Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P19075

- TSN8_HUMAN

UniProt

P19075 - TSN8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tetraspanin-8

Gene

TSPAN8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. negative regulation of blood coagulation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Alternative name(s):
Transmembrane 4 superfamily member 3
Tumor-associated antigen CO-029
Gene namesi
Name:TSPAN8
Synonyms:TM4SF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:11855. TSPAN8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3324HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 5724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7215HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 8311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei84 – 10926HelicalSequence AnalysisAdd
BLAST
Topological domaini110 – 20596ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 23025HelicalSequence AnalysisAdd
BLAST
Topological domaini231 – 2377CytoplasmicSequence Analysis

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Tetraspanin-8PRO_0000219252Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19075.
PaxDbiP19075.
PRIDEiP19075.

PTM databases

PhosphoSiteiP19075.

Expressioni

Tissue specificityi

Gastric, colon, rectal, and pancreatic carcinomas.

Gene expression databases

BgeeiP19075.
CleanExiHS_TSPAN8.
GenevestigatoriP19075.

Organism-specific databases

HPAiCAB026009.
HPA044337.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247829.

Structurei

3D structure databases

ProteinModelPortaliP19075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312327.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19075.
KOiK17349.
OMAiANHKAKK.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP19075.
TreeFamiTF352895.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19075-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS
60 70 80 90 100
SSYVAVDILI AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV
110 120 130 140 150
ATGILGAVFK SKSDRIVNET LYENTKLLSA TGESEKQFQE AIIVFQEEFK
160 170 180 190 200
CCGLVNGAAD WGNNFQHYPE LCACLDKQRP CQSYNGKQVY KETCISFIKD
210 220 230
FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK
Length:237
Mass (Da):26,044
Last modified:November 1, 1990 - v1
Checksum:iD1058F054EE8C14E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351V → I.1 Publication
Corresponds to variant rs17849952 [ dbSNP | Ensembl ].
VAR_061848
Natural varianti73 – 731G → A.1 Publication
Corresponds to variant rs3763978 [ dbSNP | Ensembl ].
VAR_020093
Natural varianti213 – 2131S → A.
Corresponds to variant rs1051334 [ dbSNP | Ensembl ].
VAR_012054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35252 mRNA. Translation: AAA35709.1.
AK313112 mRNA. Translation: BAG35934.1.
CH471054 Genomic DNA. Translation: EAW97257.1.
BC005246 mRNA. Translation: AAH05246.1.
CCDSiCCDS8999.1.
PIRiA36056.
RefSeqiNP_004607.1. NM_004616.2.
XP_006719646.1. XM_006719583.1.
UniGeneiHs.170563.

Genome annotation databases

EnsembliENST00000247829; ENSP00000247829; ENSG00000127324.
ENST00000393330; ENSP00000377003; ENSG00000127324.
ENST00000546561; ENSP00000447160; ENSG00000127324.
GeneIDi7103.
KEGGihsa:7103.
UCSCiuc001swj.1. human.

Polymorphism databases

DMDMi116589.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35252 mRNA. Translation: AAA35709.1 .
AK313112 mRNA. Translation: BAG35934.1 .
CH471054 Genomic DNA. Translation: EAW97257.1 .
BC005246 mRNA. Translation: AAH05246.1 .
CCDSi CCDS8999.1.
PIRi A36056.
RefSeqi NP_004607.1. NM_004616.2.
XP_006719646.1. XM_006719583.1.
UniGenei Hs.170563.

3D structure databases

ProteinModelPortali P19075.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000247829.

PTM databases

PhosphoSitei P19075.

Polymorphism databases

DMDMi 116589.

Proteomic databases

MaxQBi P19075.
PaxDbi P19075.
PRIDEi P19075.

Protocols and materials databases

DNASUi 7103.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247829 ; ENSP00000247829 ; ENSG00000127324 .
ENST00000393330 ; ENSP00000377003 ; ENSG00000127324 .
ENST00000546561 ; ENSP00000447160 ; ENSG00000127324 .
GeneIDi 7103.
KEGGi hsa:7103.
UCSCi uc001swj.1. human.

Organism-specific databases

CTDi 7103.
GeneCardsi GC12M071518.
HGNCi HGNC:11855. TSPAN8.
HPAi CAB026009.
HPA044337.
MIMi 600769. gene.
neXtProti NX_P19075.
PharmGKBi PA36556.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312327.
GeneTreei ENSGT00760000118983.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi P19075.
KOi K17349.
OMAi ANHKAKK.
OrthoDBi EOG7PGDRZ.
PhylomeDBi P19075.
TreeFami TF352895.

Miscellaneous databases

ChiTaRSi TSPAN8. human.
GeneWikii TSPAN8.
GenomeRNAii 7103.
NextBioi 27789.
PROi P19075.
SOURCEi Search...

Gene expression databases

Bgeei P19075.
CleanExi HS_TSPAN8.
Genevestigatori P19075.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens."
    Szala S., Kasai Y., Steplewski Z., Rodeck U., Koprowski H., Linnenbach A.J.
    Proc. Natl. Acad. Sci. U.S.A. 87:6833-6837(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-35 AND ALA-73.
    Tissue: Liver.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
    Tissue: Liver.

Entry informationi

Entry nameiTSN8_HUMAN
AccessioniPrimary (citable) accession number: P19075
Secondary accession number(s): B2R7T7, Q9BS78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3