSWANR RTYIGPFASS YDLWVKPVSG YTPKKARDLP
160 170 180 190 200
QNENKNYQHR DTYGYSIGIN GKVGAEVNKD GPKVGGEVSG SFTYNYSKTL
210 220 230 240 250
VFDTKDYRIN NRSSLSDFDI SFEREFGECD ELRRQELGCY FTAAHWGSGW
260 270 280 290 300
VFDKTKFNPI SYSNFKPNYD VLYEAPVSET GVTDFEMGVK LNYRARFGTV
310 320 330 340 350
LPSALFSVYG SAGSSTNSST VKQRIRIDWN HPLFEAEAHV TLQSLSNNDL
360 370 380 390 400
CLDVYGENGD KTVAGGSVNG WSCHGSWNQV WGLDKEERYR SRVASDRCLT
410 420 430 440 450
VNADKTLTVE QCGANLAQKW YWEGDKLISR YVDGNNTRYL LNIVGGRNVQ
460 470
VTPENEANQA RWKPTLQQVK L
Length:471
Mass (Da):52,899
Last modified:February 1, 2003 - v2
Checksum:iF5F41B504552BAFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13A → R in AAA03245 (PubMed:2370116).Curated1
Sequence conflicti338A → R in AAA03245 (PubMed:2370116).Curated1
Sequence conflicti435N → S in AAA03245 (PubMed:2370116).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34670 Unassigned DNA Translation: AAA03245.1
AE016796 Genomic DNA Translation: AAO07360.2
PIRiA41478
RefSeqiWP_011081361.1, NC_004460.2

Genome annotation databases

EnsemblBacteriaiAAO07360; AAO07360; VV2_0404
KEGGivvu:VV2_0404

Similar proteinsi

Entry informationi

Entry nameiVVHA_VIBVU
AccessioniPrimary (citable) accession number: P19247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 2003
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

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