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P19012

- K1C15_HUMAN

UniProt

P19012 - K1C15_HUMAN

Protein

Keratin, type I cytoskeletal 15

Gene

KRT15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. scaffold protein binding Source: BHF-UCL
    3. structural constituent of cytoskeleton Source: ProtInc

    GO - Biological processi

    1. epidermis development Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cytoskeletal 15
    Alternative name(s):
    Cytokeratin-15
    Short name:
    CK-15
    Keratin-15
    Short name:
    K15
    Gene namesi
    Name:KRT15
    Synonyms:KRTB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6421. KRT15.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. intermediate filament Source: ProtInc
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30208.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Keratin, type I cytoskeletal 15PRO_0000063657Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei301 – 3011PhosphothreonineBy similarity
    Modified residuei323 – 3231PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP19012.
    PaxDbiP19012.
    PeptideAtlasiP19012.
    PRIDEiP19012.

    PTM databases

    PhosphoSiteiP19012.

    Expressioni

    Tissue specificityi

    Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.2 Publications

    Gene expression databases

    ArrayExpressiP19012.
    BgeeiP19012.
    CleanExiHS_KRT15.
    GenevestigatoriP19012.

    Organism-specific databases

    HPAiCAB000135.
    HPA023910.
    HPA024554.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RCOR3Q9P2K32EBI-739566,EBI-743428
    USP2O756042EBI-739566,EBI-743272

    Protein-protein interaction databases

    BioGridi110064. 55 interactions.
    IntActiP19012. 53 interactions.
    MINTiMINT-1433992.
    STRINGi9606.ENSP00000254043.

    Structurei

    3D structure databases

    ProteinModelPortaliP19012.
    SMRiP19012. Positions 156-254, 270-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 104104HeadAdd
    BLAST
    Regioni105 – 413309RodAdd
    BLAST
    Regioni105 – 14036Coil 1AAdd
    BLAST
    Regioni141 – 15919Linker 1Add
    BLAST
    Regioni160 – 25192Coil 1BAdd
    BLAST
    Regioni252 – 27120Linker 12Add
    BLAST
    Regioni272 – 413142Coil 2Add
    BLAST
    Regioni414 – 45643TailAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 10390Gly-richAdd
    BLAST
    Compositional biasi428 – 4314Poly-Gly

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG148784.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiP19012.
    KOiK07604.
    OMAiMAGIGTR.
    PhylomeDBiP19012.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    SUPFAMiSSF46579. SSF46579. 1 hit.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P19012-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR    50
    FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL 100
    LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE 150
    CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA 200
    LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE 250
    FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 300
    TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL 350
    AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE 400
    QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS 450
    SHKREI 456
    Length:456
    Mass (Da):49,212
    Last modified:November 2, 2010 - v3
    Checksum:i812C1343905EBE41
    GO
    Isoform 2 (identifier: P19012-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-29: TTFLQTSSSTFGGGSTRGGSLLAGGGG → GTRSRPQPAQNATTANTSRPLKSSGTR
         30-194: Missing.
         417-456: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:251
    Mass (Da):28,602
    Checksum:i0EED60B048471B9B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471T → A.2 Publications
    Corresponds to variant rs1050784 [ dbSNP | Ensembl ].
    VAR_047429
    Natural varianti416 – 4161K → R.1 Publication
    Corresponds to variant rs2305556 [ dbSNP | Ensembl ].
    VAR_047430
    Natural varianti421 – 4211A → G.6 Publications
    Corresponds to variant rs897420 [ dbSNP | Ensembl ].
    VAR_047431

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei3 – 2927TTFLQ…AGGGG → GTRSRPQPAQNATTANTSRP LKSSGTR in isoform 2. 1 PublicationVSP_056507Add
    BLAST
    Alternative sequencei30 – 194165Missing in isoform 2. 1 PublicationVSP_056508Add
    BLAST
    Alternative sequencei417 – 45640Missing in isoform 2. 1 PublicationVSP_056509Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07696 mRNA. Translation: CAA30535.1.
    AF202320 Genomic DNA. Translation: AAF27047.1.
    BT007261 mRNA. Translation: AAP35925.1.
    AK090604 mRNA. Translation: BAG52193.1.
    AK091239 mRNA. Translation: BAG52314.1.
    AC019349 Genomic DNA. No translation available.
    BC002641 mRNA. Translation: AAH02641.1.
    CCDSiCCDS11398.1.
    PIRiS01069. KRHU5.
    RefSeqiNP_002266.2. NM_002275.3.
    XP_005257402.1. XM_005257345.1.
    UniGeneiHs.654570.

    Genome annotation databases

    EnsembliENST00000254043; ENSP00000254043; ENSG00000171346.
    ENST00000393976; ENSP00000377546; ENSG00000171346.
    ENST00000393981; ENSP00000377550; ENSG00000171346.
    GeneIDi3866.
    KEGGihsa:3866.
    UCSCiuc002hwy.3. human.

    Polymorphism databases

    DMDMi311033438.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07696 mRNA. Translation: CAA30535.1 .
    AF202320 Genomic DNA. Translation: AAF27047.1 .
    BT007261 mRNA. Translation: AAP35925.1 .
    AK090604 mRNA. Translation: BAG52193.1 .
    AK091239 mRNA. Translation: BAG52314.1 .
    AC019349 Genomic DNA. No translation available.
    BC002641 mRNA. Translation: AAH02641.1 .
    CCDSi CCDS11398.1.
    PIRi S01069. KRHU5.
    RefSeqi NP_002266.2. NM_002275.3.
    XP_005257402.1. XM_005257345.1.
    UniGenei Hs.654570.

    3D structure databases

    ProteinModelPortali P19012.
    SMRi P19012. Positions 156-254, 270-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110064. 55 interactions.
    IntActi P19012. 53 interactions.
    MINTi MINT-1433992.
    STRINGi 9606.ENSP00000254043.

    PTM databases

    PhosphoSitei P19012.

    Polymorphism databases

    DMDMi 311033438.

    Proteomic databases

    MaxQBi P19012.
    PaxDbi P19012.
    PeptideAtlasi P19012.
    PRIDEi P19012.

    Protocols and materials databases

    DNASUi 3866.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254043 ; ENSP00000254043 ; ENSG00000171346 .
    ENST00000393976 ; ENSP00000377546 ; ENSG00000171346 .
    ENST00000393981 ; ENSP00000377550 ; ENSG00000171346 .
    GeneIDi 3866.
    KEGGi hsa:3866.
    UCSCi uc002hwy.3. human.

    Organism-specific databases

    CTDi 3866.
    GeneCardsi GC17M039675.
    HGNCi HGNC:6421. KRT15.
    HPAi CAB000135.
    HPA023910.
    HPA024554.
    MIMi 148030. gene.
    neXtProti NX_P19012.
    PharmGKBi PA30208.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148784.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi P19012.
    KOi K07604.
    OMAi MAGIGTR.
    PhylomeDBi P19012.
    TreeFami TF332742.

    Miscellaneous databases

    ChiTaRSi KRT15. human.
    GeneWikii Keratin_15.
    GenomeRNAii 3866.
    NextBioi 15201.
    PROi P19012.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19012.
    Bgeei P19012.
    CleanExi HS_KRT15.
    Genevestigatori P19012.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    SUPFAMi SSF46579. SSF46579. 1 hit.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene."
      Bader B.L., Jahn L., Franke W.W.
      Eur. J. Cell Biol. 47:300-319(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-147 AND GLY-421.
    2. "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15."
      Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T., Franke W.W.
      J. Cell Biol. 106:1249-1261(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS ALA-147 AND GLY-421.
    3. "Genomic organization and amplification of the human keratin 15 and 19 genes."
      Whittock N.V., Eady R.A.J., McGrath J.A.
      Biochem. Biophys. Res. Commun. 267:462-465(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-421.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ARG-416 AND GLY-421.
      Tissue: Tongue.
    6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-421.
      Tissue: Pancreas.
    8. "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes."
      Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S., Lalli A., Machesney M., Leigh I.M.
      J. Invest. Dermatol. 112:362-369(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiK1C15_HUMAN
    AccessioniPrimary (citable) accession number: P19012
    Secondary accession number(s): B3KQY1
    , B3KRA2, E0CX14, Q53XV8, Q9BUG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3