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P19075 (TSN8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-8

Short name=Tspan-8
Alternative name(s):
Transmembrane 4 superfamily member 3
Tumor-associated antigen CO-029
Gene names
Name:TSPAN8
Synonyms:TM4SF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Gastric, colon, rectal, and pancreatic carcinomas.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Tetraspanin-8
PRO_0000219252

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3324Helical; Potential
Topological domain34 – 5724Extracellular Potential
Transmembrane58 – 7215Helical; Potential
Topological domain73 – 8311Cytoplasmic Potential
Transmembrane84 – 10926Helical; Potential
Topological domain110 – 20596Extracellular Potential
Transmembrane206 – 23025Helical; Potential
Topological domain231 – 2377Cytoplasmic Potential

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Ref.5

Natural variations

Natural variant351V → I. Ref.4
Corresponds to variant rs17849952 [ dbSNP | Ensembl ].
VAR_061848
Natural variant731G → A. Ref.4
Corresponds to variant rs3763978 [ dbSNP | Ensembl ].
VAR_020093
Natural variant2131S → A.
Corresponds to variant rs1051334 [ dbSNP | Ensembl ].
VAR_012054

Sequences

Sequence LengthMass (Da)Tools
P19075 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: D1058F054EE8C14E

FASTA23726,044
        10         20         30         40         50         60 
MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS SSYVAVDILI 

        70         80         90        100        110        120 
AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV ATGILGAVFK SKSDRIVNET 

       130        140        150        160        170        180 
LYENTKLLSA TGESEKQFQE AIIVFQEEFK CCGLVNGAAD WGNNFQHYPE LCACLDKQRP 

       190        200        210        220        230 
CQSYNGKQVY KETCISFIKD FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens."
Szala S., Kasai Y., Steplewski Z., Rodeck U., Koprowski H., Linnenbach A.J.
Proc. Natl. Acad. Sci. U.S.A. 87:6833-6837(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon carcinoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-35 AND ALA-73.
Tissue: Liver.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M35252 mRNA. Translation: AAA35709.1.
AK313112 mRNA. Translation: BAG35934.1.
CH471054 Genomic DNA. Translation: EAW97257.1.
BC005246 mRNA. Translation: AAH05246.1.
CCDSCCDS8999.1.
PIRA36056.
RefSeqNP_004607.1. NM_004616.2.
XP_006719646.1. XM_006719583.1.
UniGeneHs.170563.

3D structure databases

ProteinModelPortalP19075.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000247829.

PTM databases

PhosphoSiteP19075.

Polymorphism databases

DMDM116589.

Proteomic databases

MaxQBP19075.
PaxDbP19075.
PRIDEP19075.

Protocols and materials databases

DNASU7103.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000247829; ENSP00000247829; ENSG00000127324.
ENST00000393330; ENSP00000377003; ENSG00000127324.
ENST00000546561; ENSP00000447160; ENSG00000127324.
GeneID7103.
KEGGhsa:7103.
UCSCuc001swj.1. human.

Organism-specific databases

CTD7103.
GeneCardsGC12M071518.
HGNCHGNC:11855. TSPAN8.
HPACAB026009.
HPA044337.
MIM600769. gene.
neXtProtNX_P19075.
PharmGKBPA36556.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312327.
HOGENOMHOG000230651.
HOVERGENHBG002324.
InParanoidP19075.
KOK17349.
OMAANHKAKK.
OrthoDBEOG7PGDRZ.
PhylomeDBP19075.
TreeFamTF352895.

Gene expression databases

ArrayExpressP19075.
BgeeP19075.
CleanExHS_TSPAN8.
GenevestigatorP19075.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTSPAN8.
GenomeRNAi7103.
NextBio27789.
PROP19075.
SOURCESearch...

Entry information

Entry nameTSN8_HUMAN
AccessionPrimary (citable) accession number: P19075
Secondary accession number(s): B2R7T7, Q9BS78
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM