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Protein

Cell division control protein 42

Gene

CDC42

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi57 – 615GTPBy similarity
Nucleotide bindingi115 – 1184GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • budding cell apical bud growth Source: SGD
  • budding cell isotropic bud growth Source: SGD
  • cell cycle Source: UniProtKB-KW
  • conjugation with cellular fusion Source: SGD
  • establishment of cell polarity Source: SGD
  • invasive growth in response to glucose limitation Source: SGD
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
  • positive regulation of exocytosis Source: SGD
  • positive regulation of pseudohyphal growth Source: SGD
  • regulation of cell morphogenesis Source: AgBase
  • regulation of exit from mitosis Source: SGD
  • regulation of exocyst localization Source: SGD
  • regulation of initiation of mating projection growth Source: SGD
  • regulation of vacuole fusion, non-autophagic Source: SGD
  • septin ring organization Source: SGD
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Pheromone response

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32343-MONOMER.
ReactomeiR-SCE-193648. NRAGE signals death through JNK.
R-SCE-194840. Rho GTPase cycle.
R-SCE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-SCE-389359. CD28 dependent Vav1 pathway.
R-SCE-3928662. EPHB-mediated forward signaling.
R-SCE-416482. G alpha (12/13) signalling events.
R-SCE-4420097. VEGFA-VEGFR2 Pathway.
R-SCE-445144. Signal transduction by L1.
R-SCE-5626467. RHO GTPases activate IQGAPs.
R-SCE-5627123. RHO GTPases activate PAKs.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 42
Alternative name(s):
Suppressor of RHO3 protein 2
Gene namesi
Name:CDC42
Synonyms:SRO2
Ordered Locus Names:YLR229C
ORF Names:L8083.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR229C.
SGDiS000004219. CDC42.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud tip Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • incipient cellular bud site Source: SGD
  • mating projection tip Source: SGD
  • nuclear membrane Source: SGD
  • plasma membrane Source: SGD
  • septin ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi12 – 121G → V: Enhances interaction with RGA1. 1 Publication
Mutagenesisi58 – 581T → A: Temperature-sensitive mutant. 1 Publication
Mutagenesisi61 – 611Q → L: Enhances interaction with RGA1. 1 Publication
Mutagenesisi71 – 711S → P: Temperature-sensitive mutant. 1 Publication
Mutagenesisi97 – 971W → R: Temperature-sensitive mutant. 1 Publication
Mutagenesisi118 – 1181D → A: Dramatically reduces interaction with RGA1. 1 Publication
Mutagenesisi142 – 1421G → S in CDC42-1; temperature-sensitive mutant. 1 Publication
Mutagenesisi188 – 1881C → S: Enhances interaction with RGA1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Cell division control protein 42PRO_0000198955Add
BLAST
Propeptidei189 – 1913Removed in mature formBy similarityPRO_0000281285

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881Cysteine methyl esterBy similarity
Lipidationi188 – 1881S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP19073.

Interactioni

Subunit structurei

Interacts with AXL2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RDI1Q124342EBI-4274,EBI-7525
STE20Q034974EBI-4274,EBI-18285

Protein-protein interaction databases

BioGridi31499. 187 interactions.
DIPiDIP-862N.
IntActiP19073. 10 interactions.
MINTiMINT-393961.

Structurei

3D structure databases

ProteinModelPortaliP19073.
SMRiP19073. Positions 1-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector regionSequence analysis

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
InParanoidiP19073.
KOiK04393.
OMAiXRDAPST.
OrthoDBiEOG092C4TDG.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLKCVVVG DGAVGKTCLL ISYTTNQFPA DYVPTVFDNY AVTVMIGDEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPSTDVFLV CFSVISPPSF ENVKEKWFPE
110 120 130 140 150
VHHHCPGVPC LVVGTQIDLR DDKVIIEKLQ RQRLRPITSE QGSRLARELK
160 170 180 190
AVKYVECSAL TQRGLKNVFD EAIVAALEPP VIKKSKKCAI L
Length:191
Mass (Da):21,323
Last modified:November 1, 1997 - v2
Checksum:i30BD644BA9836B2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891A → T in CAA36186 (PubMed:2164028).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51906 Genomic DNA. Translation: CAA36186.1.
U19027 Genomic DNA. Translation: AAB67416.1.
AY557933 Genomic DNA. Translation: AAS56259.1.
BK006945 Genomic DNA. Translation: DAA09547.1.
PIRiS51452.
RefSeqiNP_013330.1. NM_001182116.1.

Genome annotation databases

EnsemblFungiiYLR229C; YLR229C; YLR229C.
GeneIDi850930.
KEGGisce:YLR229C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51906 Genomic DNA. Translation: CAA36186.1.
U19027 Genomic DNA. Translation: AAB67416.1.
AY557933 Genomic DNA. Translation: AAS56259.1.
BK006945 Genomic DNA. Translation: DAA09547.1.
PIRiS51452.
RefSeqiNP_013330.1. NM_001182116.1.

3D structure databases

ProteinModelPortaliP19073.
SMRiP19073. Positions 1-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31499. 187 interactions.
DIPiDIP-862N.
IntActiP19073. 10 interactions.
MINTiMINT-393961.

Proteomic databases

MaxQBiP19073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR229C; YLR229C; YLR229C.
GeneIDi850930.
KEGGisce:YLR229C.

Organism-specific databases

EuPathDBiFungiDB:YLR229C.
SGDiS000004219. CDC42.

Phylogenomic databases

GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
InParanoidiP19073.
KOiK04393.
OMAiXRDAPST.
OrthoDBiEOG092C4TDG.

Enzyme and pathway databases

BioCyciYEAST:G3O-32343-MONOMER.
ReactomeiR-SCE-193648. NRAGE signals death through JNK.
R-SCE-194840. Rho GTPase cycle.
R-SCE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-SCE-389359. CD28 dependent Vav1 pathway.
R-SCE-3928662. EPHB-mediated forward signaling.
R-SCE-416482. G alpha (12/13) signalling events.
R-SCE-4420097. VEGFA-VEGFR2 Pathway.
R-SCE-445144. Signal transduction by L1.
R-SCE-5626467. RHO GTPases activate IQGAPs.
R-SCE-5627123. RHO GTPases activate PAKs.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiP19073.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC42_YEAST
AccessioniPrimary (citable) accession number: P19073
Secondary accession number(s): D6VYN1, Q05978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.