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Protein

Alpha-S1-casein

Gene

Csn1s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Short name:
Alpha-casein
Gene namesi
Name:Csn1s1
Synonyms:Csn1, Csna
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88540. Csn1s1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Chaini16 – 313298Alpha-S1-caseinPRO_0000004457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911PhosphoserineBy similarity
Modified residuei93 – 931PhosphoserineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei95 – 951PhosphoserineBy similarity
Modified residuei96 – 961PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19228.
PRIDEiP19228.

PTM databases

PhosphoSiteiP19228.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiP19228.
CleanExiMM_CSN1S1.
ExpressionAtlasiP19228. baseline and differential.
GenevisibleiP19228. MM.

Interactioni

Protein-protein interaction databases

IntActiP19228. 2 interactions.
STRINGi10090.ENSMUSP00000092225.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati135 – 14061
Repeati141 – 14662
Repeati147 – 15263
Repeati153 – 15864
Repeati159 – 16465
Repeati165 – 17066
Repeati171 – 17667
Repeati177 – 18268
Repeati183 – 18869
Repeati189 – 194610
Repeati195 – 200611
Repeati201 – 206612
Repeati207 – 212613
Repeati213 – 218614
Repeati219 – 224615

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 2249015 X 6 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J2MD. Eukaryota.
ENOG41114JX. LUCA.
GeneTreeiENSGT00730000113823.
HOGENOMiHOG000214193.
HOVERGENiHBG098347.
InParanoidiP19228.
OMAiRMNAYSQ.
OrthoDBiEOG7W1561.
TreeFamiTF340763.

Family and domain databases

InterProiIPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLILTCLV AAAFAMPRLH SRNAVSSQTQ QQHSSSEEIF KQPKYLNLNQ
60 70 80 90 100
EFVNNMNRQR ALLTEQNDEI KVTMDAASEE QAMASAQEDS SISSSSEESE
110 120 130 140 150
EAIPNITEQK NIANEDMLNQ CTLEQLQRQF KYNQLLQKAS LAKQASLFQQ
160 170 180 190 200
PSLVQQASLF QQPSLLQQAS LFQQPSMAQQ ASLLQQLLLA QQPSLALQVS
210 220 230 240 250
PAQQSSLVQQ AFLAQQASLA QKHHPRLSQS YYPHMEQPYR MNAYSQVQMR
260 270 280 290 300
HPMSVVDQAL AQFSVQPFPQ IFQYDAFPLW AYFPQDMQYL TPKAVLNTFK
310
PIVSKDTEKT NVW
Length:313
Mass (Da):35,602
Last modified:November 1, 1990 - v1
Checksum:i7006C03C59409D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36780 mRNA. Translation: AAA37142.1.
BC003859 mRNA. Translation: AAH03859.1.
CCDSiCCDS51534.1.
PIRiA36060.
RefSeqiNP_001272944.1. NM_001286015.1.
NP_001272945.1. NM_001286016.1.
NP_031810.1. NM_007784.3.
UniGeneiMm.427467.

Genome annotation databases

EnsembliENSMUST00000094641; ENSMUSP00000092225; ENSMUSG00000070702.
GeneIDi12990.
KEGGimmu:12990.
UCSCiuc029vix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36780 mRNA. Translation: AAA37142.1.
BC003859 mRNA. Translation: AAH03859.1.
CCDSiCCDS51534.1.
PIRiA36060.
RefSeqiNP_001272944.1. NM_001286015.1.
NP_001272945.1. NM_001286016.1.
NP_031810.1. NM_007784.3.
UniGeneiMm.427467.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19228. 2 interactions.
STRINGi10090.ENSMUSP00000092225.

PTM databases

PhosphoSiteiP19228.

Proteomic databases

PaxDbiP19228.
PRIDEiP19228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094641; ENSMUSP00000092225; ENSMUSG00000070702.
GeneIDi12990.
KEGGimmu:12990.
UCSCiuc029vix.2. mouse.

Organism-specific databases

CTDi1446.
MGIiMGI:88540. Csn1s1.

Phylogenomic databases

eggNOGiENOG410J2MD. Eukaryota.
ENOG41114JX. LUCA.
GeneTreeiENSGT00730000113823.
HOGENOMiHOG000214193.
HOVERGENiHBG098347.
InParanoidiP19228.
OMAiRMNAYSQ.
OrthoDBiEOG7W1561.
TreeFamiTF340763.

Miscellaneous databases

ChiTaRSiCsn1s1. mouse.
PROiP19228.
SOURCEiSearch...

Gene expression databases

BgeeiP19228.
CleanExiMM_CSN1S1.
ExpressionAtlasiP19228. baseline and differential.
GenevisibleiP19228. MM.

Family and domain databases

InterProiIPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCASA1_MOUSE
AccessioniPrimary (citable) accession number: P19228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.