Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vitellogenin-6

Gene

vit-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance (PubMed:24957743).Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of protein oxidation Source: UniProtKB
  • negative regulation of reactive oxygen species biosynthetic process Source: UniProtKB
  • positive regulation of cholesterol import Source: UniProtKB

Keywordsi

Molecular functionStorage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin-6
Gene namesi
Name:vit-6
ORF Names:K07H8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK07H8.6a ; CE28594 ; WBGene00006930 ; vit-6
K07H8.6b ; CE34921 ; WBGene00006930 ; vit-6
K07H8.6c ; CE18026 ; WBGene00006930 ; vit-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes a reduction in the uptake of cholesterol analog dehydroergosterol (DHE). Simulteneous RNAi-mediated knockdown of zmp-2 prevents a reduction in survival upon heat stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000004153716 – 1651Vitellogenin-6Add BLAST1636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi252N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1288N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP18948
PaxDbiP18948
PeptideAtlasiP18948
PRIDEiP18948

2D gel databases

World-2DPAGE0011:P18948

PTM databases

iPTMnetiP18948

Expressioni

Tissue specificityi

Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

Gene expression databases

BgeeiWBGene00006930

Interactioni

Protein-protein interaction databases

BioGridi42732, 5 interactors
IntActiP18948, 5 interactors
STRINGi6239.K07H8.6c

Structurei

3D structure databases

ProteinModelPortaliP18948
SMRiP18948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 716VitellogeninPROSITE-ProRule annotationAdd BLAST683
Domaini1340 – 1550VWFDPROSITE-ProRule annotationAdd BLAST211

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
GeneTreeiENSGT00530000064273
HOGENOMiHOG000004768
InParanoidiP18948
OMAiRTQYPWT
OrthoDBiEOG091G07SB
PhylomeDBiP18948

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SM00216 VWD, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
PS51233 VWFD, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform c (identifier: P18948-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFFIALALL GAALASTHLD RYNSIERNIQ ESSFRAGREY RYLFNGQLSA
60 70 80 90 100
GLPVPSTPQG ISRLQSQVTL QWTDGNTVRM QLQKTRFATS QQESNSMKML
110 120 130 140 150
PFERFEEVER MNREHQELLS MPVEFDYEHG LVREIRFAEN DQPWSENIKR
160 170 180 190 200
AVINMLQVNI LKKEKYEGAE KSDNQEPTFS FTNVERTLEG ECEVLYTVEE
210 220 230 240 250
IKKEDEQRWA KSINFDKCTR RPYIHHVQTP VCKDCQQTLE QDKMSSTVLN
260 270 280 290 300
YNITGTSSSF LINSVELRSQ HLFAPISEKH QLVSAFTLNT MELIYAGEKK
310 320 330 340 350
TEIKQVRNEK TSELVYNQES EWAEQQWAQT GEEKYLRQLP QWTENKVEMI
360 370 380 390 400
KKMFSLMAKQ IEQGEAELEA AHTVARIVKV LRECNEEQLE QIYRHVAEHK
410 420 430 440 450
DEKIAEQLRS IYFNTLALAG TRVTIQQFVD KVQSRKNIAP LKASVAIKTL
460 470 480 490 500
VDMRYPSLAI AEDIARLCES DVSSSFPALR QSCWLTYGAI VNGVCGQTPR
510 520 530 540 550
VFVQKNGVKM CPRDAKQRIV DKLVQQFESA STRYEKVLAL KTLANAGLDL
560 570 580 590 600
SVYPLEKIIL NEQHETTIRT QAIESFRRLR TQMPTKIQRV LMPVYLNRQQ
610 620 630 640 650
PQHIRMSALH QIIYTQPEWS VLSQIGNQLR QERNQQVRAF TLSLLRSYAN
660 670 680 690 700
NESPCEQTFS SRVQSLLNNI PFSSQEIDRF ESVYGKWSTY SRRHQSGFEA
710 720 730 740 750
NFASLFTTES VLPTEMMASI EGVLSGEWNQ YFAQIGFTQK NMEKIIKKLL
760 770 780 790 800
SNVQEKGLEQ IVVRGKRASG SFQPTEFLSN LLEKLRITRR QSSEQDPHAF
810 820 830 840 850
VYIRHRDMDY AFLPIDADSI PEVVRSMIQG GRLEIGDIER VLAQGIHFSA
860 870 880 890 900
SNAAFLYETV RRVPTPMGLP VQFTSKMPTI SSIRGQVTFE LEPKNGKSFD
910 920 930 940 950
GLRLRVQAGP RVASTHVLSL RVICPIAEVG TKFLHQAVLN TPVDTEIRMN
960 970 980 990 1000
WEDKVVIRAI YNTPSEEKRI AMIQSRPVTF TRTVAPDARQ YPEPIEMTYM
1010 1020 1030 1040 1050
LPAHKQLSQS LDREYPQIRV QGTLNRPTSV RIPQWIVDSN VEVYYKPNVE
1060 1070 1080 1090 1100
QYEAIFELNL YNNYKMEKNY EKVYKKHNGR RYLEAEPEYD EEEHREQITK
1110 1120 1130 1140 1150
KFEWLQNEKV YQHVAKFEIK PEVVKMEVEA VCNNDFHFCK TQIRGEELKA
1160 1170 1180 1190 1200
TIQYVYPQTP RTVEELKEQK YRQLVVMGEM NYGENTIHIN INGQQSQEQK
1210 1220 1230 1240 1250
KFVKQIEQAP EHETLLEASR LDQYQTVVEY EFEPKPAQYF ARYWNMVQAY
1260 1270 1280 1290 1300
LRTQYPWTSR IETREEPSRK NMIRATINVE PRQRLTVNMT IETPMETTVL
1310 1320 1330 1340 1350
ERVELPFRLP TAQIHYQPRN SRYEQKPVME KIAHHASKQA NCVVKSTKIN
1360 1370 1380 1390 1400
TFDQVAYRNQ FTPCYSVLAK DCGSEKSEPR FVVLMKKINE KKEWKNVKVV
1410 1420 1430 1440 1450
YGENEIEMYK TEEGLICRVN GEEIEYQPES EIEKKQYNII WLNKNTLKFD
1460 1470 1480 1490 1500
SDDVTVQFDG VNARIHLSAL YRNQQCGLCG HYDNEKETEF YDAENQENTI
1510 1520 1530 1540 1550
PKFAKSYLYK DSKCNYEREM FEKEENFQRI EKNQEEEKDQ EMNYEESRRE
1560 1570 1580 1590 1600
QDDEPTEQVA IVERQHEICF TQKPVLRCQN GKSQESKKQK VTSVYCLPSS
1610 1620 1630 1640 1650
NSWARRQMRE IRREPLAQWP EHKLRNLRDQ PQMEERTVRV AVDQKCDKFD

