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Protein

Guanine nucleotide-binding protein G(z) subunit alpha

Gene

GNAZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47MagnesiumBy similarity1
Metal bindingi182MagnesiumBy similarity1
Binding sitei327GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi176 – 182GTPBy similarity7
Nucleotide bindingi201 – 205GTPBy similarity5
Nucleotide bindingi270 – 273GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128266-MONOMER.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-202040. G-protein activation.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiP19086.
SIGNORiP19086.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(z) subunit alpha
Alternative name(s):
G(x) alpha chain
Gz-alpha
Gene namesi
Name:GNAZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:4395. GNAZ.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: Ensembl
  • cytosol Source: Ensembl
  • dendrite Source: Ensembl
  • endoplasmic reticulum Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • heterotrimeric G-protein complex Source: GO_Central
  • nuclear envelope Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2781.
OpenTargetsiENSG00000128266.
PharmGKBiPA28775.

Polymorphism and mutation databases

BioMutaiGNAZ.
DMDMi121005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00002036962 – 355Guanine nucleotide-binding protein G(z) subunit alphaAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Modified residuei179ADP-ribosylarginine; by cholera toxinBy similarity1

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiP19086.
MaxQBiP19086.
PaxDbiP19086.
PeptideAtlasiP19086.
PRIDEiP19086.

PTM databases

iPTMnetiP19086.
PhosphoSitePlusiP19086.
SwissPalmiP19086.

Expressioni

Gene expression databases

BgeeiENSG00000128266.
CleanExiHS_GNAZ.
GenevisibleiP19086. HS.

Organism-specific databases

HPAiHPA003011.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109043. 42 interactors.
IntActiP19086. 12 interactors.
MINTiMINT-139942.
STRINGi9606.ENSP00000248996.

Structurei

3D structure databases

ProteinModelPortaliP19086.
SMRiP19086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(i/o/t/z) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
HOVERGENiHBG063184.
InParanoidiP19086.
KOiK04535.
OMAiNIVETGK.
OrthoDBiEOG091G0VUT.
PhylomeDBiP19086.
TreeFamiTF300673.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV
60 70 80 90 100
KQMKIIHSGG FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR
110 120 130 140 150
AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FSRSSEYHLE
160 170 180 190 200
DNAAYYLNDL ERIAAADYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV
210 220 230 240 250
DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL
260 270 280 290 300
FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA
310 320 330 340 350
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK

YIGLC
Length:355
Mass (Da):40,924
Last modified:January 23, 2007 - v3
Checksum:iE868FAE7CD2873EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132W → Y (PubMed:1908722).Curated1
Sequence conflicti230G → A in BAA14180 (PubMed:2115889).Curated1
Sequence conflicti273D → N (PubMed:1908722).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03260 mRNA. Translation: AAA52580.1.
D90150 Genomic DNA. Translation: BAA14180.1.
AF493899 mRNA. Translation: AAM12613.1.
CR456495 mRNA. Translation: CAG30381.1.
AK312519 mRNA. Translation: BAG35418.1.
CH471095 Genomic DNA. Translation: EAW59559.1.
BC078163 mRNA. Translation: AAH78163.1.
BC096828 mRNA. Translation: AAH96828.1.
CCDSiCCDS13804.1.
PIRiA36628. RGHUGX.
RefSeqiNP_002064.1. NM_002073.2.
UniGeneiHs.584760.

Genome annotation databases

EnsembliENST00000615612; ENSP00000478892; ENSG00000128266.
GeneIDi2781.
KEGGihsa:2781.
UCSCiuc002zwu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03260 mRNA. Translation: AAA52580.1.
D90150 Genomic DNA. Translation: BAA14180.1.
AF493899 mRNA. Translation: AAM12613.1.
CR456495 mRNA. Translation: CAG30381.1.
AK312519 mRNA. Translation: BAG35418.1.
CH471095 Genomic DNA. Translation: EAW59559.1.
BC078163 mRNA. Translation: AAH78163.1.
BC096828 mRNA. Translation: AAH96828.1.
CCDSiCCDS13804.1.
PIRiA36628. RGHUGX.
RefSeqiNP_002064.1. NM_002073.2.
UniGeneiHs.584760.

3D structure databases

ProteinModelPortaliP19086.
SMRiP19086.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109043. 42 interactors.
IntActiP19086. 12 interactors.
MINTiMINT-139942.
STRINGi9606.ENSP00000248996.

PTM databases

iPTMnetiP19086.
PhosphoSitePlusiP19086.
SwissPalmiP19086.

Polymorphism and mutation databases

BioMutaiGNAZ.
DMDMi121005.

Proteomic databases

EPDiP19086.
MaxQBiP19086.
PaxDbiP19086.
PeptideAtlasiP19086.
PRIDEiP19086.

Protocols and materials databases

DNASUi2781.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615612; ENSP00000478892; ENSG00000128266.
GeneIDi2781.
KEGGihsa:2781.
UCSCiuc002zwu.2. human.

Organism-specific databases

CTDi2781.
DisGeNETi2781.
GeneCardsiGNAZ.
HGNCiHGNC:4395. GNAZ.
HPAiHPA003011.
MIMi139160. gene.
neXtProtiNX_P19086.
OpenTargetsiENSG00000128266.
PharmGKBiPA28775.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
HOVERGENiHBG063184.
InParanoidiP19086.
KOiK04535.
OMAiNIVETGK.
OrthoDBiEOG091G0VUT.
PhylomeDBiP19086.
TreeFamiTF300673.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128266-MONOMER.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-202040. G-protein activation.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiP19086.
SIGNORiP19086.

Miscellaneous databases

GeneWikiiGNAZ.
GenomeRNAii2781.
PROiP19086.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128266.
CleanExiHS_GNAZ.
GenevisibleiP19086. HS.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGNAZ_HUMAN
AccessioniPrimary (citable) accession number: P19086
Secondary accession number(s): B2R6C1, Q4QRJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 174 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.