P19012 (K1C15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cytoskeletal 15

Alternative name(s):
Cytokeratin-15
Short name=CK-15
Keratin-15
Short name=K15

Gene names

Name:	KRT15
Synonyms:	KRTB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins.
Tissue specificity	Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate. Ref.2 Ref.8
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	epidermis development Traceable author statement Ref.2. Source: ProtInc
Cellular_component	intermediate filament Traceable author statement PubMed 2580298. Source: ProtInc
Molecular_function	structural constituent of cytoskeleton Traceable author statement PubMed 2580298. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RCOR3	Q9P2K3	2	EBI-739566,EBI-743428
USP2	O75604	2	EBI-739566,EBI-743272

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Keratin, type I cytoskeletal 15		PRO_0000063657
Regions
	Region	1 – 104	104	Head
	Region	105 – 413	309	Rod
	Region	105 – 140	36	Coil 1A
	Region	141 – 159	19	Linker 1
	Region	160 – 251	92	Coil 1B
	Region	252 – 271	20	Linker 12
	Region	272 – 413	142	Coil 2
	Region	414 – 456	43	Tail
	Compositional bias	14 – 103	90	Gly-rich
	Compositional bias	428 – 431	4	Poly-Gly
Natural variations
	Natural variant	147	1	T → A. Ref.1 Ref.2 Corresponds to variant rs1050784 [ dbSNP | Ensembl ].		VAR_047429
	Natural variant	416	1	K → R. Ref.5 Corresponds to variant rs2305556 [ dbSNP | Ensembl ].		VAR_047430
	Natural variant	421	1	A → G. Ref.1 Ref.2 Ref.4 Ref.5 Ref.7 Ref.9 Corresponds to variant rs897420 [ dbSNP | Ensembl ].		VAR_047431

Sequences

	Sequence		Length	Mass (Da)
	P19012 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: 812C1343905EBE41	FASTA	456	49,212
	10 20 30 40 50 60 MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY 70 80 90 100 110 120 GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL 130 140 150 160 170 180 DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE 190 200 210 220 230 240 IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL 250 260 270 280 290 300 KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 310 320 330 340 350 360 TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ 370 380 390 400 410 420 LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI 430 440 450 AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene." Bader B.L., Jahn L., Franke W.W. Eur. J. Cell Biol. 47:300-319(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-147 AND GLY-421.
[2]	"Molecular characterization and expression of the stratification-related cytokeratins 4 and 15." Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T., Franke W.W. J. Cell Biol. 106:1249-1261(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ALA-147 AND GLY-421.
[3]	"Genomic organization and amplification of the human keratin 15 and 19 genes." Whittock N.V., Eady R.A.J., McGrath J.A. Biochem. Biophys. Res. Commun. 267:462-465(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-421.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-416 AND GLY-421.
[6]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-421. Tissue: Pancreas.
[8]	"Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes." Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S., Lalli A., Machesney M., Leigh I.M. J. Invest. Dermatol. 112:362-369(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-421, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07696 mRNA. Translation: CAA30535.1. AF202320 Genomic DNA. Translation: AAF27047.1. BT007261 mRNA. Translation: AAP35925.1. AK090604 mRNA. Translation: BAG52193.1. AC019349 Genomic DNA. No translation available. BC002641 mRNA. Translation: AAH02641.1.
IPI	IPI00290077.
PIR	KRHU5. S01069.
RefSeq	NP_002266.2. NM_002275.3.
UniGene	Hs.654570.
3D structure databases
ProteinModelPortal	P19012.
SMR	P19012. Positions 101-254, 270-412.
ModBase	Search...
Protein-protein interaction databases
IntAct	P19012. 51 interactions.
MINT	MINT-1433992.
STRING	9606.ENSP00000254043.
PTM databases
PhosphoSite	P19012.
Polymorphism databases
DMDM	311033438.
Proteomic databases
PaxDb	P19012.
PeptideAtlas	P19012.
PRIDE	P19012.
Protocols and materials databases
DNASU	3866.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254043; ENSP00000254043; ENSG00000171346. ENST00000393976; ENSP00000377546; ENSG00000171346.
GeneID	3866.
KEGG	hsa:3866.
UCSC	uc002hwy.3. human.
Organism-specific databases
CTD	3866.
GeneCards	GC17M039675.
HGNC	HGNC:6421. KRT15.
HPA	CAB000135. HPA023910. HPA024554.
MIM	148030. gene.
neXtProt	NX_P19012.
PharmGKB	PA30208.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148784.
HOGENOM	HOG000230975.
HOVERGEN	HBG013015.
InParanoid	P19012.
KO	K07604.
OMA	MAGIGTR.
OrthoDB	EOG4RR6HT.
PhylomeDB	P19012.
Gene expression databases
ArrayExpress	P19012.
Bgee	P19012.
CleanEx	HS_KRT15.
Genevestigator	P19012.
GermOnline	ENSG00000171346. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KRT15. human.
GenomeRNAi	3866.
NextBio	15201.
SOURCE	Search...

Entry information

Entry name

K1C15_HUMAN

Accession

Primary (citable) accession number: P19012
Secondary accession number(s): B3KQY1, Q53XV8, Q9BUG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 119 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.