Y
Note: No experimental confirmation available.
Length:1,651
Mass (Da):193,318
Last modified:September 5, 2006 - v5
Checksum:iCD9D49B72546611C
GO
Isoform a (identifier: P18948-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1591-1591: Missing.

Show »
Length:1,650
Mass (Da):193,219
Checksum:i8258153500C48673
GO
Isoform b (identifier: P18948-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-1637: Missing.

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):23,468
Checksum:i083A570F9FB3057E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23N → F in CAA39670 (PubMed:1904098).Curated1
Sequence conflicti23N → F in AAA28165 (PubMed:3841791).Curated1
Sequence conflicti23N → F in CAA26533 (PubMed:4022780).Curated1
Sequence conflicti206E → K in CAA39670 (PubMed:1904098).Curated1
Sequence conflicti206E → K in AAA28165 (PubMed:3841791).Curated1
Sequence conflicti215F → L in CAA39670 (PubMed:1904098).Curated1
Sequence conflicti215F → L in AAA28165 (PubMed:3841791).Curated1
Sequence conflicti371A → P in CAA39670 (PubMed:1904098).Curated1
Sequence conflicti417A → R in CAA39670 (PubMed:1904098).Curated1
Sequence conflicti634N → D in CAA39670 (PubMed:1904098).Curated1
Sequence conflicti1623 – 1624KL → NV in CAA39670 (PubMed:1904098).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020106188 – 1637Missing in isoform b. CuratedAdd BLAST1450
Alternative sequenceiVSP_0201071591Missing in isoform a. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56213 Genomic DNA Translation: CAA39670.1
FO081300 Genomic DNA Translation: CCD70603.1
FO081300 Genomic DNA Translation: CCD70604.1
FO081300 Genomic DNA Translation: CCD70605.1
M11499 Genomic DNA Translation: AAA28165.1
X02756 Genomic DNA Translation: CAA26533.1
PIRiB43081
F88750
RefSeqiNP_001023274.1, NM_001028103.2 [P18948-2]
NP_001023275.1, NM_001028104.5 [P18948-3]
NP_001023276.1, NM_001028105.3 [P18948-1]
UniGeneiCel.12248

Genome annotation databases

EnsemblMetazoaiK07H8.6c; K07H8.6c; WBGene00006930 [P18948-1]
GeneIDi177619
KEGGicel:CELE_K07H8.6
UCSCiK07H8.6b c. elegans [P18948-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVIT6_CAEEL
AccessioniPrimary (citable) accession number: P18948
Secondary accession number(s): O45176, Q7KPP7, Q7YXH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 137 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health