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Protein

Xylose isomerase

Gene

xylA

Organism
Thermoanaerobacterium thermosulfurigenes (Clostridium thermosulfurogenes)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Co2+Note: Binds 2 cobalt ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1011
Active sitei104By similarity1
Metal bindingi232Cobalt 11
Metal bindingi268Cobalt 11
Metal bindingi268Cobalt 21
Metal bindingi271Cobalt 21
Metal bindingi296Cobalt 11
Metal bindingi307Cobalt 21
Metal bindingi309Cobalt 21
Metal bindingi339Cobalt 11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandCobalt, Metal-binding

Enzyme and pathway databases

SABIO-RKP19148

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiThermoanaerobacterium thermosulfurigenes (Clostridium thermosulfurogenes)
Taxonomic identifieri33950 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisThermoanaerobacterium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi101H → F: Abolishes activity. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958171 – 439Xylose isomeraseAdd BLAST439

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 26Combined sources6
Helixi38 – 42Combined sources5
Beta strandi44 – 47Combined sources4
Helixi48 – 52Combined sources5
Helixi68 – 71Combined sources4
Helixi75 – 93Combined sources19
Beta strandi96 – 101Combined sources6
Helixi102 – 105Combined sources4
Helixi112 – 130Combined sources19
Beta strandi136 – 141Combined sources6
Beta strandi145 – 147Combined sources3
Helixi148 – 150Combined sources3
Helixi160 – 179Combined sources20
Beta strandi183 – 187Combined sources5
Beta strandi192 – 195Combined sources4
Helixi197 – 199Combined sources3
Helixi202 – 222Combined sources21
Beta strandi227 – 231Combined sources5
Beta strandi237 – 244Combined sources8
Helixi247 – 256Combined sources10
Turni260 – 262Combined sources3
Beta strandi263 – 268Combined sources6
Helixi269 – 274Combined sources6
Helixi279 – 288Combined sources10
Beta strandi292 – 296Combined sources5
Beta strandi304 – 306Combined sources3
Helixi315 – 327Combined sources13
Beta strandi336 – 338Combined sources3
Helixi350 – 375Combined sources26
Helixi378 – 386Combined sources9
Helixi388 – 390Combined sources3
Helixi393 – 399Combined sources7
Helixi405 – 414Combined sources10
Helixi425 – 436Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0CX-ray2.50A/B/C/D2-439[»]
ProteinModelPortaliP19148
SMRiP19148
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19148

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013452 Xylose_isom_bac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02630 xylose_isom_A, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P19148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKYFENVSK IKYEGPKSNN PYSFKFYNPE EVIDGKTMEE HLRFSIAYWH
60 70 80 90 100
TFTADGTDQF GKATMQRPWN HYTDPMDIAK ARVEAAFEFF DKINAPYFCF
110 120 130 140 150
HDRDIAPEGD TLRETNKNLD TIVAMIKDYL KTSKTKVLWG TANLFSNPRF
160 170 180 190 200
VHGASTSCNA DVFAYSAAQV KKALEITKEL GGENYVFWGG REGYETLLNT
210 220 230 240 250
DMEFELDNFA RFLHMAVDYA KEIGFEGQFL IEPKPKEPTK HQYDFDVANV
260 270 280 290 300
LAFLRKYDLD KYFKVNIEAN HATLAFHDFQ HELRYARING VLGSIDANTG
310 320 330 340 350
DMLLGWDTDQ FPTDIRMTTL AMYEVIKMGG FDKGGLNFDA KVRRASFEPE
360 370 380 390 400
DLFLGHIAGM DAFAKGFKVA YKLVKDRVFD KFIEERYASY KDGIGADIVS
410 420 430
GKADFRSLEK YALERSQIVN KSGRQELLES ILNQYLFAE
Length:439
Mass (Da):50,475
Last modified:November 1, 1990 - v1
Checksum:i55A227DBDD0EECB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05650 Genomic DNA Translation: AAA23285.1
PIRiA36598 ISCLXM

Similar proteinsi

Entry informationi

Entry nameiXYLA_THETU
AccessioniPrimary (citable) accession number: P19148
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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