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Protein

Carboxypeptidase B

Gene

Cpb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential release of a C-terminal lysine or arginine amino acid.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi174Zinc; catalyticBy similarity1
Metal bindingi177Zinc; catalyticBy similarity1
Binding sitei232SubstrateBy similarity1
Metal bindingi302Zinc; catalyticBy similarity1
Binding sitei354SubstrateBy similarity1
Active sitei376Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • carboxypeptidase activity Source: RGD
  • metallocarboxypeptidase activity Source: GO_Central
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase B (EC:3.4.17.2By similarity)
Gene namesi
Name:Cpb1
Synonyms:Cpb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2391. Cpb1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13By similarityAdd BLAST13
PropeptideiPRO_000000437514 – 108Activation peptide1 PublicationAdd BLAST95
ChainiPRO_0000004376109 – 415Carboxypeptidase BAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi171 ↔ 184By similarity
Disulfide bondi243 ↔ 266By similarity
Disulfide bondi257 ↔ 271By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP19223.
PRIDEiP19223.

PTM databases

PhosphoSitePlusiP19223.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048109.

Structurei

3D structure databases

ProteinModelPortaliP19223.
SMRiP19223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 177Substrate bindingBy similarity4
Regioni249 – 250Substrate bindingBy similarity2
Regioni303 – 304Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
HOGENOMiHOG000252968.
HOVERGENiHBG050815.
InParanoidiP19223.
PhylomeDBiP19223.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLALVSV ALAHASEEHF DGNRVYRVSV HGEDHVNLIQ ELANTKEIDF
60 70 80 90 100
WKPDSATQVK PLTTVDFHVK AEDVADVENF LEENEVHYEV LISNVRNALE
110 120 130 140 150
SQFDSHTRAS GHSYTKYNKW ETIEAWIQQV ATDNPDLVTQ SVIGTTFEGR
160 170 180 190 200
NMYVLKIGKT RPNKPAIFID CGFHAREWIS PAFCQWFVRE AVRTYNQEIH
210 220 230 240 250
MKQLLDELDF YVLPVVNIDG YVYTWTKDRM WRKTRSTMAG SSCLGVRPNR
260 270 280 290 300
NFNAGWCEVG ASRSPCSETY CGPAPESEKE TKALADFIRN NLSTIKAYLT
310 320 330 340 350
IHSYSQMMLY PYSYDYKLPE NYEELNALVK GAAKELATLH GTKYTYGPGA
360 370 380 390 400
TTIYPAAGGS DDWSYDQGIK YSFTFELRDT GFFGFLLPES QIRQTCEETM
410
LAVKYIANYV REHLY
Length:415
Mass (Da):47,515
Last modified:November 1, 1990 - v1
Checksum:i8EA06CCADE30B6F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23959
, M23947, M23950, M23952, M23953, M23954 Genomic DNA. Translation: AAA40872.1.
PIRiA32129.
UniGeneiRn.12780.

Genome annotation databases

UCSCiRGD:2391. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23959
, M23947, M23950, M23952, M23953, M23954 Genomic DNA. Translation: AAA40872.1.
PIRiA32129.
UniGeneiRn.12780.

3D structure databases

ProteinModelPortaliP19223.
SMRiP19223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048109.

Protein family/group databases

MEROPSiM14.003.

PTM databases

PhosphoSitePlusiP19223.

Proteomic databases

PaxDbiP19223.
PRIDEiP19223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2391. rat.

Organism-specific databases

RGDi2391. Cpb1.

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
HOGENOMiHOG000252968.
HOVERGENiHBG050815.
InParanoidiP19223.
PhylomeDBiP19223.

Miscellaneous databases

PROiP19223.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPB1_RAT
AccessioniPrimary (citable) accession number: P19223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.