ID K1C15_HUMAN Reviewed; 456 AA. AC P19012; B3KQY1; B3KRA2; E0CX14; Q53XV8; Q9BUG4; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 02-NOV-2010, sequence version 3. DT 24-JAN-2024, entry version 202. DE RecName: Full=Keratin, type I cytoskeletal 15; DE AltName: Full=Cytokeratin-15; DE Short=CK-15; DE AltName: Full=Keratin-15; DE Short=K15; GN Name=KRT15; Synonyms=KRTB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-147 AND GLY-421. RX PubMed=2468493; RA Bader B.L., Jahn L., Franke W.W.; RT "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth RT muscle cells of human umbilical cord and in cultured cells derived RT therefrom, with an analysis of the chromosomal locus containing the RT cytokeratin 19 gene."; RL Eur. J. Cell Biol. 47:300-319(1988). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS RP ALA-147 AND GLY-421. RX PubMed=2452170; DOI=10.1083/jcb.106.4.1249; RA Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T., RA Franke W.W.; RT "Molecular characterization and expression of the stratification-related RT cytokeratins 4 and 15."; RL J. Cell Biol. 106:1249-1261(1988). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10623642; DOI=10.1006/bbrc.1999.1966; RA Whittock N.V., Eady R.A.J., McGrath J.A.; RT "Genomic organization and amplification of the human keratin 15 and 19 RT genes."; RL Biochem. Biophys. Res. Commun. 267:462-465(2000). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLY-421. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS RP ARG-416 AND GLY-421. RC TISSUE=Tongue; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLY-421. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP TISSUE SPECIFICITY. RX PubMed=10084315; DOI=10.1046/j.1523-1747.1999.00535.x; RA Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S., Lalli A., RA Machesney M., Leigh I.M.; RT "Keratin 15 expression in stratified epithelia: downregulation in activated RT keratinocytes."; RL J. Invest. Dermatol. 112:362-369(1999). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [10] RP IDENTIFICATION IN A COMPLEX WITH KRT14, AND INTERACTION WITH KRT14 AND RP PLEC. RX PubMed=24940650; DOI=10.1038/jid.2014.255; RA Bouameur J.E., Favre B., Fontao L., Lingasamy P., Begre N., Borradori L.; RT "Interaction of plectin with keratins 5 and 14: dependence on several RT plectin domains and keratin quaternary structure."; RL J. Invest. Dermatol. 134:2776-2783(2014). RN [11] RP INTERACTION WITH NOD2. RX PubMed=27812135; DOI=10.1371/journal.pone.0165420; RA Thiebaut R., Esmiol S., Lecine P., Mahfouz B., Hermant A., Nicoletti C., RA Parnis S., Perroy J., Borg J.P., Pascoe L., Hugot J.P., Ollendorff V.; RT "Characterization and Genetic Analyses of New Genes Coding for NOD2 RT Interacting Proteins."; RL PLoS ONE 11:E0165420-E0165420(2016). CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins (By CC similarity). Forms a heterodimer with KRT14 (PubMed:24940650). CC Interacts with PLEC isoform 1C, when in a heterodimer with KRT14 CC (PubMed:24940650). Interacts with NOD2 (PubMed:27812135). CC {ECO:0000250|UniProtKB:Q61414, ECO:0000269|PubMed:24940650, CC ECO:0000269|PubMed:27812135}. CC -!- INTERACTION: CC P19012; Q9NYB9: ABI2; NbExp=6; IntAct=EBI-739566, EBI-743598; CC P19012; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-739566, EBI-11096309; CC P19012; A2BDD9: AMOT; NbExp=3; IntAct=EBI-739566, EBI-17286414; CC P19012; Q4VCS5-2: AMOT; NbExp=3; IntAct=EBI-739566, EBI-3891843; CC P19012; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-739566, EBI-10187270; CC P19012; Q96IX9: ANKRD36BP1; NbExp=4; IntAct=EBI-739566, EBI-744859; CC P19012; P53365: ARFIP2; NbExp=6; IntAct=EBI-739566, EBI-638194; CC P19012; P48047: ATP5PO; NbExp=3; IntAct=EBI-739566, EBI-355815; CC