P19130 (FRIH_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin heavy chain
Short name=Ferritin H subunit
EC=1.16.3.1

Gene names

Name:	FTH1
Synonyms:	FTH

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.
Sequence similarities	Belongs to the ferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Ferritin heavy chain		PRO_0000201051
Regions
	Domain	11 – 160	150	Ferritin-like diiron
Amino acid modifications
	Modified residue	179	1	Phosphoserine By similarity
Natural variations
	Natural variant	111	1	V → M.
	Natural variant	116	1	L → H.
Experimental info
	Sequence conflict	103	1	F → C AA sequence Ref.2
	Sequence conflict	107 – 108	2	VV → LE AA sequence Ref.2
	Sequence conflict	112	1	Y → N AA sequence Ref.2
	Sequence conflict	140	1	H → D AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P19130 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 8E6D9710CC57F757	FASTA	181	21,045
	10 20 30 40 50 60 MTTSCSSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS 70 80 90 100 110 120 HGGRGHAEKL MKLQTQRGAR IFLQDIMKPE RDDWENGLTA MEFALHVVKN VYQSLLELHK 130 140 150 160 170 180 LATDKNDPHL CDFIETHYLH EQVKAIKELG DHITNLHRMG APEYGMAEYL FDKHTLGSSE S

References

[1]	Hamasima N., Suzuki H., Fujii H., Ito T., Murakami Y., Yamada R., Yazawa T., Yasue H. Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and partial amino acid sequence of three subunit species of porcine spleen ferritin: evidence of multiple H subunits." Collawn J.F. Jr., Gowan L.K., Crow H., Schwabe C., Fish W.W. Arch. Biochem. Biophys. 259:105-113(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 102-181. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D15071 mRNA. Translation: BAA03666.1.
PIR	S06279.
RefSeq	NP_999140.1. NM_213975.1.
UniGene	Ssc.23940. Ssc.42834. Ssc.61.
3D structure databases
ProteinModelPortal	P19130.
SMR	P19130. Positions 6-177.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397030.
KEGG	ssc:397030.
Organism-specific databases
CTD	2495.
Phylogenomic databases
HOVERGEN	HBG000410.
KO	K00522.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR014034. Ferritin_CS. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00540. FERRITIN_1. False negative. PS00204. FERRITIN_2. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRIH_PIG

Accession

Primary (citable) accession number: P19130
Secondary accession number(s): P19131

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 87 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program