P19123 (TNNC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Troponin C, slow skeletal and cardiac muscles
Short name=TN-C

Gene names

Name:	Tnnc1
Synonyms:	Tncc

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Miscellaneous	Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.
Sequence similarities	Belongs to the troponin C family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle contraction Inferred from electronic annotation. Source: Compara regulation of ATPase activity Inferred from direct assay PubMed 8785301. Source: BHF-UCL regulation of muscle filament sliding speed Inferred from mutant phenotype PubMed 10747195. Source: BHF-UCL ventricular cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	troponin complex Inferred from electronic annotation. Source: Compara
Molecular_function	actin filament binding Inferred from direct assay PubMed 8785301. Source: BHF-UCL calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	Troponin C, slow skeletal and cardiac muscles		PRO_0000073698
Regions
	Domain	16 – 51	36	EF-hand 1
	Domain	52 – 87	36	EF-hand 2
	Domain	92 – 127	36	EF-hand 3
	Domain	128 – 161	34	EF-hand 4
	Calcium binding	65 – 76	12	1
	Calcium binding	105 – 116	12	2
	Calcium binding	141 – 152	12	3
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P19123 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 34DCC903C157A312	FASTA	161	18,421
	10 20 30 40 50 60 MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ NPTPEELQEM 70 80 90 100 110 120 IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL FRMFDKNADG YIDLDELKMM 130 140 150 160 LQATGETITE DDIEELMKDG DKNNDGRIDY DEFLEFMKGV E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of the murine slow/cardiac troponin C gene." Parmacek M.S., Leiden J.M. J. Biol. Chem. 264:13217-13225(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04971 Genomic DNA. Translation: AAA37492.1. M29793 mRNA. Translation: AAA37493.1. BC061172 mRNA. Translation: AAH61172.1.
IPI	IPI00113712.
PIR	A32620.
RefSeq	NP_033419.1. NM_009393.2.
UniGene	Mm.439921.
3D structure databases
ProteinModelPortal	P19123.
SMR	P19123. Positions 1-161.
ModBase	Search...
Protein-protein interaction databases
IntAct	P19123. 1 interaction.
STRING	10090.ENSMUSP00000022468.
PTM databases
PhosphoSite	P19123.
Proteomic databases
PaxDb	P19123.
PRIDE	P19123.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898.
GeneID	21924.
KEGG	mmu:21924.
UCSC	uc007sxd.1. mouse.
Organism-specific databases
CTD	7134.
MGI	MGI:98779. Tnnc1.
Phylogenomic databases
eggNOG	COG5126.
GeneTree	ENSGT00690000101871.
HOGENOM	HOG000233018.
HOVERGEN	HBG012180.
InParanoid	P19123.
KO	K05865.
OMA	MNDIYKA.
OrthoDB	EOG46WZ9P.
Gene expression databases
ArrayExpress	P19123.
Bgee	P19123.
CleanEx	MM_TNNC1.
Genevestigator	P19123.
GermOnline	ENSMUSG00000021909. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001125. Recoverin. [Graphical view]
Pfam	PF13499. EF_hand_5. 1 hit. [Graphical view]
PRINTS	PR00450. RECOVERIN.
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	301500.
SOURCE	Search...

Entry information

Entry name

TNNC1_MOUSE

Accession

Primary (citable) accession number: P19123

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program