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Protein

Tetraspanin-8

Gene

TSPAN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127324-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Alternative name(s):
Transmembrane 4 superfamily member 3
Tumor-associated antigen CO-029
Gene namesi
Name:TSPAN8
Synonyms:TM4SF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11855. TSPAN8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 33HelicalSequence analysisAdd BLAST24
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 72HelicalSequence analysisAdd BLAST15
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 109HelicalSequence analysisAdd BLAST26
Topological domaini110 – 205ExtracellularSequence analysisAdd BLAST96
Transmembranei206 – 230HelicalSequence analysisAdd BLAST25
Topological domaini231 – 237CytoplasmicSequence analysis7

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7103.
OpenTargetsiENSG00000127324.
PharmGKBiPA36556.

Polymorphism and mutation databases

BioMutaiTSPAN8.
DMDMi116589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192521 – 237Tetraspanin-8Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19075.
PaxDbiP19075.
PeptideAtlasiP19075.
PRIDEiP19075.

PTM databases

iPTMnetiP19075.
PhosphoSitePlusiP19075.

Expressioni

Tissue specificityi

Gastric, colon, rectal, and pancreatic carcinomas.

Gene expression databases

BgeeiENSG00000127324.
CleanExiHS_TSPAN8.
GenevisibleiP19075. HS.

Organism-specific databases

HPAiCAB026009.
HPA044337.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247829.

Structurei

3D structure databases

ProteinModelPortaliP19075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19075.
KOiK17349.
OMAiNYKSCEC.
OrthoDBiEOG091G0K9H.
PhylomeDBiP19075.
TreeFamiTF352895.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS
60 70 80 90 100
SSYVAVDILI AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV
110 120 130 140 150
ATGILGAVFK SKSDRIVNET LYENTKLLSA TGESEKQFQE AIIVFQEEFK
160 170 180 190 200
CCGLVNGAAD WGNNFQHYPE LCACLDKQRP CQSYNGKQVY KETCISFIKD
210 220 230
FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK
Length:237
Mass (Da):26,044
Last modified:November 1, 1990 - v1
Checksum:iD1058F054EE8C14E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06184835V → I.1 PublicationCorresponds to variant rs17849952dbSNPEnsembl.1
Natural variantiVAR_02009373G → A.1 PublicationCorresponds to variant rs3763978dbSNPEnsembl.1
Natural variantiVAR_012054213S → A.Corresponds to variant rs1051334dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35252 mRNA. Translation: AAA35709.1.
AK313112 mRNA. Translation: BAG35934.1.
CH471054 Genomic DNA. Translation: EAW97257.1.
BC005246 mRNA. Translation: AAH05246.1.
CCDSiCCDS8999.1.
PIRiA36056.
RefSeqiNP_004607.1. NM_004616.2.
XP_006719646.1. XM_006719583.3.
XP_016875402.1. XM_017019913.1.
UniGeneiHs.170563.

Genome annotation databases

EnsembliENST00000247829; ENSP00000247829; ENSG00000127324.
ENST00000393330; ENSP00000377003; ENSG00000127324.
ENST00000546561; ENSP00000447160; ENSG00000127324.
GeneIDi7103.
KEGGihsa:7103.
UCSCiuc001swj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35252 mRNA. Translation: AAA35709.1.
AK313112 mRNA. Translation: BAG35934.1.
CH471054 Genomic DNA. Translation: EAW97257.1.
BC005246 mRNA. Translation: AAH05246.1.
CCDSiCCDS8999.1.
PIRiA36056.
RefSeqiNP_004607.1. NM_004616.2.
XP_006719646.1. XM_006719583.3.
XP_016875402.1. XM_017019913.1.
UniGeneiHs.170563.

3D structure databases

ProteinModelPortaliP19075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000247829.

PTM databases

iPTMnetiP19075.
PhosphoSitePlusiP19075.

Polymorphism and mutation databases

BioMutaiTSPAN8.
DMDMi116589.

Proteomic databases

MaxQBiP19075.
PaxDbiP19075.
PeptideAtlasiP19075.
PRIDEiP19075.

Protocols and materials databases

DNASUi7103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247829; ENSP00000247829; ENSG00000127324.
ENST00000393330; ENSP00000377003; ENSG00000127324.
ENST00000546561; ENSP00000447160; ENSG00000127324.
GeneIDi7103.
KEGGihsa:7103.
UCSCiuc001swj.2. human.

Organism-specific databases

CTDi7103.
DisGeNETi7103.
GeneCardsiTSPAN8.
HGNCiHGNC:11855. TSPAN8.
HPAiCAB026009.
HPA044337.
MIMi600769. gene.
neXtProtiNX_P19075.
OpenTargetsiENSG00000127324.
PharmGKBiPA36556.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19075.
KOiK17349.
OMAiNYKSCEC.
OrthoDBiEOG091G0K9H.
PhylomeDBiP19075.
TreeFamiTF352895.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127324-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN8. human.
GeneWikiiTSPAN8.
GenomeRNAii7103.
PROiP19075.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127324.
CleanExiHS_TSPAN8.
GenevisibleiP19075. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN8_HUMAN
AccessioniPrimary (citable) accession number: P19075
Secondary accession number(s): B2R7T7, Q9BS78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.