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P19123

- TNNC1_MOUSE

UniProt

P19123 - TNNC1_MOUSE

Protein

Troponin C, slow skeletal and cardiac muscles

Gene

Tnnc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi65 – 76121Add
    BLAST
    Calcium bindingi105 – 116122Add
    BLAST
    Calcium bindingi141 – 152123Add
    BLAST

    GO - Molecular functioni

    1. actin filament binding Source: BHF-UCL
    2. calcium ion binding Source: Ensembl

    GO - Biological processi

    1. cardiac muscle contraction Source: Ensembl
    2. diaphragm contraction Source: Ensembl
    3. regulation of ATPase activity Source: BHF-UCL
    4. regulation of muscle filament sliding speed Source: BHF-UCL
    5. response to metal ion Source: Ensembl
    6. ventricular cardiac muscle tissue morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin C, slow skeletal and cardiac muscles
    Short name:
    TN-C
    Gene namesi
    Name:Tnnc1
    Synonyms:Tncc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:98779. Tnnc1.

    Subcellular locationi

    GO - Cellular componenti

    1. troponin complex Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Troponin C, slow skeletal and cardiac musclesPRO_0000073698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP19123.
    PaxDbiP19123.
    PRIDEiP19123.

    PTM databases

    PhosphoSiteiP19123.

    Expressioni

    Gene expression databases

    ArrayExpressiP19123.
    BgeeiP19123.
    CleanExiMM_TNNC1.
    GenevestigatoriP19123.

    Interactioni

    Protein-protein interaction databases

    IntActiP19123. 3 interactions.
    MINTiMINT-4138131.
    STRINGi10090.ENSMUSP00000022468.

    Structurei

    3D structure databases

    ProteinModelPortaliP19123.
    SMRiP19123. Positions 1-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini52 – 8736EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini92 – 12736EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini128 – 16134EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the troponin C family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    GeneTreeiENSGT00690000101871.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiP19123.
    KOiK05865.
    OMAiMNDIYKA.
    OrthoDBiEOG76X61W.
    PhylomeDBiP19123.
    TreeFamiTF318191.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19123-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ    50
    NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL 100
    FRMFDKNADG YIDLDELKMM LQATGETITE DDIEELMKDG DKNNDGRIDY 150
    DEFLEFMKGV E 161
    Length:161
    Mass (Da):18,421
    Last modified:November 1, 1990 - v1
    Checksum:i34DCC903C157A312
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04971 Genomic DNA. Translation: AAA37492.1.
    M29793 mRNA. Translation: AAA37493.1.
    BC061172 mRNA. Translation: AAH61172.1.
    CCDSiCCDS36854.1.
    PIRiA32620.
    RefSeqiNP_033419.1. NM_009393.2.
    UniGeneiMm.439921.

    Genome annotation databases

    EnsembliENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898.
    GeneIDi21924.
    KEGGimmu:21924.
    UCSCiuc007sxd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04971 Genomic DNA. Translation: AAA37492.1 .
    M29793 mRNA. Translation: AAA37493.1 .
    BC061172 mRNA. Translation: AAH61172.1 .
    CCDSi CCDS36854.1.
    PIRi A32620.
    RefSeqi NP_033419.1. NM_009393.2.
    UniGenei Mm.439921.

    3D structure databases

    ProteinModelPortali P19123.
    SMRi P19123. Positions 1-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P19123. 3 interactions.
    MINTi MINT-4138131.
    STRINGi 10090.ENSMUSP00000022468.

    PTM databases

    PhosphoSitei P19123.

    Proteomic databases

    MaxQBi P19123.
    PaxDbi P19123.
    PRIDEi P19123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000169169 ; ENSMUSP00000131991 ; ENSMUSG00000091898 .
    GeneIDi 21924.
    KEGGi mmu:21924.
    UCSCi uc007sxd.1. mouse.

    Organism-specific databases

    CTDi 7134.
    MGIi MGI:98779. Tnnc1.

    Phylogenomic databases

    eggNOGi COG5126.
    GeneTreei ENSGT00690000101871.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi P19123.
    KOi K05865.
    OMAi MNDIYKA.
    OrthoDBi EOG76X61W.
    PhylomeDBi P19123.
    TreeFami TF318191.

    Miscellaneous databases

    NextBioi 301500.
    PROi P19123.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19123.
    Bgeei P19123.
    CleanExi MM_TNNC1.
    Genevestigatori P19123.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the murine slow/cardiac troponin C gene."
      Parmacek M.S., Leiden J.M.
      J. Biol. Chem. 264:13217-13225(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart and Lung.

    Entry informationi

    Entry nameiTNNC1_MOUSE
    AccessioniPrimary (citable) accession number: P19123
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3