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P19022 (CADH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-2
Alternative name(s):
CDw325
Neural cadherin
Short name=N-cadherin
CD_antigen=CD325
Gene names
Name:CDH2
Synonyms:CDHN, NCAD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length906 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density By similarity.

Subunit structure

Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway By similarity. Ref.9

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 By similarity.

Sequence similarities

Contains 5 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Metal-binding
   PTMCleavage on pair of basic residues
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadherens junction organization

Traceable author statement. Source: Reactome

blood vessel morphogenesis

Inferred from electronic annotation. Source: Ensembl

calcium-dependent cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

cell adhesion

Traceable author statement Ref.7. Source: ProtInc

cell junction assembly

Traceable author statement. Source: Reactome

cell migration

Inferred from electronic annotation. Source: Ensembl

cell-cell junction organization

Traceable author statement. Source: Reactome

heterophilic cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

homophilic cell adhesion

Inferred from electronic annotation. Source: Ensembl

muscle cell differentiation

Traceable author statement. Source: Reactome

negative regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of muscle cell differentiation

Traceable author statement. Source: Reactome

striated muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

catenin complex

Inferred from direct assay PubMed 7650039. Source: BHF-UCL

cell-cell adherens junction

Inferred from direct assay PubMed 19101069. Source: BHF-UCL

cell-cell junction

Inferred from direct assay PubMed 7650039. Source: BHF-UCL

fascia adherens

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intercalated disc

Inferred from sequence or structural similarity. Source: BHF-UCL

lamellipodium

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

synapse

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionalpha-catenin binding

Inferred from physical interaction PubMed 7650039. Source: BHF-UCL

beta-catenin binding

Traceable author statement PubMed 16344550. Source: AgBase

calcium ion binding

Inferred from electronic annotation. Source: InterPro

gamma-catenin binding

Inferred from physical interaction PubMed 7650039. Source: BHF-UCL

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CTNNB1P352222EBI-2256711,EBI-491549

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 159134
PRO_0000003731
Chain160 – 906747Cadherin-2
PRO_0000003732

Regions

Topological domain160 – 724565Extracellular Potential
Transmembrane725 – 74521Helical; Potential
Topological domain746 – 906161Cytoplasmic Potential
Domain160 – 267108Cadherin 1
Domain268 – 382115Cadherin 2
Domain383 – 497115Cadherin 3
Domain498 – 603106Cadherin 4
Domain604 – 714111Cadherin 5
Compositional bias863 – 87816Ser-rich

Sites

Metal binding2621Calcium 1 By similarity
Metal binding2621Calcium 2 By similarity
Metal binding2931Calcium 3 By similarity

Amino acid modifications

Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Ref.10
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Ref.10
Glycosylation5721N-linked (GlcNAc...) Ref.10
Glycosylation6511N-linked (GlcNAc...) Potential
Glycosylation6921N-linked (GlcNAc...) Ref.10

Natural variations

Natural variant211A → T.
Corresponds to variant rs17495042 [ dbSNP | Ensembl ].
VAR_028254
Natural variant1181A → T.
Corresponds to variant rs17445840 [ dbSNP | Ensembl ].
VAR_028255
Natural variant1961S → T. Ref.1
Corresponds to variant rs1041970 [ dbSNP | Ensembl ].
VAR_028256
Natural variant2121I → L. Ref.7
Corresponds to variant rs1041972 [ dbSNP | Ensembl ].
VAR_028257
Natural variant4541T → A. Ref.6
Corresponds to variant rs17857112 [ dbSNP | Ensembl ].
VAR_048503
Natural variant8451N → S.
Corresponds to variant rs2289664 [ dbSNP | Ensembl ].
VAR_028258

Experimental info

Sequence conflict121Missing in AAB22854. Ref.3
Sequence conflict161A → L in CAA38213. Ref.1
Sequence conflict1641P → S in AAH36470. Ref.6
Sequence conflict3571N → I in CAA38213. Ref.1
Sequence conflict4371P → Q in AAH36470. Ref.6
Sequence conflict4841V → M in AAH36470. Ref.6
Sequence conflict6291D → G in AAH36470. Ref.6
Sequence conflict8671A → L in AAB22854. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P19022 [UniParc].

