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P19121 (ALBU_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serum albumin
Alternative name(s):
Alpha-livetin
Allergen=Gal d 5
Gene names
Name:ALB
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length615 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.

Subcellular location

Secreted.

Tissue specificity

Plasma.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE. Partially heat-labile allergen that may cause both respiratory and food-allergy symptoms in patients with the bird-egg syndrome. Ref.4

Sequence similarities

Belongs to the ALB/AFP/VDB family.

Contains 3 albumin domains.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainRepeat
Signal
   LigandCopper
Lipid-binding
Metal-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to starvation

Inferred from sequence or structural similarity. Source: UniProtKB

hemolysis by symbiont of host erythrocytes

Inferred from sequence or structural similarity. Source: UniProtKB

maintenance of mitochondrion location

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

response to virus

Inferred from direct assay PubMed 1310111PubMed 2746374. Source: AgBase

response to vitamin A

Inferred from direct assay PubMed 2746374. Source: AgBase

transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from direct assay PubMed 1310111PubMed 2746374. Source: AgBase

protein complex

Inferred from sequence or structural similarity. Source: UniProtKB

yolk

Inferred from direct assay PubMed 7548118. Source: AgBase

   Molecular_functionDNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

drug binding

Inferred from sequence or structural similarity. Source: UniProtKB

fatty acid binding

Inferred from sequence or structural similarity. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

pyridoxal phosphate binding

Inferred from sequence or structural similarity. Source: UniProtKB

toxin binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.3
Propeptide19 – 235
PRO_0000001083
Chain24 – 615592Serum albumin
PRO_0000001084

Regions

Domain22 – 214193Albumin 1
Domain215 – 407193Albumin 2
Domain408 – 605198Albumin 3

Sites

Metal binding301Copper By similarity

Amino acid modifications

Glycosylation5001N-linked (GlcNAc...) Potential
Disulfide bond80 ↔ 89 By similarity
Disulfide bond102 ↔ 118 By similarity
Disulfide bond117 ↔ 128 By similarity
Disulfide bond152 ↔ 197 By similarity
Disulfide bond196 ↔ 205 By similarity
Disulfide bond228 ↔ 274 By similarity
Disulfide bond273 ↔ 281 By similarity
Disulfide bond293 ↔ 307 By similarity
Disulfide bond306 ↔ 317 By similarity
Disulfide bond344 ↔ 389 By similarity
Disulfide bond388 ↔ 397 By similarity
Disulfide bond420 ↔ 466 By similarity
Disulfide bond465 ↔ 476 By similarity
Disulfide bond489 ↔ 505 By similarity
Disulfide bond504 ↔ 515 By similarity
Disulfide bond542 ↔ 587 By similarity
Disulfide bond586 ↔ 595 By similarity

Experimental info

Sequence conflict241F → M AA sequence Ref.3

Sequences

Sequence LengthMass (Da)Tools
P19121 [UniParc].

Last modified August 1, 1992. Version 2.
Checksum: E59E4BBCAEC066C6

FASTA61569,918
        10         20         30         40         50         60 
MKWVTLISFI FLFSSATSRN LQRFARDAEH KSEIAHRYND LKEETFKAVA MITFAQYLQR 

        70         80         90        100        110        120 
CSYEGLSKLV KDVVDLAQKC VANEDAPECS KPLPSIILDE ICQVEKLRDS YGAMADCCSK 

       130        140        150        160        170        180 
ADPERNECFL SFKVSQPDFV QPYQRPASDV ICQEYQDNRV SFLGHFIYSV ARRHPFLYAP 

       190        200        210        220        230        240 
AILSFAVDFE HALQSCCKES DVGACLDTKE IVMREKAKGV SVKQQYFCGI LKQFGDRVFQ 

       250        260        270        280        290        300 
ARQLIYLSQK YPKAPFSEVS KFVHDSIGVH KECCEGDMVE CMDDMARMMS NLCSQQDVFS 

       310        320        330        340        350        360 
GKIKDCCEKP IVERSQCIME AEFDEKPADL PSLVEKYIED KEVCKSFEAG HDAFMAEFVY 

       370        380        390        400        410        420 
EYSRRHPEFS IQLIMRIAKG YESLLEKCCK TDNPAECYAN AQEQLNQHIK ETQDVVKTNC 

       430        440        450        460        470        480 
DLLHDHGEAD FLKSILIRYT KKMPQVPTDL LLETGKKMTT IGTKCCQLGE DRRMACSEGY 

       490        500        510        520        530        540 
LSIVIHDTCR KQETTPINDN VSQCCSQLYA NRRPCFTAMG VDTKYVPPPF NPDMFSFDEK 

       550        560        570        580        590        600 
LCSAPAEERE VGQMKLLINL IKRKPQMTEE QIKTIADGFT AMVDKCCKQS DINTCFGEEG 

       610 
ANLIVQSRAT LGIGA

« Hide

References

[1]Cassady A.I., Salklld C.K., Baverstock P., Wallace J.C.
Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The 5' noncoding and flanking regions of the avian very low density apolipoprotein II and serum albumin genes. Homologies with the egg white protein genes."
Hache R.J.G., Wiskocil R., Vasa M., Roy R.N., Lau P.C.K., Deeley R.G.
J. Biol. Chem. 258:4556-4564(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
[3]"Chicken microsomal albumin: amino terminal sequence of chicken proalbumin."
Rosen A.M., Geller D.M.
Biochem. Biophys. Res. Commun. 78:1060-1066(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-30.
[4]"Chicken serum albumin (Gal d 5*) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome."
Quirce S., Maranon F., Umpierrez A., de las Heras M., Fernandez-Caldas E., Sastre J.
Allergy 56:754-762(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: ALLERGEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X60688 mRNA. Translation: CAA43098.1.
V00381 Genomic DNA. Translation: CAA23680.1.
IPIIPI00574195.
PIRABCHS. S15571.
RefSeqNP_990592.1. NM_205261.1.
UniGeneGga.4510.

3D structure databases

ProteinModelPortalP19121.
ModBaseSearch...

Protein-protein interaction databases

IntActP19121. 1 interaction.
STRING9031.ENSGALP00000019031.

Protein family/group databases

Allergome3295. Gal d 5.0101.
363. Gal d 5.

Proteomic databases

PaxDbP19121.
PRIDEP19121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396197.
KEGGgga:396197.

Organism-specific databases

CTD213.

Phylogenomic databases

eggNOGNOG45992.
HOGENOMHOG000293137.
HOVERGENHBG004207.
InParanoidP19121.
KOK16141.
OrthoDBEOG4Z0B55.

Family and domain databases

InterProIPR000264. ALB/AFP/VDB.
IPR001703. Alpha-fetoprotein.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMSSF48552. Serum_albumin. 3 hits.
PROSITEPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816249.
PMAP-CutDBP19121.

Entry information

Entry nameALBU_CHICK
AccessionPrimary (citable) accession number: P19121
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 1, 1992
Last modified: May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Recent format changes

Overview of recent format changes

Allergens

Nomenclature of allergens and list of entries

SIMILARITY comments

Index of protein domains and families

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