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P19132

- FRIH_RAT

UniProt

P19132 - FRIH_RAT

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Protein

Ferritin heavy chain

Gene

Fth1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Iron 1PROSITE-ProRule annotation
Metal bindingi63 – 631Iron 1PROSITE-ProRule annotation
Metal bindingi63 – 631Iron 2PROSITE-ProRule annotation
Metal bindingi66 – 661Iron 1PROSITE-ProRule annotation
Metal bindingi108 – 1081Iron 2PROSITE-ProRule annotation
Metal bindingi142 – 1421Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. immune response Source: UniProtKB
  3. iron ion transport Source: InterPro
  4. negative regulation of cell proliferation Source: UniProtKB
  5. negative regulation of fibroblast proliferation Source: UniProtKB
  6. negative regulation of necrotic cell death Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Cleaved into the following chain:
Gene namesi
Name:Fth1
Synonyms:Fth
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2635. Fth1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Ferritin heavy chainPRO_0000201053Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 182181Ferritin heavy chain, N-terminally processedPRO_0000424476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylthreonine; in Ferritin heavy chain, N-terminally processedBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19132.
PRIDEiP19132.

PTM databases

PhosphoSiteiP19132.

Expressioni

Gene expression databases

GenevestigatoriP19132.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

BioGridi247358. 1 interaction.
IntActiP19132. 1 interaction.
MINTiMINT-4567905.

Structurei

3D structure databases

ProteinModelPortaliP19132.
SMRiP19132. Positions 7-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 160150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1528.
HOVERGENiHBG000410.
InParanoidiP19132.
KOiK00522.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19132-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSC YFDRDDVALK
60 70 80 90 100
NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWESGLNA
110 120 130 140 150
MRCALHLEKS VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKSIKELG
160 170 180
DHVTNLRKMG APESGMAEYL FDKHTLGHGD ES
Length:182
Mass (Da):21,127
Last modified:January 23, 2007 - v3
Checksum:iF27E105373235B43
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021R → E in AAB39890. 1 PublicationCurated
Sequence conflicti182 – 1821S → E AA sequence (PubMed:6546756)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18053, M18051, M18052 Genomic DNA. Translation: AAA41153.1.
U58829 mRNA. Translation: AAB39890.1.
M29330 mRNA. Translation: AAA42300.1.
PIRiA39884.
RefSeqiNP_036980.1. NM_012848.2.
UniGeneiRn.54447.

Genome annotation databases

GeneIDi25319.
KEGGirno:25319.
UCSCiRGD:2635. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18053 , M18051 , M18052 Genomic DNA. Translation: AAA41153.1 .
U58829 mRNA. Translation: AAB39890.1 .
M29330 mRNA. Translation: AAA42300.1 .
PIRi A39884.
RefSeqi NP_036980.1. NM_012848.2.
UniGenei Rn.54447.

3D structure databases

ProteinModelPortali P19132.
SMRi P19132. Positions 7-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247358. 1 interaction.
IntActi P19132. 1 interaction.
MINTi MINT-4567905.

PTM databases

PhosphoSitei P19132.

Proteomic databases

PaxDbi P19132.
PRIDEi P19132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25319.
KEGGi rno:25319.
UCSCi RGD:2635. rat.

Organism-specific databases

CTDi 2495.
RGDi 2635. Fth1.

Phylogenomic databases

eggNOGi COG1528.
HOVERGENi HBG000410.
InParanoidi P19132.
KOi K00522.

Miscellaneous databases

NextBioi 606157.
PROi P19132.

Gene expression databases

Genevestigatori P19132.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression."
    Murray M.T., White K., Munro H.N.
    Proc. Natl. Acad. Sci. U.S.A. 84:7438-7442(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Wu C.G., Groenink M., Bosma A., Reitsma P.H., van Deventer J.H., Chamuleau R.A.F.M.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.
  3. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 81-87, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "TSH regulation of ferritin H chain messenger RNA levels in the rat thyroids."
    Ursini M.V., de Franciscis V.
    Biochem. Biophys. Res. Commun. 150:287-295(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-182.
  5. "Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit."
    Leibold E.A., Aziz N., Brown A.J.P., Munro H.N.
    J. Biol. Chem. 259:4327-4334(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 159-182.
    Tissue: Liver.

Entry informationi

Entry nameiFRIH_RAT
AccessioniPrimary (citable) accession number: P19132
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3