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P19100

- CP17A_PIG

UniProt

P19100 - CP17A_PIG

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group.By similarity

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. glucocorticoid biosynthetic process Source: Ensembl
  2. hormone biosynthetic process Source: UniProtKB
  3. progesterone metabolic process Source: UniProtKB
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_210511. Glucocorticoid biosynthesis.
REACT_211636. Endogenous sterols.
REACT_221517. Androgen biosynthesis.
UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 14

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. axon Source: Ensembl
  2. membrane Source: UniProtKB-KW
  3. mitochondrion Source: Ensembl
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051940Add
BLAST

Proteomic databases

PaxDbiP19100.

Structurei

3D structure databases

ProteinModelPortaliP19100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP19100.
KOiK00512.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19100-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWVLLVFFLL TLTYLFWPKT KGSGAKYPRS LPVLPVVGSL PFLPRRGHQH
60 70 80 90 100
MNFFKLQDKY GPIFSFRLGS KTTVVIGDHQ LAKEVLLKKG KEFSGRPRVM
110 120 130 140 150
TLDILSDNQK GIAFADHGTS WQLHRKLALS TFSLFKGGNL KLENIINQEI
160 170 180 190 200
KVLCDFLATR NGESIDLAQP LSLAMTNIVS FICFNFSFKK GDPALQAIVN
210 220 230 240 250
FNDGILDAVG KEILYDMFPG IRILPSQTLE NMKQCVRMRN ELLREILENR
260 270 280 290 300
KENYSRNSIT NLLDIMIQAK TNAESNTGGP DHNLKLLSDR HMLATVADIF
310 320 330 340 350
GAGVETSASV VKWIVAFLLH YPLLRKKIQD AIDQNIGFNR APSISDRNQL
360 370 380 390 400
VLLEATIREV LRFRPVSPTL IPHRAIIDSS IGEFTIDKDT DVVVNLWALH
410 420 430 440 450
HNEKEWHRPD LFMPERFLDP TGTQLISPSL SYLPFGAGPR SCVGEMLARQ
460 470 480 490 500
ELFLFTAGLL QRFDLELPDD GQLPCLVGNP SLVLQIDPFK VKIKERQAWK

EAHTEGSTS
Length:509
Mass (Da):57,447
Last modified:November 1, 1997 - v3
Checksum:i9497D185A1B446B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 538RGHQHMNF → FL no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti51 – 511M → I in CAA77878. (PubMed:1627653)Curated
Sequence conflicti70 – 701S → D no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti98 – 981R → K no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti108 – 1169Missing in CAA77878. (PubMed:1627653)Curated
Sequence conflicti117 – 1171H → E no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti126 – 14015KLALS…KGGNL → SLF no nucleotide entry (PubMed:3025870)CuratedAdd
BLAST
Sequence conflicti161 – 19131NGESI…SFKKG → VIQNACEMDRLKEI no nucleotide entry (PubMed:3025870)CuratedAdd
BLAST
Sequence conflicti196 – 1961Q → D no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti201 – 21010FNDGILDAVG → IEEGELT no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti238 – 2381M → E no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti257 – 26610NSITNLLDIM → IL no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti270 – 28415Missing no nucleotide entry (PubMed:3025870)CuratedAdd
BLAST
Sequence conflicti291 – 30313HMLAT…IFGAG → AC no nucleotide entry (PubMed:3025870)CuratedAdd
BLAST
Sequence conflicti292 – 2921M → S in CAA77878. (PubMed:1627653)Curated
Sequence conflicti308 – 3081A → V no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti311 – 33323VKWIV…QDAID → FIWIQEAIE no nucleotide entry (PubMed:3025870)CuratedAdd
BLAST
Sequence conflicti319 – 3213LHY → ATLC in CAA77878. (PubMed:1627653)Curated
Sequence conflicti330 – 3301D → E in CAA77878. (PubMed:1627653)Curated
Sequence conflicti333 – 3331D → E in CAA77878. (PubMed:1627653)Curated
Sequence conflicti389 – 3891D → A no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti395 – 3973NLW → SLF no nucleotide entry (PubMed:3025870)Curated
Sequence conflicti407 – 4071H → L in AAA31008. (PubMed:1543750)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63507 mRNA. Translation: AAA31008.1.
U41525
, U41519, U41520, U41521, U41522, U41523, U41524 Genomic DNA. Translation: AAA84419.1.
Z11854, Z11855, Z11856 Genomic DNA. Translation: CAA77878.1.
PIRiS22339.
RefSeqiNP_999593.1. NM_214428.1.
UniGeneiSsc.51528.

Genome annotation databases

EnsembliENSSSCT00000011585; ENSSSCP00000011283; ENSSSCG00000010591.
GeneIDi403330.
KEGGissc:403330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63507 mRNA. Translation: AAA31008.1 .
U41525
, U41519 , U41520 , U41521 , U41522 , U41523 , U41524 Genomic DNA. Translation: AAA84419.1 .
Z11854 , Z11855 , Z11856 Genomic DNA. Translation: CAA77878.1 .
PIRi S22339.
RefSeqi NP_999593.1. NM_214428.1.
UniGenei Ssc.51528.

3D structure databases

ProteinModelPortali P19100.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P19100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000011585 ; ENSSSCP00000011283 ; ENSSSCG00000010591 .
GeneIDi 403330.
KEGGi ssc:403330.

Organism-specific databases

CTDi 1586.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P19100.
KOi K00512.
OrthoDBi EOG7RBZ85.
TreeFami TF105095.

Enzyme and pathway databases

UniPathwayi UPA00062 .
Reactomei REACT_210511. Glucocorticoid biosynthesis.
REACT_211636. Endogenous sterols.
REACT_221517. Androgen biosynthesis.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues."
    Chung B.-C., Picado-Leonard J., Haniu M., Bienkowski M., Hall P.F., Shively J.E., Miller W.L.
    Proc. Natl. Acad. Sci. U.S.A. 84:407-411(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland and Testis.
  2. "Nucleotide sequence of a cDNA encoding porcine testis 17 alpha-hydroxylase cytochrome P-450."
    Conley A.J., Graham-Lorence S.E., Kagimoto M., Lorence M.C., Murry B.A., Oka K., Sanders D., Mason J.I.
    Biochim. Biophys. Acta 1130:75-77(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Gene for 17 alpha-hydroxylase/C (17-20) lyase P-450: complete nucleotide sequence of the porcine gene and 5' upstream sequence of the rat gene."
    Zhang P., Nason T.F., Han X.G., Hall P.F.
    Biochim. Biophys. Acta 1131:345-348(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Kidney.
  4. Conley A.J., Chu X., Corbin C.J.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiCP17A_PIG
AccessioniPrimary (citable) accession number: P19100
Secondary accession number(s): Q29553, Q99030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3