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Protein

Vitellogenin-6

Gene

vit-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin-6
Gene namesi
Name:vit-6
ORF Names:K07H8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK07H8.6a; CE28594; WBGene00006930; vit-6.
K07H8.6b; CE34921; WBGene00006930; vit-6.
K07H8.6c; CE18026; WBGene00006930; vit-6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 16511636Vitellogenin-6PRO_0000041537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi252 – 2521N-linked (GlcNAc...)1 Publication
Glycosylationi1288 – 12881N-linked (GlcNAc...)2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP18948.
PaxDbiP18948.
PRIDEiP18948.

2D gel databases

World-2DPAGE0011:P18948.

Expressioni

Tissue specificityi

Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

Interactioni

Protein-protein interaction databases

BioGridi42732. 5 interactions.
IntActiP18948. 5 interactions.
MINTiMINT-212008.
STRINGi6239.K07H8.6c.

Structurei

3D structure databases

ProteinModelPortaliP18948.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 716683VitellogeninPROSITE-ProRule annotationAdd
BLAST
Domaini1340 – 1550211VWFDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
GeneTreeiENSGT00530000064273.
HOGENOMiHOG000004768.
InParanoidiP18948.
OMAiNTVRMQL.
OrthoDBiEOG7T4MJ8.
PhylomeDBiP18948.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform c (identifier: P18948-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFFIALALL GAALASTHLD RYNSIERNIQ ESSFRAGREY RYLFNGQLSA
60 70 80 90 100
GLPVPSTPQG ISRLQSQVTL QWTDGNTVRM QLQKTRFATS QQESNSMKML
110 120 130 140 150
PFERFEEVER MNREHQELLS MPVEFDYEHG LVREIRFAEN DQPWSENIKR
160 170 180 190 200
AVINMLQVNI LKKEKYEGAE KSDNQEPTFS FTNVERTLEG ECEVLYTVEE
210 220 230 240 250
IKKEDEQRWA KSINFDKCTR RPYIHHVQTP VCKDCQQTLE QDKMSSTVLN
260 270 280 290 300
YNITGTSSSF LINSVELRSQ HLFAPISEKH QLVSAFTLNT MELIYAGEKK
310 320 330 340 350
TEIKQVRNEK TSELVYNQES EWAEQQWAQT GEEKYLRQLP QWTENKVEMI
360 370 380 390 400
KKMFSLMAKQ IEQGEAELEA AHTVARIVKV LRECNEEQLE QIYRHVAEHK
410 420 430 440 450
DEKIAEQLRS IYFNTLALAG TRVTIQQFVD KVQSRKNIAP LKASVAIKTL
460 470 480 490 500
VDMRYPSLAI AEDIARLCES DVSSSFPALR QSCWLTYGAI VNGVCGQTPR
510 520 530 540 550
VFVQKNGVKM CPRDAKQRIV DKLVQQFESA STRYEKVLAL KTLANAGLDL
560 570 580 590 600
SVYPLEKIIL NEQHETTIRT QAIESFRRLR TQMPTKIQRV LMPVYLNRQQ
610 620 630 640 650
PQHIRMSALH QIIYTQPEWS VLSQIGNQLR QERNQQVRAF TLSLLRSYAN
660 670 680 690 700
NESPCEQTFS SRVQSLLNNI PFSSQEIDRF ESVYGKWSTY SRRHQSGFEA
710 720 730 740 750
NFASLFTTES VLPTEMMASI EGVLSGEWNQ YFAQIGFTQK NMEKIIKKLL
760 770 780 790 800
SNVQEKGLEQ IVVRGKRASG SFQPTEFLSN LLEKLRITRR QSSEQDPHAF
810 820 830 840 850
VYIRHRDMDY AFLPIDADSI PEVVRSMIQG GRLEIGDIER VLAQGIHFSA
860 870 880 890 900
SNAAFLYETV RRVPTPMGLP VQFTSKMPTI SSIRGQVTFE LEPKNGKSFD
910 920 930 940 950
GLRLRVQAGP RVASTHVLSL RVICPIAEVG TKFLHQAVLN TPVDTEIRMN
960 970 980 990 1000
WEDKVVIRAI YNTPSEEKRI AMIQSRPVTF TRTVAPDARQ YPEPIEMTYM
1010 1020 1030 1040 1050
LPAHKQLSQS LDREYPQIRV QGTLNRPTSV RIPQWIVDSN VEVYYKPNVE
1060 1070 1080 1090 1100
QYEAIFELNL YNNYKMEKNY EKVYKKHNGR RYLEAEPEYD EEEHREQITK
1110 1120 1130 1140 1150
KFEWLQNEKV YQHVAKFEIK PEVVKMEVEA VCNNDFHFCK TQIRGEELKA
1160 1170 1180 1190 1200
TIQYVYPQTP RTVEELKEQK YRQLVVMGEM NYGENTIHIN INGQQSQEQK
1210 1220 1230 1240 1250
KFVKQIEQAP EHETLLEASR LDQYQTVVEY EFEPKPAQYF ARYWNMVQAY
1260 1270 1280 1290 1300
LRTQYPWTSR IETREEPSRK NMIRATINVE PRQRLTVNMT IETPMETTVL
1310 1320 1330 1340 1350
ERVELPFRLP TAQIHYQPRN SRYEQKPVME KIAHHASKQA NCVVKSTKIN
1360 1370 1380 1390 1400
TFDQVAYRNQ FTPCYSVLAK DCGSEKSEPR FVVLMKKINE KKEWKNVKVV
1410 1420 1430 1440 1450
YGENEIEMYK TEEGLICRVN GEEIEYQPES EIEKKQYNII WLNKNTLKFD
1460 1470 1480 1490 1500
SDDVTVQFDG VNARIHLSAL YRNQQCGLCG HYDNEKETEF YDAENQENTI
1510 1520 1530 1540 1550
PKFAKSYLYK DSKCNYEREM FEKEENFQRI EKNQEEEKDQ EMNYEESRRE
1560 1570 1580 1590 1600
QDDEPTEQVA IVERQHEICF TQKPVLRCQN GKSQESKKQK VTSVYCLPSS
1610 1620 1630 1640 1650
NSWARRQMRE IRREPLAQWP EHKLRNLRDQ PQMEERTVRV AVDQKCDKFD

