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Protein

Tetraspanin-8

Gene

TSPAN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Alternative name(s):
Transmembrane 4 superfamily member 3
Tumor-associated antigen CO-029
Gene namesi
Name:TSPAN8
Synonyms:TM4SF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11855. TSPAN8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3324HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 5724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7215HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 8311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei84 – 10926HelicalSequence AnalysisAdd
BLAST
Topological domaini110 – 20596ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 23025HelicalSequence AnalysisAdd
BLAST
Topological domaini231 – 2377CytoplasmicSequence Analysis

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36556.

Polymorphism and mutation databases

BioMutaiTSPAN8.
DMDMi116589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Tetraspanin-8PRO_0000219252Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19075.
PaxDbiP19075.
PRIDEiP19075.

PTM databases

PhosphoSiteiP19075.

Expressioni

Tissue specificityi

Gastric, colon, rectal, and pancreatic carcinomas.

Gene expression databases

BgeeiP19075.
CleanExiHS_TSPAN8.
GenevisibleiP19075. HS.

Organism-specific databases

HPAiCAB026009.
HPA044337.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247829.

Structurei

3D structure databases

ProteinModelPortaliP19075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312327.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19075.
KOiK17349.
OMAiYENTKLL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP19075.
TreeFamiTF352895.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS
60 70 80 90 100
SSYVAVDILI AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV
110 120 130 140 150
ATGILGAVFK SKSDRIVNET LYENTKLLSA TGESEKQFQE AIIVFQEEFK
160 170 180 190 200
CCGLVNGAAD WGNNFQHYPE LCACLDKQRP CQSYNGKQVY KETCISFIKD
210 220 230
FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK
Length:237
Mass (Da):26,044
Last modified:November 1, 1990 - v1
Checksum:iD1058F054EE8C14E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351V → I.1 Publication
Corresponds to variant rs17849952 [ dbSNP | Ensembl ].
VAR_061848
Natural varianti73 – 731G → A.1 Publication
Corresponds to variant rs3763978 [ dbSNP | Ensembl ].
VAR_020093
Natural varianti213 – 2131S → A.
Corresponds to variant rs1051334 [ dbSNP | Ensembl ].
VAR_012054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35252 mRNA. Translation: AAA35709.1.
AK313112 mRNA. Translation: BAG35934.1.
CH471054 Genomic DNA. Translation: EAW97257.1.
BC005246 mRNA. Translation: AAH05246.1.
CCDSiCCDS8999.1.
PIRiA36056.
RefSeqiNP_004607.1. NM_004616.2.
XP_006719646.1. XM_006719583.2.
UniGeneiHs.170563.

Genome annotation databases

EnsembliENST00000247829; ENSP00000247829; ENSG00000127324.
ENST00000393330; ENSP00000377003; ENSG00000127324.
ENST00000546561; ENSP00000447160; ENSG00000127324.
GeneIDi7103.
KEGGihsa:7103.
UCSCiuc001swj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35252 mRNA. Translation: AAA35709.1.
AK313112 mRNA. Translation: BAG35934.1.
CH471054 Genomic DNA. Translation: EAW97257.1.
BC005246 mRNA. Translation: AAH05246.1.
CCDSiCCDS8999.1.
PIRiA36056.
RefSeqiNP_004607.1. NM_004616.2.
XP_006719646.1. XM_006719583.2.
UniGeneiHs.170563.

3D structure databases

ProteinModelPortaliP19075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000247829.

PTM databases

PhosphoSiteiP19075.

Polymorphism and mutation databases

BioMutaiTSPAN8.
DMDMi116589.

Proteomic databases

MaxQBiP19075.
PaxDbiP19075.
PRIDEiP19075.

Protocols and materials databases

DNASUi7103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247829; ENSP00000247829; ENSG00000127324.
ENST00000393330; ENSP00000377003; ENSG00000127324.
ENST00000546561; ENSP00000447160; ENSG00000127324.
GeneIDi7103.
KEGGihsa:7103.
UCSCiuc001swj.1. human.

Organism-specific databases

CTDi7103.
GeneCardsiGC12M071518.
HGNCiHGNC:11855. TSPAN8.
HPAiCAB026009.
HPA044337.
MIMi600769. gene.
neXtProtiNX_P19075.
PharmGKBiPA36556.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312327.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19075.
KOiK17349.
OMAiYENTKLL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP19075.
TreeFamiTF352895.

Miscellaneous databases

ChiTaRSiTSPAN8. human.
GeneWikiiTSPAN8.
GenomeRNAii7103.
NextBioi27789.
PROiP19075.
SOURCEiSearch...

Gene expression databases

BgeeiP19075.
CleanExiHS_TSPAN8.
GenevisibleiP19075. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens."
    Szala S., Kasai Y., Steplewski Z., Rodeck U., Koprowski H., Linnenbach A.J.
    Proc. Natl. Acad. Sci. U.S.A. 87:6833-6837(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-35 AND ALA-73.
    Tissue: Liver.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
    Tissue: Liver.

Entry informationi

Entry nameiTSN8_HUMAN
AccessioniPrimary (citable) accession number: P19075
Secondary accession number(s): B2R7T7, Q9BS78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 24, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.