P19208 (HSP7C_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock 70 kDa protein C

Gene names

Name:	hsp-3
ORF Names:	CBG14829

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	661 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.
Subcellular location	Endoplasmic reticulum lumen.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 661	644	Heat shock 70 kDa protein C		PRO_0000013540
Regions
	Motif	658 – 661	4	Prevents secretion from ER
Experimental info
	Sequence conflict	126	1	L → F in AAA28075. Ref.2
	Sequence conflict	140	1	A → S in AAA28075. Ref.2
	Sequence conflict	183	1	D → V in AAA28075. Ref.2
	Sequence conflict	189 – 191	3	TKD → LKY in AAA28075. Ref.2
	Sequence conflict	196	1	A → V in AAA28075. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P19208 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 4358AA747A128F0D	FASTA	661	72,945
	10 20 30 40 50 60 MKTLFLLGLI ALTAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY KNGRVEIIAN 70 80 90 100 110 120 DQGNRITPSY VAFSGEQGDR LIGDAAKNQL TINPENTIFD AKRLIGRDYN DKTVQADIKH 130 140 150 160 170 180 WPFKVLDKSN KPSVEVKVGA DNKQFTPEEV SAMVLVKMKE IAESYLGKEV KHAVVTVPAY 190 200 210 220 230 240 FNDAQRQATK DAGTIAGLNV VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML 250 260 270 280 290 300 TIDNGVFEVL ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA 310 320 330 340 350 360 KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV LEDSDLKKDD 370 380 390 400 410 420 VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA YGAAVQGGVI SGEEDTGEIV 430 440 450 460 470 480 LLDVNPLTMG IETVGGVMTK LISRNTVIPT KKSQVFSTAA DNQPTVTIQV FEGERPMTKD 490 500 510 520 530 540 NHQLGKFDLT GIPPAPRGVP QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP 550 560 570 580 590 600 EDIERMINDA EKFAEDDKKV KEKAEARNEL ESYAYSLKNQ IGDKEKLGGK LDEDDKKTIE 610 620 630 640 650 660 EAVDEAISWL GSNADASAEE LKEQKKELEG KVQPIVSKLY KDGGAGGEEA PEEGSDDKDE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.
[2]	"Functional elements and domains inferred from sequence comparisons of a heat shock gene in two nematodes." Heschl M.F.P., Baillie D.L. J. Mol. Evol. 31:3-9(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-441.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE600983 Genomic DNA. Translation: CAP33250.1. M26906 Genomic DNA. Translation: AAA28075.1.
RefSeq	XP_002644811.1. XM_002644765.1.
3D structure databases
ProteinModelPortal	P19208.
SMR	P19208. Positions 33-575.
ModBase	Search...
Protein-protein interaction databases
STRING	6238.CBG14829.
Proteomic databases
PRIDE	P19208.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG14829; CBG14829; CBG14829.
GeneID	8586807.
KEGG	cbr:CBG14829.
Organism-specific databases
CTD	8586807.
WormBase	CBG14829; CBP03479; WBGene00035220; Cbr-hsp-3.
Phylogenomic databases
eggNOG	COG0443.
HOGENOM	HOG000228135.
KO	K09490.
OMA	DKRAVQK.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSP7C_CAEBR

Accession

Primary (citable) accession number: P19208
Secondary accession number(s): A8XKS6, Q617T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project