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Protein

Histidine decarboxylase

Gene

HDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of histamine from histidine.1 Publication

Catalytic activityi

L-histidine = histamine + CO2.1 Publication

Cofactori

pyridoxal 5'-phosphate1 Publication

Kineticsi

  1. KM=0.1 mM for histidine1 Publication
  1. Vmax=1880 nmol/min/mg enzyme1 Publication

Pathwayi: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:
  1. Histidine decarboxylase (HDC)
This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Substrate; via amide nitrogen1
Binding sitei194Substrate1

GO - Molecular functioni

  • histidine decarboxylase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • catecholamine biosynthetic process Source: UniProtKB-KW
  • histamine biosynthetic process Source: UniProtKB
  • histidine catabolic process Source: UniProtKB
  • histidine metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06697-MONOMER.
ZFISH:HS06697-MONOMER.
BRENDAi4.1.1.22. 2681.
ReactomeiR-HSA-70921. Histidine catabolism.
UniPathwayiUPA00822; UER00786.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:HDC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:4855. HDC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi305K → G: Loss of enzyme activity. 1 Publication1
Mutagenesisi334Y → F: Loss of enzyme activity. 1 Publication1
Mutagenesisi354S → G: Strongly decreases affinity for histidine. Strongly increases affinity for L-DOPA and confers enzyme activity toward L-DOPA. 1 Publication1

Organism-specific databases

DisGeNETi3067.
MalaCardsiHDC.
OpenTargetsiENSG00000140287.
Orphaneti856. Tourette syndrome.
PharmGKBiPA29233.

Chemistry databases

DrugBankiDB00117. L-Histidine.

Polymorphism and mutation databases

BioMutaiHDC.
DMDMi1352220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469501 – 662Histidine decarboxylaseAdd BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305N6-(pyridoxal phosphate)lysine1

Proteomic databases

EPDiP19113.
PaxDbiP19113.
PeptideAtlasiP19113.
PRIDEiP19113.

PTM databases

iPTMnetiP19113.
PhosphoSitePlusiP19113.

Expressioni

Gene expression databases

BgeeiENSG00000140287.
CleanExiHS_HDC.
ExpressionAtlasiP19113. baseline and differential.
GenevisibleiP19113. HS.

Organism-specific databases

HPAiHPA038891.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DTX2Q4ZH493EBI-10200283,EBI-10192429
DTX2Q86UW93EBI-10200283,EBI-740376

Protein-protein interaction databases

BioGridi109317. 2 interactors.
IntActiP19113. 2 interactors.
STRINGi9606.ENSP00000267845.

Structurei

Secondary structure

1662
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 23Combined sources20
Helixi25 – 27Combined sources3
Turni36 – 39Combined sources4
Helixi40 – 42Combined sources3
Helixi54 – 64Combined sources11
Helixi66 – 68Combined sources3
Beta strandi79 – 81Combined sources3
Helixi87 – 99Combined sources13
Turni106 – 108Combined sources3
Helixi110 – 127Combined sources18
Helixi131 – 133Combined sources3
Beta strandi143 – 148Combined sources6
Helixi150 – 172Combined sources23
Helixi178 – 182Combined sources5
Beta strandi185 – 190Combined sources6
Helixi195 – 204Combined sources10
Beta strandi207 – 211Combined sources5
Helixi221 – 233Combined sources13
Beta strandi237 – 246Combined sources10
Turni248 – 250Combined sources3
Helixi256 – 266Combined sources11
Beta strandi269 – 273Combined sources5
Helixi277 – 282Combined sources6
Helixi284 – 290Combined sources7
Helixi293 – 295Combined sources3
Beta strandi297 – 301Combined sources5
Helixi303 – 306Combined sources4
Beta strandi314 – 320Combined sources7
Helixi321 – 325Combined sources5
Turni326 – 328Combined sources3
Helixi333 – 335Combined sources3
Turni338 – 342Combined sources5
Helixi346 – 349Combined sources4
Beta strandi350 – 353Combined sources4
Helixi359 – 393Combined sources35
Beta strandi406 – 415Combined sources10
Helixi417 – 430Combined sources14
Beta strandi432 – 434Combined sources3
Beta strandi436 – 440Combined sources5
Beta strandi443 – 449Combined sources7
Helixi457 – 475Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E1OX-ray1.80A/B/C/D/E/F2-477[»]
ProteinModelPortaliP19113.
SMRiP19113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP19113.
KOiK01590.
OMAiPEHFLHH.
OrthoDBiEOG091G03KI.
PhylomeDBiP19113.
TreeFamiTF313863.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19113-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEPEEYRER GREMVDYICQ YLSTVRERRV TPDVQPGYLR AQLPESAPED
60 70 80 90 100
PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN
110 120 130 140 150
CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPSS QGGGVLQSTV
160 170 180 190 200
SESTLIALLA ARKNKILEMK TSEPDADESC LNARLVAYAS DQAHSSVEKA
210 220 230 240 250
GLISLVKMKF LPVDDNFSLR GEALQKAIEE DKQRGLVPVF VCATLGTTGV
260 270 280 290 300
CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
310 320 330 340 350
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV NPIYLRHANS GVATDFMHWQ
360 370 380 390 400
IPLSRRFRSV KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPSFEI
410 420 430 440 450
PAKRHLGLVV FRLKGPNCLT ENVLKEIAKA GRLFLIPATI QDKLIIRFTV
460 470 480 490 500
TSQFTTRDDI LRDWNLIRDA ATLILSQHCT SQPSPRVGNL ISQIRGARAW
510 520 530 540 550
ACGTSLQSVS GAGDDPVQAR KIIKQPQRVG AGPMKRENGL HLETLLDPVD
560 570 580 590 600
DCFSEEAPDA TKHKLSSFLF SYLSVQTKKK TVRSLSCNSV PVSAQKPLPT
610 620 630 640 650
EASVKNGGSS RVRIFSRFPE DMMMLKKSAF KKLIKFYSVP SFPECSSQCG
660
LQLPCCPLQA MV
Length:662
Mass (Da):74,141
Last modified:February 1, 1996 - v2
Checksum:iD7611CFAAD60F469
GO
Isoform 2 (identifier: P19113-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-380: Missing.