Y
Note: No experimental confirmation available.
Length:1,651
Mass (Da):193,318
Last modified:September 5, 2006 - v5
Checksum:iCD9D49B72546611C
GO
Isoform a (identifier: P18948-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1591-1591: Missing.

Show »
Length:1,650
Mass (Da):193,219
Checksum:i8258153500C48673
GO
Isoform b (identifier: P18948-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-1637: Missing.

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):23,468
Checksum:i083A570F9FB3057E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231N → F in CAA39670 (PubMed:1904098).Curated
Sequence conflicti23 – 231N → F in AAA28165 (PubMed:3841791).Curated
Sequence conflicti23 – 231N → F in CAA26533 (PubMed:4022780).Curated
Sequence conflicti206 – 2061E → K in CAA39670 (PubMed:1904098).Curated
Sequence conflicti206 – 2061E → K in AAA28165 (PubMed:3841791).Curated
Sequence conflicti215 – 2151F → L in CAA39670 (PubMed:1904098).Curated
Sequence conflicti215 – 2151F → L in AAA28165 (PubMed:3841791).Curated
Sequence conflicti371 – 3711A → P in CAA39670 (PubMed:1904098).Curated
Sequence conflicti417 – 4171A → R in CAA39670 (PubMed:1904098).Curated
Sequence conflicti634 – 6341N → D in CAA39670 (PubMed:1904098).Curated
Sequence conflicti1623 – 16242KL → NV in CAA39670 (PubMed:1904098).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei188 – 16371450Missing in isoform b. CuratedVSP_020106Add
BLAST
Alternative sequencei1591 – 15911Missing in isoform a. CuratedVSP_020107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56213 Genomic DNA. Translation: CAA39670.1.
FO081300 Genomic DNA. Translation: CCD70603.1.
FO081300 Genomic DNA. Translation: CCD70604.1.
FO081300 Genomic DNA. Translation: CCD70605.1.
M11499 Genomic DNA. Translation: AAA28165.1.
X02756 Genomic DNA. Translation: CAA26533.1.
PIRiB43081.
F88750.
RefSeqiNP_001023274.1. NM_001028103.2. [P18948-2]
NP_001023275.1. NM_001028104.5. [P18948-3]
NP_001023276.1. NM_001028105.3. [P18948-1]
UniGeneiCel.12248.

Genome annotation databases

EnsemblMetazoaiK07H8.6c; K07H8.6c; WBGene00006930. [P18948-1]
GeneIDi177619.
KEGGicel:CELE_K07H8.6.
UCSCiK07H8.6b. c. elegans. [P18948-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56213 Genomic DNA. Translation: CAA39670.1.
FO081300 Genomic DNA. Translation: CCD70603.1.
FO081300 Genomic DNA. Translation: CCD70604.1.
FO081300 Genomic DNA. Translation: CCD70605.1.
M11499 Genomic DNA. Translation: AAA28165.1.
X02756 Genomic DNA. Translation: CAA26533.1.
PIRiB43081.
F88750.
RefSeqiNP_001023274.1. NM_001028103.2. [P18948-2]
NP_001023275.1. NM_001028104.5. [P18948-3]
NP_001023276.1. NM_001028105.3. [P18948-1]
UniGeneiCel.12248.

3D structure databases

ProteinModelPortaliP18948.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42732. 5 interactions.
IntActiP18948. 5 interactions.
MINTiMINT-212008.
STRINGi6239.K07H8.6c.

2D gel databases

World-2DPAGE0011:P18948.

Proteomic databases

EPDiP18948.
PaxDbiP18948.
PRIDEiP18948.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK07H8.6c; K07H8.6c; WBGene00006930. [P18948-1]
GeneIDi177619.
KEGGicel:CELE_K07H8.6.
UCSCiK07H8.6b. c. elegans. [P18948-1]

Organism-specific databases

CTDi177619.
WormBaseiK07H8.6a; CE28594; WBGene00006930; vit-6.
K07H8.6b; CE34921; WBGene00006930; vit-6.
K07H8.6c; CE18026; WBGene00006930; vit-6.

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
GeneTreeiENSGT00530000064273.
HOGENOMiHOG000004768.
InParanoidiP18948.
OMAiNTVRMQL.
OrthoDBiEOG7T4MJ8.
PhylomeDBiP18948.

Miscellaneous databases

NextBioi897632.
PROiP18948.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Vitellogenin motifs conserved in nematodes and vertebrates."
    Spieth J., Nettleton M., Zucker-Aprison E., Lea K., Blumenthal T.
    J. Mol. Evol. 32:429-438(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM A).
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  3. "The Caenorhabditis elegans vitellogenin gene family includes a gene encoding a distantly related protein."
    Spieth J., Blumenthal T.
    Mol. Cell. Biol. 5:2495-2501(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-259.
  4. "The C. elegans vitellogenin genes: short sequence repeats in the promoter regions and homology to the vertebrate genes."
    Spieth J., Denison K., Kirtland S., Cane J., Blumenthal T.
    Nucleic Acids Res. 13:5283-5295(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
  5. "Vitellogenin-6 is a major carbonylated protein in aged nematode, Caenorhabditis elegans."
    Nakamura A., Yasuda K., Adachi H., Sakurai Y., Ishii N., Goto S.
    Biochem. Biophys. Res. Commun. 264:580-583(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 779-780 AND 1220-1232.
  6. "Identification of the hydrophobic glycoproteins of Caenorhabditis elegans."
    Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H., Mahuran D.J.
    Glycobiology 15:952-964(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-252 AND ASN-1288, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1288, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiVIT6_CAEEL
AccessioniPrimary (citable) accession number: P18948
Secondary accession number(s): O45176, Q7KPP7, Q7YXH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: September 5, 2006
Last modified: May 11, 2016
This is version 119 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.