Cadherin-2 precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P19022 (CADH2_HUMAN)

Last modified June 16, 2009. Version 93. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cadherin-2
Alternative name(s):
    Neural cadherin
      Short name=N-cadherin
    CDw325
    CD_antigen=CD325

Gene names

Name:	CDH2
Synonyms:	CDHN, NCAD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	906 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.
Subunit structure	Interacts with CDCP1. Ref.8
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 5 cadherin domains.

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Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein Phosphoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
PTPN12	Q05209	1	EBI-2256711,EBI-2266035
PTPN22	Q9Y2R2	1	EBI-2256711,EBI-1211241
PTPN6	P29350	1	EBI-2256711,EBI-78260
PTPN7	P35236	1	EBI-2256711,EBI-2265723
PTPRB	P23467	1	EBI-2256711,EBI-1265766
PTPRC	P08575	1	EBI-2256711,EBI-1341
PTPRG	P23470	1	EBI-2256711,EBI-2258115
PTPRJ	Q12913	1	EBI-2256711,EBI-2264500
PTPRK	Q15262	1	EBI-2256711,EBI-474052
PTPRO	Q16827	1	EBI-2256711,EBI-723739
PTPRR	Q15256	1	EBI-2256711,EBI-2265659

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

Potential

Propeptide

26 – 159

134

PRO_0000003731

Chain

160 – 906

747

Cadherin-2

PRO_0000003732

Regions

Topological domain

160 – 724

565

Extracellular Potential

Transmembrane

725 – 745

Potential

Topological domain

746 – 906

161

Cytoplasmic Potential

Domain

160 – 267

108

Cadherin 1

Domain

268 – 382

115

Cadherin 2

Domain

383 – 497

115

Cadherin 3

Domain

498 – 603

106

Cadherin 4

Domain

604 – 714

111

Cadherin 5

Compositional bias

863 – 878

Ser-rich

Amino acid modifications

Modified residue

785

Phosphotyrosine Ref.7

Glycosylation

190

N-linked (GlcNAc...) Potential

Glycosylation

273

N-linked (GlcNAc...)

Glycosylation

325

N-linked (GlcNAc...) Potential

Glycosylation

402

N-linked (GlcNAc...)

Glycosylation

572

N-linked (GlcNAc...)

Glycosylation

651

N-linked (GlcNAc...) Potential

Glycosylation

692

N-linked (GlcNAc...)

Natural variations

Natural variant

A → T: dbSNP rs17495042.

VAR_028254

Natural variant

118

A → T: dbSNP rs17445840.

VAR_028255

Natural variant

196

S → T: dbSNP rs1041970. Ref.1

VAR_028256

Natural variant

212

I → L: dbSNP rs1041972. Ref.5

VAR_028257

Natural variant

454

T → A: dbSNP rs17857112. Ref.4

VAR_048503

Natural variant

845

N → S: dbSNP rs2289664.

VAR_028258

Experimental info

Sequence conflict

Missing in AAB22854. Ref.3

Sequence conflict

A → L in CAA38213. Ref.1

Sequence conflict

164

P → S in AAH36470. Ref.4

Sequence conflict

357

N → I in CAA38213. Ref.1

Sequence conflict

437

P → Q in AAH36470. Ref.4

Sequence conflict

484

V → M in AAH36470. Ref.4

Sequence conflict

629

D → G in AAH36470. Ref.4

Sequence conflict

867

A → L in AAB22854. Ref.3

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Sequences

Sequence

Length

Mass (Da)

Tools

P19022-1 [UniParc].

