ID   CP19A_CHICK             Reviewed;         507 AA.
AC   P19098;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Aromatase;
DE            EC=1.14.14.14 {ECO:0000250|UniProtKB:P11511};
DE   AltName: Full=CYPXIX;
DE   AltName: Full=Cytochrome P-450AROM;
DE   AltName: Full=Cytochrome P450 19A1;
DE   AltName: Full=Estrogen synthase;
GN   Name=CYP19A1; Synonyms=AROM, CYP19;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=3182796; DOI=10.1016/s0021-9258(18)37601-4;
RA   McPhaul M.J., Noble J.F., Simpson E.R., Mendelson C.R., Wilson J.D.;
RT   "The expression of a functional cDNA encoding the chicken cytochrome P-
RT   450arom (aromatase) that catalyzes the formation of estrogen from
RT   androgen.";
RL   J. Biol. Chem. 263:16358-16363(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 1-47.
RC   STRAIN=Leghorn; TISSUE=Liver;
RA   Kudo T., Yamamoto H., Sato S., Sutou S.;
RT   "Comparison of 5' upstream regions of chicken and quail aromatase genes.";
RL   J. Reprod. Dev. 42:101-107(1996).
CC   -!- FUNCTION: Catalyzes the formation of aromatic C18 estrogens from C19
CC       androgens.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone
CC         = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized
CC         [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38191, Rhea:RHEA-
CC         COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:16469, ChEBI:CHEBI:17347, ChEBI:CHEBI:57618,
CC         ChEBI:CHEBI:58210; EC=1.14.14.14;
CC         Evidence={ECO:0000250|UniProtKB:P11511};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=androst-4-ene-3,17-dione + 3 O2 + 3 reduced
CC         [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O +
CC         3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38195,
CC         Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:16422, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618,
CC         ChEBI:CHEBI:58210; EC=1.14.14.14;
CC         Evidence={ECO:0000250|UniProtKB:P11511};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA48739.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; J04047; AAA48738.1; -; mRNA.
DR   EMBL; J04047; AAA48739.1; ALT_INIT; mRNA.
DR   EMBL; D50335; BAA08871.1; -; Genomic_DNA.
DR   PIR; A31916; A31916.
DR   AlphaFoldDB; P19098; -.
DR   SMR; P19098; -.
DR   STRING; 9031.ENSGALP00000066452; -.
DR   PaxDb; 9031-ENSGALP00000038215; -.
DR   VEuPathDB; HostDB:geneid_414854; -.
DR   eggNOG; KOG0157; Eukaryota.
DR   InParanoid; P19098; -.
DR   PhylomeDB; P19098; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0008585; P:female gonad development; IEP:AgBase.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032355; P:response to estradiol; IBA:GO_Central.
DR   CDD; cd20616; CYP19A1; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24291:SF43; AROMATASE; 1.
DR   PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Lipid metabolism; Membrane; Metal-binding; Monooxygenase;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..507
FT                   /note="Aromatase"
FT                   /id="PRO_0000051964"
FT   BINDING         436
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
SQ   SEQUENCE   507 AA;  58146 MW;  DDDC1EF7AEC1577F CRC64;
     MIPETLNPLN YFTSLVPDLM PVATVPIIIL ICFLFLIWNH EETSSIPGPG YCMGIGPLIS
     HGRFLWMGVG NACNYYNKTY GEFVRVWISG EETFIISKSS SVFHVMKHWN YVSRFGSKLG
     LQCIGMYENG IIFNNNPAHW KEIRPFFTKA LSGPGLVRMI AICVESTIVH LDKLEEVTTE
     VGNVNVLNLM RRIMLDTSNK LFLGVPLDES AIVLKIQNYF DAWQALLLKP DIFFKISWLC
     KKYEEAAKDL KGAMEILIEQ KRQKLSTVEK LDEHMDFASQ LIFAQNRGDL TAENVNQCVL
     EMMIAAPDTL SVTLFIMLIL IADDPTVEEK MMREIETVMG DREVQSDDMP NLKIVENFIY
     ESMRYQPVVD LIMRKALQDD VIDGYPVKKG TNIILNIGRM HKLEFFPKPN EFSLENFEKN
     VPSRYFQPFG FGPRGCVGKF IAMVMMKAIL VTLLRRCRVQ TMKGRGLNNI QKNNDLSMHP
     IERQPLLEMV FTQEAQTRIR VTKVDQH
//