Ppp1r1a

Functionⁱ

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

GO - Molecular functionⁱ

protein serine/threonine phosphatase inhibitor activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

glycogen metabolic process Source: UniProtKB-KW
intracellular signal transduction Source: GO_Central
negative regulation of protein kinase activity Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Protein phosphatase inhibitor
Biological process	Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase 1 regulatory subunit 1A Alternative name(s): Protein phosphatase inhibitor 1 Short name: I-1 Short name: IPP-1
Gene namesⁱ	Name:Ppp1r1a Synonyms:Ipp1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	62018. Ppp1r1a.

RGDⁱ

62018. Ppp1r1a.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm
Source: RGD
Inferred from direct assayⁱ
- 23557701
extracellular space
Source: RGD
Inferred from direct assayⁱ
- 23557701

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071480	1 – 171	Protein phosphatase 1 regulatory subunit 1AAdd BLAST		171

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	35	Phosphothreonine; by PKABy similarity	1
Modified residueⁱ	43	PhosphoserineBy similarity	1
Modified residueⁱ	46	PhosphoserineCombined sources	1
Modified residueⁱ	47	PhosphoserineCombined sources	1
Modified residueⁱ	67	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation of Thr-35 is required for activity.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P19103.
PRIDEⁱ	P19103.

PTM databases

iPTMnetⁱ	P19103.
PhosphoSitePlusⁱ	P19103.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000036827.
Genevisibleⁱ	P19103. RN.

Interactionⁱ

Subunit structureⁱ

Interacts with PPP1R15A.By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000052146.

STRINGⁱ

10116.ENSRNOP00000052146.

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	9 – 12	Essential for activity	4
Regionⁱ	42 – 54	Essential for activityCuratedAdd BLAST	13
Regionⁱ	143 – 171	Interaction with PPP1R15ABy similarityAdd BLAST	29

Sequence similaritiesⁱ

Belongs to the protein phosphatase inhibitor 1 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410J0ZP. Eukaryota. ENOG41125ZM. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110965.
HOGENOMⁱ	HOG000115665.
HOVERGENⁱ	HBG096069.
InParanoidⁱ	P19103.
KEGG Orthology (KO) More...KOⁱ	K08050.
OMAⁱ	MEPDNSP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1A3V.
PhylomeDBⁱ	P19103.
TreeFamⁱ	TF332576.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008466. PPP1R1A/B/C.
PANTHERⁱ	PTHR15417. PTHR15417. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05395. DARPP-32. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P19103-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEV 
        60         70         80         90        100
DEDRIPNPLL KSTLSMSPRQ RKKMTRTTPT MKELQTMVEH HLGQQKQGEE 
       110        120        130        140        150
PEGATESTGN QESCPPGIPD TGSASRPDTS GTAQKPAESK PKTQEQRGVE 
       160        170 
PSTEDLSAHM LPLDSQGASL V

Length:171

Mass (Da):18,738

Last modified:November 1, 1990 - v1

Checksum:ⁱ4D26478008245956

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05592 mRNA. Translation: AAA41933.1. AJ276593 mRNA. Translation: CAB77674.1. AY648296 mRNA. Translation: AAT66740.1. BC078820 mRNA. Translation: AAH78820.1.
PIRⁱ	A37110.
NCBI Reference Sequences More...RefSeqⁱ	NP_073167.1. NM_022676.3.
UniGeneⁱ	Rn.9756.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000055271; ENSRNOP00000052146; ENSRNOG00000036827.
GeneIDⁱ	58977.
KEGGⁱ	rno:58977.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05592 mRNA. Translation: AAA41933.1. AJ276593 mRNA. Translation: CAB77674.1. AY648296 mRNA. Translation: AAT66740.1. BC078820 mRNA. Translation: AAH78820.1.
PIRⁱ	A37110.
NCBI Reference Sequences More...RefSeqⁱ	NP_073167.1. NM_022676.3.
UniGeneⁱ	Rn.9756.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000052146.

STRINGⁱ

10116.ENSRNOP00000052146.

PTM databases

iPTMnetⁱ	P19103.
PhosphoSitePlusⁱ	P19103.

Proteomic databases

PaxDbⁱ	P19103.
PRIDEⁱ	P19103.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000055271; ENSRNOP00000052146; ENSRNOG00000036827.
GeneIDⁱ	58977.
KEGGⁱ	rno:58977.

Organism-specific databases

CTDⁱ	5502.
Rat genome database More...RGDⁱ	62018. Ppp1r1a.

Phylogenomic databases

eggNOGⁱ	ENOG410J0ZP. Eukaryota. ENOG41125ZM. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110965.
HOGENOMⁱ	HOG000115665.
HOVERGENⁱ	HBG096069.
InParanoidⁱ	P19103.
KEGG Orthology (KO) More...KOⁱ	K08050.
OMAⁱ	MEPDNSP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1A3V.
PhylomeDBⁱ	P19103.
TreeFamⁱ	TF332576.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P19103.

PROⁱ

PR:P19103.

Gene expression databases

Bgeeⁱ	ENSRNOG00000036827.
Genevisibleⁱ	P19103. RN.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008466. PPP1R1A/B/C.
PANTHERⁱ	PTHR15417. PTHR15417. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05395. DARPP-32. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPR1A_RAT
Accessionⁱ	P19103Primary (citable) accession number: P19103 Secondary accession number(s): Q6DSU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	June 7, 2017
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P19103 (PPR1A_RAT)

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Protein phosphatase 1 regulatory subunit 1A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