SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P19022

- CADH2_HUMAN

UniProt

P19022 - CADH2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cadherin-2

Gene
CDH2, CDHN, NCAD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi262 – 2621Calcium 1 By similarity
Metal bindingi262 – 2621Calcium 2 By similarity
Metal bindingi293 – 2931Calcium 3 By similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: BHF-UCL
  2. beta-catenin binding Source: AgBase
  3. calcium ion binding Source: InterPro
  4. gamma-catenin binding Source: BHF-UCL
  5. protein binding Source: IntAct

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. blood vessel morphogenesis Source: Ensembl
  3. calcium-dependent cell-cell adhesion Source: Ensembl
  4. cell adhesion Source: ProtInc
  5. cell-cell junction organization Source: Reactome
  6. cell junction assembly Source: Reactome
  7. cell migration Source: Ensembl
  8. heterophilic cell-cell adhesion Source: Ensembl
  9. homophilic cell adhesion Source: Ensembl
  10. muscle cell differentiation Source: Reactome
  11. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  12. positive regulation of MAPK cascade Source: Ensembl
  13. positive regulation of muscle cell differentiation Source: Reactome
  14. striated muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.
REACT_21402. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-2
Alternative name(s):
CDw325
Neural cadherin
Short name:
N-cadherin
CD_antigen: CD325
Gene namesi
Name:CDH2
Synonyms:CDHN, NCAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:1759. CDH2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini160 – 724565Extracellular Reviewed predictionAdd
BLAST
Transmembranei725 – 74521Helical; Reviewed predictionAdd
BLAST
Topological domaini746 – 906161Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. catenin complex Source: BHF-UCL
  3. cell-cell adherens junction Source: BHF-UCL
  4. cell-cell junction Source: BHF-UCL
  5. extracellular vesicular exosome Source: UniProt
  6. fascia adherens Source: Ensembl
  7. integral component of membrane Source: UniProtKB-KW
  8. intercalated disc Source: BHF-UCL
  9. lamellipodium Source: Ensembl
  10. plasma membrane Source: Reactome
  11. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Propeptidei26 – 159134PRO_0000003731Add
BLAST
Chaini160 – 906747Cadherin-2PRO_0000003732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi273 – 2731N-linked (GlcNAc...)1 Publication
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...)1 Publication
Glycosylationi572 – 5721N-linked (GlcNAc...)1 Publication
Glycosylationi651 – 6511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi692 – 6921N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP19022.
PaxDbiP19022.
PeptideAtlasiP19022.
PRIDEiP19022.

PTM databases

PhosphoSiteiP19022.

Miscellaneous databases

PMAP-CutDBP19022.

Expressioni

Gene expression databases

ArrayExpressiP19022.
BgeeiP19022.
CleanExiHS_CDH2.
GenevestigatoriP19022.

Organism-specific databases

HPAiCAB000141.
CAB018580.

Interactioni

Subunit structurei

Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352222EBI-2256711,EBI-491549

Protein-protein interaction databases

BioGridi107435. 46 interactions.
DIPiDIP-43894N.
IntActiP19022. 16 interactions.
MINTiMINT-441636.
STRINGi9606.ENSP00000269141.

Structurei

3D structure databases

ProteinModelPortaliP19022.
SMRiP19022. Positions 24-701, 806-904.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 267108Cadherin 1Add
BLAST
Domaini268 – 382115Cadherin 2Add
BLAST
Domaini383 – 497115Cadherin 3Add
BLAST
Domaini498 – 603106Cadherin 4Add
BLAST
Domaini604 – 714111Cadherin 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi863 – 87816Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251747.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP19022.
KOiK06736.
OMAiHSGHLQR.
OrthoDBiEOG7RJPQM.
PhylomeDBiP19022.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19022-1 [UniParc]FASTAAdd to Basket

« Hide

MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH    50
EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA 100
KFLIYAQDKE TQEKWQVAVK LSLKPTLTEE SVKESAEVEE IVFPRQFSKH 150
SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP 200
GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP 250
IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ 350
ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV 400
ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI 450
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN 500
PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN 550
GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR 650
NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV 700
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD 750
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA 800
IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP 850
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900
YGGGDD 906
Length:906
Mass (Da):99,809
Last modified:October 17, 2006 - v4
Checksum:i7267E2A00489DF94
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211A → T.
Corresponds to variant rs17495042 [ dbSNP | Ensembl ].
VAR_028254
Natural varianti118 – 1181A → T.
Corresponds to variant rs17445840 [ dbSNP | Ensembl ].
VAR_028255
Natural varianti196 – 1961S → T.1 Publication
Corresponds to variant rs1041970 [ dbSNP | Ensembl ].
VAR_028256
Natural varianti212 – 2121I → L.1 Publication
Corresponds to variant rs1041972 [ dbSNP | Ensembl ].
VAR_028257
Natural varianti454 – 4541T → A.1 Publication
Corresponds to variant rs17857112 [ dbSNP | Ensembl ].
VAR_048503
Natural varianti845 – 8451N → S.
Corresponds to variant rs2289664 [ dbSNP | Ensembl ].
VAR_028258

