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Protein

Interferon-related developmental regulator 1

Gene

Ifrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal.

GO - Molecular functioni

GO - Biological processi

  • muscle cell differentiation Source: MGI
  • negative regulation of axon extension Source: MGI
  • negative regulation of collateral sprouting Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • skeletal muscle tissue regeneration Source: MGI
  • striated muscle tissue development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-related developmental regulator 1
Alternative name(s):
Nerve growth factor-inducible protein PC4
TPA-induced sequence 7
Short name:
TIS7 protein
Gene namesi
Name:Ifrd1
Synonyms:Tis7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1316717. Ifrd1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532861 – 449Interferon-related developmental regulator 1Add BLAST449

Proteomic databases

EPDiP19182.
MaxQBiP19182.
PaxDbiP19182.
PeptideAtlasiP19182.
PRIDEiP19182.

PTM databases

iPTMnetiP19182.
PhosphoSitePlusiP19182.

Expressioni

Inductioni

By mitogens such as TPA in 373 cells and by nerve growth factor in PC12 pheochromocytoma cells.

Gene expression databases

BgeeiENSMUSG00000001627.
CleanExiMM_IFRD1.
ExpressionAtlasiP19182. baseline and differential.
GenevisibleiP19182. MM.

Interactioni

Subunit structurei

Interacts with PSIP1/LEDGF.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200544. 5 interactors.
IntActiP19182. 1 interactor.
MINTiMINT-1652065.
STRINGi10090.ENSMUSP00000001672.

Structurei

3D structure databases

ProteinModelPortaliP19182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 21Poly-Gly9
Compositional biasi142 – 147Poly-Ala6

Sequence similaritiesi

Belongs to the IFRD family.Curated

Phylogenomic databases

eggNOGiKOG2842. Eukaryota.
ENOG410XSIZ. LUCA.
GeneTreeiENSGT00390000013347.
HOGENOMiHOG000252918.
HOVERGENiHBG052089.
InParanoidiP19182.
OMAiFYEDMEL.
OrthoDBiEOG091G083T.
TreeFamiTF313638.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006921. Interferon-rel_develop_reg_C.
IPR007701. Interferon-rel_develop_reg_N.
[Graphical view]
PfamiPF05004. IFRD. 1 hit.
PF04836. IFRD_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

P19182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKKRNAP HRGGGGGGGS GAATSAATAG GPHRTVQPFS DEDASIETMS
60 70 80 90 100
HCSGYSDPSS FAEDGPEVLD EEGTQEDLEY KLKGLIDLTL DKSAKTRQAA
110 120 130 140 150
LEGLKNALSS KVLYEFVLER RMTLTDSIER CLKKGKSDEQ RAAAAVASVL
160 170 180 190 200
CIQLGPGFES EEILKTLGPI LKKIICDGAA SIQARQTCAT CFGVCCFIAT
210 220 230 240 250
DDITELYSTL ECFENIFTKS YLKEKDTNVT CSTPNTVLHI SSLLAWTLLL
260 270 280 290 300
TICPINEVKK KLELHFHKLP SLLSCDDVNM RIAAGESLAL LFELARGMES
310 320 330 340 350
DFFYEDMDSL TQMLRALATD GNKHRAKVDK RKQRSVFRDV LRAVEERDFP
360 370 380 390 400
TETVKFGPER MYIDSWVKKH TYDTFKEVLG SGMQYHLQTN EFLRNVFELG
410 420 430 440
PPVMLDAATL KTMKISRFER HLYNSAAFKA RTKARSKCRD KRADVGEFL
Length:449
Mass (Da):49,935
Last modified:July 27, 2011 - v2
Checksum:i01ACFC575F8AE6E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43D → H in CAA35258 (PubMed:2797820).Curated1
Sequence conflicti104L → V in CAA35258 (PubMed:2797820).Curated1
Sequence conflicti399L → V in CAA24133 (PubMed:6179042).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17400 mRNA. Translation: CAA35258.1.
CH466526 Genomic DNA. Translation: EDL36825.1.
BC043723 mRNA. Translation: AAH43723.1.
V00756 mRNA. Translation: CAA24133.1. Sequence problems.
CCDSiCCDS25893.1.
PIRiA44989.
RefSeqiNP_038590.2. NM_013562.2.
UniGeneiMm.168.

Genome annotation databases

EnsembliENSMUST00000001672; ENSMUSP00000001672; ENSMUSG00000001627.
GeneIDi15982.
KEGGimmu:15982.
UCSCiuc007nky.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17400 mRNA. Translation: CAA35258.1.
CH466526 Genomic DNA. Translation: EDL36825.1.
BC043723 mRNA. Translation: AAH43723.1.
V00756 mRNA. Translation: CAA24133.1. Sequence problems.
CCDSiCCDS25893.1.
PIRiA44989.
RefSeqiNP_038590.2. NM_013562.2.
UniGeneiMm.168.

3D structure databases

ProteinModelPortaliP19182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200544. 5 interactors.
IntActiP19182. 1 interactor.
MINTiMINT-1652065.
STRINGi10090.ENSMUSP00000001672.

PTM databases

iPTMnetiP19182.
PhosphoSitePlusiP19182.

Proteomic databases

EPDiP19182.
MaxQBiP19182.
PaxDbiP19182.
PeptideAtlasiP19182.
PRIDEiP19182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001672; ENSMUSP00000001672; ENSMUSG00000001627.
GeneIDi15982.
KEGGimmu:15982.
UCSCiuc007nky.2. mouse.

Organism-specific databases

CTDi3475.
MGIiMGI:1316717. Ifrd1.

Phylogenomic databases

eggNOGiKOG2842. Eukaryota.
ENOG410XSIZ. LUCA.
GeneTreeiENSGT00390000013347.
HOGENOMiHOG000252918.
HOVERGENiHBG052089.
InParanoidiP19182.
OMAiFYEDMEL.
OrthoDBiEOG091G083T.
TreeFamiTF313638.

Miscellaneous databases

ChiTaRSiIfrd1. mouse.
PROiP19182.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001627.
CleanExiMM_IFRD1.
ExpressionAtlasiP19182. baseline and differential.
GenevisibleiP19182. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006921. Interferon-rel_develop_reg_C.
IPR007701. Interferon-rel_develop_reg_N.
[Graphical view]
PfamiPF05004. IFRD. 1 hit.
PF04836. IFRD_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFRD1_MOUSE
AccessioniPrimary (citable) accession number: P19182
Secondary accession number(s): P21835, P70228, Q80XM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be interferon beta-2.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.