P19012; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-739566, EBI-745073; CC P19012; Q8TAB5: C1orf216; NbExp=4; IntAct=EBI-739566, EBI-747505; CC P19012; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-739566, EBI-739879; CC P19012; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-739566, EBI-11530605; CC P19012; Q9NVE4: CCDC87; NbExp=3; IntAct=EBI-739566, EBI-749261; CC P19012; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-739566, EBI-10175300; CC P19012; Q9NPC3: CCNB1IP1; NbExp=4; IntAct=EBI-739566, EBI-745269; CC P19012; P24863: CCNC; NbExp=3; IntAct=EBI-739566, EBI-395261; CC P19012; Q07002: CDK18; NbExp=3; IntAct=EBI-739566, EBI-746238; CC P19012; Q86XR8: CEP57; NbExp=3; IntAct=EBI-739566, EBI-308614; CC P19012; P10606: COX5B; NbExp=3; IntAct=EBI-739566, EBI-1053725; CC P19012; Q02930-3: CREB5; NbExp=3; IntAct=EBI-739566, EBI-10192698; CC P19012; Q8WWE8: CYTH4; NbExp=3; IntAct=EBI-739566, EBI-10277443; CC P19012; P17661: DES; NbExp=3; IntAct=EBI-739566, EBI-1055572; CC P19012; Q05D60: DEUP1; NbExp=6; IntAct=EBI-739566, EBI-748597; CC P19012; O60941-5: DTNB; NbExp=3; IntAct=EBI-739566, EBI-11984733; CC P19012; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-739566, EBI-743105; CC P19012; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-739566, EBI-744099; CC P19012; Q9H2F5: EPC1; NbExp=3; IntAct=EBI-739566, EBI-769270; CC P19012; Q9BQ89: FAM110A; NbExp=6; IntAct=EBI-739566, EBI-1752811; CC P19012; O95995: GAS8; NbExp=3; IntAct=EBI-739566, EBI-1052570; CC P19012; P14136: GFAP; NbExp=9; IntAct=EBI-739566, EBI-744302; CC P19012; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-739566, EBI-748515; CC P19012; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-739566, EBI-11956675; CC P19012; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-739566, EBI-2514791; CC P19012; O14964: HGS; NbExp=6; IntAct=EBI-739566, EBI-740220; CC P19012; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-739566, EBI-713401; CC P19012; Q70UQ0: IKBIP; NbExp=3; IntAct=EBI-739566, EBI-2557212; CC P19012; Q7Z3B3: KANSL1; NbExp=5; IntAct=EBI-739566, EBI-740244; CC P19012; O60341: KDM1A; NbExp=3; IntAct=EBI-739566, EBI-710124; CC P19012; Q5T5P2-6: KIAA1217; NbExp=3; IntAct=EBI-739566, EBI-10188326; CC P19012; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-739566, EBI-2125614; CC P19012; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-739566, EBI-14069005; CC P19012; Q6P597: KLC3; NbExp=3; IntAct=EBI-739566, EBI-1643885; CC P19012; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-739566, EBI-949319; CC P19012; P04264: KRT1; NbExp=7; IntAct=EBI-739566, EBI-298429; CC P19012; P35908: KRT2; NbExp=7; IntAct=EBI-739566, EBI-1247312; CC P19012; P35900: KRT20; NbExp=5; IntAct=EBI-739566, EBI-742094; CC P19012; P19013: KRT4; NbExp=6; IntAct=EBI-739566, EBI-2371606; CC P19012; P13647: KRT5; NbExp=6; IntAct=EBI-739566, EBI-702187; CC P19012; P02538: KRT6A; NbExp=15; IntAct=EBI-739566, EBI-702198; CC P19012; P04259: KRT6B; NbExp=7; IntAct=EBI-739566, EBI-740907; CC P19012; P48668: KRT6C; NbExp=3; IntAct=EBI-739566, EBI-2564105; CC P19012; Q3SY84: KRT71; NbExp=6; IntAct=EBI-739566, EBI-2952676; CC P19012; Q14CN4: KRT72; NbExp=3; IntAct=EBI-739566, EBI-1221280; CC P19012; Q86Y46: KRT73; NbExp=3; IntAct=EBI-739566, EBI-2830994; CC P19012; Q86Y46-2: KRT73; NbExp=3; IntAct=EBI-739566, EBI-12039441; CC P19012; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-739566, EBI-968660; CC P19012; O95678: KRT75; NbExp=3; IntAct=EBI-739566, EBI-2949715; CC P19012; Q0IIN1: KRT77; NbExp=3; IntAct=EBI-739566, EBI-2511085; CC P19012; Q7Z794: KRT77; NbExp=3; IntAct=EBI-739566, EBI-3045529; CC P19012; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-739566, EBI-1056564; CC