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Protein

Cell division control protein 42

Gene

CDC42

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • budding cell apical bud growth Source: SGD
  • budding cell isotropic bud growth Source: SGD
  • cell cycle Source: UniProtKB-KW
  • conjugation with cellular fusion Source: SGD
  • establishment of cell polarity Source: SGD
  • invasive growth in response to glucose limitation Source: SGD
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
  • positive regulation of exocytosis Source: SGD
  • positive regulation of pseudohyphal growth Source: SGD
  • regulation of cell morphogenesis Source: AgBase
  • regulation of exit from mitosis Source: SGD
  • regulation of exocyst localization Source: SGD
  • regulation of initiation of mating projection growth Source: SGD
  • regulation of vacuole fusion, non-autophagic Source: SGD
  • septin ring organization Source: SGD
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Biological processCell cycle, Cell division, Pheromone response
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32343-MONOMER.
ReactomeiR-SCE-193648. NRAGE signals death through JNK.
R-SCE-194840. Rho GTPase cycle.
R-SCE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-SCE-389359. CD28 dependent Vav1 pathway.
R-SCE-3928662. EPHB-mediated forward signaling.
R-SCE-416482. G alpha (12/13) signalling events.
R-SCE-445144. Signal transduction by L1.
R-SCE-5626467. RHO GTPases activate IQGAPs.
R-SCE-5627123. RHO GTPases activate PAKs.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 42
Alternative name(s):
Suppressor of RHO3 protein 2
Gene namesi
Name:CDC42
Synonyms:SRO2
Ordered Locus Names:YLR229C
ORF Names:L8083.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR229C.
SGDiS000004219. CDC42.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12G → V: Enhances interaction with RGA1. 1 Publication1
Mutagenesisi58T → A: Temperature-sensitive mutant. 1 Publication1
Mutagenesisi61Q → L: Enhances interaction with RGA1. 1 Publication1
Mutagenesisi71S → P: Temperature-sensitive mutant. 1 Publication1
Mutagenesisi97W → R: Temperature-sensitive mutant. 1 Publication1
Mutagenesisi118D → A: Dramatically reduces interaction with RGA1. 1 Publication1
Mutagenesisi142G → S in CDC42-1; temperature-sensitive mutant. 1 Publication1
Mutagenesisi188C → S: Enhances interaction with RGA1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989551 – 188Cell division control protein 42Add BLAST188
PropeptideiPRO_0000281285189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP19073.
PRIDEiP19073.

Interactioni

Subunit structurei

Interacts with AXL2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31499. 266 interactors.
DIPiDIP-862N.
IntActiP19073. 17 interactors.
MINTiMINT-393961.
STRINGi4932.YLR229C.

Structurei

3D structure databases

ProteinModelPortaliP19073.
SMRiP19073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
InParanoidiP19073.
KOiK04393.
OMAiMQTLKCV.
OrthoDBiEOG092C4TDG.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51420. RHO. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLKCVVVG DGAVGKTCLL ISYTTNQFPA DYVPTVFDNY AVTVMIGDEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPSTDVFLV CFSVISPPSF ENVKEKWFPE
110 120 130 140 150
VHHHCPGVPC LVVGTQIDLR DDKVIIEKLQ RQRLRPITSE QGSRLARELK
160 170 180 190
AVKYVECSAL TQRGLKNVFD EAIVAALEPP VIKKSKKCAI L
Length:191
Mass (Da):21,323
Last modified:November 1, 1997 - v2
Checksum:i30BD644BA9836B2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189A → T in CAA36186 (PubMed:2164028).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51906 Genomic DNA. Translation: CAA36186.1.
U19027 Genomic DNA. Translation: AAB67416.1.
AY557933 Genomic DNA. Translation: AAS56259.1.
BK006945 Genomic DNA. Translation: DAA09547.1.
PIRiS51452.
RefSeqiNP_013330.1. NM_001182116.1.

Genome annotation databases

EnsemblFungiiYLR229C; YLR229C; YLR229C.
GeneIDi850930.
KEGGisce:YLR229C.

Similar proteinsi

Entry informationi

Entry nameiCDC42_YEAST
AccessioniPrimary (citable) accession number: P19073
Secondary accession number(s): D6VYN1, Q05978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names