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Protein

Serum albumin

Gene

ALB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi30 – 301CopperBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Alpha-livetin
Allergen: Gal d 5
Gene namesi
Name:ALB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
  • protein complex Source: UniProtKB
  • yolk Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. Partially heat-labile allergen that may cause both respiratory and food-allergy symptoms in patients with the bird-egg syndrome.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3295. Gal d 5.0101.
363. Gal d 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Propeptidei19 – 235PRO_0000001083
Chaini24 – 615592Serum albuminPRO_0000001084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 89PROSITE-ProRule annotation
Disulfide bondi102 ↔ 118PROSITE-ProRule annotation
Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
Disulfide bondi152 ↔ 197PROSITE-ProRule annotation
Disulfide bondi196 ↔ 205PROSITE-ProRule annotation
Disulfide bondi228 ↔ 274PROSITE-ProRule annotation
Disulfide bondi273 ↔ 281PROSITE-ProRule annotation
Disulfide bondi293 ↔ 307PROSITE-ProRule annotation
Disulfide bondi306 ↔ 317PROSITE-ProRule annotation
Disulfide bondi344 ↔ 389PROSITE-ProRule annotation
Disulfide bondi388 ↔ 397PROSITE-ProRule annotation
Disulfide bondi420 ↔ 466PROSITE-ProRule annotation
Disulfide bondi465 ↔ 476PROSITE-ProRule annotation
Disulfide bondi489 ↔ 505PROSITE-ProRule annotation
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
Disulfide bondi542 ↔ 587PROSITE-ProRule annotation
Disulfide bondi586 ↔ 595PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP19121.
PRIDEiP19121.

Miscellaneous databases

PMAP-CutDBP19121.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

BioGridi676457. 1 interaction.
IntActiP19121. 1 interaction.
STRINGi9031.ENSGALP00000019031.

Structurei

3D structure databases

ProteinModelPortaliP19121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 214193Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini215 – 407193Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini408 – 605198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP19121.
PhylomeDBiP19121.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTLISFI FLFSSATSRN LQRFARDAEH KSEIAHRYND LKEETFKAVA
60 70 80 90 100
MITFAQYLQR CSYEGLSKLV KDVVDLAQKC VANEDAPECS KPLPSIILDE
110 120 130 140 150
ICQVEKLRDS YGAMADCCSK ADPERNECFL SFKVSQPDFV QPYQRPASDV
160 170 180 190 200
ICQEYQDNRV SFLGHFIYSV ARRHPFLYAP AILSFAVDFE HALQSCCKES
210 220 230 240 250
DVGACLDTKE IVMREKAKGV SVKQQYFCGI LKQFGDRVFQ ARQLIYLSQK
260 270 280 290 300
YPKAPFSEVS KFVHDSIGVH KECCEGDMVE CMDDMARMMS NLCSQQDVFS
310 320 330 340 350
GKIKDCCEKP IVERSQCIME AEFDEKPADL PSLVEKYIED KEVCKSFEAG
360 370 380 390 400
HDAFMAEFVY EYSRRHPEFS IQLIMRIAKG YESLLEKCCK TDNPAECYAN
410 420 430 440 450
AQEQLNQHIK ETQDVVKTNC DLLHDHGEAD FLKSILIRYT KKMPQVPTDL
460 470 480 490 500
LLETGKKMTT IGTKCCQLGE DRRMACSEGY LSIVIHDTCR KQETTPINDN
510 520 530 540 550
VSQCCSQLYA NRRPCFTAMG VDTKYVPPPF NPDMFSFDEK LCSAPAEERE
560 570 580 590 600
VGQMKLLINL IKRKPQMTEE QIKTIADGFT AMVDKCCKQS DINTCFGEEG
610
ANLIVQSRAT LGIGA
Length:615
Mass (Da):69,918
Last modified:August 1, 1992 - v2
Checksum:iE59E4BBCAEC066C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241F → M AA sequence (PubMed:911327).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60688 mRNA. Translation: CAA43098.1.
V00381 Genomic DNA. Translation: CAA23680.1.
PIRiS15571. ABCHS.
UniGeneiGga.4510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60688 mRNA. Translation: CAA43098.1.
V00381 Genomic DNA. Translation: CAA23680.1.
PIRiS15571. ABCHS.
UniGeneiGga.4510.

3D structure databases

ProteinModelPortaliP19121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676457. 1 interaction.
IntActiP19121. 1 interaction.
STRINGi9031.ENSGALP00000019031.

Protein family/group databases

Allergomei3295. Gal d 5.0101.
363. Gal d 5.

Proteomic databases

PaxDbiP19121.
PRIDEiP19121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP19121.
PhylomeDBiP19121.

Miscellaneous databases

PMAP-CutDBP19121.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cassady A.I., Salklld C.K., Baverstock P., Wallace J.C.
    Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The 5' noncoding and flanking regions of the avian very low density apolipoprotein II and serum albumin genes. Homologies with the egg white protein genes."
    Hache R.J.G., Wiskocil R., Vasa M., Roy R.N., Lau P.C.K., Deeley R.G.
    J. Biol. Chem. 258:4556-4564(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
  3. "Chicken microsomal albumin: amino terminal sequence of chicken proalbumin."
    Rosen A.M., Geller D.M.
    Biochem. Biophys. Res. Commun. 78:1060-1066(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-30.
  4. "Chicken serum albumin (Gal d 5*) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome."
    Quirce S., Maranon F., Umpierrez A., de las Heras M., Fernandez-Caldas E., Sastre J.
    Allergy 56:754-762(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALLERGEN.

Entry informationi

Entry nameiALBU_CHICK
AccessioniPrimary (citable) accession number: P19121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 1, 1992
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.