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P19237

- TNNI1_HUMAN

UniProt

P19237 - TNNI1_HUMAN

Protein

Troponin I, slow skeletal muscle

Gene

TNNI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi106 – 11712By similarityAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. muscle filament sliding Source: Reactome
    2. regulation of striated muscle contraction Source: UniProtKB
    3. ventricular cardiac muscle tissue morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_16969. Striated Muscle Contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin I, slow skeletal muscle
    Alternative name(s):
    Troponin I, slow-twitch isoform
    Gene namesi
    Name:TNNI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11945. TNNI1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. troponin complex Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36634.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Troponin I, slow skeletal musclePRO_0000186139Add
    BLAST

    Proteomic databases

    PaxDbiP19237.
    PRIDEiP19237.

    PTM databases

    PhosphoSiteiP19237.

    Expressioni

    Tissue specificityi

    Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.2 Publications

    Gene expression databases

    ArrayExpressiP19237.
    BgeeiP19237.
    GenevestigatoriP19237.

    Organism-specific databases

    HPAiCAB009349.
    HPA028190.

    Interactioni

    Subunit structurei

    Binds to actin and tropomyosin.

    Protein-protein interaction databases

    BioGridi112989. 7 interactions.
    IntActiP19237. 2 interactions.
    MINTiMINT-1467470.

    Structurei

    3D structure databases

    ProteinModelPortaliP19237.
    SMRiP19237. Positions 5-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4848Involved in binding TNCAdd
    BLAST
    Regioni97 – 11822Involved in binding TNC and actinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the troponin I family.Curated

    Phylogenomic databases

    eggNOGiNOG328514.
    HOVERGENiHBG052737.
    InParanoidiP19237.
    KOiK10371.
    OMAiCRDLHAK.
    OrthoDBiEOG71G9WD.
    PhylomeDBiP19237.
    TreeFamiTF313374.

    Family and domain databases

    InterProiIPR001978. Troponin.
    [Graphical view]
    PfamiPF00992. Troponin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19237-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP    50
    TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK 100
    VMDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT 150
    EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ 187
    Length:187
    Mass (Da):21,692
    Last modified:January 23, 2007 - v3
    Checksum:i7A8363CC7559B962
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 52VE → FQ in AC096677. (PubMed:16710414)Curated
    Sequence conflicti30 – 301W → R in CAG29297. 1 PublicationCurated
    Sequence conflicti103 – 1031D → A in CAD91135. (PubMed:17974005)Curated
    Sequence conflicti131 – 1311K → R in CAC44240. 1 PublicationCurated
    Sequence conflicti143 – 1431K → T in CAG46793. 1 PublicationCurated
    Sequence conflicti182 – 1832KS → NA in AAA61228. (PubMed:2365354)Curated
    Sequence conflicti182 – 1832KS → NA in CAG46827. 1 PublicationCurated
    Sequence conflicti182 – 1832KS → NA in CAG46793. 1 PublicationCurated
    Sequence conflicti182 – 1832KS → NA in CAG29297. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671R → W.
    Corresponds to variant rs2296695 [ dbSNP | Ensembl ].
    VAR_052403

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04760 mRNA. Translation: AAA61228.1.
    L21910
    , L21906, L21908, L21909 Genomic DNA. Translation: AAC14461.1.
    AJ315823 mRNA. Translation: CAC44240.1.
    CR450301 mRNA. Translation: CAG29297.1.
    CR541996 mRNA. Translation: CAG46793.1.
    CR542030 mRNA. Translation: CAG46827.1.
    AL831820 mRNA. Translation: CAD38534.1.
    AL831975 mRNA. Translation: CAH56221.1.
    BX510903 mRNA. Translation: CAD91135.1.
    AK223588 mRNA. Translation: BAD97308.1.
    AK311896 mRNA. Translation: BAG34837.1.
    AC096677 Genomic DNA. No translation available.
    BC012600 mRNA. Translation: AAH12600.1.
    BC012601 mRNA. Translation: AAH12601.1.
    CCDSiCCDS1411.1.
    PIRiA53740. TPHUIW.
    RefSeqiNP_003272.3. NM_003281.3.
    UniGeneiHs.320890.

