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P19208

- HSP7C_CAEBR

UniProt

P19208 - HSP7C_CAEBR

Protein

Heat shock 70 kDa protein C

Gene

hsp-3

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock 70 kDa protein C
    Gene namesi
    Name:hsp-3
    ORF Names:CBG14829
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG14829; CBP03479; WBGene00035220; Cbr-hsp-3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 661644Heat shock 70 kDa protein CPRO_0000013540Add
    BLAST

    Proteomic databases

    PRIDEiP19208.

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG14829.

    Structurei

    3D structure databases

    ProteinModelPortaliP19208.
    SMRiP19208. Positions 33-575.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi658 – 6614Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228135.
    KOiK09490.
    OMAiDKRAVQK.
    OrthoDBiEOG780RKX.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLFLLGLI ALTAVSVYCE EEEKTEKKET KYGTIIGIDL GTTYSCVGVY    50
    KNGRVEIIAN DQGNRITPSY VAFSGEQGDR LIGDAAKNQL TINPENTIFD 100
    AKRLIGRDYN DKTVQADIKH WPFKVLDKSN KPSVEVKVGA DNKQFTPEEV 150
    SAMVLVKMKE IAESYLGKEV KHAVVTVPAY FNDAQRQATK DAGTIAGLNV 200
    VRIINEPTAA AIAYGLDKKD GERNILVFDL GGGTFDVSML TIDNGVFEVL 250
    ATNGDTHLGG EDFDQRVMEY FIKLYKKKSG KDLRKDKRAV QKLRREVEKA 300
    KRALSTQHQT KVEIESLFDG EDFSETLTRA KFEELNMDLF RATLKPVQKV 350
    LEDSDLKKDD VHEIVLVGGS TRIPKVQQLI KEFFNGKEPS RGINPDEAVA 400
    YGAAVQGGVI SGEEDTGEIV LLDVNPLTMG IETVGGVMTK LISRNTVIPT 450
    KKSQVFSTAA DNQPTVTIQV FEGERPMTKD NHQLGKFDLT GIPPAPRGVP 500
    QIEVTFEIDV NGILHVTAED KGTGNKNKIT ITNDQNRLSP EDIERMINDA 550
    EKFAEDDKKV KEKAEARNEL ESYAYSLKNQ IGDKEKLGGK LDEDDKKTIE 600
    EAVDEAISWL GSNADASAEE LKEQKKELEG KVQPIVSKLY KDGGAGGEEA 650
    PEEGSDDKDE L 661
    Length:661
    Mass (Da):72,945
    Last modified:February 1, 2005 - v2
    Checksum:i4358AA747A128F0D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti126 – 1261L → F in AAA28075. (PubMed:2116528)Curated
    Sequence conflicti140 – 1401A → S in AAA28075. (PubMed:2116528)Curated
    Sequence conflicti183 – 1831D → V in AAA28075. (PubMed:2116528)Curated
    Sequence conflicti189 – 1913TKD → LKY in AAA28075. (PubMed:2116528)Curated
    Sequence conflicti196 – 1961A → V in AAA28075. (PubMed:2116528)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600983 Genomic DNA. Translation: CAP33250.1.
    M26906 Genomic DNA. Translation: AAA28075.1.
    RefSeqiXP_002644811.1. XM_002644765.1.

    Genome annotation databases

    EnsemblMetazoaiCBG14829; CBG14829; CBG14829.
    GeneIDi8586807.
    KEGGicbr:CBG14829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600983 Genomic DNA. Translation: CAP33250.1 .
    M26906 Genomic DNA. Translation: AAA28075.1 .
    RefSeqi XP_002644811.1. XM_002644765.1.

    3D structure databases

    ProteinModelPortali P19208.
    SMRi P19208. Positions 33-575.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG14829.

    Proteomic databases

    PRIDEi P19208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG14829 ; CBG14829 ; CBG14829 .
    GeneIDi 8586807.
    KEGGi cbr:CBG14829.

    Organism-specific databases

    CTDi 8586807.
    WormBasei CBG14829 ; CBP03479 ; WBGene00035220 ; Cbr-hsp-3.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228135.
    KOi K09490.
    OMAi DKRAVQK.
    OrthoDBi EOG780RKX.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.
    2. "Functional elements and domains inferred from sequence comparisons of a heat shock gene in two nematodes."
      Heschl M.F.P., Baillie D.L.
      J. Mol. Evol. 31:3-9(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-441.

    Entry informationi

    Entry nameiHSP7C_CAEBR
    AccessioniPrimary (citable) accession number: P19208
    Secondary accession number(s): A8XKS6, Q617T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3