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Reviewed, UniProtKB/Swiss-Prot P19139 (CSK21_RAT)

Last modified November 3, 2009. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Casein kinase II subunit alpha
      Short name=CK II
    EC=2.7.11.1
Gene names
Name: Csnk2a1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-390' of p53/TP53 following UV irradiation By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Tetramer composed of an alpha chain, an alpha' and two beta chains. Interacts with RNPS1. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Casein kinase II subunit alpha
PRO_0000085886

Regions

Domain39 – 324286Protein kinase
Nucleotide binding45 – 539ATP By similarity

Sites

Active site1561Proton acceptor By similarity
Binding site681ATP By similarity

Amino acid modifications

Modified residue21Phosphoserine By similarity
Modified residue1021N6-acetyllysine By similarity
Modified residue1941Phosphoserine By similarity
Modified residue3621Phosphoserine By similarity
Modified residue3701Phosphoserine By similarity

Secondary structure

........................................................... 391
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P19139-1 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 83A4E2CC80824F66

FASTA39145,073
        10         20         30         40         50         60 
MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT 

        70         80         90        100        110        120 
NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD 

       130        140        150        160        170        180 
FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE 

       190        200        210        220        230        240 
FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD 

       250        260        270        280        290        300 
QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF 

       310        320        330        340        350        360 
LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMSSAGMA GGSTPVSSAN MMSGISSVPT 

       370        380        390 
PSPLGPLAGS PVIAAANSLG IPVPAAAGAQ Q 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate."
Ahmed K., Davis A., Hanten J., Lambert D., McIvor R.S., Goueli S.A.
Cell. Mol. Biol. Res. 39:451-462(1993) [PubMed: 8173590] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[3]"Molecular cloning of the human casein kinase II alpha subunit."
Meisner H., Heller-Harrison R., Buxton J., Czech M.P.
Biochemistry 28:4072-4076(1989) [PubMed: 2752008] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-391.
+Additional computationally mapped references.

Cross-references

Sequence databases

L15618 mRNA. Translation: AAA74462.1.
BC091130 mRNA. Translation: AAH91130.1.
J02853 mRNA. No translation available.
IPIIPI00192586.
PIRB30319.
RefSeqNP_446276.1.
UniGeneRn.4231

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2R7IX-ray3.00A/B/C/D1-335[»]
SMRP19139. Positions 2-334.
ModBaseSearch...

Protein-protein interaction databases

STRINGP19139.

PTM databases

PhosphoSiteP19139.

Genome annotation databases

EnsemblENSRNOT00000007558; ENSRNOP00000007558; ENSRNOG00000005276; Rattus norvegicus. [Genome view]
GeneID116549.
KEGGrno:116549.
UCSCNM_053824. rat.

Organism-specific databases

CTD116549.
RGD621663. Csnk2a1.

Phylogenomic databases

HOVERGENP19139.
OMAALIFEHV.

Enzyme and pathway databases

BRENDA2.7.11.1. 248.

Gene expression databases

ArrayExpressP19139.
GenevestigatorP19139.
GermOnlineENSRNOG00000005276. Rattus norvegicus.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio619175.

Entry information

Entry nameCSK21_RAT
AccessionPrimary (citable) accession number: P19139
Secondary accession number(s): Q5BKC1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1995
Last modified: November 3, 2009
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents