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P19098 (CP19A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:AROM, CYP19
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AAA48739.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Aromatase
PRO_0000051964

Sites

Metal binding4361Iron (heme axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P19098 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: DDDC1EF7AEC1577F

FASTA50758,146
        10         20         30         40         50         60 
MIPETLNPLN YFTSLVPDLM PVATVPIIIL ICFLFLIWNH EETSSIPGPG YCMGIGPLIS 

        70         80         90        100        110        120 
HGRFLWMGVG NACNYYNKTY GEFVRVWISG EETFIISKSS SVFHVMKHWN YVSRFGSKLG 

       130        140        150        160        170        180 
LQCIGMYENG IIFNNNPAHW KEIRPFFTKA LSGPGLVRMI AICVESTIVH LDKLEEVTTE 

       190        200        210        220        230        240 
VGNVNVLNLM RRIMLDTSNK LFLGVPLDES AIVLKIQNYF DAWQALLLKP DIFFKISWLC 

       250        260        270        280        290        300 
KKYEEAAKDL KGAMEILIEQ KRQKLSTVEK LDEHMDFASQ LIFAQNRGDL TAENVNQCVL 

       310        320        330        340        350        360 
EMMIAAPDTL SVTLFIMLIL IADDPTVEEK MMREIETVMG DREVQSDDMP NLKIVENFIY 

       370        380        390        400        410        420 
ESMRYQPVVD LIMRKALQDD VIDGYPVKKG TNIILNIGRM HKLEFFPKPN EFSLENFEKN 

       430        440        450        460        470        480 
VPSRYFQPFG FGPRGCVGKF IAMVMMKAIL VTLLRRCRVQ TMKGRGLNNI QKNNDLSMHP 

       490        500 
IERQPLLEMV FTQEAQTRIR VTKVDQH 

« Hide

References

[1]"The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen."
McPhaul M.J., Noble J.F., Simpson E.R., Mendelson C.R., Wilson J.D.
J. Biol. Chem. 263:16358-16363(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"Comparison of 5' upstream regions of chicken and quail aromatase genes."
Kudo T., Yamamoto H., Sato S., Sutou S.
J. Reprod. Dev. 42:101-107(1996)
Cited for: NUCLEOTIDE SEQUENCE OF 1-47.
Strain: Leghorn.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04047 mRNA. Translation: AAA48738.1.
J04047 mRNA. Translation: AAA48739.1. Different initiation.
D50335 Genomic DNA. Translation: BAA08871.1.
PIRA31916.
RefSeqNP_001001761.1. NM_001001761.1.
UniGeneGga.859.

3D structure databases

ProteinModelPortalP19098.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000038215.

Proteomic databases

PaxDbP19098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414854.
KEGGgga:414854.

Organism-specific databases

CTD1588.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000111912.
HOVERGENHBG050750.
InParanoidP19098.
KOK07434.
PhylomeDBP19098.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818747.
PROP19098.

Entry information

Entry nameCP19A_CHICK
AccessionPrimary (citable) accession number: P19098
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families