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Protein

Troponin I, slow skeletal muscle

Gene

TNNI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi106 – 117By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159173-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene namesi
Name:TNNI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11945. TNNI1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7135.
OpenTargetsiENSG00000159173.
PharmGKBiPA36634.

Polymorphism and mutation databases

BioMutaiTNNI1.
DMDMi1351298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861392 – 187Troponin I, slow skeletal muscleAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP19237.
PeptideAtlasiP19237.
PRIDEiP19237.

PTM databases

iPTMnetiP19237.
PhosphoSitePlusiP19237.

Expressioni

Tissue specificityi

Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.2 Publications

Gene expression databases

BgeeiENSG00000159173.
ExpressionAtlasiP19237. baseline and differential.
GenevisibleiP19237. HS.

Organism-specific databases

HPAiHPA028190.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-746692,EBI-724076
PNMA1Q8ND905EBI-746692,EBI-302345
TNNC1P633163EBI-746692,EBI-3906339

Protein-protein interaction databases

BioGridi112989. 14 interactors.
IntActiP19237. 4 interactors.
MINTiMINT-1467470.
STRINGi9606.ENSP00000337022.

Structurei

3D structure databases

ProteinModelPortaliP19237.
SMRiP19237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 118Involved in binding TNC and actinAdd BLAST22

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOVERGENiHBG052737.
InParanoidiP19237.
KOiK10371.
PhylomeDBiP19237.
TreeFamiTF313374.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP
60 70 80 90 100
TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK
110 120 130 140 150
VMDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT
160 170 180
EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ
Length:187
Mass (Da):21,692
Last modified:January 23, 2007 - v3
Checksum:i7A8363CC7559B962
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 5VE → FQ in AC096677 (PubMed:16710414).Curated2
Sequence conflicti30W → R in CAG29297 (Ref. 4) Curated1
Sequence conflicti103D → A in CAD91135 (PubMed:17974005).Curated1
Sequence conflicti131K → R in CAC44240 (Ref. 3) Curated1
Sequence conflicti143K → T in CAG46793 (Ref. 4) Curated1
Sequence conflicti182 – 183KS → NA in AAA61228 (PubMed:2365354).Curated2
Sequence conflicti182 – 183KS → NA in CAG46827 (Ref. 4) Curated2
Sequence conflicti182 – 183KS → NA in CAG46793 (Ref. 4) Curated2
Sequence conflicti182 – 183KS → NA in CAG29297 (Ref. 4) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05240367R → W.Corresponds to variant rs2296695dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04760 mRNA. Translation: AAA61228.1.
L21910
, L21906, L21908, L21909 Genomic DNA. Translation: AAC14461.1.
AJ315823 mRNA. Translation: CAC44240.1.
CR450301 mRNA. Translation: CAG29297.1.
CR541996 mRNA. Translation: CAG46793.1.
CR542030 mRNA. Translation: CAG46827.1.
AL831820 mRNA. Translation: CAD38534.1.
AL831975 mRNA. Translation: CAH56221.1.
BX510903 mRNA. Translation: CAD91135.1.
AK223588 mRNA. Translation: BAD97308.1.
AK311896 mRNA. Translation: BAG34837.1.
AC096677 Genomic DNA. No translation available.
BC012600 mRNA. Translation: AAH12600.1.
BC012601 mRNA. Translation: AAH12601.1.
CCDSiCCDS1411.1.
PIRiA53740. TPHUIW.
RefSeqiNP_003272.3. NM_003281.3.
UniGeneiHs.320890.

Genome annotation databases

EnsembliENST00000336092; ENSP00000337022; ENSG00000159173.
ENST00000361379; ENSP00000354488; ENSG00000159173.
ENST00000367312; ENSP00000356281; ENSG00000159173.
GeneIDi7135.
KEGGihsa:7135.
UCSCiuc057oib.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04760 mRNA. Translation: AAA61228.1.
L21910
, L21906, L21908, L21909 Genomic DNA. Translation: AAC14461.1.
AJ315823 mRNA. Translation: CAC44240.1.
CR450301 mRNA. Translation: CAG29297.1.
CR541996 mRNA. Translation: CAG46793.1.
CR542030 mRNA. Translation: CAG46827.1.
AL831820 mRNA. Translation: CAD38534.1.
AL831975 mRNA. Translation: CAH56221.1.
BX510903 mRNA. Translation: CAD91135.1.
AK223588 mRNA. Translation: BAD97308.1.
AK311896 mRNA. Translation: BAG34837.1.
AC096677 Genomic DNA. No translation available.
BC012600 mRNA. Translation: AAH12600.1.
BC012601 mRNA. Translation: AAH12601.1.
CCDSiCCDS1411.1.
PIRiA53740. TPHUIW.
RefSeqiNP_003272.3. NM_003281.3.
UniGeneiHs.320890.

3D structure databases

ProteinModelPortaliP19237.
SMRiP19237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112989. 14 interactors.
IntActiP19237. 4 interactors.
MINTiMINT-1467470.
STRINGi9606.ENSP00000337022.

PTM databases

iPTMnetiP19237.
PhosphoSitePlusiP19237.

Polymorphism and mutation databases

BioMutaiTNNI1.
DMDMi1351298.

Proteomic databases

PaxDbiP19237.
PeptideAtlasiP19237.
PRIDEiP19237.

Protocols and materials databases

DNASUi7135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336092; ENSP00000337022; ENSG00000159173.
ENST00000361379; ENSP00000354488; ENSG00000159173.
ENST00000367312; ENSP00000356281; ENSG00000159173.
GeneIDi7135.
KEGGihsa:7135.
UCSCiuc057oib.1. human.

Organism-specific databases

CTDi7135.
DisGeNETi7135.
GeneCardsiTNNI1.
HGNCiHGNC:11945. TNNI1.
HPAiHPA028190.
MIMi191042. gene.
neXtProtiNX_P19237.
OpenTargetsiENSG00000159173.
PharmGKBiPA36634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOVERGENiHBG052737.
InParanoidiP19237.
KOiK10371.
PhylomeDBiP19237.
TreeFamiTF313374.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159173-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSiTNNI1. human.
GeneWikiiTNNI1.
GenomeRNAii7135.
PROiP19237.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159173.
ExpressionAtlasiP19237. baseline and differential.
GenevisibleiP19237. HS.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI1_HUMAN
AccessioniPrimary (citable) accession number: P19237
Secondary accession number(s): A6NEH3
, A8MSJ0, Q659A5, Q6FGS7, Q6FGW1, Q6ICU2, Q86T57, Q96DT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.