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Protein

Plastin-1

Gene

PLS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi24 – 35121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi64 – 75122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • actin binding Source: AgBase
  • calcium ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-1
Alternative name(s):
Fimbrin
Gene namesi
Name:PLS1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

  • brush border Source: AgBase
  • extracellular exosome Source: Ensembl
  • terminal web Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Plastin-1PRO_0000073751Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19179.
PRIDEiP19179.

Expressioni

Gene expression databases

BgeeiENSGALG00000002647.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • actin binding Source: AgBase

Protein-protein interaction databases

BioGridi676550. 1 interaction.
STRINGi9031.ENSGALP00000004164.

Structurei

3D structure databases

ProteinModelPortaliP19179.
SMRiP19179. Positions 120-374, 515-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 4636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini51 – 8636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 375268Actin-binding 1Add
BLAST
Domaini122 – 238117CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 377112CH 2PROSITE-ProRule annotationAdd
BLAST
Domaini376 – 624249Actin-binding 2Add
BLAST
Domaini396 – 505110CH 3PROSITE-ProRule annotationAdd
BLAST
Domaini517 – 624108CH 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 114114Fimbrin headpieceAdd
BLAST
Regioni115 – 630516Fimbrin coreAdd
BLAST

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiP19179.
KOiK17275.
OMAiKREDLSY.
OrthoDBiEOG091G03YP.
PhylomeDBiP19179.
TreeFamiTF300680.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNVTTISR EELEELREAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY
60 70 80 90 100
KVREIIEKIF AVTDSNKDGK INFEEFVSLI QELKSKDVSK SYRKSINKKL
110 120 130 140 150
GITALGGTSS ISTEGTQHSY SEEEKVAFVN WINKALQDDP DCKHILPMNP
160 170 180 190 200
SDASLFKSLA DGILLCKMIN FSQPDTIDER AINKKKLTPF TISENLNLAL
210 220 230 240 250
NSASAIGCTV VNIGSQDLQE GKPHLVLGLL WQIIKVGLFA DIEISRNEAL
260 270 280 290 300
IALLNEGEEL DQLMKLSPEE LLLRWVNYHL ANAGWQKISN FSQDIRDSRA
310 320 330 340 350
YYHLLNQIAP KGDDFDEIHV EIDFSGFNDK NDLRRAECML QQADKLGCRQ
360 370 380 390 400
FVTPADVVAG NPKLNLAFVA NLFNTYPALH KPDNSSYDLT LLEGESNEER
410 420 430 440 450
TFRNWMNSLG VSPYVNHLYS DLSDALIIFQ LYEMTRVPVD WTHVNKRPYP
460 470 480 490 500
LLGGNMKKIE NCNYAVELGK TKAKFSLVGI AGHDLNEGNP TLTLALIWQL
510 520 530 540 550
MRRYTLNVLS DLGEGEKVND EIIIKWVNQT LANANKKTSI TSFKDKSIST
560 570 580 590 600
SLPVLDLIDA IAPKAVRQEM VKREDLSYQD KLNNAKYAIS VARKIGARIY
610 620 630
ALPDDLVEVK PKMVMTVFAC LMGRGLNKIK
Length:630
Mass (Da):70,939
Last modified:November 1, 1990 - v1
Checksum:iF616F228A86E8F1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52562 mRNA. Translation: CAA36796.1.
PIRiA37097.
RefSeqiNP_990678.1. NM_205347.1.
XP_015132331.1. XM_015276845.1.
UniGeneiGga.749.

Genome annotation databases

EnsembliENSGALT00000004173; ENSGALP00000004164; ENSGALG00000002647.
GeneIDi396291.
KEGGigga:396291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52562 mRNA. Translation: CAA36796.1.
PIRiA37097.
RefSeqiNP_990678.1. NM_205347.1.
XP_015132331.1. XM_015276845.1.
UniGeneiGga.749.

3D structure databases

ProteinModelPortaliP19179.
SMRiP19179. Positions 120-374, 515-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676550. 1 interaction.
STRINGi9031.ENSGALP00000004164.

Proteomic databases

PaxDbiP19179.
PRIDEiP19179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000004173; ENSGALP00000004164; ENSGALG00000002647.
GeneIDi396291.
KEGGigga:396291.

Organism-specific databases

CTDi5357.

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiP19179.
KOiK17275.
OMAiKREDLSY.
OrthoDBiEOG091G03YP.
PhylomeDBiP19179.
TreeFamiTF300680.

Miscellaneous databases

PROiP19179.

Gene expression databases

BgeeiENSGALG00000002647.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLSI_CHICK
AccessioniPrimary (citable) accession number: P19179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.