Note: No experimental confirmation available.
Show »
Length:629
Mass (Da):70,059
Checksum:i72BDB69D63CE7606
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118N → M no nucleotide entry (PubMed:1425659).Curated1
Sequence conflicti148S → Q in CAA38196 (PubMed:2216786).Curated1
Sequence conflicti148S → Q no nucleotide entry (PubMed:1425659).Curated1
Sequence conflicti500W → M no nucleotide entry (PubMed:1425659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04887331T → M.1 PublicationCorresponds to variant rs17740607dbSNPEnsembl.1
Natural variantiVAR_03647049E → V in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036471285E → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_048874553F → L.Corresponds to variant rs16963486dbSNPEnsembl.1
Natural variantiVAR_033846644E → D.Corresponds to variant rs2073440dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056296348 – 380Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54297 mRNA. Translation: CAA38196.1.
M60445 mRNA. Translation: AAC41698.1.
D16583 Genomic DNA. Translation: BAA04015.1.
AC009753 Genomic DNA. No translation available.
AC022087 Genomic DNA. No translation available.
BC130527 mRNA. Translation: AAI30528.1.
BC144173 mRNA. Translation: AAI44174.1.
CCDSiCCDS10134.1. [P19113-1]
CCDS76754.1. [P19113-2]
PIRiA49882.
RefSeqiNP_001293075.1. NM_001306146.1. [P19113-2]
NP_002103.2. NM_002112.3. [P19113-1]
UniGeneiHs.1481.

Genome annotation databases

EnsembliENST00000267845; ENSP00000267845; ENSG00000140287. [P19113-1]
ENST00000543581; ENSP00000440252; ENSG00000140287. [P19113-2]
GeneIDi3067.
KEGGihsa:3067.
UCSCiuc001zxz.4. human. [P19113-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54297 mRNA. Translation: CAA38196.1.
M60445 mRNA. Translation: AAC41698.1.
D16583 Genomic DNA. Translation: BAA04015.1.
AC009753 Genomic DNA. No translation available.
AC022087 Genomic DNA. No translation available.
BC130527 mRNA. Translation: AAI30528.1.
BC144173 mRNA. Translation: AAI44174.1.
CCDSiCCDS10134.1. [P19113-1]
CCDS76754.1. [P19113-2]
PIRiA49882.
RefSeqiNP_001293075.1. NM_001306146.1. [P19113-2]
NP_002103.2. NM_002112.3. [P19113-1]
UniGeneiHs.1481.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E1OX-ray1.80A/B/C/D/E/F2-477[»]
ProteinModelPortaliP19113.
SMRiP19113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109317. 2 interactors.
IntActiP19113. 2 interactors.
STRINGi9606.ENSP00000267845.

Chemistry databases

DrugBankiDB00117. L-Histidine.

PTM databases

iPTMnetiP19113.
PhosphoSitePlusiP19113.

Polymorphism and mutation databases

BioMutaiHDC.
DMDMi1352220.

Proteomic databases

EPDiP19113.
PaxDbiP19113.
PeptideAtlasiP19113.
PRIDEiP19113.

Protocols and materials databases

DNASUi3067.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267845; ENSP00000267845; ENSG00000140287. [P19113-1]
ENST00000543581; ENSP00000440252; ENSG00000140287. [P19113-2]
GeneIDi3067.
KEGGihsa:3067.
UCSCiuc001zxz.4. human. [P19113-1]

Organism-specific databases

CTDi3067.
DisGeNETi3067.
GeneCardsiHDC.
HGNCiHGNC:4855. HDC.
HPAiHPA038891.
MalaCardsiHDC.
MIMi142704. gene.
neXtProtiNX_P19113.
OpenTargetsiENSG00000140287.
Orphaneti856. Tourette syndrome.
PharmGKBiPA29233.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP19113.
KOiK01590.
OMAiPEHFLHH.
OrthoDBiEOG091G03KI.
PhylomeDBiP19113.
TreeFamiTF313863.

Enzyme and pathway databases

UniPathwayiUPA00822; UER00786.
BioCyciMetaCyc:HS06697-MONOMER.
ZFISH:HS06697-MONOMER.
BRENDAi4.1.1.22. 2681.
ReactomeiR-HSA-70921. Histidine catabolism.

Miscellaneous databases

GeneWikiiHistidine_decarboxylase.
GenomeRNAii3067.
PROiP19113.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140287.
CleanExiHS_HDC.
ExpressionAtlasiP19113. baseline and differential.
GenevisibleiP19113. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCHS_HUMAN
AccessioniPrimary (citable) accession number: P19113
Secondary accession number(s): A1L4G0, B7ZM01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.