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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Gene

Ndufv2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[2Fe-2S] clusterCuratedNote: Binds 1 [2Fe-2S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi139Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi175Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi179Iron-sulfur (2Fe-2S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.
R-RNO-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH-ubiquinone oxidoreductase 24 kDa subunit
Gene namesi
Name:Ndufv2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621733. Ndufv2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionAdd BLAST31
ChainiPRO_000002000532 – 248NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192Phosphotyrosine; by SRCBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19234.
PRIDEiP19234.

2D gel databases

UCD-2DPAGEiP19234.

PTM databases

iPTMnetiP19234.
PhosphoSitePlusiP19234.

Miscellaneous databases

PMAP-CutDBiP19234.

Expressioni

Gene expression databases

BgeeiENSRNOG00000042503.
GenevisibleiP19234. RN.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Protein-protein interaction databases

BioGridi249601. 2 interactors.
IntActiP19234. 1 interactor.
STRINGi10116.ENSRNOP00000016965.

Structurei

3D structure databases

ProteinModelPortaliP19234.
SMRiP19234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 24 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3196. Eukaryota.
COG1905. LUCA.
GeneTreeiENSGT00390000017580.
HOGENOMiHOG000257748.
HOVERGENiHBG029601.
InParanoidiP19234.
KOiK03943.
OMAiLTAKDMQ.
OrthoDBiEOG091G0GRD.
PhylomeDBiP19234.
TreeFamiTF300004.

Family and domain databases

CDDicd03064. TRX_Fd_NuoE. 1 hit.
InterProiView protein in InterPro
IPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR10371. PTHR10371. 1 hit.
PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiView protein in PROSITE
PS01099. COMPLEX1_24K. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLALRARA SGLTAQWGRH ARNLHKTAVQ NGAGGALFVH RDTPENNPDT
60 70 80 90 100
PFDFTPENYE RIEAIVRNYP EGHRAAAVLP VLDLAQRQNG WLPISAMNKV
110 120 130 140 150
AEVLQVPPMR VYEVATFYTM YNRKPVGKYH IQVCTTTPCM LRDSDSILET
160 170 180 190 200
LQRKLGIKVG ETTPDKLFTL IEVECLGACV NAPMVQINDD YYEDLTPKDI
210 220 230 240
EEIIDELRAG KVPKPGPRSG RFCCEPAGGL TSLTEPPKGP GFGVQAGL
Length:248
Mass (Da):27,378
Last modified:December 6, 2005 - v2
Checksum:i3A6AA85BB7A870B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245Q → P in AAA41669 (PubMed:2974699).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058495 mRNA. Translation: AAH58495.1.
M22756 mRNA. Translation: AAA41669.1.
PIRiA31868.
RefSeqiNP_112326.1. NM_031064.2.
UniGeneiRn.28882.

Genome annotation databases

EnsembliENSRNOT00000016965; ENSRNOP00000016965; ENSRNOG00000042503.
GeneIDi81728.
KEGGirno:81728.

Similar proteinsi

Entry informationi

Entry nameiNDUV2_RAT
AccessioniPrimary (citable) accession number: P19234
Secondary accession number(s): Q6PDU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 6, 2005
Last modified: August 30, 2017
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families