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Protein

Troponin C, slow skeletal and cardiac muscles

Gene

Tnnc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi65 – 76121Add
BLAST
Calcium bindingi105 – 116122Add
BLAST
Calcium bindingi141 – 152123Add
BLAST

GO - Molecular functioni

  1. actin filament binding Source: BHF-UCL
  2. calcium-dependent protein binding Source: MGI
  3. calcium ion binding Source: AgBase
  4. protein homodimerization activity Source: MGI
  5. troponin I binding Source: MGI
  6. troponin T binding Source: MGI

GO - Biological processi

  1. cardiac muscle contraction Source: MGI
  2. diaphragm contraction Source: Ensembl
  3. regulation of ATPase activity Source: BHF-UCL
  4. regulation of muscle contraction Source: MGI
  5. regulation of muscle filament sliding speed Source: BHF-UCL
  6. response to metal ion Source: Ensembl
  7. transition between fast and slow fiber Source: MGI
  8. ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_324616. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, slow skeletal and cardiac muscles
Short name:
TN-C
Gene namesi
Name:Tnnc1
Synonyms:Tncc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98779. Tnnc1.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: MGI
  2. mitochondrion Source: MGI
  3. nucleoplasm Source: MGI
  4. troponin complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Troponin C, slow skeletal and cardiac musclesPRO_0000073698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP19123.
PaxDbiP19123.
PRIDEiP19123.

PTM databases

PhosphoSiteiP19123.

Expressioni

Gene expression databases

BgeeiP19123.
CleanExiMM_TNNC1.
ExpressionAtlasiP19123. baseline and differential.
GenevestigatoriP19123.

Interactioni

Protein-protein interaction databases

IntActiP19123. 3 interactions.
MINTiMINT-4138131.
STRINGi10090.ENSMUSP00000022468.

Structurei

3D structure databases

ProteinModelPortaliP19123.
SMRiP19123. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini52 – 8736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 12736EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 16134EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the troponin C family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP19123.
KOiK05865.
OMAiMNDIYKA.
OrthoDBiEOG76X61W.
PhylomeDBiP19123.
TreeFamiTF318191.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ
60 70 80 90 100
NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL
110 120 130 140 150
FRMFDKNADG YIDLDELKMM LQATGETITE DDIEELMKDG DKNNDGRIDY
160
DEFLEFMKGV E
Length:161
Mass (Da):18,421
Last modified:November 1, 1990 - v1
Checksum:i34DCC903C157A312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04971 Genomic DNA. Translation: AAA37492.1.
M29793 mRNA. Translation: AAA37493.1.
BC061172 mRNA. Translation: AAH61172.1.
CCDSiCCDS36854.1.
PIRiA32620.
RefSeqiNP_033419.1. NM_009393.2.
UniGeneiMm.439921.

Genome annotation databases

EnsembliENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898.
GeneIDi21924.
KEGGimmu:21924.
UCSCiuc007sxd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04971 Genomic DNA. Translation: AAA37492.1.
M29793 mRNA. Translation: AAA37493.1.
BC061172 mRNA. Translation: AAH61172.1.
CCDSiCCDS36854.1.
PIRiA32620.
RefSeqiNP_033419.1. NM_009393.2.
UniGeneiMm.439921.

3D structure databases

ProteinModelPortaliP19123.
SMRiP19123. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19123. 3 interactions.
MINTiMINT-4138131.
STRINGi10090.ENSMUSP00000022468.

PTM databases

PhosphoSiteiP19123.

Proteomic databases

MaxQBiP19123.
PaxDbiP19123.
PRIDEiP19123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898.
GeneIDi21924.
KEGGimmu:21924.
UCSCiuc007sxd.1. mouse.

Organism-specific databases

CTDi7134.
MGIiMGI:98779. Tnnc1.

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP19123.
KOiK05865.
OMAiMNDIYKA.
OrthoDBiEOG76X61W.
PhylomeDBiP19123.
TreeFamiTF318191.

Enzyme and pathway databases

ReactomeiREACT_324616. Striated Muscle Contraction.

Miscellaneous databases

NextBioi301500.
PROiP19123.
SOURCEiSearch...

Gene expression databases

BgeeiP19123.
CleanExiMM_TNNC1.
ExpressionAtlasiP19123. baseline and differential.
GenevestigatoriP19123.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the murine slow/cardiac troponin C gene."
    Parmacek M.S., Leiden J.M.
    J. Biol. Chem. 264:13217-13225(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.

Entry informationi

Entry nameiTNNC1_MOUSE
AccessioniPrimary (citable) accession number: P19123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 1, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.