Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P19144

- PRTX_DICCH

UniProt

P19144 - PRTX_DICCH

Protein

Serralysin C

Gene

prtC

Organism
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Preferential cleavage of bonds with hydrophobic residues in P1'.1 Publication

    Cofactori

    Binds 7 calcium ions per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Zinc; catalyticPROSITE-ProRule annotation
    Active sitei188 – 1881PROSITE-ProRule annotation
    Metal bindingi191 – 1911Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi227 – 2271Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi264 – 2641Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi266 – 2661Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi296 – 2961Calcium 1By similarity
    Metal bindingi298 – 2981Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi299 – 2991Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi301 – 3011Calcium 1By similarity
    Metal bindingi301 – 3011Calcium 2By similarity
    Metal bindingi338 – 3381Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi340 – 3401Calcium 2By similarity
    Metal bindingi345 – 3451Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi347 – 3471Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi349 – 3491Calcium 3By similarity
    Metal bindingi354 – 3541Calcium 4; via carbonyl oxygenBy similarity
    Metal bindingi356 – 3561Calcium 4; via carbonyl oxygenBy similarity
    Metal bindingi358 – 3581Calcium 4By similarity
    Metal bindingi362 – 3621Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi363 – 3631Calcium 5; via carbonyl oxygenBy similarity
    Metal bindingi364 – 3641Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi365 – 3651Calcium 5; via carbonyl oxygenBy similarity
    Metal bindingi367 – 3671Calcium 3By similarity
    Metal bindingi367 – 3671Calcium 5By similarity
    Metal bindingi371 – 3711Calcium 4; via carbonyl oxygenBy similarity
    Metal bindingi372 – 3721Calcium 6; via carbonyl oxygenBy similarity
    Metal bindingi374 – 3741Calcium 6; via carbonyl oxygenBy similarity
    Metal bindingi376 – 3761Calcium 4By similarity
    Metal bindingi376 – 3761Calcium 6By similarity
    Metal bindingi380 – 3801Calcium 5; via carbonyl oxygenBy similarity
    Metal bindingi381 – 3811Calcium 7; via carbonyl oxygenBy similarity
    Metal bindingi383 – 3831Calcium 7; via carbonyl oxygenBy similarity
    Metal bindingi385 – 3851Calcium 5By similarity
    Metal bindingi385 – 3851Calcium 7By similarity
    Metal bindingi394 – 3941Calcium 6By similarity
    Metal bindingi401 – 4011Calcium 6By similarity
    Metal bindingi411 – 4111Calcium 7By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. metalloendopeptidase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM10.052.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serralysin C (EC:3.4.24.40)
    Alternative name(s):
    Secreted protease C
    Short name:
    ProC
    Gene namesi
    Name:prtC
    OrganismiDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
    Taxonomic identifieri556 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: InterPro
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1717CuratedPRO_0000028685Add
    BLAST
    Chaini18 – 478461Serralysin CPRO_0000028686Add
    BLAST

    Keywords - PTMi

    Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP19144.
    SMRiP19144. Positions 20-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati343 – 36018Hemolysin-type calcium-binding 1Add
    BLAST
    Repeati361 – 37818Hemolysin-type calcium-binding 2Add
    BLAST

    Domaini

    The Gly-rich repeats may be important in the extracellular secretion of this metalloprotease.

    Sequence similaritiesi

    Belongs to the peptidase M10B family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di2.150.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR018511. Hemolysin-typ_Ca-bd_CS.
    IPR001343. Hemolysn_Ca-bd.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR016294. Pept_M10B.
    IPR013858. Peptidase_M10B_C.
    IPR006026. Peptidase_Metallo.
    IPR011049. Serralysin-like_metalloprot_C.
    [Graphical view]
    PfamiPF00353. HemolysinCabind. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF08548. Peptidase_M10_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001205. Peptidase_M10B. 1 hit.
    SMARTiSM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF51120. SSF51120. 1 hit.
    PROSITEiPS00330. HEMOLYSIN_CALCIUM. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19144-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKNLSSRDD DALHSLSAPS SSYNSIYDLL HYHERGNGLT INGKPSYSIE    50
    DAGDQITRDN VSWNGANVFG KSANLTFKFL QSARSTPDGD TGFVKFNAAQ 100
    ISQAKLALQS WADVANVTFT EVTGNQSANV TFGNYTRDSS GRLDYGTQAY 150
    AYLPGSGSAS GTTWYNYNVD NIRSPDTMEY GRQTLTHEIG HALGLNHPGD 200
    YNAGEGNPSY SDVTYAEDTR QFSIMSYWSE KNTGGDFKGH YAAGPMLDDI 250
    AAIQRLYGAN MTTRTGDSVY GFNSNTDRDF YTATSSSKAL IFSAWDAGGN 300
    DTFDFSGYSN NQRINLNDGS LSDVGGLKGN VSIAEGVTIE NAIGGSGNDL 350
    LIGNNADNTL RGGAGDDVLF GGSGADRLYG GSGRDTFVYT AASDSKVAAP 400
    DWLLDFQTGA DKIDLSALNT GNNLHFVNQF SGSGGEIMLN WDASANTSNL 450
    YLNLDNNTSP EFLVKIVGQV SQTADFVV 478
    Length:478
    Mass (Da):51,148
    Last modified:November 1, 1990 - v1
    Checksum:i91CEFBB8AE7B8598
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37390 Genomic DNA. Translation: AAA24859.1.
    PIRiA36137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37390 Genomic DNA. Translation: AAA24859.1 .
    PIRi A36137.

    3D structure databases

    ProteinModelPortali P19144.
    SMRi P19144. Positions 20-473.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M10.052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.150.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR018511. Hemolysin-typ_Ca-bd_CS.
    IPR001343. Hemolysn_Ca-bd.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR016294. Pept_M10B.
    IPR013858. Peptidase_M10B_C.
    IPR006026. Peptidase_Metallo.
    IPR011049. Serralysin-like_metalloprot_C.
    [Graphical view ]
    Pfami PF00353. HemolysinCabind. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF08548. Peptidase_M10_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001205. Peptidase_M10B. 1 hit.
    SMARTi SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51120. SSF51120. 1 hit.
    PROSITEi PS00330. HEMOLYSIN_CALCIUM. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16."
      Dahler G.S., Barras F., Keen N.T.
      J. Bacteriol. 172:5803-5815(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY.
      Strain: EC16.

    Entry informationi

    Entry nameiPRTX_DICCH
    AccessioniPrimary (citable) accession number: P19144
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Could be the homolog of prtA from strain B374.

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3