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P19208 (HSP7C_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock 70 kDa protein C
Gene names
Name:hsp-3
ORF Names:CBG14829
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 661644Heat shock 70 kDa protein C
PRO_0000013540

Regions

Motif658 – 6614Prevents secretion from ER

Experimental info

Sequence conflict1261L → F in AAA28075. Ref.2
Sequence conflict1401A → S in AAA28075. Ref.2
Sequence conflict1831D → V in AAA28075. Ref.2
Sequence conflict189 – 1913TKD → LKY in AAA28075. Ref.2
Sequence conflict1961A → V in AAA28075. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P19208 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 4358AA747A128F0D

FASTA66172,945
        10         20         30         40         50         60 
MKTLFLLGLI ALTAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY KNGRVEIIAN 

        70         80         90        100        110        120 
DQGNRITPSY VAFSGEQGDR LIGDAAKNQL TINPENTIFD AKRLIGRDYN DKTVQADIKH 

       130        140        150        160        170        180 
WPFKVLDKSN KPSVEVKVGA DNKQFTPEEV SAMVLVKMKE IAESYLGKEV KHAVVTVPAY 

       190        200        210        220        230        240 
FNDAQRQATK DAGTIAGLNV VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML 

       250        260        270        280        290        300 
TIDNGVFEVL ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA 

       310        320        330        340        350        360 
KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV LEDSDLKKDD 

       370        380        390        400        410        420 
VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA YGAAVQGGVI SGEEDTGEIV 

       430        440        450        460        470        480 
LLDVNPLTMG IETVGGVMTK LISRNTVIPT KKSQVFSTAA DNQPTVTIQV FEGERPMTKD 

       490        500        510        520        530        540 
NHQLGKFDLT GIPPAPRGVP QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP 

       550        560        570        580        590        600 
EDIERMINDA EKFAEDDKKV KEKAEARNEL ESYAYSLKNQ IGDKEKLGGK LDEDDKKTIE 

       610        620        630        640        650        660 
EAVDEAISWL GSNADASAEE LKEQKKELEG KVQPIVSKLY KDGGAGGEEA PEEGSDDKDE 


L 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics."
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. expand/collapse author list , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H.
PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AF16.
[2]"Functional elements and domains inferred from sequence comparisons of a heat shock gene in two nematodes."
Heschl M.F.P., Baillie D.L.
J. Mol. Evol. 31:3-9(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-441.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600983 Genomic DNA. Translation: CAP33250.1.
M26906 Genomic DNA. Translation: AAA28075.1.
RefSeqXP_002644811.1. XM_002644765.1.

3D structure databases

ProteinModelPortalP19208.
SMRP19208. Positions 33-575.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG14829.

Proteomic databases

PRIDEP19208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG14829; CBG14829; CBG14829.
GeneID8586807.
KEGGcbr:CBG14829.

Organism-specific databases

CTD8586807.
WormBaseCBG14829; CBP03479; WBGene00035220; Cbr-hsp-3.

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228135.
KOK09490.
OMADKRAVQK.
OrthoDBEOG780RKX.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHSP7C_CAEBR
AccessionPrimary (citable) accession number: P19208
Secondary accession number(s): A8XKS6, Q617T9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 2005
Last modified: November 13, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families