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Protein

Apolipoprotein C-III

Gene

APOC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Sialic acid

Enzyme and pathway databases

ReactomeiR-BTA-174800. Chylomicron-mediated lipid transport.
R-BTA-194223. HDL-mediated lipid transport.
R-BTA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-III
Short name:
Apo-CIII
Short name:
ApoC-III
Alternative name(s):
Apolipoprotein C3
Gene namesi
Name:APOC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9673Apolipoprotein C-IIIPRO_0000002028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Methionine sulfoxideBy similarity
Glycosylationi92 – 921O-linked (GalNAc...)By similarity

Post-translational modificationi

The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-92 with a core 1 or possibly core 8 glycan.By similarity

Keywords - PTMi

Glycoprotein, Oxidation

Proteomic databases

PaxDbiP19035.
PRIDEiP19035.

Expressioni

Gene expression databases

ExpressionAtlasiP19035. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016453.

Structurei

3D structure databases

ProteinModelPortaliP19035.
SMRiP19035. Positions 21-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 9629Lipid-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein C3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE3N. Eukaryota.
ENOG4111APE. LUCA.
HOGENOMiHOG000247042.
HOVERGENiHBG050549.
InParanoidiP19035.
KOiK08759.
OMAiSLKDYWS.
OrthoDBiEOG7JMGHK.
TreeFamiTF338209.

Family and domain databases

InterProiIPR008403. Apo-CIII.
[Graphical view]
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiPF05778. Apo-CIII. 1 hit.
[Graphical view]
ProDomiPD010414. Apo-CIII. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRLLLLAA FLALLVLPEA TKAEEGSLLD KMQGYVKEAT KTAKDALSSV
60 70 80 90
QESQVAQQAR DWMTESFSSL KDYWSSFKGK FTDFWESATS PTQSPP
Length:96
Mass (Da):10,692
Last modified:February 1, 2005 - v2
Checksum:iC39C5A5B57294497
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871S → L AA sequence (PubMed:2209608).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126687 mRNA. Translation: BAD15291.1.
BC111661 mRNA. Translation: AAI11662.1.
PIRiS13188.
RefSeqiNP_001001175.1. NM_001001175.2.
UniGeneiBt.7741.

Genome annotation databases

EnsembliENSBTAT00000016453; ENSBTAP00000016453; ENSBTAG00000012398.
GeneIDi408009.
KEGGibta:408009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126687 mRNA. Translation: BAD15291.1.
BC111661 mRNA. Translation: AAI11662.1.
PIRiS13188.
RefSeqiNP_001001175.1. NM_001001175.2.
UniGeneiBt.7741.

3D structure databases

ProteinModelPortaliP19035.
SMRiP19035. Positions 21-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016453.

Proteomic databases

PaxDbiP19035.
PRIDEiP19035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016453; ENSBTAP00000016453; ENSBTAG00000012398.
GeneIDi408009.
KEGGibta:408009.

Organism-specific databases

CTDi345.

Phylogenomic databases

eggNOGiENOG410JE3N. Eukaryota.
ENOG4111APE. LUCA.
HOGENOMiHOG000247042.
HOVERGENiHBG050549.
InParanoidiP19035.
KOiK08759.
OMAiSLKDYWS.
OrthoDBiEOG7JMGHK.
TreeFamiTF338209.

Enzyme and pathway databases

ReactomeiR-BTA-174800. Chylomicron-mediated lipid transport.
R-BTA-194223. HDL-mediated lipid transport.
R-BTA-975634. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi20818628.

Gene expression databases

ExpressionAtlasiP19035. baseline.

Family and domain databases

InterProiIPR008403. Apo-CIII.
[Graphical view]
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiPF05778. Apo-CIII. 1 hit.
[Graphical view]
ProDomiPD010414. Apo-CIII. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bovine apolipoprotein C-III (ApoC3) gene, complete CDS."
    Nitanai A., Endoh D., Oikawa S., Katoh N.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.
  3. "Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing."
    Bengtsson-Olivecrona G., Sletten K.
    Eur. J. Biochem. 192:515-521(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-89.

Entry informationi

Entry nameiAPOC3_BOVIN
AccessioniPrimary (citable) accession number: P19035
Secondary accession number(s): Q2M2T0, Q75T83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 2005
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.