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P19098

- CP19A_CHICK

UniProt

P19098 - CP19A_CHICK

Protein

Aromatase

Gene

CYP19A1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    GO - Biological processi

    1. female gonad development Source: AgBase

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:AROM, CYP19
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507AromatasePRO_0000051964Add
    BLAST

    Proteomic databases

    PaxDbiP19098.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000038215.

    Structurei

    3D structure databases

    ProteinModelPortaliP19098.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.
    InParanoidiP19098.
    KOiK07434.
    PhylomeDBiP19098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19098-1 [UniParc]FASTAAdd to Basket

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    MIPETLNPLN YFTSLVPDLM PVATVPIIIL ICFLFLIWNH EETSSIPGPG    50
    YCMGIGPLIS HGRFLWMGVG NACNYYNKTY GEFVRVWISG EETFIISKSS 100
    SVFHVMKHWN YVSRFGSKLG LQCIGMYENG IIFNNNPAHW KEIRPFFTKA 150
    LSGPGLVRMI AICVESTIVH LDKLEEVTTE VGNVNVLNLM RRIMLDTSNK 200
    LFLGVPLDES AIVLKIQNYF DAWQALLLKP DIFFKISWLC KKYEEAAKDL 250
    KGAMEILIEQ KRQKLSTVEK LDEHMDFASQ LIFAQNRGDL TAENVNQCVL 300
    EMMIAAPDTL SVTLFIMLIL IADDPTVEEK MMREIETVMG DREVQSDDMP 350
    NLKIVENFIY ESMRYQPVVD LIMRKALQDD VIDGYPVKKG TNIILNIGRM 400
    HKLEFFPKPN EFSLENFEKN VPSRYFQPFG FGPRGCVGKF IAMVMMKAIL 450
    VTLLRRCRVQ TMKGRGLNNI QKNNDLSMHP IERQPLLEMV FTQEAQTRIR 500
    VTKVDQH 507
    Length:507
    Mass (Da):58,146
    Last modified:November 1, 1990 - v1
    Checksum:iDDDC1EF7AEC1577F
    GO

    Sequence cautioni

    The sequence AAA48739.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04047 mRNA. Translation: AAA48738.1.
    J04047 mRNA. Translation: AAA48739.1. Different initiation.
    D50335 Genomic DNA. Translation: BAA08871.1.
    PIRiA31916.
    RefSeqiNP_001001761.1. NM_001001761.1.
    UniGeneiGga.859.

    Genome annotation databases

    GeneIDi414854.
    KEGGigga:414854.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04047 mRNA. Translation: AAA48738.1 .
    J04047 mRNA. Translation: AAA48739.1 . Different initiation.
    D50335 Genomic DNA. Translation: BAA08871.1 .
    PIRi A31916.
    RefSeqi NP_001001761.1. NM_001001761.1.
    UniGenei Gga.859.

    3D structure databases

    ProteinModelPortali P19098.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000038215.

    Proteomic databases

    PaxDbi P19098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414854.
    KEGGi gga:414854.

    Organism-specific databases

    CTDi 1588.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.
    InParanoidi P19098.
    KOi K07434.
    PhylomeDBi P19098.

    Miscellaneous databases

    NextBioi 20818747.
    PROi P19098.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen."
      McPhaul M.J., Noble J.F., Simpson E.R., Mendelson C.R., Wilson J.D.
      J. Biol. Chem. 263:16358-16363(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "Comparison of 5' upstream regions of chicken and quail aromatase genes."
      Kudo T., Yamamoto H., Sato S., Sutou S.
      J. Reprod. Dev. 42:101-107(1996)
      Cited for: NUCLEOTIDE SEQUENCE OF 1-47.
      Strain: Leghorn.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP19A_CHICK
    AccessioniPrimary (citable) accession number: P19098
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3