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P19022

- CADH2_HUMAN

UniProt

P19022 - CADH2_HUMAN

Protein

Cadherin-2

Gene

CDH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 4 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi262 – 2621Calcium 1By similarity
    Metal bindingi262 – 2621Calcium 2By similarity
    Metal bindingi293 – 2931Calcium 3By similarity

    GO - Molecular functioni

    1. alpha-catenin binding Source: BHF-UCL
    2. beta-catenin binding Source: AgBase
    3. calcium ion binding Source: InterPro
    4. gamma-catenin binding Source: BHF-UCL
    5. protein binding Source: IntAct

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. blood vessel morphogenesis Source: Ensembl
    3. calcium-dependent cell-cell adhesion Source: Ensembl
    4. cell adhesion Source: ProtInc
    5. cell-cell junction organization Source: Reactome
    6. cell junction assembly Source: Reactome
    7. cell migration Source: Ensembl
    8. heterophilic cell-cell adhesion Source: Ensembl
    9. homophilic cell adhesion Source: Ensembl
    10. muscle cell differentiation Source: Reactome
    11. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    12. positive regulation of MAPK cascade Source: Ensembl
    13. positive regulation of muscle cell differentiation Source: Reactome
    14. striated muscle cell differentiation Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.
    REACT_21402. CDO in myogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-2
    Alternative name(s):
    CDw325
    Neural cadherin
    Short name:
    N-cadherin
    CD_antigen: CD325
    Gene namesi
    Name:CDH2
    Synonyms:CDHN, NCAD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:1759. CDH2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. catenin complex Source: BHF-UCL
    3. cell-cell adherens junction Source: BHF-UCL
    4. cell-cell junction Source: BHF-UCL
    5. extracellular vesicular exosome Source: UniProt
    6. fascia adherens Source: Ensembl
    7. integral component of membrane Source: UniProtKB-KW
    8. intercalated disc Source: BHF-UCL
    9. lamellipodium Source: Ensembl
    10. plasma membrane Source: Reactome
    11. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26293.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 159134PRO_0000003731Add
    BLAST
    Chaini160 – 906747Cadherin-2PRO_0000003732Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi273 – 2731N-linked (GlcNAc...)1 Publication
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi402 – 4021N-linked (GlcNAc...)1 Publication
    Glycosylationi572 – 5721N-linked (GlcNAc...)1 Publication
    Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi692 – 6921N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    MaxQBiP19022.
    PaxDbiP19022.
    PeptideAtlasiP19022.
    PRIDEiP19022.

    PTM databases

    PhosphoSiteiP19022.

    Miscellaneous databases

    PMAP-CutDBP19022.

    Expressioni

    Gene expression databases

    ArrayExpressiP19022.
    BgeeiP19022.
    CleanExiHS_CDH2.
    GenevestigatoriP19022.

    Organism-specific databases

    HPAiCAB000141.
    CAB018580.

    Interactioni

    Subunit structurei

    Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTNNB1P352222EBI-2256711,EBI-491549

    Protein-protein interaction databases

    BioGridi107435. 46 interactions.
    DIPiDIP-43894N.
    IntActiP19022. 16 interactions.
    MINTiMINT-441636.
    STRINGi9606.ENSP00000269141.

    Structurei

    3D structure databases

    ProteinModelPortaliP19022.
    SMRiP19022. Positions 24-701, 806-904.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini160 – 724565ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini746 – 906161CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei725 – 74521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini160 – 267108Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 382115Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini383 – 497115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini498 – 603106Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini604 – 714111Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi863 – 87816Ser-richAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 By similarity.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251747.
    HOGENOMiHOG000231254.
    HOVERGENiHBG106438.
    InParanoidiP19022.
    KOiK06736.
    OMAiHSGHLQR.
    OrthoDBiEOG7RJPQM.
    PhylomeDBiP19022.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01820. DESMOCOLLIN.
    SMARTiSM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P19022-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH    50
    EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA 100
    KFLIYAQDKE TQEKWQVAVK LSLKPTLTEE SVKESAEVEE IVFPRQFSKH 150
    SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP 200
    GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP 250
    IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300
    NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ 350
    ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV 400
    ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI 450
    DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN 500
    PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN 550
    GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
    NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR 650
    NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV 700
    CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD 750
    KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA 800
    IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP 850
    PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900
    YGGGDD 906
    Length:906
    Mass (Da):99,809
    Last modified:October 17, 2006 - v4
    Checksum:i7267E2A00489DF94
    GO
    Isoform 2 (identifier: P19022-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-57: MCRIAGALRT...DVHEGQPLLN → MFLLRRYVCIFTEKLKNQAELYVFLS

