P19045 (NU3C_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 3
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase subunit 3
NADH-plastoquinone oxidoreductase subunit 3
NDH-1 subunit 3
Short name=NDH-C

Gene names

Name:	ndhC
Ordered Locus Names:	slr1279

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration By similarity. HAMAP MF_01394
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01394
Subunit structure	NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.
Subcellular location	Cellular thylakoid membrane; Multi-pass membrane protein Probable HAMAP MF_01394.
Sequence similarities	Belongs to the complex I subunit 3 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	NAD(P)H-quinone oxidoreductase subunit 3 HAMAP MF_01394		PRO_0000117859
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P19045 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 39343E8AFEAD8184	FASTA	120	13,662
	10 20 30 40 50 60 MFVLTGYEYF LGFLFICSLV PVLALTASKL LRPRDGGPER QTTYESGMEP IGGAWIQFNI 70 80 90 100 110 120 RYYMFALVFV VFDVETVFLY PWAVAFNQLG LLAFVEALIF IAILVVALVY AWRKGALEWS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the ndhC-psbG-ORF157/159 operon of maize plastid DNA and of the cyanobacterium Synechocystis sp. PCC6803." Steinmueller K., Ley A.C., Steinmetz A.A., Sayre R.T., Bogorad L. Mol. Gen. Genet. 216:60-69(1989) [PubMed: 2499764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[3]	"Subunit composition of NDH-1 complexes of Synechocystis sp. PCC 6803: identification of two new ndh gene products with nuclear-encoded homologues in the chloroplast Ndh complex." Prommeenate P., Lennon A.M., Markert C., Hippler M., Nixon P.J. J. Biol. Chem. 279:28165-28173(2004) [PubMed: 15102833] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-6, CHARACTERIZATION AS A MEMBER OF THE NAD(P)H-QUINONE OXIDOREDUCTASE COMPLEX, SUBCOMPLEXES OF NDH-1.
[4]	"Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes of Synechocystis sp. PCC 6803." Battchikova N., Zhang P., Rudd S., Ogawa T., Aro E.-M. J. Biol. Chem. 280:2587-2595(2005) [PubMed: 15548534] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROSCOPY, CHARACTERIZATION AS A MEMBER OF THE NAD(P)H-QUINONE OXIDOREDUCTASE COMPLEX, SUBCOMPLEXES OF NDH-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17439 Genomic DNA. Translation: CAA35484.1. BA000022 Genomic DNA. Translation: BAA18283.1.
PIR	S04435.
RefSeq	NP_441603.1. NC_000911.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P19045. 3 interactions.
STRING	P19045.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	953053.
GenomeReviews	Gene locus slr1279 in contig BA000022_GR.
KEGG	syn:slr1279.
NMPDR	fig|1148.1.peg.1704.
PATRIC	23840645. VBISynSp132158_1877.
Phylogenomic databases
eggNOG	COG0838.
HOGENOM	HBG605540.
OMA	GERELTY.
PhylomeDB	P19045.
ProtClustDB	PRK06602.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1279-MONOMER.
Family and domain databases
HAMAP	MF_01394. NDH1_NuoA. [Tree]
InterPro	IPR023043. NAD(P)H_OxRDtase_bac/plastid. IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3. [Graphical view]
KO	K05574.
PANTHER	PTHR11058. Oxidored_q4. 1 hit.
Pfam	PF00507. Oxidored_q4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU3C_SYNY3

Accession

Primary (citable) accession number: P19045

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program