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P19225 (CP270_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome P450 2C70
EC=1.14.14.1
Alternative name(s):
CYPIIC70
Cytochrome P-450Md
Cytochrome P450 P49
Gene names
Name:Cyp2c70
Synonyms:Cyp2c-70, Cyp2c22, P450md
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Cytochrome P450 2C70
PRO_0000051727

Sites

Metal binding4341Iron (heme axial ligand)

Experimental info

Sequence conflict501I → M in AAA40950. Ref.2
Sequence conflict1771V → L in AAA40950. Ref.2
Sequence conflict4561T → I in AAA40950. Ref.2
Sequence conflict4781V → L in AAA40950. Ref.2
Sequence conflict4831E → Q in AAA40950. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P19225 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: E4C5B082AB81CB4D

FASTA48956,157
        10         20         30         40         50         60 
MALFIFLGIW LSCLVFLFLW NQHHVRRKLP PGPTPLPIFG NILQVGVKNI SKSMCMLAKE 

        70         80         90        100        110        120 
YGPVFTMYLG MKPTVVLYGY EVLKEALIDR GEEFSDKMHS SMLSKVSQGL GIVFSNGEIW 

       130        140        150        160        170        180 
KQTRRFSLMV LRSMGMGKRT IENRIQEEVV YLLEALRKTN GSPCDPSFLL ACVPCNVISS 

       190        200        210        220        230        240 
VIFQHRFDYS DEKFQKFIEN FHTKIEILAS PWAQLCSAYP VLYYLPGIHN KFLKDVTEQK 

       250        260        270        280        290        300 
KFILMEINRH RASLNLSNPQ DFIDYFLIKM EKEKHNEKSE FTMDNLIVTI GDLFGAGTET 

       310        320        330        340        350        360 
TSSTIKYGLL LLLKYPEVTA KIQEEITRVI GRHRRPCMQD RNHMPYTDAV LHEIQRYIDF 

       370        380        390        400        410        420 
VPIPLPRKTT QDVEFRGYHI PKGTSVMACL TSALHDDKEF PNPEKFDPGH FLDEKGNFKK 

       430        440        450        460        470        480 
SDYFMAFSAG RRACIGEGLA RMEMFLILTS ILQHFTLKPL VNPEDIDTTP VQPGLLSVPP 


PFELCFIPV

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References

[1]"cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats."
Nagata K., Sasamura H., Miyata M., Shimada M., Yamazoe Y., Kato R.
Nucleic Acids Res. 18:4934-4934(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[2]"A different cytochrome P450 form is induced in primary cultures of rat hepatocytes."
Emi Y., Chijiiwa C., Omura T.
Proc. Natl. Acad. Sci. U.S.A. 87:9746-9750(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X53477 mRNA. Translation: CAA37570.1.
M58041 mRNA. Translation: AAA40950.1.
IPIIPI00778443.
PIRA39257. S11160.
RefSeqNP_612521.1. NM_138512.1.
UniGeneRn.88025.

3D structure databases

ProteinModelPortalP19225.
SMRP19225. Positions 30-489.
ModBaseSearch...

Proteomic databases

PaxDbP19225.
PRIDEP19225.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000054724; ENSRNOP00000051607; ENSRNOG00000021924.
GeneID171518.
KEGGrno:171518.
UCSCRGD:620368. rat.

Organism-specific databases

CTD171518.
RGD620368. Cyp2c22.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
KOK07413.
OrthoDBEOG48WC22.

Gene expression databases

ArrayExpressP19225.
GenevestigatorP19225.
GermOnlineENSRNOG00000021924. Rattus norvegicus.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio622489.

Entry information

Entry nameCP270_RAT
AccessionPrimary (citable) accession number: P19225
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 3, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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