##gff-version 3 P19022 UniProtKB Signal peptide 1 25 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P19022 UniProtKB Propeptide 26 159 . . . ID=PRO_0000003731 P19022 UniProtKB Chain 160 906 . . . ID=PRO_0000003732;Note=Cadherin-2 P19022 UniProtKB Topological domain 160 724 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P19022 UniProtKB Transmembrane 725 745 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P19022 UniProtKB Topological domain 746 906 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P19022 UniProtKB Domain 160 267 . . . Note=Cadherin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 P19022 UniProtKB Domain 268 382 . . . Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 P19022 UniProtKB Domain 383 497 . . . Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 P19022 UniProtKB Domain 498 603 . . . Note=Cadherin 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 P19022 UniProtKB Domain 604 714 . . . Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 P19022 UniProtKB Region 863 884 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P19022 UniProtKB Compositional bias 864 883 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P19022 UniProtKB Binding site 170 170 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 170 170 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 226 226 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 228 228 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 228 228 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 259 259 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 260 260 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 261 261 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 262 262 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 262 262 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 263 263 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 293 293 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 295 295 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 301 301 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Binding site 353 353 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15116 P19022 UniProtKB Modified residue 96 96 . . . Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039 P19022 UniProtKB Modified residue 135 135 . . . Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039 P19022 UniProtKB Glycosylation 190 190 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P19022 UniProtKB Glycosylation 273 273 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 P19022 UniProtKB Glycosylation 325 325 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P19022 UniProtKB Glycosylation 402 402 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 P19022 UniProtKB Glycosylation 572 572 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 P19022 UniProtKB Glycosylation 651 651 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P19022 UniProtKB Glycosylation 692 692 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 P19022 UniProtKB Alternative sequence 1 57 . . . ID=VSP_056448;Note=In isoform 2. MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLN->MFLLRRYVCIFTEKLKNQAELYVFLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P19022 UniProtKB Natural variant 21 21 . . . ID=VAR_028254;Note=A->T;Dbxref=dbSNP:rs17495042 P19022 UniProtKB Natural variant 118 118 . . . ID=VAR_028255;Note=A->T;Dbxref=dbSNP:rs17445840 P19022 UniProtKB Natural variant 150 150 . . . ID=VAR_087507;Note=In ADHD8%3B decreased propeptide cleavage. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34702855;Dbxref=PMID:34702855 P19022 UniProtKB Natural variant 162 162 . . . ID=VAR_084438;Note=In ACOGS%3B uncertain significance. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31650526;Dbxref=dbSNP:rs2013111940,PMID:31650526 P19022 UniProtKB Natural variant 196 196 . . . ID=VAR_028256;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2216790;Dbxref=dbSNP:rs1041970,PMID:2216790 P19022 UniProtKB Natural variant 212 212 . . . ID=VAR_028257;Note=I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2384753;Dbxref=dbSNP:rs1041972,PMID:2384753 P19022 UniProtKB Natural variant 229 229 . . . ID=VAR_084439;Note=In ARVD14%3B uncertain significance. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28280076;Dbxref=PMID:28280076 P19022 UniProtKB Natural variant 353 353 . . . ID=VAR_084440;Note=In ACOGS%3B decreased function in cell-cell adhesion. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31585109;Dbxref=dbSNP:rs1599017933,PMID:31585109 P19022 UniProtKB Natural variant 407 407 . . . ID=VAR_084441;Note=In ARVD14%3B uncertain significance. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28280076,ECO:0000269|PubMed:28326674;Dbxref=dbSNP:rs568089577,PMID:28280076,PMID:28326674 P19022 UniProtKB Natural variant 454 454 . . . ID=VAR_048503;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857112,PMID:15489334 P19022 UniProtKB Natural variant 525 525 . . . ID=VAR_084442;Note=In ACOGS%3B uncertain significance. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31650526;Dbxref=PMID:31650526 P19022 UniProtKB Natural variant 597 597 . . . ID=VAR_084443;Note=In ACOGS%3B decreased function in cell-cell adhesion. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31585109;Dbxref=dbSNP:rs1599011050,PMID:31585109 P19022 UniProtKB Natural variant 597 597 . . . ID=VAR_084444;Note=In ACOGS. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31585109;Dbxref=dbSNP:rs1599011050,PMID:31585109 P19022 UniProtKB Natural variant 601 601 . . . ID=VAR_084445;Note=In ACOGS%3B decreased function in cell-cell adhesion. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31585109;Dbxref=dbSNP:rs201775968,PMID:31585109 P19022 UniProtKB Natural variant 603 603 . . . ID=VAR_084446;Note=In ACOGS%3B uncertain significance. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31650526;Dbxref=PMID:31650526 P19022 UniProtKB Natural variant 613 613 . . . ID=VAR_084447;Note=In ACOGS%3B decreased function in cell-cell adhesion. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31585109;Dbxref=dbSNP:rs754880999,PMID:31585109 P19022 UniProtKB Natural variant 627 627 . . . ID=VAR_084448;Note=In ACOGS%3B decreased function in cell-cell adhesion. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31585109;Dbxref=dbSNP:rs1599010918,PMID:31585109 P19022 UniProtKB Natural variant 676 676 . . . ID=VAR_084449;Note=In ACOGS%3B decreased function in cell-cell adhesion. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31585109;Dbxref=dbSNP:rs199984052,PMID:31585109 P19022 UniProtKB Natural variant 845 845 . . . ID=VAR_028258;Note=N->S;Dbxref=dbSNP:rs2289664 P19022 UniProtKB Sequence conflict 12 12 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P19022 UniProtKB Sequence conflict 16 16 . . . Note=A->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P19022 UniProtKB Sequence conflict 164 164 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P19022 UniProtKB Sequence conflict 357 357 . . . Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 P19022 UniProtKB Sequence conflict 437 437 . . . Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 P19022 UniProtKB Sequence conflict 484 484 . . . Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 P19022 UniProtKB Sequence conflict 629 629 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P19022 UniProtKB Sequence conflict 867 867 . . . Note=A->L;Ontology_term=ECO:0000305;evidence=ECO:0000305