    Note: No experimental confirmation available.

    Show »
    Length:875
    Mass (Da):97,040
    Checksum:i04DCB2F62C61C998
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121Missing in AAB22854. (PubMed:1500442)Curated
    Sequence conflicti16 – 161A → L in CAA38213. (PubMed:2216790)Curated
    Sequence conflicti164 – 1641P → S in AAH36470. (PubMed:15489334)Curated
    Sequence conflicti357 – 3571N → I in CAA38213. (PubMed:2216790)Curated
    Sequence conflicti437 – 4371P → Q in AAH36470. (PubMed:15489334)Curated
    Sequence conflicti484 – 4841V → M in AAH36470. (PubMed:15489334)Curated
    Sequence conflicti629 – 6291D → G in AAH36470. (PubMed:15489334)Curated
    Sequence conflicti867 – 8671A → L in AAB22854. (PubMed:1500442)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211A → T.
    Corresponds to variant rs17495042 [ dbSNP | Ensembl ].
    VAR_028254
    Natural varianti118 – 1181A → T.
    Corresponds to variant rs17445840 [ dbSNP | Ensembl ].
    VAR_028255
    Natural varianti196 – 1961S → T.1 Publication
    Corresponds to variant rs1041970 [ dbSNP | Ensembl ].
    VAR_028256
    Natural varianti212 – 2121I → L.1 Publication
    Corresponds to variant rs1041972 [ dbSNP | Ensembl ].
    VAR_028257
    Natural varianti454 – 4541T → A.1 Publication
    Corresponds to variant rs17857112 [ dbSNP | Ensembl ].
    VAR_048503
    Natural varianti845 – 8451N → S.
    Corresponds to variant rs2289664 [ dbSNP | Ensembl ].
    VAR_028258

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5757MCRIA…QPLLN → MFLLRRYVCIFTEKLKNQAE LYVFLS in isoform 2. 1 PublicationVSP_056448Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54315 mRNA. Translation: CAA38213.1.
    S42303 mRNA. Translation: AAB22854.1.
    AK302831 mRNA. Translation: BAH13814.1.
    AC006249 Genomic DNA. No translation available.
    AC015933 Genomic DNA. No translation available.
    AC110015 Genomic DNA. No translation available.
    EF444966 Genomic DNA. Translation: ACA05964.1.
    CH471088 Genomic DNA. Translation: EAX01240.1.
    BC036470 mRNA. Translation: AAH36470.1.
    M34064 mRNA. Translation: AAA03236.1.
    X57548 mRNA. Translation: CAA40773.1.
    Z27420 Genomic DNA. Translation: CAA81799.1.
    CCDSiCCDS11891.1.
    PIRiA38870. IJHUCN.
    RefSeqiNP_001783.2. NM_001792.3.
    XP_005258239.1. XM_005258182.1.
    UniGeneiHs.464829.
    Hs.606106.

    Genome annotation databases

    EnsembliENST00000269141; ENSP00000269141; ENSG00000170558.
    ENST00000399380; ENSP00000382312; ENSG00000170558.
    GeneIDi1000.
    KEGGihsa:1000.
    UCSCiuc002kwg.2. human.