    Genome annotation databases

    EnsembliENST00000336092; ENSP00000337022; ENSG00000159173.
    ENST00000361379; ENSP00000354488; ENSG00000159173.
    ENST00000367312; ENSP00000356281; ENSG00000159173.
    GeneIDi7135.
    KEGGihsa:7135.
    UCSCiuc001gwp.3. human.

    Polymorphism databases

    DMDMi1351298.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04760 mRNA. Translation: AAA61228.1 .
    L21910
    , L21906 , L21908 , L21909 Genomic DNA. Translation: AAC14461.1 .
    AJ315823 mRNA. Translation: CAC44240.1 .
    CR450301 mRNA. Translation: CAG29297.1 .
    CR541996 mRNA. Translation: CAG46793.1 .
    CR542030 mRNA. Translation: CAG46827.1 .
    AL831820 mRNA. Translation: CAD38534.1 .
    AL831975 mRNA. Translation: CAH56221.1 .
    BX510903 mRNA. Translation: CAD91135.1 .
    AK223588 mRNA. Translation: BAD97308.1 .
    AK311896 mRNA. Translation: BAG34837.1 .
    AC096677 Genomic DNA. No translation available.
    BC012600 mRNA. Translation: AAH12600.1 .
    BC012601 mRNA. Translation: AAH12601.1 .
    CCDSi CCDS1411.1.
    PIRi A53740. TPHUIW.
    RefSeqi NP_003272.3. NM_003281.3.
    UniGenei Hs.320890.

    3D structure databases

    ProteinModelPortali P19237.
    SMRi P19237. Positions 5-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112989. 7 interactions.
    IntActi P19237. 2 interactions.
    MINTi MINT-1467470.

    PTM databases

    PhosphoSitei P19237.

    Polymorphism databases

    DMDMi 1351298.

    Proteomic databases

    PaxDbi P19237.
    PRIDEi P19237.

    Protocols and materials databases

    DNASUi 7135.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336092 ; ENSP00000337022 ; ENSG00000159173 .
    ENST00000361379 ; ENSP00000354488 ; ENSG00000159173 .
    ENST00000367312 ; ENSP00000356281 ; ENSG00000159173 .
    GeneIDi 7135.
    KEGGi hsa:7135.
    UCSCi uc001gwp.3. human.

    Organism-specific databases

    CTDi 7135.
    GeneCardsi GC01M201372.
    HGNCi HGNC:11945. TNNI1.
    HPAi CAB009349.
    HPA028190.
    MIMi 191042. gene.
    neXtProti NX_P19237.
    PharmGKBi PA36634.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328514.
    HOVERGENi HBG052737.
    InParanoidi P19237.
    KOi K10371.
    OMAi CRDLHAK.
    OrthoDBi EOG71G9WD.
    PhylomeDBi P19237.
    TreeFami TF313374.

    Enzyme and pathway databases

    Reactomei REACT_16969. Striated Muscle Contraction.

    Miscellaneous databases

    ChiTaRSi TNNI1. human.
    GeneWikii TNNI1.
    GenomeRNAii 7135.
    NextBioi 27917.
    PROi P19237.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19237.
    Bgeei P19237.
    Genevestigatori P19237.

    Family and domain databases

    InterProi IPR001978. Troponin.
    [Graphical view ]
    Pfami PF00992. Troponin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I."
      Wade R., Eddy R., Shows T.B., Kedes L.
      Genomics 7:346-357(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Skeletal muscle.
    2. "Structure and expression of the human slow twitch skeletal muscle troponin I gene."
      Corin S.J., Juhasz O., Zhu L., Conley P., Kedes L., Wade R.
      J. Biol. Chem. 269:10651-10659(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Tissue: Blood.
    3. "Full length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)."
      Frigimelica E., Ievolella C., Lanfranchi G.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiTNNI1_HUMAN
    AccessioniPrimary (citable) accession number: P19237
    Secondary accession number(s): A6NEH3
    , A8MSJ0, Q659A5, Q6FGS7, Q6FGW1, Q6ICU2, Q86T57, Q96DT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3