P19012; Q5XKE5: KRT79; NbExp=7; IntAct=EBI-739566, EBI-2514135; CC P19012; P05787: KRT8; NbExp=6; IntAct=EBI-739566, EBI-297852; CC P19012; Q6KB66: KRT80; NbExp=3; IntAct=EBI-739566, EBI-3046635; CC P19012; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-739566, EBI-11999246; CC P19012; Q14533: KRT81; NbExp=4; IntAct=EBI-739566, EBI-739648; CC P19012; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-739566, EBI-1045341; CC P19012; P78385: KRT83; NbExp=3; IntAct=EBI-739566, EBI-10221390; CC P19012; P78386: KRT85; NbExp=3; IntAct=EBI-739566, EBI-1049371; CC P19012; O43790: KRT86; NbExp=7; IntAct=EBI-739566, EBI-9996498; CC P19012; P25791: LMO2; NbExp=3; IntAct=EBI-739566, EBI-739696; CC P19012; P61968: LMO4; NbExp=6; IntAct=EBI-739566, EBI-2798728; CC P19012; Q8TBB1: LNX1; NbExp=5; IntAct=EBI-739566, EBI-739832; CC P19012; O95983: MBD3; NbExp=3; IntAct=EBI-739566, EBI-1783068; CC P19012; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-739566, EBI-14086479; CC P19012; Q6PF18: MORN3; NbExp=3; IntAct=EBI-739566, EBI-9675802; CC P19012; P00540: MOS; NbExp=6; IntAct=EBI-739566, EBI-1757866; CC P19012; I6L9F6: NEFL; NbExp=3; IntAct=EBI-739566, EBI-10178578; CC P19012; P07196: NEFL; NbExp=3; IntAct=EBI-739566, EBI-475646; CC P19012; Q9BVI4: NOC4L; NbExp=4; IntAct=EBI-739566, EBI-395927; CC P19012; Q7Z3B4: NUP54; NbExp=4; IntAct=EBI-739566, EBI-741048; CC P19012; O43482: OIP5; NbExp=4; IntAct=EBI-739566, EBI-536879; CC P19012; O00459: PIK3R2; NbExp=3; IntAct=EBI-739566, EBI-346930; CC P19012; Q16512: PKN1; NbExp=3; IntAct=EBI-739566, EBI-602382; CC P19012; Q6NYC8: PPP1R18; NbExp=6; IntAct=EBI-739566, EBI-2557469; CC P19012; Q8WWY3: PRPF31; NbExp=9; IntAct=EBI-739566, EBI-1567797; CC P19012; P25786: PSMA1; NbExp=4; IntAct=EBI-739566, EBI-359352; CC P19012; P20618: PSMB1; NbExp=7; IntAct=EBI-739566, EBI-372273; CC P19012; O75771: RAD51D; NbExp=7; IntAct=EBI-739566, EBI-1055693; CC P19012; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-739566, EBI-744023; CC P19012; Q9P2K3: RCOR3; NbExp=5; IntAct=EBI-739566, EBI-743428; CC P19012; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-739566, EBI-1504830; CC P19012; Q8N443: RIBC1; NbExp=3; IntAct=EBI-739566, EBI-10265323; CC P19012; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-739566, EBI-16428950; CC P19012; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-739566, EBI-366570; CC P19012; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-739566, EBI-748350; CC P19012; Q96ES7: SGF29; NbExp=7; IntAct=EBI-739566, EBI-743117; CC P19012; Q96GM5: SMARCD1; NbExp=4; IntAct=EBI-739566, EBI-358489; CC P19012; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-739566, EBI-455078; CC P19012; O95295: SNAPIN; NbExp=3; IntAct=EBI-739566, EBI-296723; CC P19012; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-739566, EBI-742688; CC P19012; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-739566, EBI-2212028; CC P19012; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-739566, EBI-12018146; CC P19012; Q9BT92: TCHP; NbExp=5; IntAct=EBI-739566, EBI-740781; CC P19012; O60220: TIMM8A; NbExp=3; IntAct=EBI-739566, EBI-1049822; CC P19012; Q08117: TLE5; NbExp=3; IntAct=EBI-739566, EBI-717810; CC P19012; Q0P5Q0: TMSB4X; NbExp=3; IntAct=EBI-739566, EBI-10226570; CC P19012; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-739566, EBI-5235829; CC P19012; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-739566, EBI-11059915; CC P19012; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-739566, EBI-9090990; CC P19012; P40222: TXLNA; NbExp=6; IntAct=EBI-739566, EBI-359793; CC P19012; Q8N3L3: TXLNB; NbExp=6; IntAct=EBI-739566, EBI-6116822; CC P19012; O75604: