Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytolysin

Gene

vvhA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-3264-MONOMER.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
TCDBi1.C.14.1.3. the cytohemolysin (chl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytolysin
Gene namesi
Name:vvhA
Ordered Locus Names:VV2_0404
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 471451CytolysinPRO_0000013365Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV2_0404.

Structurei

Secondary structure

1
471
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi339 – 3479Combined sources
Beta strandi351 – 3577Combined sources
Beta strandi360 – 3634Combined sources
Beta strandi367 – 3715Combined sources
Helixi377 – 3793Combined sources
Beta strandi380 – 3834Combined sources
Beta strandi389 – 3913Combined sources
Beta strandi394 – 3963Combined sources
Beta strandi398 – 4014Combined sources
Beta strandi407 – 4104Combined sources
Helixi416 – 4183Combined sources
Beta strandi420 – 4234Combined sources
Beta strandi426 – 4294Combined sources
Beta strandi439 – 4457Combined sources
Beta strandi448 – 4536Combined sources
Helixi454 – 4563Combined sources
Beta strandi462 – 4665Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4OWJX-ray2.00A/B/C/D/E/F/G338-471[»]
4OWKX-ray2.00A/B/C/D/E/F/G338-471[»]
4OWLX-ray2.10A/B/C/D/E/F/G338-471[»]
ProteinModelPortaliP19247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini338 – 465128Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HlyA hemolysin family.Curated
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000144471.
KOiK10948.
OrthoDBiPOG091H05ZS.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR016183. Leukocidin/porin.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56959. SSF56959. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKMTLFTLS LLATAVQVGA QEYVPIVEKP IYITSSKIKC VLHTSGDFNA
60 70 80 90 100
TRDWCNAGAS IDVRVNVAQM RSVQSATSDG FTPDAKIVRF TVDADKPGTG
110 120 130 140 150
IHLVNELQQD HSWFQSWANR RTYIGPFASS YDLWVKPVSG YTPKKARDLP
160 170 180 190 200
QNENKNYQHR DTYGYSIGIN GKVGAEVNKD GPKVGGEVSG SFTYNYSKTL
210 220 230 240 250
VFDTKDYRIN NRSSLSDFDI SFEREFGECD ELRRQELGCY FTAAHWGSGW
260 270 280 290 300
VFDKTKFNPI SYSNFKPNYD VLYEAPVSET GVTDFEMGVK LNYRARFGTV
310 320 330 340 350
LPSALFSVYG SAGSSTNSST VKQRIRIDWN HPLFEAEAHV TLQSLSNNDL
360 370 380 390 400
CLDVYGENGD KTVAGGSVNG WSCHGSWNQV WGLDKEERYR SRVASDRCLT
410 420 430 440 450
VNADKTLTVE QCGANLAQKW YWEGDKLISR YVDGNNTRYL LNIVGGRNVQ
460 470
VTPENEANQA RWKPTLQQVK L
Length:471
Mass (Da):52,899
Last modified:February 1, 2003 - v2
Checksum:iF5F41B504552BAFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131A → R in AAA03245 (PubMed:2370116).Curated
Sequence conflicti338 – 3381A → R in AAA03245 (PubMed:2370116).Curated
Sequence conflicti435 – 4351N → S in AAA03245 (PubMed:2370116).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34670 Unassigned DNA. Translation: AAA03245.1.
AE016796 Genomic DNA. Translation: AAO07360.2.
PIRiA41478.
RefSeqiWP_011081361.1. NC_004460.2.

Genome annotation databases

EnsemblBacteriaiAAO07360; AAO07360; VV2_0404.
KEGGivvu:VV2_0404.
PATRICi20164204. VBIVibVul94426_3563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34670 Unassigned DNA. Translation: AAA03245.1.
AE016796 Genomic DNA. Translation: AAO07360.2.
PIRiA41478.
RefSeqiWP_011081361.1. NC_004460.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4OWJX-ray2.00A/B/C/D/E/F/G338-471[»]
4OWKX-ray2.00A/B/C/D/E/F/G338-471[»]
4OWLX-ray2.10A/B/C/D/E/F/G338-471[»]
ProteinModelPortaliP19247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV2_0404.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
TCDBi1.C.14.1.3. the cytohemolysin (chl) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO07360; AAO07360; VV2_0404.
KEGGivvu:VV2_0404.
PATRICi20164204. VBIVibVul94426_3563.

Phylogenomic databases

HOGENOMiHOG000144471.
KOiK10948.
OrthoDBiPOG091H05ZS.

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-3264-MONOMER.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR016183. Leukocidin/porin.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56959. SSF56959. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVVHA_VIBVU
AccessioniPrimary (citable) accession number: P19247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 2003
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.