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Protein

Cytochrome P450 2C70

Gene

Cyp2c70

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi434Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C70 (EC:1.14.14.1)
Alternative name(s):
CYPIIC70
Cytochrome P-450Md
Cytochrome P450 P49
Gene namesi
Name:Cyp2c70
Synonyms:Cyp2c-70, Cyp2c22, P450md
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620368 Cyp2c22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517271 – 489Cytochrome P450 2C70Add BLAST489

Proteomic databases

PaxDbiP19225
PRIDEiP19225

PTM databases

iPTMnetiP19225
PhosphoSitePlusiP19225

Expressioni

Gene expression databases

BgeeiENSRNOG00000021924
ExpressionAtlasiP19225 baseline and differential
GenevisibleiP19225 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051607

Structurei

3D structure databases

ProteinModelPortaliP19225
SMRiP19225
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP19225
KOiK07413
OMAiRSVAAEC
OrthoDBiEOG091G0BT8
PhylomeDBiP19225
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P19225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFIFLGIW LSCLVFLFLW NQHHVRRKLP PGPTPLPIFG NILQVGVKNI
60 70 80 90 100
SKSMCMLAKE YGPVFTMYLG MKPTVVLYGY EVLKEALIDR GEEFSDKMHS
110 120 130 140 150
SMLSKVSQGL GIVFSNGEIW KQTRRFSLMV LRSMGMGKRT IENRIQEEVV
160 170 180 190 200
YLLEALRKTN GSPCDPSFLL ACVPCNVISS VIFQHRFDYS DEKFQKFIEN
210 220 230 240 250
FHTKIEILAS PWAQLCSAYP VLYYLPGIHN KFLKDVTEQK KFILMEINRH
260 270 280 290 300
RASLNLSNPQ DFIDYFLIKM EKEKHNEKSE FTMDNLIVTI GDLFGAGTET
310 320 330 340 350
TSSTIKYGLL LLLKYPEVTA KIQEEITRVI GRHRRPCMQD RNHMPYTDAV
360 370 380 390 400
LHEIQRYIDF VPIPLPRKTT QDVEFRGYHI PKGTSVMACL TSALHDDKEF
410 420 430 440 450
PNPEKFDPGH FLDEKGNFKK SDYFMAFSAG RRACIGEGLA RMEMFLILTS
460 470 480
ILQHFTLKPL VNPEDIDTTP VQPGLLSVPP PFELCFIPV
Length:489
Mass (Da):56,157
Last modified:November 1, 1990 - v1
Checksum:iE4C5B082AB81CB4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50I → M in AAA40950 (PubMed:2263625).Curated1
Sequence conflicti177V → L in AAA40950 (PubMed:2263625).Curated1
Sequence conflicti456T → I in AAA40950 (PubMed:2263625).Curated1
Sequence conflicti478V → L in AAA40950 (PubMed:2263625).Curated1
Sequence conflicti483E → Q in AAA40950 (PubMed:2263625).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53477 mRNA Translation: CAA37570.1
M58041 mRNA Translation: AAA40950.1
PIRiS11160 A39257
RefSeqiNP_612521.1, NM_138512.1
UniGeneiRn.88025

Genome annotation databases

EnsembliENSRNOT00000054724; ENSRNOP00000051607; ENSRNOG00000021924
GeneIDi171518
KEGGirno:171518
UCSCiRGD:620368 rat

Similar proteinsi

Entry informationi

Entry nameiCP270_RAT
AccessioniPrimary (citable) accession number: P19225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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