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P19225

- CP270_RAT

UniProt

P19225 - CP270_RAT

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Protein

Cytochrome P450 2C70

Gene
Cyp2c70, Cyp2c-70, Cyp2c22, P450md
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi434 – 4341Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C70 (EC:1.14.14.1)
Alternative name(s):
CYPIIC70
Cytochrome P-450Md
Cytochrome P450 P49
Gene namesi
Name:Cyp2c70
Synonyms:Cyp2c-70, Cyp2c22, P450md
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi620368. Cyp2c22.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. intracellular membrane-bounded organelle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Cytochrome P450 2C70PRO_0000051727Add
BLAST

Proteomic databases

PaxDbiP19225.
PRIDEiP19225.

Expressioni

Gene expression databases

GenevestigatoriP19225.

Interactioni

Protein-protein interaction databases

MINTiMINT-4563718.

Structurei

3D structure databases

ProteinModelPortaliP19225.
SMRiP19225. Positions 30-489.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00680000099783.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
KOiK07413.
OrthoDBiEOG7RBZ85.
PhylomeDBiP19225.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19225-1 [UniParc]FASTAAdd to Basket

« Hide

MALFIFLGIW LSCLVFLFLW NQHHVRRKLP PGPTPLPIFG NILQVGVKNI    50
SKSMCMLAKE YGPVFTMYLG MKPTVVLYGY EVLKEALIDR GEEFSDKMHS 100
SMLSKVSQGL GIVFSNGEIW KQTRRFSLMV LRSMGMGKRT IENRIQEEVV 150
YLLEALRKTN GSPCDPSFLL ACVPCNVISS VIFQHRFDYS DEKFQKFIEN 200
FHTKIEILAS PWAQLCSAYP VLYYLPGIHN KFLKDVTEQK KFILMEINRH 250
RASLNLSNPQ DFIDYFLIKM EKEKHNEKSE FTMDNLIVTI GDLFGAGTET 300
TSSTIKYGLL LLLKYPEVTA KIQEEITRVI GRHRRPCMQD RNHMPYTDAV 350
LHEIQRYIDF VPIPLPRKTT QDVEFRGYHI PKGTSVMACL TSALHDDKEF 400
PNPEKFDPGH FLDEKGNFKK SDYFMAFSAG RRACIGEGLA RMEMFLILTS 450
ILQHFTLKPL VNPEDIDTTP VQPGLLSVPP PFELCFIPV 489
Length:489
Mass (Da):56,157
Last modified:November 1, 1990 - v1
Checksum:iE4C5B082AB81CB4D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501I → M in AAA40950. 1 Publication
Sequence conflicti177 – 1771V → L in AAA40950. 1 Publication
Sequence conflicti456 – 4561T → I in AAA40950. 1 Publication
Sequence conflicti478 – 4781V → L in AAA40950. 1 Publication
Sequence conflicti483 – 4831E → Q in AAA40950. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53477 mRNA. Translation: CAA37570.1.
M58041 mRNA. Translation: AAA40950.1.
PIRiS11160. A39257.
RefSeqiNP_612521.1. NM_138512.1.
UniGeneiRn.88025.

Genome annotation databases

EnsembliENSRNOT00000054724; ENSRNOP00000051607; ENSRNOG00000021924.
GeneIDi171518.
KEGGirno:171518.
UCSCiRGD:620368. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53477 mRNA. Translation: CAA37570.1 .
M58041 mRNA. Translation: AAA40950.1 .
PIRi S11160. A39257.
RefSeqi NP_612521.1. NM_138512.1.
UniGenei Rn.88025.

3D structure databases

ProteinModelPortali P19225.
SMRi P19225. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4563718.

Proteomic databases

PaxDbi P19225.
PRIDEi P19225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000054724 ; ENSRNOP00000051607 ; ENSRNOG00000021924 .
GeneIDi 171518.
KEGGi rno:171518.
UCSCi RGD:620368. rat.

Organism-specific databases

CTDi 171518.
RGDi 620368. Cyp2c22.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00680000099783.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
KOi K07413.
OrthoDBi EOG7RBZ85.
PhylomeDBi P19225.
TreeFami TF352043.

Miscellaneous databases

NextBioi 622489.

Gene expression databases

Genevestigatori P19225.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats."
    Nagata K., Sasamura H., Miyata M., Shimada M., Yamazoe Y., Kato R.
    Nucleic Acids Res. 18:4934-4934(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "A different cytochrome P450 form is induced in primary cultures of rat hepatocytes."
    Emi Y., Chijiiwa C., Omura T.
    Proc. Natl. Acad. Sci. U.S.A. 87:9746-9750(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiCP270_RAT
AccessioniPrimary (citable) accession number: P19225
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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