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Reviewed, UniProtKB/Swiss-Prot P19086 (GNAZ_HUMAN)

Last modified June 16, 2009. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Guanine nucleotide-binding protein G(z) subunit alpha
Alternative name(s):
    G(x) alpha chain
    Gz-alpha
Gene names
Name: GNAZ
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Subunit structure

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Subcellular location

Membrane; Lipid-anchor.

Sequence similarities

Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Probable
Chain2 – 355354Guanine nucleotide-binding protein G(z) subunit alpha
PRO_0000203696

Regions

Nucleotide binding40 – 478GTP By similarity
Nucleotide binding201 – 2055GTP By similarity
Nucleotide binding270 – 2734GTP By similarity

Amino acid modifications

Modified residue1791ADP-ribosylarginine; by cholera toxin By similarity
Lipidation21N-myristoyl glycine By similarity
Lipidation31S-palmitoyl cysteine By similarity

Experimental info

Sequence conflict1321W → Y Ref.3
Sequence conflict2301G → A in BAA14180. Ref.2
Sequence conflict2731D → N Ref.3

Sequences

Sequence LengthMass (Da)Tools
P19086-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: E868FAE7CD2873EB

FASTA35540,924
        10         20         30         40         50         60 
MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV KQMKIIHSGG 

        70         80         90        100        110        120 
FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR AYDAVQLFAL TGPAESKGEI 

       130        140        150        160        170        180 
TPELLGVMRR LWADPGAQAC FSRSSEYHLE DNAAYYLNDL ERIAAADYIP TVEDILRSRD 

       190        200        210        220        230        240 
MTTGIVENKF TFKELTFKMV DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ 

       250        260        270        280        290        300 
TSRMAESLRL FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA 

       310        320        330        340        350 
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK YIGLC 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin."
Fong H.K.W., Yoshimoto K.K., Eversole-Cire P., Simon M.I.
Proc. Natl. Acad. Sci. U.S.A. 85:3066-3070(1988) [PubMed: 3129724] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein."
Matsuoka M., Itoh H., Kaziro Y.
J. Biol. Chem. 265:13215-13220(1990) [PubMed: 2115889] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes."
Gagnon A.W., Manning D.R., Catani L., Gewirtz A., Poncz M., Brass L.F.
Blood 78:1247-1253(1991) [PubMed: 1908722] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS.
+Additional computationally mapped references.

Cross-references

Sequence databases

J03260 mRNA. Translation: AAA52580.1.
D90150 Genomic DNA. Translation: BAA14180.1.
AF493899 mRNA. Translation: AAM12613.1.
CR456495 mRNA. Translation: CAG30381.1.
BC078163 mRNA. Translation: AAH78163.1.
BC096828 mRNA. Translation: AAH96828.1.
IPIIPI00328128.
PIRRGHUGX. A36628.
RefSeqNP_002064.1.
UniGeneHs.584760

3D structure databases

HSSPHSSP built from PDB template 1AS3 based on UniProtKB P10824.
ModBaseSearch...

PTM databases

PhosphoSiteP19086.

Proteomic databases

PRIDEP19086.

Genome annotation databases

EnsemblENSG00000128266. Homo sapiens. [Contig view]
GeneID2781.
KEGGhsa:2781.

Organism-specific databases

GeneCardsGC22P021728.
H-InvDBHIX0027841.
HGNCHGNC:4395. GNAZ.
HPAHPA003011.
MIM139160. gene.
PharmGKBPA28775.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP19086.
HOVERGENP19086.
OMAP19086. IPLTVCF.

Enzyme and pathway databases

Pathway_Interaction_DBendothelinpathway. Endothelins.
hedgehog_glipathway. Hedgehog signaling events mediated by Gli proteins.
lysophospholipid_pathway. LPA receptor mediated events.
er_nongenomic_pathway. Plasma membrane estrogen receptor signaling.
s1p_s1p1_pathway. S1P1 pathway.
s1p_s1p2_pathway. S1P2 pathway.
s1p_s1p3_pathway. S1P3 pathway.
s1p_s1p4_pathway. S1P4 pathway.
s1p_s1p5_pathway. S1P5 pathway.
s1p_meta_pathway. Sphingosine 1-phosphate (S1P) pathway.

Gene expression databases

ArrayExpressP19086.
BgeeP19086.
CleanExHS_GNAZ.
GermOnlineENSG00000128266. Homo sapiens.

Family and domain databases

InterProIPR001019. Gprotein_alph_bd.
IPR001408. Gprotein_alpha_I.
[Graphical view]
PANTHERPTHR10218. Gprotein_alph_bd. 1 hit.
PfamPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSPR00318. GPROTEINA.
PR00441. GPROTEINAI.
ProDomPD000281. Gprotein_alpha. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

NextBio10955.
SOURCESearch...

Entry information

Entry nameGNAZ_HUMAN
AccessionPrimary (citable) accession number: P19086
Secondary accession number(s): Q4QRJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents