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Protein

Aromatase

Gene

CYP19A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

GO - Biological processi

  1. female gonad development Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:AROM, CYP19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507AromatasePRO_0000051964Add
BLAST

Proteomic databases

PaxDbiP19098.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038215.

Structurei

3D structure databases

ProteinModelPortaliP19098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP19098.
KOiK07434.
PhylomeDBiP19098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19098-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPETLNPLN YFTSLVPDLM PVATVPIIIL ICFLFLIWNH EETSSIPGPG
60 70 80 90 100
YCMGIGPLIS HGRFLWMGVG NACNYYNKTY GEFVRVWISG EETFIISKSS
110 120 130 140 150
SVFHVMKHWN YVSRFGSKLG LQCIGMYENG IIFNNNPAHW KEIRPFFTKA
160 170 180 190 200
LSGPGLVRMI AICVESTIVH LDKLEEVTTE VGNVNVLNLM RRIMLDTSNK
210 220 230 240 250
LFLGVPLDES AIVLKIQNYF DAWQALLLKP DIFFKISWLC KKYEEAAKDL
260 270 280 290 300
KGAMEILIEQ KRQKLSTVEK LDEHMDFASQ LIFAQNRGDL TAENVNQCVL
310 320 330 340 350
EMMIAAPDTL SVTLFIMLIL IADDPTVEEK MMREIETVMG DREVQSDDMP
360 370 380 390 400
NLKIVENFIY ESMRYQPVVD LIMRKALQDD VIDGYPVKKG TNIILNIGRM
410 420 430 440 450
HKLEFFPKPN EFSLENFEKN VPSRYFQPFG FGPRGCVGKF IAMVMMKAIL
460 470 480 490 500
VTLLRRCRVQ TMKGRGLNNI QKNNDLSMHP IERQPLLEMV FTQEAQTRIR

VTKVDQH
Length:507
Mass (Da):58,146
Last modified:November 1, 1990 - v1
Checksum:iDDDC1EF7AEC1577F
GO

Sequence cautioni

The sequence AAA48739.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04047 mRNA. Translation: AAA48738.1.
J04047 mRNA. Translation: AAA48739.1. Different initiation.
D50335 Genomic DNA. Translation: BAA08871.1.
PIRiA31916.
RefSeqiNP_001001761.1. NM_001001761.1.
UniGeneiGga.859.

Genome annotation databases

GeneIDi414854.
KEGGigga:414854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04047 mRNA. Translation: AAA48738.1.
J04047 mRNA. Translation: AAA48739.1. Different initiation.
D50335 Genomic DNA. Translation: BAA08871.1.
PIRiA31916.
RefSeqiNP_001001761.1. NM_001001761.1.
UniGeneiGga.859.

3D structure databases

ProteinModelPortaliP19098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038215.

Proteomic databases

PaxDbiP19098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414854.
KEGGigga:414854.

Organism-specific databases

CTDi1588.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP19098.
KOiK07434.
PhylomeDBiP19098.

Miscellaneous databases

NextBioi20818747.
PROiP19098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen."
    McPhaul M.J., Noble J.F., Simpson E.R., Mendelson C.R., Wilson J.D.
    J. Biol. Chem. 263:16358-16363(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Comparison of 5' upstream regions of chicken and quail aromatase genes."
    Kudo T., Yamamoto H., Sato S., Sutou S.
    J. Reprod. Dev. 42:101-107(1996)
    Cited for: NUCLEOTIDE SEQUENCE OF 1-47.
    Strain: Leghorn.
    Tissue: Liver.

Entry informationi

Entry nameiCP19A_CHICK
AccessioniPrimary (citable) accession number: P19098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.