    Polymorphism databases

    DMDMi116241277.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54315 mRNA. Translation: CAA38213.1 .
    S42303 mRNA. Translation: AAB22854.1 .
    AK302831 mRNA. Translation: BAH13814.1 .
    AC006249 Genomic DNA. No translation available.
    AC015933 Genomic DNA. No translation available.
    AC110015 Genomic DNA. No translation available.
    EF444966 Genomic DNA. Translation: ACA05964.1 .
    CH471088 Genomic DNA. Translation: EAX01240.1 .
    BC036470 mRNA. Translation: AAH36470.1 .
    M34064 mRNA. Translation: AAA03236.1 .
    X57548 mRNA. Translation: CAA40773.1 .
    Z27420 Genomic DNA. Translation: CAA81799.1 .
    CCDSi CCDS11891.1.
    PIRi A38870. IJHUCN.
    RefSeqi NP_001783.2. NM_001792.3.
    XP_005258239.1. XM_005258182.1.
    UniGenei Hs.464829.
    Hs.606106.

    3D structure databases

    ProteinModelPortali P19022.
    SMRi P19022. Positions 24-701, 806-904.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107435. 46 interactions.
    DIPi DIP-43894N.
    IntActi P19022. 16 interactions.
    MINTi MINT-441636.
    STRINGi 9606.ENSP00000269141.

    Chemistry

    BindingDBi P19022.
    ChEMBLi CHEMBL1697669.

    PTM databases

    PhosphoSitei P19022.

    Polymorphism databases

    DMDMi 116241277.

    Proteomic databases

    MaxQBi P19022.
    PaxDbi P19022.
    PeptideAtlasi P19022.
    PRIDEi P19022.

    Protocols and materials databases

    DNASUi 1000.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269141 ; ENSP00000269141 ; ENSG00000170558 .
    ENST00000399380 ; ENSP00000382312 ; ENSG00000170558 .
    GeneIDi 1000.
    KEGGi hsa:1000.
    UCSCi uc002kwg.2. human.

    Organism-specific databases

    CTDi 1000.
    GeneCardsi GC18M025530.
    H-InvDB HIX0027368.
    HGNCi HGNC:1759. CDH2.
    HPAi CAB000141.
    CAB018580.
    MIMi 114020. gene.
    neXtProti NX_P19022.
    PharmGKBi PA26293.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251747.
    HOGENOMi HOG000231254.
    HOVERGENi HBG106438.
    InParanoidi P19022.
    KOi K06736.
    OMAi HSGHLQR.
    OrthoDBi EOG7RJPQM.
    PhylomeDBi P19022.
    TreeFami TF316817.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.
    REACT_21402. CDO in myogenesis.

    Miscellaneous databases

    ChiTaRSi CDH2. human.
    GeneWikii CDH2.
    GenomeRNAii 1000.
    NextBioi 4204.
    PMAP-CutDB P19022.
    PROi P19022.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19022.
    Bgeei P19022.
    CleanExi HS_CDH2.
    Genevestigatori P19022.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01820. DESMOCOLLIN.
    SMARTi SM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human N-cadherin: nucleotide and deduced amino acid sequence."
      Reid R.A., Hemperly J.J.
      Nucleic Acids Res. 18:5896-5896(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-196.
    2. Reid R.A.
      Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 341; 699 AND 705.
    3. "Extrajunctional distribution of N-cadherin in cultured human endothelial cells."
      Salomon D., Ayalon O., Patel-King R., Hynes R.O., Geiger B.
      J. Cell Sci. 102:7-17(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    5. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-454.
      Tissue: Brain.
    9. "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene."
      Walsh F.S., Barton C.H., Putt W., Moore S.E., Kelsell D., Spurr N., Goodfellow P.N.
      J. Neurochem. 55:805-812(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 160-906 (ISOFORM 1), VARIANT LEU-212.
    10. "Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2."
      Wallis J.A., Fox M., Walsh F.S.
      Genomics 22:172-179(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
    11. "Adhesion signaling by a novel mitotic substrate of src kinases."
      Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M.
      Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDCP1.
    12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-273; ASN-402; ASN-572 AND ASN-692.
      Tissue: Liver.

    Entry informationi

    Entry nameiCADH2_HUMAN
    AccessioniPrimary (citable) accession number: P19022
    Secondary accession number(s): A8MWK3
    , B0YIY6, Q14923, Q8N173
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 148 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3