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Protein

Interferon-related developmental regulator 1

Gene

Ifrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal.

Caution

Was originally thought to be interferon beta-2.1 Publication

GO - Molecular functioni

GO - Biological processi

  • muscle cell differentiation Source: MGI
  • negative regulation of axon extension Source: MGI
  • negative regulation of collateral sprouting Source: MGI
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • skeletal muscle tissue regeneration Source: MGI
  • striated muscle tissue development Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-related developmental regulator 1
Alternative name(s):
Nerve growth factor-inducible protein PC4
TPA-induced sequence 7
Short name:
TIS7 protein
Gene namesi
Name:Ifrd1
Synonyms:Tis7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1316717 Ifrd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532861 – 449Interferon-related developmental regulator 1Add BLAST449

Proteomic databases

EPDiP19182
MaxQBiP19182
PaxDbiP19182
PeptideAtlasiP19182
PRIDEiP19182

PTM databases

iPTMnetiP19182
PhosphoSitePlusiP19182

Expressioni

Inductioni

By mitogens such as TPA in 373 cells and by nerve growth factor in PC12 pheochromocytoma cells.

Gene expression databases

BgeeiENSMUSG00000001627
CleanExiMM_IFRD1
ExpressionAtlasiP19182 baseline and differential
GenevisibleiP19182 MM

Interactioni

Subunit structurei

Interacts with PSIP1/LEDGF.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2005445 interactors.
CORUMiP19182
IntActiP19182 1 interactor.
STRINGi10090.ENSMUSP00000001672

Structurei

3D structure databases

ProteinModelPortaliP19182
SMRiP19182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 21Poly-Gly9
Compositional biasi142 – 147Poly-Ala6

Sequence similaritiesi

Belongs to the IFRD family.Curated

Phylogenomic databases

eggNOGiKOG2842 Eukaryota
ENOG410XSIZ LUCA
GeneTreeiENSGT00390000013347
HOGENOMiHOG000252918
HOVERGENiHBG052089
InParanoidiP19182
OMAiIICDGTA
OrthoDBiEOG091G083T
TreeFamiTF313638

Family and domain databases

Gene3Di1.25.10.101 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR006921 Interferon-rel_develop_reg_C
IPR007701 Interferon-rel_develop_reg_N
PfamiView protein in Pfam
PF05004 IFRD, 1 hit
PF04836 IFRD_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

P19182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKKRNAP HRGGGGGGGS GAATSAATAG GPHRTVQPFS DEDASIETMS
60 70 80 90 100
HCSGYSDPSS FAEDGPEVLD EEGTQEDLEY KLKGLIDLTL DKSAKTRQAA
110 120 130 140 150
LEGLKNALSS KVLYEFVLER RMTLTDSIER CLKKGKSDEQ RAAAAVASVL
160 170 180 190 200
CIQLGPGFES EEILKTLGPI LKKIICDGAA SIQARQTCAT CFGVCCFIAT
210 220 230 240 250
DDITELYSTL ECFENIFTKS YLKEKDTNVT CSTPNTVLHI SSLLAWTLLL
260 270 280 290 300
TICPINEVKK KLELHFHKLP SLLSCDDVNM RIAAGESLAL LFELARGMES
310 320 330 340 350
DFFYEDMDSL TQMLRALATD GNKHRAKVDK RKQRSVFRDV LRAVEERDFP
360 370 380 390 400
TETVKFGPER MYIDSWVKKH TYDTFKEVLG SGMQYHLQTN EFLRNVFELG
410 420 430 440
PPVMLDAATL KTMKISRFER HLYNSAAFKA RTKARSKCRD KRADVGEFL
Length:449
Mass (Da):49,935
Last modified:July 27, 2011 - v2
Checksum:i01ACFC575F8AE6E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43D → H in CAA35258 (PubMed:2797820).Curated1
Sequence conflicti104L → V in CAA35258 (PubMed:2797820).Curated1
Sequence conflicti399L → V in CAA24133 (PubMed:6179042).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17400 mRNA Translation: CAA35258.1
CH466526 Genomic DNA Translation: EDL36825.1
BC043723 mRNA Translation: AAH43723.1
V00756 mRNA Translation: CAA24133.1 Sequence problems.
CCDSiCCDS25893.1
PIRiA44989
RefSeqiNP_038590.2, NM_013562.2
UniGeneiMm.168

Genome annotation databases

EnsembliENSMUST00000001672; ENSMUSP00000001672; ENSMUSG00000001627
GeneIDi15982
KEGGimmu:15982
UCSCiuc007nky.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIFRD1_MOUSE
AccessioniPrimary (citable) accession number: P19182
Secondary accession number(s): P21835, P70228, Q80XM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome