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P19132

- FRIH_RAT

UniProt

P19132 - FRIH_RAT

Protein

Ferritin heavy chain

Gene

Fth1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Iron 1PROSITE-ProRule annotation
    Metal bindingi63 – 631Iron 1PROSITE-ProRule annotation
    Metal bindingi63 – 631Iron 2PROSITE-ProRule annotation
    Metal bindingi66 – 661Iron 1PROSITE-ProRule annotation
    Metal bindingi108 – 1081Iron 2PROSITE-ProRule annotation
    Metal bindingi142 – 1421Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC
    3. protein binding Source: RGD

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. immune response Source: UniProtKB
    3. iron ion transport Source: InterPro
    4. negative regulation of cell proliferation Source: UniProtKB
    5. negative regulation of fibroblast proliferation Source: UniProtKB
    6. negative regulation of necrotic cell death Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin heavy chain (EC:1.16.3.1)
    Short name:
    Ferritin H subunit
    Cleaved into the following chain:
    Gene namesi
    Name:Fth1
    Synonyms:Fth
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2635. Fth1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Ferritin heavy chainPRO_0000201053Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 182181Ferritin heavy chain, N-terminally processedPRO_0000424476Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylthreonine; in Ferritin heavy chain, N-terminally processedBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP19132.
    PRIDEiP19132.

    PTM databases

    PhosphoSiteiP19132.

    Expressioni

    Gene expression databases

    GenevestigatoriP19132.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

    Protein-protein interaction databases

    BioGridi247358. 1 interaction.
    IntActiP19132. 1 interaction.
    MINTiMINT-4567905.

    Structurei

    3D structure databases

    ProteinModelPortaliP19132.
    SMRiP19132. Positions 7-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 160150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    HOVERGENiHBG000410.
    KOiK00522.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19132-1 [UniParc]FASTAAdd to Basket

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    MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSC YFDRDDVALK    50
    NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWESGLNA 100
    MRCALHLEKS VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKSIKELG 150
    DHVTNLRKMG APESGMAEYL FDKHTLGHGD ES 182
    Length:182
    Mass (Da):21,127
    Last modified:January 23, 2007 - v3
    Checksum:iF27E105373235B43
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021R → E in AAB39890. 1 PublicationCurated
    Sequence conflicti182 – 1821S → E AA sequence (PubMed:6546756)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18053, M18051, M18052 Genomic DNA. Translation: AAA41153.1.
    U58829 mRNA. Translation: AAB39890.1.
    M29330 mRNA. Translation: AAA42300.1.
    PIRiA39884.
    RefSeqiNP_036980.1. NM_012848.2.
    UniGeneiRn.54447.

    Genome annotation databases

    GeneIDi25319.
    KEGGirno:25319.
    UCSCiRGD:2635. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18053 , M18051 , M18052 Genomic DNA. Translation: AAA41153.1 .
    U58829 mRNA. Translation: AAB39890.1 .
    M29330 mRNA. Translation: AAA42300.1 .
    PIRi A39884.
    RefSeqi NP_036980.1. NM_012848.2.
    UniGenei Rn.54447.

    3D structure databases

    ProteinModelPortali P19132.
    SMRi P19132. Positions 7-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247358. 1 interaction.
    IntActi P19132. 1 interaction.
    MINTi MINT-4567905.

    PTM databases

    PhosphoSitei P19132.

    Proteomic databases

    PaxDbi P19132.
    PRIDEi P19132.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25319.
    KEGGi rno:25319.
    UCSCi RGD:2635. rat.

    Organism-specific databases

    CTDi 2495.
    RGDi 2635. Fth1.

    Phylogenomic databases

    eggNOGi COG1528.
    HOVERGENi HBG000410.
    KOi K00522.

    Miscellaneous databases

    NextBioi 606157.
    PROi P19132.

    Gene expression databases

    Genevestigatori P19132.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression."
      Murray M.T., White K., Munro H.N.
      Proc. Natl. Acad. Sci. U.S.A. 84:7438-7442(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Wu C.G., Groenink M., Bosma A., Reitsma P.H., van Deventer J.H., Chamuleau R.A.F.M.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Liver.
    3. Lubec G., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 81-87, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    4. "TSH regulation of ferritin H chain messenger RNA levels in the rat thyroids."
      Ursini M.V., de Franciscis V.
      Biochem. Biophys. Res. Commun. 150:287-295(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-182.
    5. "Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit."
      Leibold E.A., Aziz N., Brown A.J.P., Munro H.N.
      J. Biol. Chem. 259:4327-4334(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 159-182.
      Tissue: Liver.

    Entry informationi

    Entry nameiFRIH_RAT
    AccessioniPrimary (citable) accession number: P19132
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3