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Protein

Myosin regulatory light chain 12A

Gene

MYL12A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).By similarity

Miscellaneous

This chain binds calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 52Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-3928664 Ephrin signaling
R-HSA-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 12A
Alternative name(s):
Epididymis secretory protein Li 24
Short name:
HEL-S-24
MLC-2B
Myosin RLC
Myosin regulatory light chain 2, nonsarcomeric
Myosin regulatory light chain MRLC3
Gene namesi
Name:MYL12A
Synonyms:MLCB, MRLC3, RLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101608.12
HGNCiHGNC:16701 MYL12A
MIMi609211 gene
neXtProtiNX_P19105

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi103910
10627
OpenTargetsiENSG00000101608
PharmGKBiPA164723273

Polymorphism and mutation databases

BioMutaiMYL12A
DMDMi127169

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987331 – 171Myosin regulatory light chain 12AAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Phosphothreonine; by MLCK1 Publication1
Modified residuei19Phosphoserine; by MLCK1 Publication1

Post-translational modificationi

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP19105
PaxDbiP19105
PeptideAtlasiP19105
PRIDEiP19105
TopDownProteomicsiP19105

2D gel databases

OGPiP19105
SWISS-2DPAGEiP19105

PTM databases

iPTMnetiP19105
PhosphoSitePlusiP19105
SwissPalmiP19105

Expressioni

Gene expression databases

BgeeiENSG00000101608
ExpressionAtlasiP19105 baseline and differential
GenevisibleiP19105 HS

Organism-specific databases

HPAiCAB004503
HPA039262
HPA045244
HPA059197

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11587158 interactors.
CORUMiP19105
IntActiP19105 45 interactors.
MINTiP19105
STRINGi9606.ENSP00000217652

Structurei

3D structure databases

ProteinModelPortaliP19105
SMRiP19105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini97 – 132EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini133 – 168EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000119196
HOGENOMiHOG000233018
InParanoidiP19105
KOiK12757
PhylomeDBiP19105
TreeFamiTF314218

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR015070 EF_hand_DJBP
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF08976 EF-hand_11, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

P19105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKRTKTKT KKRPQRATSN VFAMFDQSQI QEFKEAFNMI DQNRDGFIDK
60 70 80 90 100
EDLHDMLASL GKNPTDEYLD AMMNEAPGPI NFTMFLTMFG EKLNGTDPED
110 120 130 140 150
VIRNAFACFD EEATGTIQED YLRELLTTMG DRFTDEEVDE LYREAPIDKK
160 170
GNFNYIEFTR ILKHGAKDKD D
Length:171
Mass (Da):19,794
Last modified:January 23, 2007 - v2
Checksum:iC871AA881BF5C215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54304 mRNA Translation: CAA38201.1
D82059 mRNA Translation: BAB88919.1
EU794621 mRNA Translation: ACJ13675.1
AK291145 mRNA Translation: BAF83834.1
CH471113 Genomic DNA Translation: EAX01678.1
CH471113 Genomic DNA Translation: EAX01680.1
CH471113 Genomic DNA Translation: EAX01681.1
BC016372 mRNA Translation: AAH16372.1
BC031972 mRNA Translation: AAH31972.1
BC032748 mRNA Translation: AAH32748.1
CCDSiCCDS11830.1
PIRiS11493 MOHULP
RefSeqiNP_001289976.1, NM_001303047.1
NP_001289977.1, NM_001303048.1
NP_001289978.1, NM_001303049.1
NP_006462.1, NM_006471.3
UniGeneiHs.190086

Genome annotation databases

EnsembliENST00000217652; ENSP00000217652; ENSG00000101608
ENST00000536605; ENSP00000441231; ENSG00000101608
ENST00000578611; ENSP00000463614; ENSG00000101608
ENST00000579226; ENSP00000462171; ENSG00000101608
GeneIDi10627
KEGGihsa:10627
UCSCiuc002klr.3 human

Similar proteinsi

Entry informationi

Entry nameiML12A_HUMAN
AccessioniPrimary (citable) accession number: P19105
Secondary accession number(s): Q53X45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome