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P19234

- NDUV2_RAT

UniProt

P19234 - NDUV2_RAT

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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Gene

Ndufv2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[2Fe-2S] clusterCuratedNote: Binds 1 [2Fe-2S] cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi139 – 1391Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi175 – 1751Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi179 – 1791Iron-sulfur (2Fe-2S)Sequence Analysis

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. electron carrier activity Source: RefGenome
  3. metal ion binding Source: UniProtKB-KW
  4. NADH dehydrogenase (ubiquinone) activity Source: RefGenome

GO - Biological processi

  1. cardiac muscle tissue development Source: Ensembl
  2. mitochondrial electron transport, NADH to ubiquinone Source: RefGenome
  3. nervous system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_262146. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH-ubiquinone oxidoreductase 24 kDa subunit
Gene namesi
Name:Ndufv2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi621733. Ndufv2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex I Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionAdd
BLAST
Chaini32 – 248217NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialPRO_0000020005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921Phosphotyrosine; by SRCBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19234.
PRIDEiP19234.

2D gel databases

UCD-2DPAGEP19234.

Miscellaneous databases

PMAP-CutDBP19234.

Expressioni

Gene expression databases

GenevestigatoriP19234.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Protein-protein interaction databases

BioGridi249601. 1 interaction.
IntActiP19234. 1 interaction.
STRINGi10116.ENSRNOP00000016965.

Structurei

3D structure databases

ProteinModelPortaliP19234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 24 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1905.
GeneTreeiENSGT00390000017580.
HOGENOMiHOG000257748.
HOVERGENiHBG029601.
InParanoidiP19234.
KOiK03943.
OMAiVHRDTPY.
OrthoDBiEOG73JKW9.
PhylomeDBiP19234.
TreeFamiTF300004.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10371. PTHR10371. 1 hit.
PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19234-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSLALRARA SGLTAQWGRH ARNLHKTAVQ NGAGGALFVH RDTPENNPDT
60 70 80 90 100
PFDFTPENYE RIEAIVRNYP EGHRAAAVLP VLDLAQRQNG WLPISAMNKV
110 120 130 140 150
AEVLQVPPMR VYEVATFYTM YNRKPVGKYH IQVCTTTPCM LRDSDSILET
160 170 180 190 200
LQRKLGIKVG ETTPDKLFTL IEVECLGACV NAPMVQINDD YYEDLTPKDI
210 220 230 240
EEIIDELRAG KVPKPGPRSG RFCCEPAGGL TSLTEPPKGP GFGVQAGL
Length:248
Mass (Da):27,378
Last modified:December 6, 2005 - v2
Checksum:i3A6AA85BB7A870B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti245 – 2451Q → P in AAA41669. (PubMed:2974699)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058495 mRNA. Translation: AAH58495.1.
M22756 mRNA. Translation: AAA41669.1.
PIRiA31868.
RefSeqiNP_112326.1. NM_031064.2.
UniGeneiRn.28882.

Genome annotation databases

EnsembliENSRNOT00000016965; ENSRNOP00000016965; ENSRNOG00000042503.
GeneIDi81728.
KEGGirno:81728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058495 mRNA. Translation: AAH58495.1 .
M22756 mRNA. Translation: AAA41669.1 .
PIRi A31868.
RefSeqi NP_112326.1. NM_031064.2.
UniGenei Rn.28882.

3D structure databases

ProteinModelPortali P19234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249601. 1 interaction.
IntActi P19234. 1 interaction.
STRINGi 10116.ENSRNOP00000016965.

2D gel databases

UCD-2DPAGE P19234.

Proteomic databases

PaxDbi P19234.
PRIDEi P19234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016965 ; ENSRNOP00000016965 ; ENSRNOG00000042503 .
GeneIDi 81728.
KEGGi rno:81728.

Organism-specific databases

CTDi 4729.
RGDi 621733. Ndufv2.

Phylogenomic databases

eggNOGi COG1905.
GeneTreei ENSGT00390000017580.
HOGENOMi HOG000257748.
HOVERGENi HBG029601.
InParanoidi P19234.
KOi K03943.
OMAi VHRDTPY.
OrthoDBi EOG73JKW9.
PhylomeDBi P19234.
TreeFami TF300004.

Enzyme and pathway databases

Reactomei REACT_262146. Respiratory electron transport.

Miscellaneous databases

NextBioi 615388.
PMAP-CutDB P19234.
PROi P19234.

Gene expression databases

Genevestigatori P19234.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10371. PTHR10371. 1 hit.
PIRSFi PIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
PROSITEi PS01099. COMPLEX1_24K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  2. "The amino acid sequence of the 24-kDa subunit, an iron-sulfur protein, of rat liver mitochondrial NADH dehydrogenase deduced from cDNA sequence."
    Nishikimi M., Hosokawa Y., Toda H., Suzuki H., Ozawa T.
    Biochem. Biophys. Res. Commun. 157:914-920(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-248.
  3. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 42-61; 75-87; 199-208 AND 222-248, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiNDUV2_RAT
AccessioniPrimary (citable) accession number: P19234
Secondary accession number(s): Q6PDU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3