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P19234 (NDUV2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH-ubiquinone oxidoreductase 24 kDa subunit
Gene names
Name:Ndufv2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 2Fe-2S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the complex I 24 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3131Mitochondrion
Chain32 – 248217NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
PRO_0000020005

Sites

Metal binding1341Iron-sulfur (2Fe-2S) Potential
Metal binding1391Iron-sulfur (2Fe-2S) Potential
Metal binding1751Iron-sulfur (2Fe-2S) Potential
Metal binding1791Iron-sulfur (2Fe-2S) Potential

Amino acid modifications

Modified residue1921Phosphotyrosine; by SRC By similarity

Experimental info

Sequence conflict2451Q → P in AAA41669. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P19234 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 3A6AA85BB7A870B8

FASTA24827,378
        10         20         30         40         50         60 
MFSLALRARA SGLTAQWGRH ARNLHKTAVQ NGAGGALFVH RDTPENNPDT PFDFTPENYE 

        70         80         90        100        110        120 
RIEAIVRNYP EGHRAAAVLP VLDLAQRQNG WLPISAMNKV AEVLQVPPMR VYEVATFYTM 

       130        140        150        160        170        180 
YNRKPVGKYH IQVCTTTPCM LRDSDSILET LQRKLGIKVG ETTPDKLFTL IEVECLGACV 

       190        200        210        220        230        240 
NAPMVQINDD YYEDLTPKDI EEIIDELRAG KVPKPGPRSG RFCCEPAGGL TSLTEPPKGP 


GFGVQAGL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[2]"The amino acid sequence of the 24-kDa subunit, an iron-sulfur protein, of rat liver mitochondrial NADH dehydrogenase deduced from cDNA sequence."
Nishikimi M., Hosokawa Y., Toda H., Suzuki H., Ozawa T.
Biochem. Biophys. Res. Commun. 157:914-920(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-248.
[3]Lubec G., Chen W.-Q.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 42-61; 75-87; 199-208 AND 222-248, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC058495 mRNA. Translation: AAH58495.1.
M22756 mRNA. Translation: AAA41669.1.
PIRA31868.
RefSeqNP_112326.1. NM_031064.2.
UniGeneRn.28882.

3D structure databases

ProteinModelPortalP19234.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP19234. 1 interaction.
STRING10116.ENSRNOP00000016965.

2D gel databases

UCD-2DPAGEP19234.

Proteomic databases

PaxDbP19234.
PRIDEP19234.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016965; ENSRNOP00000016965; ENSRNOG00000042503.
GeneID81728.
KEGGrno:81728.

Organism-specific databases

CTD4729.
RGD621733. Ndufv2.

Phylogenomic databases

eggNOGCOG1905.
GeneTreeENSGT00390000017580.
HOGENOMHOG000257748.
HOVERGENHBG029601.
InParanoidP19234.
KOK03943.
OMAVHRDTPY.
OrthoDBEOG73JKW9.
PhylomeDBP19234.
TreeFamTF300004.

Gene expression databases

GenevestigatorP19234.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR10371. PTHR10371. 1 hit.
PIRSFPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01958. nuoE_fam. 1 hit.
PROSITEPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615388.
PMAP-CutDBP19234.
PROP19234.

Entry information

Entry nameNDUV2_RAT
AccessionPrimary (citable) accession number: P19234
Secondary accession number(s): Q6PDU9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 6, 2005
Last modified: June 11, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families