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P19075

- TSN8_HUMAN

UniProt

P19075 - TSN8_HUMAN

Protein

Tetraspanin-8

Gene

TSPAN8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of blood coagulation Source: Ensembl
    2. protein glycosylation Source: ProtInc
    3. signal transduction Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-8
    Short name:
    Tspan-8
    Alternative name(s):
    Transmembrane 4 superfamily member 3
    Tumor-associated antigen CO-029
    Gene namesi
    Name:TSPAN8
    Synonyms:TM4SF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11855. TSPAN8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosome Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36556.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Tetraspanin-8PRO_0000219252Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP19075.
    PaxDbiP19075.
    PRIDEiP19075.

    PTM databases

    PhosphoSiteiP19075.

    Expressioni

    Tissue specificityi

    Gastric, colon, rectal, and pancreatic carcinomas.

    Gene expression databases

    ArrayExpressiP19075.
    BgeeiP19075.
    CleanExiHS_TSPAN8.
    GenevestigatoriP19075.

    Organism-specific databases

    HPAiCAB026009.
    HPA044337.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000247829.

    Structurei

    3D structure databases

    ProteinModelPortaliP19075.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini34 – 5724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini73 – 8311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini110 – 20596ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini231 – 2377CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3324HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 7215HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10926HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 23025HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG312327.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiP19075.
    KOiK17349.
    OMAiANHKAKK.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiP19075.
    TreeFamiTF352895.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS    50
    SSYVAVDILI AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV 100
    ATGILGAVFK SKSDRIVNET LYENTKLLSA TGESEKQFQE AIIVFQEEFK 150
    CCGLVNGAAD WGNNFQHYPE LCACLDKQRP CQSYNGKQVY KETCISFIKD 200
    FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK 237
    Length:237
    Mass (Da):26,044
    Last modified:November 1, 1990 - v1
    Checksum:iD1058F054EE8C14E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351V → I.1 Publication
    Corresponds to variant rs17849952 [ dbSNP | Ensembl ].
    VAR_061848
    Natural varianti73 – 731G → A.1 Publication
    Corresponds to variant rs3763978 [ dbSNP | Ensembl ].
    VAR_020093
    Natural varianti213 – 2131S → A.
    Corresponds to variant rs1051334 [ dbSNP | Ensembl ].
    VAR_012054

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35252 mRNA. Translation: AAA35709.1.
    AK313112 mRNA. Translation: BAG35934.1.
    CH471054 Genomic DNA. Translation: EAW97257.1.
    BC005246 mRNA. Translation: AAH05246.1.
    CCDSiCCDS8999.1.
    PIRiA36056.
    RefSeqiNP_004607.1. NM_004616.2.
    XP_006719646.1. XM_006719583.1.
    UniGeneiHs.170563.

    Genome annotation databases

    EnsembliENST00000247829; ENSP00000247829; ENSG00000127324.
    ENST00000393330; ENSP00000377003; ENSG00000127324.
    ENST00000546561; ENSP00000447160; ENSG00000127324.
    GeneIDi7103.
    KEGGihsa:7103.
    UCSCiuc001swj.1. human.

    Polymorphism databases

    DMDMi116589.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35252 mRNA. Translation: AAA35709.1 .
    AK313112 mRNA. Translation: BAG35934.1 .
    CH471054 Genomic DNA. Translation: EAW97257.1 .
    BC005246 mRNA. Translation: AAH05246.1 .
    CCDSi CCDS8999.1.
    PIRi A36056.
    RefSeqi NP_004607.1. NM_004616.2.
    XP_006719646.1. XM_006719583.1.
    UniGenei Hs.170563.

    3D structure databases

    ProteinModelPortali P19075.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000247829.

    PTM databases

    PhosphoSitei P19075.

    Polymorphism databases

    DMDMi 116589.

    Proteomic databases

    MaxQBi P19075.
    PaxDbi P19075.
    PRIDEi P19075.

    Protocols and materials databases

    DNASUi 7103.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247829 ; ENSP00000247829 ; ENSG00000127324 .
    ENST00000393330 ; ENSP00000377003 ; ENSG00000127324 .
    ENST00000546561 ; ENSP00000447160 ; ENSG00000127324 .
    GeneIDi 7103.
    KEGGi hsa:7103.
    UCSCi uc001swj.1. human.

    Organism-specific databases

    CTDi 7103.
    GeneCardsi GC12M071518.
    HGNCi HGNC:11855. TSPAN8.
    HPAi CAB026009.
    HPA044337.
    MIMi 600769. gene.
    neXtProti NX_P19075.
    PharmGKBi PA36556.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312327.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi P19075.
    KOi K17349.
    OMAi ANHKAKK.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi P19075.
    TreeFami TF352895.

    Miscellaneous databases

    GeneWikii TSPAN8.
    GenomeRNAii 7103.
    NextBioi 27789.
    PROi P19075.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19075.
    Bgeei P19075.
    CleanExi HS_TSPAN8.
    Genevestigatori P19075.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens."
      Szala S., Kasai Y., Steplewski Z., Rodeck U., Koprowski H., Linnenbach A.J.
      Proc. Natl. Acad. Sci. U.S.A. 87:6833-6837(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon carcinoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-35 AND ALA-73.
      Tissue: Liver.
    5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
      Tissue: Liver.

    Entry informationi

    Entry nameiTSN8_HUMAN
    AccessioniPrimary (citable) accession number: P19075
    Secondary accession number(s): B2R7T7, Q9BS78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3