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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxyprogesterone + [reduced NADPH--hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxypregnenolone + [reduced NADPH--hemoprotein reductase] + O2 = 3-beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.99.9 6170
ReactomeiR-SSC-193048 Androgen biosynthesis
R-SSC-194002 Glucocorticoid biosynthesis
R-SSC-211976 Endogenous sterols
UniPathwayiUPA00062

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.19By similarity, EC:1.14.14.32By similarity)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 14

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519401 – 509Steroid 17-alpha-hydroxylase/17,20 lyaseAdd BLAST509

Proteomic databases

PaxDbiP19100
PeptideAtlasiP19100
PRIDEiP19100

Expressioni

Gene expression databases

BgeeiENSSSCG00000010591
GenevisibleiP19100 SS

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011283

Structurei

3D structure databases

ProteinModelPortaliP19100
SMRiP19100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOGENOMiHOG000036991
HOVERGENiHBG106944
InParanoidiP19100
KOiK00512
OMAiYGPIYSF
OrthoDBiEOG091G0BT8
TreeFamiTF105095

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P19100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVLLVFFLL TLTYLFWPKT KGSGAKYPRS LPVLPVVGSL PFLPRRGHQH
60 70 80 90 100
MNFFKLQDKY GPIFSFRLGS KTTVVIGDHQ LAKEVLLKKG KEFSGRPRVM
110 120 130 140 150
TLDILSDNQK GIAFADHGTS WQLHRKLALS TFSLFKGGNL KLENIINQEI
160 170 180 190 200
KVLCDFLATR NGESIDLAQP LSLAMTNIVS FICFNFSFKK GDPALQAIVN
210 220 230 240 250
FNDGILDAVG KEILYDMFPG IRILPSQTLE NMKQCVRMRN ELLREILENR
260 270 280 290 300
KENYSRNSIT NLLDIMIQAK TNAESNTGGP DHNLKLLSDR HMLATVADIF
310 320 330 340 350
GAGVETSASV VKWIVAFLLH YPLLRKKIQD AIDQNIGFNR APSISDRNQL
360 370 380 390 400
VLLEATIREV LRFRPVSPTL IPHRAIIDSS IGEFTIDKDT DVVVNLWALH
410 420 430 440 450
HNEKEWHRPD LFMPERFLDP TGTQLISPSL SYLPFGAGPR SCVGEMLARQ
460 470 480 490 500
ELFLFTAGLL QRFDLELPDD GQLPCLVGNP SLVLQIDPFK VKIKERQAWK

EAHTEGSTS
Length:509
Mass (Da):57,447
Last modified:November 1, 1997 - v3
Checksum:i9497D185A1B446B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 53RGHQHMNF → FL no nucleotide entry (PubMed:3025870).Curated8
Sequence conflicti51M → I in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti70S → D no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti98R → K no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti108 – 116Missing in CAA77878 (PubMed:1627653).Curated9
Sequence conflicti117H → E no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti126 – 140KLALS…KGGNL → SLF no nucleotide entry (PubMed:3025870).CuratedAdd BLAST15
Sequence conflicti161 – 191NGESI…SFKKG → VIQNACEMDRLKEI no nucleotide entry (PubMed:3025870).CuratedAdd BLAST31
Sequence conflicti196Q → D no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti201 – 210FNDGILDAVG → IEEGELT no nucleotide entry (PubMed:3025870).Curated10
Sequence conflicti238M → E no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti257 – 266NSITNLLDIM → IL no nucleotide entry (PubMed:3025870).Curated10
Sequence conflicti270 – 284Missing no nucleotide entry (PubMed:3025870).CuratedAdd BLAST15
Sequence conflicti291 – 303HMLAT…IFGAG → AC no nucleotide entry (PubMed:3025870).CuratedAdd BLAST13
Sequence conflicti292M → S in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti308A → V no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti311 – 333VKWIV…QDAID → FIWIQEAIE no nucleotide entry (PubMed:3025870).CuratedAdd BLAST23
Sequence conflicti319 – 321LHY → ATLC in CAA77878 (PubMed:1627653).Curated3
Sequence conflicti330D → E in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti333D → E in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti389D → A no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti395 – 397NLW → SLF no nucleotide entry (PubMed:3025870).Curated3
Sequence conflicti407H → L in AAA31008 (PubMed:1543750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63507 mRNA Translation: AAA31008.1
U41525
, U41519, U41520, U41521, U41522, U41523, U41524 Genomic DNA Translation: AAA84419.1
Z11854, Z11855, Z11856 Genomic DNA Translation: CAA77878.1
PIRiS22339
RefSeqiNP_999593.1, NM_214428.1
UniGeneiSsc.51528

Genome annotation databases

EnsembliENSSSCT00000011585; ENSSSCP00000011283; ENSSSCG00000010591
GeneIDi403330
KEGGissc:403330

Similar proteinsi

Entry informationi

Entry nameiCP17A_PIG
AccessioniPrimary (citable) accession number: P19100
Secondary accession number(s): Q29553, Q99030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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