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Protein

Heat shock 70 kDa protein C

Gene

hsp-3

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein C
Gene namesi
Name:hsp-3
ORF Names:CBG14829
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG14829; CBP03479; WBGene00035220; Cbr-hsp-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 661644Heat shock 70 kDa protein CPRO_0000013540Add
BLAST

Proteomic databases

PRIDEiP19208.

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG14829.

Structurei

3D structure databases

ProteinModelPortaliP19208.
SMRiP19208. Positions 33-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi658 – 6614Prevents secretion from ER

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP19208.
KOiK09490.
OMAiNQDTEPE.
OrthoDBiEOG780RKX.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLFLLGLI ALTAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY
60 70 80 90 100
KNGRVEIIAN DQGNRITPSY VAFSGEQGDR LIGDAAKNQL TINPENTIFD
110 120 130 140 150
AKRLIGRDYN DKTVQADIKH WPFKVLDKSN KPSVEVKVGA DNKQFTPEEV
160 170 180 190 200
SAMVLVKMKE IAESYLGKEV KHAVVTVPAY FNDAQRQATK DAGTIAGLNV
210 220 230 240 250
VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML TIDNGVFEVL
260 270 280 290 300
ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA
310 320 330 340 350
KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV
360 370 380 390 400
LEDSDLKKDD VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA
410 420 430 440 450
YGAAVQGGVI SGEEDTGEIV LLDVNPLTMG IETVGGVMTK LISRNTVIPT
460 470 480 490 500
KKSQVFSTAA DNQPTVTIQV FEGERPMTKD NHQLGKFDLT GIPPAPRGVP
510 520 530 540 550
QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP EDIERMINDA
560 570 580 590 600
EKFAEDDKKV KEKAEARNEL ESYAYSLKNQ IGDKEKLGGK LDEDDKKTIE
610 620 630 640 650
EAVDEAISWL GSNADASAEE LKEQKKELEG KVQPIVSKLY KDGGAGGEEA
660
PEEGSDDKDE L
Length:661
Mass (Da):72,945
Last modified:February 1, 2005 - v2
Checksum:i4358AA747A128F0D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261L → F in AAA28075 (PubMed:2116528).Curated
Sequence conflicti140 – 1401A → S in AAA28075 (PubMed:2116528).Curated
Sequence conflicti183 – 1831D → V in AAA28075 (PubMed:2116528).Curated
Sequence conflicti189 – 1913TKD → LKY in AAA28075 (PubMed:2116528).Curated
Sequence conflicti196 – 1961A → V in AAA28075 (PubMed:2116528).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600983 Genomic DNA. Translation: CAP33250.1.
M26906 Genomic DNA. Translation: AAA28075.1.
RefSeqiXP_002644811.1. XM_002644765.1.

Genome annotation databases

EnsemblMetazoaiCBG14829; CBG14829; CBG14829.
GeneIDi8586807.
KEGGicbr:CBG14829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600983 Genomic DNA. Translation: CAP33250.1.
M26906 Genomic DNA. Translation: AAA28075.1.
RefSeqiXP_002644811.1. XM_002644765.1.

3D structure databases

ProteinModelPortaliP19208.
SMRiP19208. Positions 33-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG14829.

Proteomic databases

PRIDEiP19208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG14829; CBG14829; CBG14829.
GeneIDi8586807.
KEGGicbr:CBG14829.

Organism-specific databases

CTDi8586807.
WormBaseiCBG14829; CBP03479; WBGene00035220; Cbr-hsp-3.

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP19208.
KOiK09490.
OMAiNQDTEPE.
OrthoDBiEOG780RKX.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.
  2. "Functional elements and domains inferred from sequence comparisons of a heat shock gene in two nematodes."
    Heschl M.F.P., Baillie D.L.
    J. Mol. Evol. 31:3-9(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-441.

Entry informationi

Entry nameiHSP7C_CAEBR
AccessioniPrimary (citable) accession number: P19208
Secondary accession number(s): A8XKS6, Q617T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 2005
Last modified: July 22, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.