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P19123 (TNNC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Troponin C, slow skeletal and cardiac muscles

Short name=TN-C
Gene names
Name:Tnnc1
Synonyms:Tncc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.

Sequence similarities

Belongs to the troponin C family.

Contains 4 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161Troponin C, slow skeletal and cardiac muscles
PRO_0000073698

Regions

Domain16 – 5136EF-hand 1
Domain52 – 8736EF-hand 2
Domain92 – 12736EF-hand 3
Domain128 – 16134EF-hand 4
Calcium binding65 – 76121
Calcium binding105 – 116122
Calcium binding141 – 152123

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P19123 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 34DCC903C157A312

FASTA16118,421
        10         20         30         40         50         60 
MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ NPTPEELQEM 

        70         80         90        100        110        120 
IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL FRMFDKNADG YIDLDELKMM 

       130        140        150        160 
LQATGETITE DDIEELMKDG DKNNDGRIDY DEFLEFMKGV E 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the murine slow/cardiac troponin C gene."
Parmacek M.S., Leiden J.M.
J. Biol. Chem. 264:13217-13225(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart and Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04971 Genomic DNA. Translation: AAA37492.1.
M29793 mRNA. Translation: AAA37493.1.
BC061172 mRNA. Translation: AAH61172.1.
PIRA32620.
RefSeqNP_033419.1. NM_009393.2.
UniGeneMm.439921.

3D structure databases

ProteinModelPortalP19123.
SMRP19123. Positions 1-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP19123. 3 interactions.
MINTMINT-4138131.
STRING10090.ENSMUSP00000022468.

PTM databases

PhosphoSiteP19123.

Proteomic databases

PaxDbP19123.
PRIDEP19123.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898.
GeneID21924.
KEGGmmu:21924.
UCSCuc007sxd.1. mouse.

Organism-specific databases

CTD7134.
MGIMGI:98779. Tnnc1.

Phylogenomic databases

eggNOGCOG5126.
GeneTreeENSGT00690000101871.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidP19123.
KOK05865.
OMAMNDIYKA.
OrthoDBEOG76X61W.
PhylomeDBP19123.
TreeFamTF318191.

Gene expression databases

ArrayExpressP19123.
BgeeP19123.
CleanExMM_TNNC1.
GenevestigatorP19123.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin_like.
[Graphical view]
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSPR00450. RECOVERIN.
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio301500.
PROP19123.
SOURCESearch...

Entry information

Entry nameTNNC1_MOUSE
AccessionPrimary (citable) accession number: P19123
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot