SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P19132

- FRIH_RAT

UniProt

P19132 - FRIH_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ferritin heavy chain
Gene
Fth1, Fth
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Iron 1 By similarity
Metal bindingi63 – 631Iron 1 By similarity
Metal bindingi63 – 631Iron 2 By similarity
Metal bindingi66 – 661Iron 1 By similarity
Metal bindingi108 – 1081Iron 2 By similarity
Metal bindingi142 – 1421Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
  3. protein binding Source: RGD

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. immune response Source: UniProtKB
  3. iron ion transport Source: InterPro
  4. negative regulation of cell proliferation Source: UniProtKB
  5. negative regulation of fibroblast proliferation Source: UniProtKB
  6. negative regulation of necrotic cell death Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Cleaved into the following chain:
Gene namesi
Name:Fth1
Synonyms:Fth
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2635. Fth1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Ferritin heavy chain
PRO_0000201053Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 182181Ferritin heavy chain, N-terminally processed
PRO_0000424476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei2 – 21N-acetylthreonine; in Ferritin heavy chain, N-terminally processed By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19132.
PRIDEiP19132.

PTM databases

PhosphoSiteiP19132.

Expressioni

Gene expression databases

GenevestigatoriP19132.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

BioGridi247358. 1 interaction.
IntActiP19132. 1 interaction.
MINTiMINT-4567905.

Structurei

3D structure databases

ProteinModelPortaliP19132.
SMRiP19132. Positions 7-177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 160150Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Phylogenomic databases

eggNOGiCOG1528.
HOVERGENiHBG000410.
KOiK00522.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19132-1 [UniParc]FASTAAdd to Basket

« Hide

MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSC YFDRDDVALK    50
NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWESGLNA 100
MRCALHLEKS VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKSIKELG 150
DHVTNLRKMG APESGMAEYL FDKHTLGHGD ES 182
Length:182
Mass (Da):21,127
Last modified:January 23, 2007 - v3
Checksum:iF27E105373235B43
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021R → E in AAB39890. 1 Publication
Sequence conflicti182 – 1821S → E AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18053, M18051, M18052 Genomic DNA. Translation: AAA41153.1.
U58829 mRNA. Translation: AAB39890.1.
M29330 mRNA. Translation: AAA42300.1.
PIRiA39884.
RefSeqiNP_036980.1. NM_012848.2.
UniGeneiRn.54447.

Genome annotation databases

GeneIDi25319.
KEGGirno:25319.
UCSCiRGD:2635. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18053 , M18051 , M18052 Genomic DNA. Translation: AAA41153.1 .
U58829 mRNA. Translation: AAB39890.1 .
M29330 mRNA. Translation: AAA42300.1 .
PIRi A39884.
RefSeqi NP_036980.1. NM_012848.2.
UniGenei Rn.54447.

3D structure databases

ProteinModelPortali P19132.
SMRi P19132. Positions 7-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247358. 1 interaction.
IntActi P19132. 1 interaction.
MINTi MINT-4567905.

PTM databases

PhosphoSitei P19132.

Proteomic databases

PaxDbi P19132.
PRIDEi P19132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25319.
KEGGi rno:25319.
UCSCi RGD:2635. rat.

Organism-specific databases

CTDi 2495.
RGDi 2635. Fth1.

Phylogenomic databases

eggNOGi COG1528.
HOVERGENi HBG000410.
KOi K00522.

Miscellaneous databases

NextBioi 606157.
PROi P19132.

Gene expression databases

Genevestigatori P19132.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression."
    Murray M.T., White K., Munro H.N.
    Proc. Natl. Acad. Sci. U.S.A. 84:7438-7442(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Wu C.G., Groenink M., Bosma A., Reitsma P.H., van Deventer J.H., Chamuleau R.A.F.M.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.
  3. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 81-87, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "TSH regulation of ferritin H chain messenger RNA levels in the rat thyroids."
    Ursini M.V., de Franciscis V.
    Biochem. Biophys. Res. Commun. 150:287-295(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-182.
  5. "Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit."
    Leibold E.A., Aziz N., Brown A.J.P., Munro H.N.
    J. Biol. Chem. 259:4327-4334(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 159-182.
    Tissue: Liver.

Entry informationi

Entry nameiFRIH_RAT
AccessioniPrimary (citable) accession number: P19132
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi