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Protein

Protein phosphatase 1 regulatory subunit 1A

Gene

Ppp1r1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1A
Alternative name(s):
Protein phosphatase inhibitor 1
Short name:
I-1
Short name:
IPP-1
Gene namesi
Name:Ppp1r1a
Synonyms:Ipp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi62018. Ppp1r1a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Protein phosphatase 1 regulatory subunit 1APRO_0000071480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei35 – 351Phosphothreonine; by PKABy similarity
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei46 – 461PhosphoserineCombined sources
Modified residuei47 – 471PhosphoserineCombined sources
Modified residuei67 – 671PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation of Thr-35 is required for activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP19103.
PRIDEiP19103.

PTM databases

iPTMnetiP19103.
PhosphoSiteiP19103.

Expressioni

Gene expression databases

GenevisibleiP19103. RN.

Interactioni

Subunit structurei

Interacts with PPP1R15A.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052146.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 124Essential for activity
Regioni42 – 5413Essential for activityCuratedAdd
BLAST
Regioni143 – 17129Interaction with PPP1R15ABy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiP19103.
KOiK08050.
OMAiTGTQESC.
OrthoDBiEOG7VQJFK.
PhylomeDBiP19103.
TreeFamiTF332576.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEV
60 70 80 90 100
DEDRIPNPLL KSTLSMSPRQ RKKMTRTTPT MKELQTMVEH HLGQQKQGEE
110 120 130 140 150
PEGATESTGN QESCPPGIPD TGSASRPDTS GTAQKPAESK PKTQEQRGVE
160 170
PSTEDLSAHM LPLDSQGASL V
Length:171
Mass (Da):18,738
Last modified:November 1, 1990 - v1
Checksum:i4D26478008245956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05592 mRNA. Translation: AAA41933.1.
AJ276593 mRNA. Translation: CAB77674.1.
AY648296 mRNA. Translation: AAT66740.1.
BC078820 mRNA. Translation: AAH78820.1.
PIRiA37110.
RefSeqiNP_073167.1. NM_022676.3.
UniGeneiRn.9756.

Genome annotation databases

EnsembliENSRNOT00000055271; ENSRNOP00000052146; ENSRNOG00000036827.
GeneIDi58977.
KEGGirno:58977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05592 mRNA. Translation: AAA41933.1.
AJ276593 mRNA. Translation: CAB77674.1.
AY648296 mRNA. Translation: AAT66740.1.
BC078820 mRNA. Translation: AAH78820.1.
PIRiA37110.
RefSeqiNP_073167.1. NM_022676.3.
UniGeneiRn.9756.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052146.

PTM databases

iPTMnetiP19103.
PhosphoSiteiP19103.

Proteomic databases

PaxDbiP19103.
PRIDEiP19103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055271; ENSRNOP00000052146; ENSRNOG00000036827.
GeneIDi58977.
KEGGirno:58977.

Organism-specific databases

CTDi5502.
RGDi62018. Ppp1r1a.

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiP19103.
KOiK08050.
OMAiTGTQESC.
OrthoDBiEOG7VQJFK.
PhylomeDBiP19103.
TreeFamiTF332576.

Miscellaneous databases

PROiP19103.

Gene expression databases

GenevisibleiP19103. RN.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues."
    Elbrecht A., Direnzo J., Smith R.G., Shenolikar S.
    J. Biol. Chem. 265:13415-13418(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Skeletal muscle.
  2. "Detection and quantification of protein phosphatase inhibitor-1 gene expression in total rat liver and isolated hepatocytes."
    Aleem E.A., Flohr T., Hunziker A., Mayer D., Bannasch P., Thielmann H.W.
    Mol. Cell. Biochem. 217:1-12(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "Drug altered brain phosphorylation by two families of PP1 inhibitory proteins activated by PKA or PKC."
    Liu Q.-R., Uhl G.R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-47 AND SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPR1A_RAT
AccessioniPrimary (citable) accession number: P19103
Secondary accession number(s): Q6DSU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.