P19189 (REP_BPCHP) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 52. History...
Names and origin
|Protein names||Recommended name:|
Replication-associated protein ORF4
|Organism||Chlamydia phage 1 (Bacteriophage Chp1) [Reference proteome]|
|Taxonomic identifier||10857 [NCBI]|
|Taxonomic lineage||Viruses › ssDNA viruses › Microviridae › Gokushovirinae › Chlamydiamicrovirus|
|Virus host||Chlamydophila psittaci (Chlamydia psittaci) [TaxID: 83554]|
|Sequence length||399 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII). In turn, viral DNA replication initiates at the 3'-OH of the cleavage site. After one round of rolling circle synthesis, protein ORF4 is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion By similarity.
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
Belongs to the microviridae Rep protein family.
The sequence BAA00512.1 differs from that shown. Reason: Erroneous initiation.
|Technical term||Complete proteome|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: GOCnucleic acid phosphodiester bond hydrolysis
Inferred from electronic annotation. Source: GOC
Inferred from electronic annotation. Source: UniProtKB-KWDNA ligase (ATP) activity
Inferred from electronic annotation. Source: UniProtKB-ECendonuclease activity
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|D00624 Genomic DNA. Translation: BAA00511.1.|
D00624 Genomic DNA. Translation: BAA00512.1. Different initiation.
|RefSeq||NP_044320.1. NC_001741.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|Accession||Primary (citable) accession number: P19189|
Secondary accession number(s): P19186
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families