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P19012 (K1C15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name=CK-15
Keratin-15
Short name=K15
Gene names
Name:KRT15
Synonyms:KRTB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins.

Tissue specificity

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate. Ref.2 Ref.8

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RCOR3Q9P2K32EBI-739566,EBI-743428
USP2O756042EBI-739566,EBI-743272

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Keratin, type I cytoskeletal 15
PRO_0000063657

Regions

Region1 – 104104Head
Region105 – 413309Rod
Region105 – 14036Coil 1A
Region141 – 15919Linker 1
Region160 – 25192Coil 1B
Region252 – 27120Linker 12
Region272 – 413142Coil 2
Region414 – 45643Tail
Compositional bias14 – 10390Gly-rich
Compositional bias428 – 4314Poly-Gly

Amino acid modifications

Modified residue3011Phosphothreonine By similarity
Modified residue3231Phosphothreonine By similarity

Natural variations

Natural variant1471T → A. Ref.1 Ref.2
Corresponds to variant rs1050784 [ dbSNP | Ensembl ].
VAR_047429
Natural variant4161K → R. Ref.5
Corresponds to variant rs2305556 [ dbSNP | Ensembl ].
VAR_047430
Natural variant4211A → G. Ref.1 Ref.2 Ref.4 Ref.5 Ref.7 Ref.9
Corresponds to variant rs897420 [ dbSNP | Ensembl ].
VAR_047431

Sequences

Sequence LengthMass (Da)Tools
P19012 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: 812C1343905EBE41

FASTA45649,212
        10         20         30         40         50         60 
MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY 

        70         80         90        100        110        120 
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL 

       130        140        150        160        170        180 
DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE 

       190        200        210        220        230        240 
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL 

       250        260        270        280        290        300 
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 

       310        320        330        340        350        360 
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ 

       370        380        390        400        410        420 
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI 

       430        440        450 
AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI 

« Hide

References

« Hide 'large scale' references
[1]"Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene."
Bader B.L., Jahn L., Franke W.W.
Eur. J. Cell Biol. 47:300-319(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-147 AND GLY-421.
[2]"Molecular characterization and expression of the stratification-related cytokeratins 4 and 15."
Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T., Franke W.W.
J. Cell Biol. 106:1249-1261(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ALA-147 AND GLY-421.
[3]"Genomic organization and amplification of the human keratin 15 and 19 genes."
Whittock N.V., Eady R.A.J., McGrath J.A.
Biochem. Biophys. Res. Commun. 267:462-465(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-421.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-416 AND GLY-421.
[6]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-421.
Tissue: Pancreas.
[8]"Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes."
Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S., Lalli A., Machesney M., Leigh I.M.
J. Invest. Dermatol. 112:362-369(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07696 mRNA. Translation: CAA30535.1.
AF202320 Genomic DNA. Translation: AAF27047.1.
BT007261 mRNA. Translation: AAP35925.1.
AK090604 mRNA. Translation: BAG52193.1.
AC019349 Genomic DNA. No translation available.
BC002641 mRNA. Translation: AAH02641.1.
CCDSCCDS11398.1.
PIRKRHU5. S01069.
RefSeqNP_002266.2. NM_002275.3.
XP_005257402.1. XM_005257345.1.
UniGeneHs.654570.

3D structure databases

ProteinModelPortalP19012.
SMRP19012. Positions 156-254, 270-412.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110064. 55 interactions.
IntActP19012. 53 interactions.
MINTMINT-1433992.
STRING9606.ENSP00000254043.

PTM databases

PhosphoSiteP19012.

Polymorphism databases

DMDM311033438.

Proteomic databases

MaxQBP19012.
PaxDbP19012.
PeptideAtlasP19012.
PRIDEP19012.

Protocols and materials databases

DNASU3866.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254043; ENSP00000254043; ENSG00000171346.
ENST00000393976; ENSP00000377546; ENSG00000171346.
GeneID3866.
KEGGhsa:3866.
UCSCuc002hwy.3. human.

Organism-specific databases

CTD3866.
GeneCardsGC17M039675.
HGNCHGNC:6421. KRT15.
HPACAB000135.
HPA023910.
HPA024554.
MIM148030. gene.
neXtProtNX_P19012.
PharmGKBPA30208.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148784.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidP19012.
KOK07604.
OMAMAGIGTR.
PhylomeDBP19012.
TreeFamTF332742.

Gene expression databases

ArrayExpressP19012.
BgeeP19012.
CleanExHS_KRT15.
GenevestigatorP19012.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
SUPFAMSSF46579. SSF46579. 1 hit.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKRT15. human.
GeneWikiKeratin_15.
GenomeRNAi3866.
NextBio15201.
PROP19012.
SOURCESearch...

Entry information

Entry nameK1C15_HUMAN
AccessionPrimary (citable) accession number: P19012
Secondary accession number(s): B3KQY1, Q53XV8, Q9BUG4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM