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P19225

- CP270_RAT

UniProt

P19225 - CP270_RAT

Protein

Cytochrome P450 2C70

Gene

Cyp2c70

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi434 – 4341Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C70 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC70
    Cytochrome P-450Md
    Cytochrome P450 P49
    Gene namesi
    Name:Cyp2c70
    Synonyms:Cyp2c-70, Cyp2c22, P450md
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620368. Cyp2c22.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Cytochrome P450 2C70PRO_0000051727Add
    BLAST

    Proteomic databases

    PaxDbiP19225.
    PRIDEiP19225.

    Expressioni

    Gene expression databases

    GenevestigatoriP19225.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4563718.

    Structurei

    3D structure databases

    ProteinModelPortaliP19225.
    SMRiP19225. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    KOiK07413.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP19225.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19225-1 [UniParc]FASTAAdd to Basket

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    MALFIFLGIW LSCLVFLFLW NQHHVRRKLP PGPTPLPIFG NILQVGVKNI    50
    SKSMCMLAKE YGPVFTMYLG MKPTVVLYGY EVLKEALIDR GEEFSDKMHS 100
    SMLSKVSQGL GIVFSNGEIW KQTRRFSLMV LRSMGMGKRT IENRIQEEVV 150
    YLLEALRKTN GSPCDPSFLL ACVPCNVISS VIFQHRFDYS DEKFQKFIEN 200
    FHTKIEILAS PWAQLCSAYP VLYYLPGIHN KFLKDVTEQK KFILMEINRH 250
    RASLNLSNPQ DFIDYFLIKM EKEKHNEKSE FTMDNLIVTI GDLFGAGTET 300
    TSSTIKYGLL LLLKYPEVTA KIQEEITRVI GRHRRPCMQD RNHMPYTDAV 350
    LHEIQRYIDF VPIPLPRKTT QDVEFRGYHI PKGTSVMACL TSALHDDKEF 400
    PNPEKFDPGH FLDEKGNFKK SDYFMAFSAG RRACIGEGLA RMEMFLILTS 450
    ILQHFTLKPL VNPEDIDTTP VQPGLLSVPP PFELCFIPV 489
    Length:489
    Mass (Da):56,157
    Last modified:November 1, 1990 - v1
    Checksum:iE4C5B082AB81CB4D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501I → M in AAA40950. (PubMed:2263625)Curated
    Sequence conflicti177 – 1771V → L in AAA40950. (PubMed:2263625)Curated
    Sequence conflicti456 – 4561T → I in AAA40950. (PubMed:2263625)Curated
    Sequence conflicti478 – 4781V → L in AAA40950. (PubMed:2263625)Curated
    Sequence conflicti483 – 4831E → Q in AAA40950. (PubMed:2263625)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53477 mRNA. Translation: CAA37570.1.
    M58041 mRNA. Translation: AAA40950.1.
    PIRiS11160. A39257.
    RefSeqiNP_612521.1. NM_138512.1.
    UniGeneiRn.88025.

    Genome annotation databases

    EnsembliENSRNOT00000054724; ENSRNOP00000051607; ENSRNOG00000021924.
    GeneIDi171518.
    KEGGirno:171518.
    UCSCiRGD:620368. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53477 mRNA. Translation: CAA37570.1 .
    M58041 mRNA. Translation: AAA40950.1 .
    PIRi S11160. A39257.
    RefSeqi NP_612521.1. NM_138512.1.
    UniGenei Rn.88025.

    3D structure databases

    ProteinModelPortali P19225.
    SMRi P19225. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4563718.

    Proteomic databases

    PaxDbi P19225.
    PRIDEi P19225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000054724 ; ENSRNOP00000051607 ; ENSRNOG00000021924 .
    GeneIDi 171518.
    KEGGi rno:171518.
    UCSCi RGD:620368. rat.

    Organism-specific databases

    CTDi 171518.
    RGDi 620368. Cyp2c22.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    KOi K07413.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P19225.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 622489.

    Gene expression databases

    Genevestigatori P19225.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats."
      Nagata K., Sasamura H., Miyata M., Shimada M., Yamazoe Y., Kato R.
      Nucleic Acids Res. 18:4934-4934(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "A different cytochrome P450 form is induced in primary cultures of rat hepatocytes."
      Emi Y., Chijiiwa C., Omura T.
      Proc. Natl. Acad. Sci. U.S.A. 87:9746-9750(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP270_RAT
    AccessioniPrimary (citable) accession number: P19225
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3