Last modified October 17, 2006. Version 4.
Checksum: 7267E2A00489DF94
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FASTA

906

99,809

        10         20         30         40         50         60 
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF 

        70         80         90        100        110        120 
SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK 

       130        140        150        160        170        180 
LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL 

       190        200        210        220        230        240 
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV 

       250        260        270        280        290        300 
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 

       310        320        330        340        350        360 
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 

       370        380        390        400        410        420 
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY 

       430        440        450        460        470        480 
RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 

       490        500        510        520        530        540 
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 

       550        560        570        580        590        600 
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 

       610        620        630        640        650        660 
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 

       670        680        690        700        710        720 
FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 

       730        740        750        760        770        780 
GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 

       790        800        810        820        830        840 
EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 

       850        860        870        880        890        900 
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 


YGGGDD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human N-cadherin: nucleotide and deduced amino acid sequence." Reid R.A., Hemperly J.J. Nucleic Acids Res. 18:5896-5896(1990) [PubMed: 2216790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-196.
[2]	Reid R.A. Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 341; 699 AND 705.
[3]	"Extrajunctional distribution of N-cadherin in cultured human endothelial cells." Salomon D., Ayalon O., Patel-King R., Hynes R.O., Geiger B. J. Cell Sci. 102:7-17(1992) [PubMed: 1500442] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-454. Tissue: Brain.
[5]	"N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene." Walsh F.S., Barton C.H., Putt W., Moore S.E., Kelsell D., Spurr N., Goodfellow P.N. J. Neurochem. 55:805-812(1990) [PubMed: 2384753] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 160-906, VARIANT LEU-212.
[6]	"Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2." Wallis J.A., Fox M., Walsh F.S. Genomics 22:172-179(1994) [PubMed: 7959764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
[7]	"Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC)." Amanchy R., Kalume D.E., Iwahori A., Zhong J., Pandey A. J. Proteome Res. 4:1661-1671(2005) [PubMed: 16212419] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-785, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Adhesion signaling by a novel mitotic substrate of src kinases." Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M. Oncogene 24:5333-5343(2005) [PubMed: 16007225] [Abstract] Cited for: INTERACTION WITH CDCP1.
[9]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-273; ASN-402; ASN-572 AND ASN-692, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	X54315 mRNA. Translation: CAA38213.1. S42303 mRNA. Translation: AAB22854.1. BC036470 mRNA. Translation: AAH36470.1. M34064 mRNA. Translation: AAA03236.1. X57548 mRNA. Translation: CAA40773.1. Z27420 Genomic DNA. Translation: CAA81799.1.
IPI	IPI00290085.
PIR	IJHUCN. A38870.
RefSeq	NP_001783.2.
UniGene	Hs.464829 Hs.606106
3D structure databases
HSSP	HSSP built from PDB template 1NCJ based on UniProtKB P15116.
SMR	P19022. Positions 24-159, 161-373, 836-901.
ModBase	Search...
Protein-protein interaction databases
IntAct	P19022. 11 interactions.
PTM databases
PhosphoSite	P19022.
Proteomic databases
PeptideAtlas	P19022.
PRIDE	P19022.
Genome annotation databases
Ensembl	ENSG00000170558. Homo sapiens. [Contig view]
GeneID	1000.
KEGG	hsa:1000.
Organism-specific databases
GeneCards	GC18M023784.
HGNC	HGNC:1759. CDH2.
HPA	CAB000141.
MIM	114020. gene.
PharmGKB	PA26293.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P19022.
HOVERGEN	P19022.
OMA	P19022. DPNSINI.
Enzyme and pathway databases
Pathway_Interaction_DB	fgf_pathway. FGF signaling pathway. ptp1bpathway. Signaling events mediated by PTP1B.
Gene expression databases
ArrayExpress	P19022.
Bgee	P19022.
CleanEx	HS_CDH2.
GermOnline	ENSG00000170558. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR000233. Cadherin_C_term. IPR014868. Cadherin_pro. IPR009124. Desmocollin. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 4 hits.
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. PF08758. Cadherin_pro. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN. PR01820. DESMOCOLLIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4204.
PMAP-CutDB	P19022.
SOURCE	Search...

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Entry information

Entry name

CADH2_HUMAN

Accession

Primary (citable) accession number: P19022
Secondary accession number(s): Q14923, Q8N173

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 93 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents