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Protein

Keratin, type I cytoskeletal 15

Gene

KRT15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • scaffold protein binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  • epidermis development Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171346-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name:
CK-15
Keratin-15
Short name:
K15
Gene namesi
Name:KRT15
Synonyms:KRTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6421. KRT15.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: ProtInc
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi3866.
OpenTargetsiENSG00000171346.
PharmGKBiPA30208.

Polymorphism and mutation databases

BioMutaiKRT15.
DMDMi311033438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636571 – 456Keratin, type I cytoskeletal 15Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Modified residuei301PhosphothreonineBy similarity1
Modified residuei323PhosphothreonineBy similarity1
Modified residuei432PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19012.
PeptideAtlasiP19012.
PRIDEiP19012.

PTM databases

iPTMnetiP19012.
PhosphoSitePlusiP19012.
SwissPalmiP19012.

Expressioni

Tissue specificityi

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.2 Publications

Gene expression databases

BgeeiENSG00000171346.
CleanExiHS_KRT15.
ExpressionAtlasiP19012. baseline and differential.
GenevisibleiP19012. HS.

Organism-specific databases

HPAiCAB000135.
HPA023910.
HPA024554.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB94EBI-739566,EBI-743598
AESQ081173EBI-739566,EBI-717810
ALS2CR11Q53TS83EBI-739566,EBI-739879
AMOTQ4VCS5-23EBI-739566,EBI-3891843
AMOTL2Q9Y2J4-43EBI-739566,EBI-10187270
ANKRD36BP1Q96IX94EBI-739566,EBI-744859
ARFIP2P533653EBI-739566,EBI-638194
ATP5OP480473EBI-739566,EBI-355815
BEX2Q9BXY83EBI-739566,EBI-745073
C1orf216Q8TAB54EBI-739566,EBI-747505
CCDC67E9PJR53EBI-739566,EBI-10177066
CCDC67Q05D603EBI-739566,EBI-748597
CCDC87Q9NVE43EBI-739566,EBI-749261
CCHCR1Q8TD31-35EBI-739566,EBI-10175300
CCNB1IP1Q9NPC33EBI-739566,EBI-745269
CCNCP248633EBI-739566,EBI-395261
CEP57Q86XR83EBI-739566,EBI-308614
COX5BP106063EBI-739566,EBI-1053725
CREB5Q02930-33EBI-739566,EBI-10192698
CYTH4Q8WWE83EBI-739566,EBI-10277443
DKFZp451B226Q5HYH73EBI-739566,EBI-10173842
EPC1Q9H2F53EBI-739566,EBI-769270
FAM110AQ9BQ895EBI-739566,EBI-1752811
GFAPP141363EBI-739566,EBI-744302
GLYCTKQ8IVS83EBI-739566,EBI-748515
HAUS1Q96CS23EBI-739566,EBI-2514791
HGSO149645EBI-739566,EBI-740220
HMG20BQ9P0W23EBI-739566,EBI-713401
IKBIPQ70UQ03EBI-739566,EBI-2557212
KANSL1I3L4J33EBI-739566,EBI-10178305
KIAA1217Q5T5P2-63EBI-739566,EBI-10188326
KIFC3Q9BVG83EBI-739566,EBI-2125614
KLC3Q6P5973EBI-739566,EBI-1643885
KLC4Q9NSK03EBI-739566,EBI-949319
KRT20P359004EBI-739566,EBI-742094
KRT4P190135EBI-739566,EBI-2371606
KRT5P136473EBI-739566,EBI-702187
KRT6AP025384EBI-739566,EBI-702198
KRT6BP042596EBI-739566,EBI-740907
KRT6CP486683EBI-739566,EBI-2564105
KRT71Q3SY845EBI-739566,EBI-2952676
KRT73Q86Y463EBI-739566,EBI-2830994
KRT77Q0IIN13EBI-739566,EBI-2511085
KRT79Q5XKE55EBI-739566,EBI-2514135
KRT8P057873EBI-739566,EBI-297852
KRT80Q6KB663EBI-739566,EBI-3046635
KRT81Q145333EBI-739566,EBI-739648
KRT86O437905EBI-739566,EBI-9996498
LMO2P257913EBI-739566,EBI-739696
LMO4P619683EBI-739566,EBI-2798728
LNX1Q8TBB13EBI-739566,EBI-739832
MBD3O959833EBI-739566,EBI-1783068
MORN3Q6PF183EBI-739566,EBI-9675802
MOSP005403EBI-739566,EBI-1757866
NEFLI6L9F63EBI-739566,EBI-10178578
NOC4LQ9BVI44EBI-739566,EBI-395927
NUP54Q7Z3B43EBI-739566,EBI-741048
OIP5O434823EBI-739566,EBI-536879
PIK3R2O004593EBI-739566,EBI-346930
PKN1Q165123EBI-739566,EBI-602382
PPP1R18Q6NYC85EBI-739566,EBI-2557469
PRPF31F1T0A53EBI-739566,EBI-10177194
PSMA1P257864EBI-739566,EBI-359352
PSMB1P206185EBI-739566,EBI-372273
RAD51DO757713EBI-739566,EBI-1055693
RCOR3Q9P2K35EBI-739566,EBI-743428
RIBC1Q8N4433EBI-739566,EBI-10265323
SGF29Q96ES74EBI-739566,EBI-743117
SMARCD1Q96GM53EBI-739566,EBI-358489
SMARCE1Q969G33EBI-739566,EBI-455078
SPG21Q9NZD83EBI-739566,EBI-742688
SSX2IPQ9Y2D83EBI-739566,EBI-2212028
taxP140793EBI-739566,EBI-9675698From a different organism.
TCHPQ9BT924EBI-739566,EBI-740781
TIMM8AO602203EBI-739566,EBI-1049822
TMSB4XQ0P5Q03EBI-739566,EBI-10226570
TRIM42A1L4B63EBI-739566,EBI-10172216
TXLNAP402223EBI-739566,EBI-359793
USP2O756045EBI-739566,EBI-743272
WACQ9BTA94EBI-739566,EBI-749118
WACQ9BTA9-23EBI-739566,EBI-10298216
ZC2HC1CQ53FD04EBI-739566,EBI-740767
ZFYVE26Q96H433EBI-739566,EBI-10286915
ZGPATQ8N5A53EBI-739566,EBI-3439227
ZNF417Q8TAU33EBI-739566,EBI-740727
ZNF576Q9H6093EBI-739566,EBI-3921014

GO - Molecular functioni

  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi110064. 119 interactors.
IntActiP19012. 146 interactors.
MINTiMINT-1433992.
STRINGi9606.ENSP00000254043.

Structurei

3D structure databases

ProteinModelPortaliP19012.
SMRiP19012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104HeadAdd BLAST104
Regioni105 – 413RodAdd BLAST309
Regioni105 – 140Coil 1AAdd BLAST36
Regioni141 – 159Linker 1Add BLAST19
Regioni160 – 251Coil 1BAdd BLAST92
Regioni252 – 271Linker 12Add BLAST20
Regioni272 – 413Coil 2Add BLAST142
Regioni414 – 456TailAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 103Gly-richAdd BLAST90
Compositional biasi428 – 431Poly-Gly4

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP19012.
KOiK07604.
OMAiVEAWFFS.
OrthoDBiEOG091G087I.
PhylomeDBiP19012.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19012-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR
60 70 80 90 100
FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL
110 120 130 140 150
LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE
160 170 180 190 200
CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA
210 220 230 240 250
LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE
260 270 280 290 300
FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK
310 320 330 340 350
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL
360 370 380 390 400
AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE
410 420 430 440 450
QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS

SHKREI
Length:456
Mass (Da):49,212
Last modified:November 2, 2010 - v3
Checksum:i812C1343905EBE41
GO
Isoform 2 (identifier: P19012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-29: TTFLQTSSSTFGGGSTRGGSLLAGGGG → GTRSRPQPAQNATTANTSRPLKSSGTR
     30-194: Missing.
     417-456: Missing.

Note: No experimental confirmation available.
Show »
Length:251
Mass (Da):28,602
Checksum:i0EED60B048471B9B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047429147T → A.2 PublicationsCorresponds to variant rs1050784dbSNPEnsembl.1
Natural variantiVAR_047430416K → R.1 PublicationCorresponds to variant rs2305556dbSNPEnsembl.1
Natural variantiVAR_047431421A → G.5 PublicationsCorresponds to variant rs897420dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565073 – 29TTFLQ…AGGGG → GTRSRPQPAQNATTANTSRP LKSSGTR in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_05650830 – 194Missing in isoform 2. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_056509417 – 456Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07696 mRNA. Translation: CAA30535.1.
AF202320 Genomic DNA. Translation: AAF27047.1.
BT007261 mRNA. Translation: AAP35925.1.
AK090604 mRNA. Translation: BAG52193.1.
AK091239 mRNA. Translation: BAG52314.1.
AC019349 Genomic DNA. No translation available.
BC002641 mRNA. Translation: AAH02641.1.
CCDSiCCDS11398.1. [P19012-1]
PIRiS01069. KRHU5.
RefSeqiNP_002266.2. NM_002275.3.
UniGeneiHs.654570.

Genome annotation databases

EnsembliENST00000254043; ENSP00000254043; ENSG00000171346. [P19012-1]
ENST00000393976; ENSP00000377546; ENSG00000171346. [P19012-1]
GeneIDi3866.
KEGGihsa:3866.
UCSCiuc002hwy.4. human. [P19012-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07696 mRNA. Translation: CAA30535.1.
AF202320 Genomic DNA. Translation: AAF27047.1.
BT007261 mRNA. Translation: AAP35925.1.
AK090604 mRNA. Translation: BAG52193.1.
AK091239 mRNA. Translation: BAG52314.1.
AC019349 Genomic DNA. No translation available.
BC002641 mRNA. Translation: AAH02641.1.
CCDSiCCDS11398.1. [P19012-1]
PIRiS01069. KRHU5.
RefSeqiNP_002266.2. NM_002275.3.
UniGeneiHs.654570.

3D structure databases

ProteinModelPortaliP19012.
SMRiP19012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110064. 119 interactors.
IntActiP19012. 146 interactors.
MINTiMINT-1433992.
STRINGi9606.ENSP00000254043.

PTM databases

iPTMnetiP19012.
PhosphoSitePlusiP19012.
SwissPalmiP19012.

Polymorphism and mutation databases

BioMutaiKRT15.
DMDMi311033438.

Proteomic databases

PaxDbiP19012.
PeptideAtlasiP19012.
PRIDEiP19012.

Protocols and materials databases

DNASUi3866.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254043; ENSP00000254043; ENSG00000171346. [P19012-1]
ENST00000393976; ENSP00000377546; ENSG00000171346. [P19012-1]
GeneIDi3866.
KEGGihsa:3866.
UCSCiuc002hwy.4. human. [P19012-1]

Organism-specific databases

CTDi3866.
DisGeNETi3866.
GeneCardsiKRT15.
HGNCiHGNC:6421. KRT15.
HPAiCAB000135.
HPA023910.
HPA024554.
MIMi148030. gene.
neXtProtiNX_P19012.
OpenTargetsiENSG00000171346.
PharmGKBiPA30208.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP19012.
KOiK07604.
OMAiVEAWFFS.
OrthoDBiEOG091G087I.
PhylomeDBiP19012.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171346-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiKRT15. human.
GeneWikiiKeratin_15.
GenomeRNAii3866.
PROiP19012.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171346.
CleanExiHS_KRT15.
ExpressionAtlasiP19012. baseline and differential.
GenevisibleiP19012. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C15_HUMAN
AccessioniPrimary (citable) accession number: P19012
Secondary accession number(s): B3KQY1
, B3KRA2, E0CX14, Q53XV8, Q9BUG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.