Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P19123

- TNNC1_MOUSE

UniProt

P19123 - TNNC1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Troponin C, slow skeletal and cardiac muscles

Gene

Tnnc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi65 – 76121Add
BLAST
Calcium bindingi105 – 116122Add
BLAST
Calcium bindingi141 – 152123Add
BLAST

GO - Molecular functioni

  1. actin filament binding Source: BHF-UCL
  2. calcium ion binding Source: Ensembl

GO - Biological processi

  1. cardiac muscle contraction Source: Ensembl
  2. diaphragm contraction Source: Ensembl
  3. regulation of ATPase activity Source: BHF-UCL
  4. regulation of muscle filament sliding speed Source: BHF-UCL
  5. response to metal ion Source: Ensembl
  6. ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_232053. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, slow skeletal and cardiac muscles
Short name:
TN-C
Gene namesi
Name:Tnnc1
Synonyms:Tncc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:98779. Tnnc1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleus Source: Ensembl
  3. troponin complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Troponin C, slow skeletal and cardiac musclesPRO_0000073698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP19123.
PaxDbiP19123.
PRIDEiP19123.

PTM databases

PhosphoSiteiP19123.

Expressioni

Gene expression databases

BgeeiP19123.
CleanExiMM_TNNC1.
ExpressionAtlasiP19123. baseline and differential.
GenevestigatoriP19123.

Interactioni

Protein-protein interaction databases

IntActiP19123. 3 interactions.
MINTiMINT-4138131.
STRINGi10090.ENSMUSP00000022468.

Structurei

3D structure databases

ProteinModelPortaliP19123.
SMRiP19123. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini52 – 8736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 12736EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 16134EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the troponin C family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP19123.
KOiK05865.
OMAiMNDIYKA.
OrthoDBiEOG76X61W.
PhylomeDBiP19123.
TreeFamiTF318191.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19123-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ
60 70 80 90 100
NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL
110 120 130 140 150
FRMFDKNADG YIDLDELKMM LQATGETITE DDIEELMKDG DKNNDGRIDY
160
DEFLEFMKGV E
Length:161
Mass (Da):18,421
Last modified:November 1, 1990 - v1
Checksum:i34DCC903C157A312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04971 Genomic DNA. Translation: AAA37492.1.
M29793 mRNA. Translation: AAA37493.1.
BC061172 mRNA. Translation: AAH61172.1.
CCDSiCCDS36854.1.
PIRiA32620.
RefSeqiNP_033419.1. NM_009393.2.
UniGeneiMm.439921.

Genome annotation databases

EnsembliENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898.
GeneIDi21924.
KEGGimmu:21924.
UCSCiuc007sxd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04971 Genomic DNA. Translation: AAA37492.1 .
M29793 mRNA. Translation: AAA37493.1 .
BC061172 mRNA. Translation: AAH61172.1 .
CCDSi CCDS36854.1.
PIRi A32620.
RefSeqi NP_033419.1. NM_009393.2.
UniGenei Mm.439921.

3D structure databases

ProteinModelPortali P19123.
SMRi P19123. Positions 1-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P19123. 3 interactions.
MINTi MINT-4138131.
STRINGi 10090.ENSMUSP00000022468.

PTM databases

PhosphoSitei P19123.

Proteomic databases

MaxQBi P19123.
PaxDbi P19123.
PRIDEi P19123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000169169 ; ENSMUSP00000131991 ; ENSMUSG00000091898 .
GeneIDi 21924.
KEGGi mmu:21924.
UCSCi uc007sxd.1. mouse.

Organism-specific databases

CTDi 7134.
MGIi MGI:98779. Tnnc1.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00760000118901.
HOGENOMi HOG000233018.
HOVERGENi HBG012180.
InParanoidi P19123.
KOi K05865.
OMAi MNDIYKA.
OrthoDBi EOG76X61W.
PhylomeDBi P19123.
TreeFami TF318191.

Enzyme and pathway databases

Reactomei REACT_232053. Striated Muscle Contraction.

Miscellaneous databases

NextBioi 301500.
PROi P19123.
SOURCEi Search...

Gene expression databases

Bgeei P19123.
CleanExi MM_TNNC1.
ExpressionAtlasi P19123. baseline and differential.
Genevestigatori P19123.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the murine slow/cardiac troponin C gene."
    Parmacek M.S., Leiden J.M.
    J. Biol. Chem. 264:13217-13225(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.

Entry informationi

Entry nameiTNNC1_MOUSE
AccessioniPrimary (citable) accession number: P19123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3