Reviewed,
UniProtKB/Swiss-Prot P19028 (POL_FIVSD)
Last modified
October 13, 2009.
Version 89.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pol polyprotein Cleaved into the following 4 chains: 1- Recommended name: Protease EC=3.4.23.- Alternative name(s): Retropepsin 2- Recommended name: Reverse transcriptase/ribonuclease H Short name=RT EC=2.7.7.49 EC=3.1.26.4 3- Recommended name: Deoxyuridine 5'-triphosphate nucleotidohydrolase Short name=dUTPase EC=3.6.1.23 4- Recommended name: Integrase Short name=IN | ||
| Gene names |
| ||
| Organism | Feline immunodeficiency virus (strain San Diego) (FIV) | ||
| Taxonomic identifier | 11675 [NCBI] | ||
| Taxonomic lineage | Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Feline lentivirus group | ||
| Virus host | Felidae (cat family) [TaxID: 9681] |
Protein attributes
| Sequence length | 1124 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase. |
| Catalytic activity | Endonucleolytic cleavage to 5'-phosphomonoester. dUTP + H2O = dUMP + diphosphate. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| Post-translational modification | Cleavage sites that yield the mature proteins remain to be determined. |
| Sequence similarities | Belongs to the retroviral Pol polyprotein family. Contains 1 integrase catalytic domain. Contains 1 integrase-type DNA-binding domain. Contains 1 integrase-type zinc finger. Contains 1 peptidase A2 domain. Contains 1 reverse transcriptase domain. Contains 1 RNase H domain. |
| Caution | The N-terminus of the polypeptide is uncertain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 39 – 154 | 116 | Protease By similarity | PRO_0000038845 | |||||
| Chain | 155 – 710 | 556 | Reverse transcriptase/ribonuclease H By similarity | PRO_0000038846 | |||||
| Chain | 711 – 843 | 133 | Deoxyuridine 5'-triphosphate nucleotidohydrolase By similarity | PRO_0000038847 | |||||
| Chain | 844 – 1124 | 281 | Integrase By similarity | PRO_0000038848 | |||||
Regions | |||||||||
| Domain | 63 – 144 | 82 | Peptidase A2 | ||||||
| Domain | 200 – 389 | 190 | Reverse transcriptase | ||||||
| Domain | 592 – 712 | 121 | RNase H | ||||||
| Domain | 899 – 1049 | 151 | Integrase catalytic | ||||||
| Zinc finger | 848 – 889 | 42 | Integrase-type | ||||||
| DNA binding | 1067 – 1115 | 49 | Integrase-type | ||||||
Sites | |||||||||
| Active site | 68 | 1 | For protease activity By similarity | ||||||
Sequences
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References
| [1] | "Comparison of two host cell range variants of feline immunodeficiency virus." Phillips T.R., Talbott R.L., Lamont C., Muir S., Lovelace K.M., Elder J.H. J. Virol. 64:4605-4613(1990) [PubMed: 1697907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate PPR. |
Cross-references
Sequence databases | |
|---|---|
| M36968 Genomic RNA. Translation: AAA43076.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 4FIV based on UniProtKB P16088. |
| SMR | P19028. Positions 42-154, 711-843. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR008180. DeoxyUTP_pyroPase_dom. IPR001037. Integrase_C_retrovir. IPR001584. Integrase_cat-core. IPR003308. Integrase_Zn-bd_dom_N. IPR018061. Pept_A2A_retrovirus_sg. IPR001995. Peptidase_A2_cat. IPR001969. Peptidase_aspartic_AS. IPR009007. Peptidase_aspartic_catalytic. IPR000477. Reverse_transcriptase. IPR002156. RNase_H. IPR010659. RVT_connect. IPR010661. RVT_thumb. [Graphical view] |
| Gene3D | G3DSA:2.30.30.10. Integrase_C. 1 hit. G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit. |
| Pfam | PF00692. dUTPase. 1 hit. PF00552. Integrase. 1 hit. PF02022. Integrase_Zn. 1 hit. PF00075. RnaseH. 1 hit. PF00665. rve. 1 hit. PF00077. RVP. 1 hit. PF00078. RVT_1. 1 hit. PF06815. RVT_connect. 1 hit. PF06817. RVT_thumb. 1 hit. [Graphical view] |
| ProDom | PD004900. dCTP_deaminase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. PS50994. INTEGRASE. 1 hit. PS51027. INTEGRASE_DBD. 1 hit. PS50879. RNASE_H. 1 hit. PS50878. RT_POL. 1 hit. PS50876. ZF_INTEGRASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | POL_FIVSD | ||||||||
| Accession | Primary (citable) accession number: P19028 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