Last modified October 17, 2006. Version 4.
Checksum: 7267E2A00489DF94

FASTA90699,809
        10         20         30         40         50         60 
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF 

        70         80         90        100        110        120 
SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK 

       130        140        150        160        170        180 
LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL 

       190        200        210        220        230        240 
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV 

       250        260        270        280        290        300 
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 

       310        320        330        340        350        360 
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 

       370        380        390        400        410        420 
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY 

       430        440        450        460        470        480 
RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 

       490        500        510        520        530        540 
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 

       550        560        570        580        590        600 
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 

       610        620        630        640        650        660 
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 

       670        680        690        700        710        720 
FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 

       730        740        750        760        770        780 
GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 

       790        800        810        820        830        840 
EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 

       850        860        870        880        890        900 
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 


YGGGDD 

« Hide

References

« Hide 'large scale' references
[1]"Human N-cadherin: nucleotide and deduced amino acid sequence."
Reid R.A., Hemperly J.J.
Nucleic Acids Res. 18:5896-5896(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-196.
[2]Reid R.A.
Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 341; 699 AND 705.
[3]"Extrajunctional distribution of N-cadherin in cultured human endothelial cells."
Salomon D., Ayalon O., Patel-King R., Hynes R.O., Geiger B.
J. Cell Sci. 102:7-17(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-454.
Tissue: Brain.
[7]"N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene."
Walsh F.S., Barton C.H., Putt W., Moore S.E., Kelsell D., Spurr N., Goodfellow P.N.
J. Neurochem. 55:805-812(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 160-906, VARIANT LEU-212.
[8]"Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2."
Wallis J.A., Fox M., Walsh F.S.
Genomics 22:172-179(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
[9]"Adhesion signaling by a novel mitotic substrate of src kinases."
Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M.
Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDCP1.
[10]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-273; ASN-402; ASN-572 AND ASN-692.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54315 mRNA. Translation: CAA38213.1.
S42303 mRNA. Translation: AAB22854.1.
EF444966 Genomic DNA. Translation: ACA05964.1.
CH471088 Genomic DNA. Translation: EAX01240.1.
BC036470 mRNA. Translation: AAH36470.1.
M34064 mRNA. Translation: AAA03236.1.
X57548 mRNA. Translation: CAA40773.1.
Z27420 Genomic DNA. Translation: CAA81799.1.
PIRIJHUCN. A38870.
RefSeqNP_001783.2. NM_001792.3.
UniGeneHs.464829.
Hs.606106.

3D structure databases

ProteinModelPortalP19022.
SMRP19022. Positions 24-701, 806-904.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107435. 46 interactions.
DIPDIP-43894N.
IntActP19022. 16 interactions.
MINTMINT-441636.
STRING9606.ENSP00000269141.

Chemistry

BindingDBP19022.
ChEMBLCHEMBL1697669.

PTM databases

PhosphoSiteP19022.

Polymorphism databases

DMDM116241277.

Proteomic databases

PaxDbP19022.
PeptideAtlasP19022.
PRIDEP19022.

Protocols and materials databases

DNASU1000.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269141; ENSP00000269141; ENSG00000170558.
GeneID1000.
KEGGhsa:1000.
UCSCuc002kwg.2. human.

Organism-specific databases

CTD1000.
GeneCardsGC18M025530.
H-InvDBHIX0027368.
HGNCHGNC:1759. CDH2.
HPACAB000141.
CAB018580.
MIM114020. gene.
neXtProtNX_P19022.
PharmGKBPA26293.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251747.
HOGENOMHOG000231254.
HOVERGENHBG106438.
InParanoidP19022.
KOK06736.
OMAHSGHLQR.
OrthoDBEOG7RJPQM.
PhylomeDBP19022.
TreeFamTF316817.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressP19022.
BgeeP19022.
CleanExHS_CDH2.
GenevestigatorP19022.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDH2. human.
GeneWikiCDH2.
GenomeRNAi1000.
NextBio4204.
PMAP-CutDBP19022.
PROP19022.
SOURCESearch...

Entry information

Entry nameCADH2_HUMAN
AccessionPrimary (citable) accession number: P19022
Secondary accession number(s): B0YIY6, Q14923, Q8N173
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries