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P19026 (CDC21_PEA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog 1

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
p34
Gene names
Name:CDC2
OrganismPisum sativum (Garden pea)
Taxonomic identifier3888 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Protein attributes

Sequence length148 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation inactivates the enzyme; while. Thr-145 phosphorylation is required for the catalytic activity of the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›148›148Cell division control protein 2 homolog 1
PRO_0000085757

Regions

Domain‹1 – ›148›148Protein kinase
Nucleotide binding‹1 – 2›2ATP By similarity

Sites

Active site1111Proton acceptor By similarity
Binding site171ATP By similarity

Amino acid modifications

Modified residue1451Phosphothreonine; by CAK By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1481

Sequences

Sequence LengthMass (Da)Tools
P19026 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 3B90EC6B2A2E74CA

FASTA14817,445
        10         20         30         40         50         60 
VVYKARDRVT NETIALKKIR LEQEDEGVPS TAIREISLLK EMQHRNIVRL QDVVHSEKRL 

        70         80         90        100        110        120 
YLVFEYLDLD LKKHMDSSPE FVKDPRQVKM FLYQMLCGIA YCHSHRVLHR DLKPQNLLID 

       130        140 
RRTNCVKLAD FGLARAFGIP VRTFTHEV 

« Hide

References

[1]"Cell division in higher plants: a cdc2 gene, its 34-kDa product, and histone H1 kinase activity in pea."
Feiler H.S., Jacobs T.W.
Proc. Natl. Acad. Sci. U.S.A. 87:5397-5401(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Alaska.
Tissue: Shoot apex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53035 mRNA. Translation: CAA37207.1.
PIRA33109. A35778.

3D structure databases

ProteinModelPortalP19026.
SMRP19026. Positions 1-148.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC21_PEA
AccessionPrimary (citable) accession number: P19026
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families