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Protein

Colipase

Gene

CLPS

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-CFA-192456. Digestion of dietary lipid.
R-CFA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Add BLAST17
PropeptideiPRO_000000569018 – 22Enterostatin, activation peptideSequence analysis5
ChainiPRO_000000569123 – 112ColipaseAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP19090.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Gene expression databases

BgeeiENSCAFG00000001349.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001934.

Structurei

3D structure databases

ProteinModelPortaliP19090.
SMRiP19090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiP19090.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG091G0Z2E.
TreeFamiTF336178.

Family and domain databases

CDDicd00039. COLIPASE. 1 hit.
InterProiView protein in InterPro
IPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiView protein in Pfam
PF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
PRINTSiPR00128. COLIPASE.
SMARTiView protein in SMART
SM00023. COLIPASE. 1 hit.
PROSITEiView protein in PROSITE
PS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKILVLLLV ALAVVYAVPD PRGIIIHLED GELCLNSVQC KSKCCHRATG
60 70 80 90 100
LSLARCAPKA SENSECSAKT LYGVYYKCPC ERGLTCEGDK SIVGSITNTN
110
FGVCHDAGRS KK
Length:112
Mass (Da):12,035
Last modified:November 1, 1990 - v1
Checksum:i96EB5B821BA8CA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53564 mRNA. Translation: CAA37636.1.
M63427 Unassigned DNA. Translation: AAA03513.1.
PIRiA46717.
RefSeqiNP_001003287.1. NM_001003287.1.
UniGeneiCfa.3839.

Genome annotation databases

EnsembliENSCAFT00000002090; ENSCAFP00000001934; ENSCAFG00000001349.
GeneIDi403970.
KEGGicfa:403970.

Similar proteinsi

Entry informationi

Entry nameiCOL_CANLF
AccessioniPrimary (citable) accession number: P19090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families