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Protein

Keratin, type I cytoskeletal 19

Gene

Krt19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei270 – 2701Stutter
Sitei330 – 3301Stutter

GO - Molecular functioni

GO - Biological processi

  • cell differentiation involved in embryonic placenta development Source: MGI
  • Notch signaling pathway Source: MGI
  • response to estrogen Source: Ensembl
  • sarcomere organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 19
Alternative name(s):
Cytokeratin-19
Short name:
CK-19
Keratin-19
Short name:
K19
Gene namesi
Name:Krt19
Synonyms:Krt1-19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96693. Krt19.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: MGI
  • costamere Source: MGI
  • dystrophin-associated glycoprotein complex Source: Ensembl
  • extracellular exosome Source: MGI
  • intermediate filament Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • sarcolemma Source: MGI
  • terminal web Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Keratin, type I cytoskeletal 19PRO_0000063672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei40 – 401PhosphoserineBy similarity
Modified residuei57 – 571PhosphoserineBy similarity
Modified residuei67 – 671PhosphoserineCombined sources
Modified residuei75 – 751PhosphoserineCombined sources
Modified residuei394 – 3941Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP19001.
PaxDbiP19001.
PRIDEiP19001.

PTM databases

iPTMnetiP19001.
PhosphoSiteiP19001.

Expressioni

Developmental stagei

Expressed throughout embryonic development with highest levels at 8.5 dpc. Expression decreases by 11.5 dpc and increases again by 17.5 dpc.1 Publication

Gene expression databases

BgeeiP19001.
CleanExiMM_KRT19.
ExpressionAtlasiP19001. baseline and differential.
GenevisibleiP19001. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD (By similarity).By similarity

Protein-protein interaction databases

BioGridi201024. 1 interaction.
IntActiP19001. 1 interaction.
MINTiMINT-1859116.
STRINGi10090.ENSMUSP00000007317.

Structurei

3D structure databases

ProteinModelPortaliP19001.
SMRiP19001. Positions 127-231, 300-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8282HeadAdd
BLAST
Regioni83 – 390308RodAdd
BLAST
Regioni83 – 11836Coil 1AAdd
BLAST
Regioni119 – 13618Linker 1Add
BLAST
Regioni137 – 22892Coil 1BAdd
BLAST
Regioni229 – 25123Linker 12Add
BLAST
Regioni247 – 393147Necessary for interaction with PNNBy similarityAdd
BLAST
Regioni252 – 390139Coil 2Add
BLAST
Regioni391 – 40313Rod-like helical tailAdd
BLAST

Domaini

This keratin differs from all other IF proteins in lacking the C-terminal tail domain.

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP19001.
KOiK07604.
OMAiSEMRSQY.
OrthoDBiEOG7FV3Q8.
PhylomeDBiP19001.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSYSYRQTS AMSSFGGTGG GSVRIGSGGV FRAPSIHGGS GGRGVSVSST
60 70 80 90 100
RFVTSSSGSY GGVRGGSFSG TLAVSDGLLS GNEKITMQNL NDRLASYLDK
110 120 130 140 150
VRALEQANGE LEVKIRDWYQ KQGPGPSRDY NHYFKTIEDL RDKILGATID
160 170 180 190 200
NSKIVLQIDN ARLAADDFRT KFETEHALRL SVEADINGLR RVLDELTLAR
210 220 230 240 250
TDLEMQIESL KEELAYLKKN HEEEITALRS QVGGQVSVEV DSTPGVDLAK
260 270 280 290 300
ILSEMRSQYE IMAEKNRKDA EATYLARIEE LNTQVAVHSE QIQISKTEVT
310 320 330 340 350
DLRRTLQGLE IELQSQLSMK AALEGTLAET EARYGVQLSQ IQSVISGFEA
360 370 380 390 400
QLSDVRADIE RQNQEYKQLM DIKSRLEQEI ATYRSLLEGQ EAHYNNLPTP

KAI
Length:403
Mass (Da):44,542
Last modified:November 1, 1990 - v1
Checksum:i8CA8A45FFE288BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28698 mRNA. Translation: AAA60432.1.
M36120 Genomic DNA. Translation: AAA39371.1.
BC034561 mRNA. Translation: AAH34561.1.
BC085304 mRNA. Translation: AAH85304.1.
CCDSiCCDS25411.1.
PIRiJQ0028.
RefSeqiNP_032497.1. NM_008471.3.
UniGeneiMm.439699.

Genome annotation databases

EnsembliENSMUST00000007317; ENSMUSP00000007317; ENSMUSG00000020911.
GeneIDi16669.
KEGGimmu:16669.
UCSCiuc007lkm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28698 mRNA. Translation: AAA60432.1.
M36120 Genomic DNA. Translation: AAA39371.1.
BC034561 mRNA. Translation: AAH34561.1.
BC085304 mRNA. Translation: AAH85304.1.
CCDSiCCDS25411.1.
PIRiJQ0028.
RefSeqiNP_032497.1. NM_008471.3.
UniGeneiMm.439699.

3D structure databases

ProteinModelPortaliP19001.
SMRiP19001. Positions 127-231, 300-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201024. 1 interaction.
IntActiP19001. 1 interaction.
MINTiMINT-1859116.
STRINGi10090.ENSMUSP00000007317.

PTM databases

iPTMnetiP19001.
PhosphoSiteiP19001.

Proteomic databases

MaxQBiP19001.
PaxDbiP19001.
PRIDEiP19001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007317; ENSMUSP00000007317; ENSMUSG00000020911.
GeneIDi16669.
KEGGimmu:16669.
UCSCiuc007lkm.2. mouse.

Organism-specific databases

CTDi3880.
MGIiMGI:96693. Krt19.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP19001.
KOiK07604.
OMAiSEMRSQY.
OrthoDBiEOG7FV3Q8.
PhylomeDBiP19001.
TreeFamiTF332742.

Miscellaneous databases

ChiTaRSiKrt19. mouse.
PROiP19001.
SOURCEiSearch...

Gene expression databases

BgeeiP19001.
CleanExiMM_KRT19.
ExpressionAtlasiP19001. baseline and differential.
GenevisibleiP19001. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19."
    Ichinose Y., Hashido K., Miyamoto H., Nagata T., Nozaki M., Morita T., Matsushiro A.
    Gene 80:315-323(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse keratin 19: complete amino acid sequence and gene expression during development."
    Lussier M., Ouellet T., Lampron C., Lapointe L., Royal A.
    Gene 85:435-444(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  3. "The mouse keratin 19-encoding gene: sequence, structure and chromosomal assignment."
    Lussier M., Filion M., Compton J.G., Nadeau J.H., Lapointe L., Royal A.
    Gene 95:203-213(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67 AND SER-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung and Pancreas.
  6. "Characterization of in vivo keratin 19 phosphorylation on tyrosine-391."
    Zhou Q., Snider N.T., Liao J., Li D.H., Hong A., Ku N.O., Cartwright C.A., Omary M.B.
    PLoS ONE 5:E13538-E13538(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-394.

Entry informationi

Entry nameiK1C19_MOUSE
AccessioniPrimary (citable) accession number: P19001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 8, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.