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P19086

- GNAZ_HUMAN

UniProt

P19086 - GNAZ_HUMAN

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Protein
Guanine nucleotide-binding protein G(z) subunit alpha
Gene
GNAZ
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Magnesium By similarity
Metal bindingi182 – 1821Magnesium By similarity
Binding sitei327 – 3271GTP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478GTP By similarity
Nucleotide bindingi176 – 1827GTP By similarity
Nucleotide bindingi201 – 2055GTP By similarity
Nucleotide bindingi270 – 2734GTP By similarity

GO - Molecular functioni

  1. G-protein beta/gamma-subunit complex binding Source: RefGenome
  2. G-protein coupled serotonin receptor binding Source: RefGenome
  3. GTP binding Source: UniProtKB-KW
  4. GTPase activity Source: RefGenome
  5. metal ion binding Source: UniProtKB-KW
  6. receptor signaling protein activity Source: ProtInc
  7. signal transducer activity Source: RefGenome

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
  4. intracellular signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15426. PLC beta mediated events.
REACT_15457. G-protein activation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
SignaLinkiP19086.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(z) subunit alpha
Alternative name(s):
G(x) alpha chain
Gz-alpha
Gene namesi
Name:GNAZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:4395. GNAZ.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: ProtInc
  3. extracellular vesicular exosome Source: UniProt
  4. extrinsic component of cytoplasmic side of plasma membrane Source: RefGenome
  5. heterotrimeric G-protein complex Source: RefGenome
  6. nuclear envelope Source: ProtInc
  7. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed Inferred
Chaini2 – 355354Guanine nucleotide-binding protein G(z) subunit alpha
PRO_0000203696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Lipidationi3 – 31S-palmitoyl cysteine By similarity
Modified residuei179 – 1791ADP-ribosylarginine; by cholera toxin By similarity

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Myristate, Palmitate

Proteomic databases

MaxQBiP19086.
PaxDbiP19086.
PRIDEiP19086.

PTM databases

PhosphoSiteiP19086.

Expressioni

Gene expression databases

BgeeiP19086.
CleanExiHS_GNAZ.
GenevestigatoriP19086.

Organism-specific databases

HPAiHPA003011.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein-protein interaction databases

BioGridi109043. 10 interactions.
IntActiP19086. 1 interaction.
MINTiMINT-139942.
STRINGi9606.ENSP00000248996.

Structurei

3D structure databases

ProteinModelPortaliP19086.
SMRiP19086. Positions 6-349.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG282619.
HOGENOMiHOG000038730.
HOVERGENiHBG063184.
InParanoidiP19086.
KOiK04535.
OMAiDYKGQNT.
OrthoDBiEOG72C50B.
PhylomeDBiP19086.
TreeFamiTF300673.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19086-1 [UniParc]FASTAAdd to Basket

« Hide

MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV    50
KQMKIIHSGG FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR 100
AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FSRSSEYHLE 150
DNAAYYLNDL ERIAAADYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV 200
DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL 250
FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA 300
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK 350
YIGLC 355
Length:355
Mass (Da):40,924
Last modified:January 23, 2007 - v3
Checksum:iE868FAE7CD2873EB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321W → Y1 Publication
Sequence conflicti230 – 2301G → A in BAA14180. 1 Publication
Sequence conflicti273 – 2731D → N1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03260 mRNA. Translation: AAA52580.1.
D90150 Genomic DNA. Translation: BAA14180.1.
AF493899 mRNA. Translation: AAM12613.1.
CR456495 mRNA. Translation: CAG30381.1.
AK312519 mRNA. Translation: BAG35418.1.
CH471095 Genomic DNA. Translation: EAW59559.1.
BC078163 mRNA. Translation: AAH78163.1.
BC096828 mRNA. Translation: AAH96828.1.
CCDSiCCDS13804.1.
PIRiA36628. RGHUGX.
RefSeqiNP_002064.1. NM_002073.2.
UniGeneiHs.584760.

Genome annotation databases

EnsembliENST00000248996; ENSP00000248996; ENSG00000128266.
GeneIDi2781.
KEGGihsa:2781.
UCSCiuc002zwu.1. human.

Polymorphism databases

DMDMi121005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03260 mRNA. Translation: AAA52580.1 .
D90150 Genomic DNA. Translation: BAA14180.1 .
AF493899 mRNA. Translation: AAM12613.1 .
CR456495 mRNA. Translation: CAG30381.1 .
AK312519 mRNA. Translation: BAG35418.1 .
CH471095 Genomic DNA. Translation: EAW59559.1 .
BC078163 mRNA. Translation: AAH78163.1 .
BC096828 mRNA. Translation: AAH96828.1 .
CCDSi CCDS13804.1.
PIRi A36628. RGHUGX.
RefSeqi NP_002064.1. NM_002073.2.
UniGenei Hs.584760.

3D structure databases

ProteinModelPortali P19086.
SMRi P19086. Positions 6-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109043. 10 interactions.
IntActi P19086. 1 interaction.
MINTi MINT-139942.
STRINGi 9606.ENSP00000248996.

PTM databases

PhosphoSitei P19086.

Polymorphism databases

DMDMi 121005.

Proteomic databases

MaxQBi P19086.
PaxDbi P19086.
PRIDEi P19086.

Protocols and materials databases

DNASUi 2781.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248996 ; ENSP00000248996 ; ENSG00000128266 .
GeneIDi 2781.
KEGGi hsa:2781.
UCSCi uc002zwu.1. human.

Organism-specific databases

CTDi 2781.
GeneCardsi GC22P023413.
HGNCi HGNC:4395. GNAZ.
HPAi HPA003011.
MIMi 139160. gene.
neXtProti NX_P19086.
PharmGKBi PA28775.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282619.
HOGENOMi HOG000038730.
HOVERGENi HBG063184.
InParanoidi P19086.
KOi K04535.
OMAi DYKGQNT.
OrthoDBi EOG72C50B.
PhylomeDBi P19086.
TreeFami TF300673.

Enzyme and pathway databases

Reactomei REACT_15426. PLC beta mediated events.
REACT_15457. G-protein activation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
SignaLinki P19086.

Miscellaneous databases

GeneWikii GNAZ.
GenomeRNAii 2781.
NextBioi 10955.
PROi P19086.
SOURCEi Search...

Gene expression databases

Bgeei P19086.
CleanExi HS_GNAZ.
Genevestigatori P19086.

Family and domain databases

Gene3Di 1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10218. PTHR10218. 1 hit.
Pfami PF00503. G-alpha. 1 hit.
[Graphical view ]
PRINTSi PR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTi SM00275. G_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin."
    Fong H.K.W., Yoshimoto K.K., Eversole-Cire P., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 85:3066-3070(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein."
    Matsuoka M., Itoh H., Kaziro Y.
    J. Biol. Chem. 265:13215-13220(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes."
    Gagnon A.W., Manning D.R., Catani L., Gewirtz A., Poncz M., Brass L.F.
    Blood 78:1247-1253(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.

Entry informationi

Entry nameiGNAZ_HUMAN
AccessioniPrimary (citable) accession number: P19086
Secondary accession number(s): B2R6C1, Q4QRJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi