P19001 (K1C19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cytoskeletal 19

Alternative name(s):
Cytokeratin-19
Short name=CK-19
Keratin-19
Short name=K19

Gene names

Name:	Krt19
Synonyms:	Krt1-19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle By similarity.
Subunit structure	Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD By similarity.
Developmental stage	Expressed throughout embryonic development with highest levels at 8.5 dpc. Expression decreases by 11.5 dpc and increases again by 17.5 dpc. Ref.2
Domain	This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation involved in embryonic placenta development Inferred from genetic interaction PubMed 11062258. Source: MGI response to estrogen stimulus Inferred from electronic annotation. Source: Compara sarcomere organization Inferred from electronic annotation. Source: Compara
Cellular_component	Z disc Inferred from direct assay PubMed 15247274. Source: MGI costamere Inferred from electronic annotation. Source: Compara dystrophin-associated glycoprotein complex Inferred from electronic annotation. Source: Compara intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW sarcolemma Inferred from direct assay PubMed 15247274. Source: MGI
Molecular_function	structural constituent of muscle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 403	403	Keratin, type I cytoskeletal 19		PRO_0000063672
Regions
	Region	1 – 82	82	Head
	Region	83 – 390	308	Rod
	Region	83 – 118	36	Coil 1A
	Region	119 – 136	18	Linker 1
	Region	137 – 228	92	Coil 1B
	Region	229 – 251	23	Linker 12
	Region	247 – 393	147	Necessary for interaction with PNN By similarity
	Region	252 – 390	139	Coil 2
	Region	391 – 403	13	Rod-like helical tail
Sites
	Site	270	1	Stutter
	Site	330	1	Stutter
Amino acid modifications
	Modified residue	13	1	Phosphoserine By similarity
	Modified residue	35	1	Phosphoserine By similarity
	Modified residue	55	1	Phosphoserine By similarity
	Modified residue	394	1	Phosphotyrosine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P19001 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 8CA8A45FFE288BB1	FASTA	403	44,542
	10 20 30 40 50 60 MTSYSYRQTS AMSSFGGTGG GSVRIGSGGV FRAPSIHGGS GGRGVSVSST RFVTSSSGSY 70 80 90 100 110 120 GGVRGGSFSG TLAVSDGLLS GNEKITMQNL NDRLASYLDK VRALEQANGE LEVKIRDWYQ 130 140 150 160 170 180 KQGPGPSRDY NHYFKTIEDL RDKILGATID NSKIVLQIDN ARLAADDFRT KFETEHALRL 190 200 210 220 230 240 SVEADINGLR RVLDELTLAR TDLEMQIESL KEELAYLKKN HEEEITALRS QVGGQVSVEV 250 260 270 280 290 300 DSTPGVDLAK ILSEMRSQYE IMAEKNRKDA EATYLARIEE LNTQVAVHSE QIQISKTEVT 310 320 330 340 350 360 DLRRTLQGLE IELQSQLSMK AALEGTLAET EARYGVQLSQ IQSVISGFEA QLSDVRADIE 370 380 390 400 RQNQEYKQLM DIKSRLEQEI ATYRSLLEGQ EAHYNNLPTP KAI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19." Ichinose Y., Hashido K., Miyamoto H., Nagata T., Nozaki M., Morita T., Matsushiro A. Gene 80:315-323(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Mouse keratin 19: complete amino acid sequence and gene expression during development." Lussier M., Ouellet T., Lampron C., Lapointe L., Royal A. Gene 85:435-444(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Tissue: Embryo.
[3]	"The mouse keratin 19-encoding gene: sequence, structure and chromosomal assignment." Lussier M., Filion M., Compton J.G., Nadeau J.H., Lapointe L., Royal A. Gene 95:203-213(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N-3. Tissue: Mammary gland.
[5]	"Characterization of in vivo keratin 19 phosphorylation on tyrosine-391." Zhou Q., Snider N.T., Liao J., Li D.H., Hong A., Ku N.O., Cartwright C.A., Omary M.B. PLoS ONE 5:E13538-E13538(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT TYR-394.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M28698 mRNA. Translation: AAA60432.1. M36120 Genomic DNA. Translation: AAA39371.1. BC034561 mRNA. Translation: AAH34561.1. BC085304 mRNA. Translation: AAH85304.1.
IPI	IPI00112947.
PIR	JQ0028.
RefSeq	NP_032497.1. NM_008471.2.
UniGene	Mm.439699.
3D structure databases
ProteinModelPortal	P19001.
SMR	P19001. Positions 127-231, 300-389.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1859116.
PTM databases
PhosphoSite	P19001.
Proteomic databases
PaxDb	P19001.
PRIDE	P19001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000007317; ENSMUSP00000007317; ENSMUSG00000020911.
GeneID	16669.
KEGG	mmu:16669.
UCSC	uc007lkm.2. mouse.
Organism-specific databases
CTD	3880.
MGI	MGI:96693. Krt19.
Phylogenomic databases
eggNOG	NOG148784.
GeneTree	ENSGT00610000085921.
HOGENOM	HOG000230975.
HOVERGEN	HBG013015.
InParanoid	P19001.
KO	K07604.
OMA	TEQLQIS.
OrthoDB	EOG4RR6HT.
Gene expression databases
ArrayExpress	P19001.
Bgee	P19001.
CleanEx	MM_KRT19.
Genevestigator	P19001.
GermOnline	ENSMUSG00000020911. Mus musculus.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KRT19. mouse.
NextBio	290391.
SOURCE	Search...

Entry information

Entry name

K1C19_MOUSE

Accession

Primary (citable) accession number: P19001

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	May 29, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program