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121Missing in AAB22854. 1 Publication
Sequence conflicti16 – 161A → L in CAA38213. 1 Publication
Sequence conflicti164 – 1641P → S in AAH36470. 1 Publication
Sequence conflicti357 – 3571N → I in CAA38213. 1 Publication
Sequence conflicti437 – 4371P → Q in AAH36470. 1 Publication
Sequence conflicti484 – 4841V → M in AAH36470. 1 Publication
Sequence conflicti629 – 6291D → G in AAH36470. 1 Publication
Sequence conflicti867 – 8671A → L in AAB22854. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54315 mRNA. Translation: CAA38213.1.
S42303 mRNA. Translation: AAB22854.1.
EF444966 Genomic DNA. Translation: ACA05964.1.
CH471088 Genomic DNA. Translation: EAX01240.1.
BC036470 mRNA. Translation: AAH36470.1.
M34064 mRNA. Translation: AAA03236.1.
X57548 mRNA. Translation: CAA40773.1.
Z27420 Genomic DNA. Translation: CAA81799.1.
CCDSiCCDS11891.1.
PIRiA38870. IJHUCN.
RefSeqiNP_001783.2. NM_001792.3.
UniGeneiHs.464829.
Hs.606106.

Genome annotation databases

EnsembliENST00000269141; ENSP00000269141; ENSG00000170558.
GeneIDi1000.
KEGGihsa:1000.
UCSCiuc002kwg.2. human.

Polymorphism databases

DMDMi116241277.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54315 mRNA. Translation: CAA38213.1 .
S42303 mRNA. Translation: AAB22854.1 .
EF444966 Genomic DNA. Translation: ACA05964.1 .
CH471088 Genomic DNA. Translation: EAX01240.1 .
BC036470 mRNA. Translation: AAH36470.1 .
M34064 mRNA. Translation: AAA03236.1 .
X57548 mRNA. Translation: CAA40773.1 .
Z27420 Genomic DNA. Translation: CAA81799.1 .
CCDSi CCDS11891.1.
PIRi A38870. IJHUCN.
RefSeqi NP_001783.2. NM_001792.3.
UniGenei Hs.464829.
Hs.606106.

3D structure databases

ProteinModelPortali P19022.
SMRi P19022. Positions 24-701, 806-904.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107435. 46 interactions.
DIPi DIP-43894N.
IntActi P19022. 16 interactions.
MINTi MINT-441636.
STRINGi 9606.ENSP00000269141.

Chemistry

BindingDBi P19022.
ChEMBLi CHEMBL1697669.

PTM databases

PhosphoSitei P19022.

Polymorphism databases

DMDMi 116241277.

Proteomic databases

MaxQBi P19022.
PaxDbi P19022.
PeptideAtlasi P19022.
PRIDEi P19022.

Protocols and materials databases

DNASUi 1000.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269141 ; ENSP00000269141 ; ENSG00000170558 .
GeneIDi 1000.
KEGGi hsa:1000.
UCSCi uc002kwg.2. human.

Organism-specific databases

CTDi 1000.
GeneCardsi GC18M025530.
H-InvDB HIX0027368.
HGNCi HGNC:1759. CDH2.
HPAi CAB000141.
CAB018580.
MIMi 114020. gene.
neXtProti NX_P19022.
PharmGKBi PA26293.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251747.
HOGENOMi HOG000231254.
HOVERGENi HBG106438.
InParanoidi P19022.
KOi K06736.
OMAi HSGHLQR.
OrthoDBi EOG7RJPQM.
PhylomeDBi P19022.
TreeFami TF316817.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.
REACT_21402. CDO in myogenesis.

Miscellaneous databases

ChiTaRSi CDH2. human.
GeneWikii CDH2.
GenomeRNAii 1000.
NextBioi 4204.
PMAP-CutDB P19022.
PROi P19022.
SOURCEi Search...

Gene expression databases

ArrayExpressi P19022.
Bgeei P19022.
CleanExi HS_CDH2.
Genevestigatori P19022.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTi SM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human N-cadherin: nucleotide and deduced amino acid sequence."
    Reid R.A., Hemperly J.J.
    Nucleic Acids Res. 18:5896-5896(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-196.
  2. Reid R.A.
    Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 341; 699 AND 705.
  3. "Extrajunctional distribution of N-cadherin in cultured human endothelial cells."
    Salomon D., Ayalon O., Patel-King R., Hynes R.O., Geiger B.
    J. Cell Sci. 102:7-17(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-454.
    Tissue: Brain.
  7. "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene."
    Walsh F.S., Barton C.H., Putt W., Moore S.E., Kelsell D., Spurr N., Goodfellow P.N.
    J. Neurochem. 55:805-812(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 160-906, VARIANT LEU-212.
  8. "Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2."
    Wallis J.A., Fox M., Walsh F.S.
    Genomics 22:172-179(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
  9. "Adhesion signaling by a novel mitotic substrate of src kinases."
    Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M.
    Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDCP1.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-273; ASN-402; ASN-572 AND ASN-692.
    Tissue: Liver.

Entry informationi

Entry nameiCADH2_HUMAN
AccessioniPrimary (citable) accession number: P19022
Secondary accession number(s): B0YIY6, Q14923, Q8N173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 147 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi