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Protein

Plastin-1

Gene

PLS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi64 – 752PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: AgBase
  • actin filament binding Source: GO_Central
  • calcium ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-1
Alternative name(s):
Fimbrin
Gene namesi
Name:PLS1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737511 – 630Plastin-1Add BLAST630

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19179.
PRIDEiP19179.

Expressioni

Gene expression databases

BgeeiENSGALG00000002647.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • actin binding Source: AgBase
  • actin filament binding Source: GO_Central

Protein-protein interaction databases

BioGridi676550. 1 interactor.
STRINGi9031.ENSGALP00000004164.

Structurei

3D structure databases

ProteinModelPortaliP19179.
SMRiP19179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini122 – 238Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST117
Domaini266 – 377Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST112
Domaini396 – 505Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST110
Domaini517 – 626Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 114Fimbrin headpieceAdd BLAST114
Regioni108 – 375Actin-binding 1Add BLAST268
Regioni115 – 630Fimbrin coreAdd BLAST516
Regioni376 – 624Actin-binding 2Add BLAST249

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiP19179.
KOiK17275.
OMAiKPDNNDI.
OrthoDBiEOG091G03YP.
PhylomeDBiP19179.
TreeFamiTF300680.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.418.10. 4 hits.
InterProiView protein in InterPro
IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR036872. CH_dom_sf.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiView protein in Pfam
PF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P19179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNVTTISR EELEELREAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY
60 70 80 90 100
KVREIIEKIF AVTDSNKDGK INFEEFVSLI QELKSKDVSK SYRKSINKKL
110 120 130 140 150
GITALGGTSS ISTEGTQHSY SEEEKVAFVN WINKALQDDP DCKHILPMNP
160 170 180 190 200
SDASLFKSLA DGILLCKMIN FSQPDTIDER AINKKKLTPF TISENLNLAL
210 220 230 240 250
NSASAIGCTV VNIGSQDLQE GKPHLVLGLL WQIIKVGLFA DIEISRNEAL
260 270 280 290 300
IALLNEGEEL DQLMKLSPEE LLLRWVNYHL ANAGWQKISN FSQDIRDSRA
310 320 330 340 350
YYHLLNQIAP KGDDFDEIHV EIDFSGFNDK NDLRRAECML QQADKLGCRQ
360 370 380 390 400
FVTPADVVAG NPKLNLAFVA NLFNTYPALH KPDNSSYDLT LLEGESNEER
410 420 430 440 450
TFRNWMNSLG VSPYVNHLYS DLSDALIIFQ LYEMTRVPVD WTHVNKRPYP
460 470 480 490 500
LLGGNMKKIE NCNYAVELGK TKAKFSLVGI AGHDLNEGNP TLTLALIWQL
510 520 530 540 550
MRRYTLNVLS DLGEGEKVND EIIIKWVNQT LANANKKTSI TSFKDKSIST
560 570 580 590 600
SLPVLDLIDA IAPKAVRQEM VKREDLSYQD KLNNAKYAIS VARKIGARIY
610 620 630
ALPDDLVEVK PKMVMTVFAC LMGRGLNKIK
Length:630
Mass (Da):70,939
Last modified:November 1, 1990 - v1
Checksum:iF616F228A86E8F1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52562 mRNA. Translation: CAA36796.1.
PIRiA37097.
RefSeqiNP_990678.1. NM_205347.1.
XP_015132331.1. XM_015276845.1.
UniGeneiGga.749.

Genome annotation databases

EnsembliENSGALT00000004173; ENSGALP00000004164; ENSGALG00000002647.
ENSGALT00000078701; ENSGALP00000056193; ENSGALG00000002647.
GeneIDi396291.
KEGGigga:396291.

Similar proteinsi

Entry informationi

Entry nameiPLSI_CHICK
AccessioniPrimary (citable) accession number: P19179
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome