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P19144

- PRTX_DICCH

UniProt

P19144 - PRTX_DICCH

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Protein

Serralysin C

Gene

prtC

Organism
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage of bonds with hydrophobic residues in P1'.1 Publication

Cofactori

Binds 7 calcium ions per subunit.By similarity
Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Zinc; catalyticPROSITE-ProRule annotation
Active sitei188 – 1881PROSITE-ProRule annotation
Metal bindingi191 – 1911Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi227 – 2271Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi264 – 2641Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi266 – 2661Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi296 – 2961Calcium 1By similarity
Metal bindingi298 – 2981Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi299 – 2991Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi301 – 3011Calcium 1By similarity
Metal bindingi301 – 3011Calcium 2By similarity
Metal bindingi338 – 3381Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi340 – 3401Calcium 2By similarity
Metal bindingi345 – 3451Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi347 – 3471Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi349 – 3491Calcium 3By similarity
Metal bindingi354 – 3541Calcium 4; via carbonyl oxygenBy similarity
Metal bindingi356 – 3561Calcium 4; via carbonyl oxygenBy similarity
Metal bindingi358 – 3581Calcium 4By similarity
Metal bindingi362 – 3621Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi363 – 3631Calcium 5; via carbonyl oxygenBy similarity
Metal bindingi364 – 3641Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi365 – 3651Calcium 5; via carbonyl oxygenBy similarity
Metal bindingi367 – 3671Calcium 3By similarity
Metal bindingi367 – 3671Calcium 5By similarity
Metal bindingi371 – 3711Calcium 4; via carbonyl oxygenBy similarity
Metal bindingi372 – 3721Calcium 6; via carbonyl oxygenBy similarity
Metal bindingi374 – 3741Calcium 6; via carbonyl oxygenBy similarity
Metal bindingi376 – 3761Calcium 4By similarity
Metal bindingi376 – 3761Calcium 6By similarity
Metal bindingi380 – 3801Calcium 5; via carbonyl oxygenBy similarity
Metal bindingi381 – 3811Calcium 7; via carbonyl oxygenBy similarity
Metal bindingi383 – 3831Calcium 7; via carbonyl oxygenBy similarity
Metal bindingi385 – 3851Calcium 5By similarity
Metal bindingi385 – 3851Calcium 7By similarity
Metal bindingi394 – 3941Calcium 6By similarity
Metal bindingi401 – 4011Calcium 6By similarity
Metal bindingi411 – 4111Calcium 7By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM10.052.

Names & Taxonomyi

Protein namesi
Recommended name:
Serralysin C (EC:3.4.24.40)
Alternative name(s):
Secreted protease C
Short name:
ProC
Gene namesi
Name:prtC
OrganismiDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Taxonomic identifieri556 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: InterPro
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1717CuratedPRO_0000028685Add
BLAST
Chaini18 – 478461Serralysin CPRO_0000028686Add
BLAST

Keywords - PTMi

Zymogen

Structurei

3D structure databases

ProteinModelPortaliP19144.
SMRiP19144. Positions 20-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati343 – 36018Hemolysin-type calcium-binding 1Add
BLAST
Repeati361 – 37818Hemolysin-type calcium-binding 2Add
BLAST

Domaini

The Gly-rich repeats may be important in the extracellular secretion of this metalloprotease.

Sequence similaritiesi

Belongs to the peptidase M10B family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.150.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR018511. Hemolysin-typ_Ca-bd_CS.
IPR001343. Hemolysn_Ca-bd.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR016294. Pept_M10B.
IPR013858. Peptidase_M10B_C.
IPR006026. Peptidase_Metallo.
IPR011049. Serralysin-like_metalloprot_C.
[Graphical view]
PfamiPF00353. HemolysinCabind. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF08548. Peptidase_M10_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001205. Peptidase_M10B. 1 hit.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF51120. SSF51120. 1 hit.
PROSITEiPS00330. HEMOLYSIN_CALCIUM. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19144-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKNLSSRDD DALHSLSAPS SSYNSIYDLL HYHERGNGLT INGKPSYSIE
60 70 80 90 100
DAGDQITRDN VSWNGANVFG KSANLTFKFL QSARSTPDGD TGFVKFNAAQ
110 120 130 140 150
ISQAKLALQS WADVANVTFT EVTGNQSANV TFGNYTRDSS GRLDYGTQAY
160 170 180 190 200
AYLPGSGSAS GTTWYNYNVD NIRSPDTMEY GRQTLTHEIG HALGLNHPGD
210 220 230 240 250
YNAGEGNPSY SDVTYAEDTR QFSIMSYWSE KNTGGDFKGH YAAGPMLDDI
260 270 280 290 300
AAIQRLYGAN MTTRTGDSVY GFNSNTDRDF YTATSSSKAL IFSAWDAGGN
310 320 330 340 350
DTFDFSGYSN NQRINLNDGS LSDVGGLKGN VSIAEGVTIE NAIGGSGNDL
360 370 380 390 400
LIGNNADNTL RGGAGDDVLF GGSGADRLYG GSGRDTFVYT AASDSKVAAP
410 420 430 440 450
DWLLDFQTGA DKIDLSALNT GNNLHFVNQF SGSGGEIMLN WDASANTSNL
460 470
YLNLDNNTSP EFLVKIVGQV SQTADFVV
Length:478
Mass (Da):51,148
Last modified:November 1, 1990 - v1
Checksum:i91CEFBB8AE7B8598
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37390 Genomic DNA. Translation: AAA24859.1.
PIRiA36137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37390 Genomic DNA. Translation: AAA24859.1 .
PIRi A36137.

3D structure databases

ProteinModelPortali P19144.
SMRi P19144. Positions 20-473.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M10.052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.150.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR018511. Hemolysin-typ_Ca-bd_CS.
IPR001343. Hemolysn_Ca-bd.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR016294. Pept_M10B.
IPR013858. Peptidase_M10B_C.
IPR006026. Peptidase_Metallo.
IPR011049. Serralysin-like_metalloprot_C.
[Graphical view ]
Pfami PF00353. HemolysinCabind. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF08548. Peptidase_M10_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001205. Peptidase_M10B. 1 hit.
SMARTi SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF51120. SSF51120. 1 hit.
PROSITEi PS00330. HEMOLYSIN_CALCIUM. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16."
    Dahler G.S., Barras F., Keen N.T.
    J. Bacteriol. 172:5803-5815(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY.
    Strain: EC16.

Entry informationi

Entry nameiPRTX_DICCH
AccessioniPrimary (citable) accession number: P19144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Could be the homolog of prtA from strain B374.

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3