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P19012

- K1C15_HUMAN

UniProt

P19012 - K1C15_HUMAN

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Protein
Keratin, type I cytoskeletal 15
Gene
KRT15, KRTB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. scaffold protein binding Source: BHF-UCL
  3. structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  1. epidermis development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name:
CK-15
Keratin-15
Short name:
K15
Gene namesi
Name:KRT15
Synonyms:KRTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6421. KRT15.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. intermediate filament Source: ProtInc
  3. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Keratin, type I cytoskeletal 15
PRO_0000063657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei301 – 3011Phosphothreonine By similarity
Modified residuei323 – 3231Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP19012.
PaxDbiP19012.
PeptideAtlasiP19012.
PRIDEiP19012.

PTM databases

PhosphoSiteiP19012.

Expressioni

Tissue specificityi

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.2 Publications

Gene expression databases

ArrayExpressiP19012.
BgeeiP19012.
CleanExiHS_KRT15.
GenevestigatoriP19012.

Organism-specific databases

HPAiCAB000135.
HPA023910.
HPA024554.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
RCOR3Q9P2K32EBI-739566,EBI-743428
USP2O756042EBI-739566,EBI-743272

Protein-protein interaction databases

BioGridi110064. 55 interactions.
IntActiP19012. 53 interactions.
MINTiMINT-1433992.
STRINGi9606.ENSP00000254043.

Structurei

3D structure databases

ProteinModelPortaliP19012.
SMRiP19012. Positions 156-254, 270-412.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 104104Head
Add
BLAST
Regioni105 – 413309Rod
Add
BLAST
Regioni105 – 14036Coil 1A
Add
BLAST
Regioni141 – 15919Linker 1
Add
BLAST
Regioni160 – 25192Coil 1B
Add
BLAST
Regioni252 – 27120Linker 12
Add
BLAST
Regioni272 – 413142Coil 2
Add
BLAST
Regioni414 – 45643Tail
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 10390Gly-rich
Add
BLAST
Compositional biasi428 – 4314Poly-Gly

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG148784.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP19012.
KOiK07604.
OMAiMAGIGTR.
PhylomeDBiP19012.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19012-1 [UniParc]FASTAAdd to Basket

« Hide

MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR    50
FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL 100
LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE 150
CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA 200
LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE 250
FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 300
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL 350
AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE 400
QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS 450
SHKREI 456
Length:456
Mass (Da):49,212
Last modified:November 2, 2010 - v3
Checksum:i812C1343905EBE41
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471T → A.2 Publications
Corresponds to variant rs1050784 [ dbSNP | Ensembl ].
VAR_047429
Natural varianti416 – 4161K → R.1 Publication
Corresponds to variant rs2305556 [ dbSNP | Ensembl ].
VAR_047430
Natural varianti421 – 4211A → G.6 Publications
Corresponds to variant rs897420 [ dbSNP | Ensembl ].
VAR_047431

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07696 mRNA. Translation: CAA30535.1.
AF202320 Genomic DNA. Translation: AAF27047.1.
BT007261 mRNA. Translation: AAP35925.1.
AK090604 mRNA. Translation: BAG52193.1.
AC019349 Genomic DNA. No translation available.
BC002641 mRNA. Translation: AAH02641.1.
CCDSiCCDS11398.1.
PIRiS01069. KRHU5.
RefSeqiNP_002266.2. NM_002275.3.
XP_005257402.1. XM_005257345.1.
UniGeneiHs.654570.

Genome annotation databases

EnsembliENST00000254043; ENSP00000254043; ENSG00000171346.
ENST00000393976; ENSP00000377546; ENSG00000171346.
GeneIDi3866.
KEGGihsa:3866.
UCSCiuc002hwy.3. human.

Polymorphism databases

DMDMi311033438.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07696 mRNA. Translation: CAA30535.1 .
AF202320 Genomic DNA. Translation: AAF27047.1 .
BT007261 mRNA. Translation: AAP35925.1 .
AK090604 mRNA. Translation: BAG52193.1 .
AC019349 Genomic DNA. No translation available.
BC002641 mRNA. Translation: AAH02641.1 .
CCDSi CCDS11398.1.
PIRi S01069. KRHU5.
RefSeqi NP_002266.2. NM_002275.3.
XP_005257402.1. XM_005257345.1.
UniGenei Hs.654570.

3D structure databases

ProteinModelPortali P19012.
SMRi P19012. Positions 156-254, 270-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110064. 55 interactions.
IntActi P19012. 53 interactions.
MINTi MINT-1433992.
STRINGi 9606.ENSP00000254043.

PTM databases

PhosphoSitei P19012.

Polymorphism databases

DMDMi 311033438.

Proteomic databases

MaxQBi P19012.
PaxDbi P19012.
PeptideAtlasi P19012.
PRIDEi P19012.

Protocols and materials databases

DNASUi 3866.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254043 ; ENSP00000254043 ; ENSG00000171346 .
ENST00000393976 ; ENSP00000377546 ; ENSG00000171346 .
GeneIDi 3866.
KEGGi hsa:3866.
UCSCi uc002hwy.3. human.

Organism-specific databases

CTDi 3866.
GeneCardsi GC17M039675.
HGNCi HGNC:6421. KRT15.
HPAi CAB000135.
HPA023910.
HPA024554.
MIMi 148030. gene.
neXtProti NX_P19012.
PharmGKBi PA30208.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148784.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi P19012.
KOi K07604.
OMAi MAGIGTR.
PhylomeDBi P19012.
TreeFami TF332742.

Miscellaneous databases

ChiTaRSi KRT15. human.
GeneWikii Keratin_15.
GenomeRNAii 3866.
NextBioi 15201.
PROi P19012.
SOURCEi Search...

Gene expression databases

ArrayExpressi P19012.
Bgeei P19012.
CleanExi HS_KRT15.
Genevestigatori P19012.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
SUPFAMi SSF46579. SSF46579. 1 hit.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene."
    Bader B.L., Jahn L., Franke W.W.
    Eur. J. Cell Biol. 47:300-319(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-147 AND GLY-421.
  2. "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15."
    Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T., Franke W.W.
    J. Cell Biol. 106:1249-1261(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ALA-147 AND GLY-421.
  3. "Genomic organization and amplification of the human keratin 15 and 19 genes."
    Whittock N.V., Eady R.A.J., McGrath J.A.
    Biochem. Biophys. Res. Commun. 267:462-465(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-421.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-416 AND GLY-421.
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-421.
    Tissue: Pancreas.
  8. "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes."
    Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S., Lalli A., Machesney M., Leigh I.M.
    J. Invest. Dermatol. 112:362-369(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiK1C15_HUMAN
AccessioniPrimary (citable) accession number: P19012
Secondary accession number(s): B3KQY1, Q53XV8, Q9BUG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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