USP2; NbExp=5; IntAct=EBI-739566, EBI-743272; CC P19012; Q9BTA9: WAC; NbExp=4; IntAct=EBI-739566, EBI-749118; CC P19012; Q9BTA9-2: WAC; NbExp=3; IntAct=EBI-739566, EBI-10298216; CC P19012; Q53FD0: ZC2HC1C; NbExp=4; IntAct=EBI-739566, EBI-740767; CC P19012; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-739566, EBI-14104088; CC P19012; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-739566, EBI-8656416; CC P19012; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-739566, EBI-3439227; CC P19012; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-739566, EBI-10183064; CC P19012; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-739566, EBI-740727; CC P19012; Q9H609: ZNF576; NbExp=3; IntAct=EBI-739566, EBI-3921014; CC P19012; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-739566, EBI-16429014; CC P19012; P14079: tax; Xeno; NbExp=3; IntAct=EBI-739566, EBI-9675698; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P19012-1; Sequence=Displayed; CC Name=2; CC IsoId=P19012-2; Sequence=VSP_056507, VSP_056508, VSP_056509; CC -!- TISSUE SPECIFICITY: Expressed in a discontinuous manner in the basal CC cell layer of adult skin epidermis, but continuously in the basal layer CC of fetal skin epidermis and nail. Also expressed in the outer root CC sheath above the hair bulb in hair follicle (at protein level). CC Expressed homogeneously in all cell layers of the esophagus and CC exocervix, but detected in the basal cell layer only of oral mucosa, CC skin and in the basal plus the next two layers of the suprabasal CC epithelium of the palate. {ECO:0000269|PubMed:10084315, CC ECO:0000269|PubMed:2452170}. CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). CC -!- SIMILARITY: Belongs to the intermediate filament family. CC {ECO:0000255|PROSITE-ProRule:PRU01188}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07696; CAA30535.1; -; mRNA. DR EMBL; AF202320; AAF27047.1; -; Genomic_DNA. DR EMBL; BT007261; AAP35925.1; -; mRNA. DR EMBL; AK090604; BAG52193.1; -; mRNA. DR EMBL; AK091239; BAG52314.1; -; mRNA. DR EMBL; AC019349; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC002641; AAH02641.1; -; mRNA. DR CCDS; CCDS11398.1; -. [P19012-1] DR PIR; S01069; KRHU5. DR RefSeq; NP_002266.2; NM_002275.3. [P19012-1] DR AlphaFoldDB; P19012; -. DR SMR; P19012; -. DR BioGRID; 110064; 178. DR IntAct; P19012; 157. DR MINT; P19012; -. DR STRING; 9606.ENSP00000377546; -. DR iPTMnet; P19012; -. DR PhosphoSitePlus; P19012; -. DR SwissPalm; P19012; -. DR BioMuta; KRT15; -. DR DMDM; 311033438; -. DR jPOST; P19012; -. DR MassIVE; P19012; -. DR MaxQB; P19012; -. DR PaxDb; 9606-ENSP00000254043; -. DR PeptideAtlas; P19012; -. DR PRIDE; P19012; -. DR ProteomicsDB; 3590; -. DR ProteomicsDB; 53620; -. [P19012-1] DR Antibodypedia; 3601; 995 antibodies from 42 providers. DR DNASU; 3866; -. DR Ensembl; ENST00000254043.8; ENSP00000254043.3; ENSG00000171346.16. [P19012-1] DR Ensembl; ENST00000393976.6; ENSP00000377546.1; ENSG00000171346.16. [P19012-1] DR GeneID; 3866; -. DR KEGG; hsa:3866; -. DR MANE-Select; ENST00000254043.8; ENSP00000254043.3; NM_002275.4; NP_002266.3. DR UCSC; uc002hwy.4; human. [P19012-1] DR AGR; HGNC:6421; -. DR CTD; 3866; -. DR DisGeNET; 3866; -. DR GeneCards; KRT15; -. DR HGNC; HGNC:6421; KRT15. DR HPA; ENSG00000171346; Group enriched (breast, esophagus, skin, vagina). DR MIM; 148030; gene. DR neXtProt; NX_P19012; -. DR OpenTargets; ENSG00000171346; -. DR PharmGKB; PA30208; -. DR VEuPathDB; HostDB:ENSG00000171346; -. DR eggNOG; ENOG502QTM6; Eukaryota. DR GeneTree; ENSGT00940000154403; -. DR HOGENOM; CLU_012560_8_1_1; -. DR InParanoid; P19012; -. DR OMA; ADLRNDM; -. DR OrthoDB; 4640531at2759; -. DR PhylomeDB; P19012; -. DR TreeFam; TF332742; -. DR PathwayCommons; P19012; -. DR Reactome; R-HSA-6805567; Keratinization. DR Reactome; R-HSA-6809371; Formation of the cornified envelope. DR SignaLink; P19012; -. DR SIGNOR; P19012; -. DR BioGRID-ORCS; 3866; 12 hits in 1160 CRISPR screens. DR ChiTaRS; KRT15; human. DR GeneWiki; Keratin_15; -. DR GenomeRNAi; 3866; -. DR Pharos; P19012; Tbio. DR PRO; PR:P19012; -. DR Proteomes; UP000005640; Chromosome 17. DR RNAct; P19012; Protein. DR Bgee; ENSG00000171346; Expressed in lower esophagus mucosa and 128 other cell types or tissues. DR ExpressionAtlas; P19012; baseline and differential. DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005882; C:intermediate filament; TAS:ProtInc. DR GO; GO:0005634; C:nucleus; HDA:UniProtKB. DR GO; GO:0097110; F:scaffold protein binding; IPI:BHF-UCL. DR GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc. DR GO; GO:0008544; P:epidermis development; TAS:ProtInc. DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central. DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central. DR Gene3D; 1.20.5.170; -; 1. DR Gene3D; 1.20.5.500; Single helix bin; 1. DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1. DR InterPro; IPR018039; IF_conserved. DR InterPro; IPR039008; IF_rod_dom. DR InterPro; IPR002957; Keratin_I. DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1. DR PANTHER; PTHR23239:SF164; KERATIN, TYPE I CYTOSKELETAL 15; 1. DR Pfam; PF00038; Filament; 1. DR PRINTS; PR01248; TYPE1KERATIN. DR SMART; SM01391; Filament; 1. DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2. DR SUPFAM; SSF46579; Prefoldin; 1. DR PROSITE; PS00226; IF_ROD_1; 1. DR PROSITE; PS51842; IF_ROD_2; 1. DR Genevisible; P19012; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Intermediate filament; Isopeptide bond; KW Keratin; Phosphoprotein; Reference proteome; Ubl conjugation. FT CHAIN 1..456 FT /note="Keratin, type I cytoskeletal 15" FT /id="PRO_0000063657" FT DOMAIN 105..417 FT /note="IF rod" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188" FT REGION 1..104 FT /note="Head" FT REGION 105..140 FT /note="Coil 1A" FT REGION 141..159 FT /note="Linker 1" FT REGION 160..251 FT /note="Coil 1B" FT REGION 252..271 FT /note="Linker 12" FT REGION 272..413 FT /note="Coil 2" FT REGION 414..456 FT /note="Tail" FT MOD_RES 17 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q04695" FT MOD_RES 34 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q61414" FT MOD_RES 36 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q04695" FT MOD_RES 48 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q04695" FT MOD_RES 56 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q04695" FT MOD_RES 301 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q6IFV3" FT MOD_RES 323 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q6IFV3" FT CROSSLNK 300 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0000250|UniProtKB:Q04695" FT VAR_SEQ 3..29 FT /note="TTFLQTSSSTFGGGSTRGGSLLAGGGG -> GTRSRPQPAQNATTANTSRPL FT KSSGTR (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_056507" FT VAR_SEQ 30..194 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_056508" FT VAR_SEQ 417..456 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_056509" FT VARIANT 147 FT /note="T -> A (in dbSNP:rs1050784)" FT /evidence="ECO:0000269|PubMed:2452170, FT ECO:0000269|PubMed:2468493" FT /id="VAR_047429" FT VARIANT 416 FT /note="K -> R (in dbSNP:rs2305556)" FT /evidence="ECO:0000269|PubMed:14702039" FT /id="VAR_047430" FT VARIANT 421 FT /note="A -> G (in dbSNP:rs897420)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:2452170, FT ECO:0000269|PubMed:2468493, ECO:0000269|Ref.4" FT /id="VAR_047431" SQ SEQUENCE 456 AA; 49212 MW; 812C1343905EBE41 CRC64; MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI //