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Protein

Vitellogenin-4

Gene

vit-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin-4
Gene namesi
Name:vit-4
ORF Names:F59D8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF59D8.2; CE26817; WBGene00006928; vit-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 16031588Vitellogenin-4PRO_0000041535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1266 – 12661N-linked (GlcNAc...)2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP18947.
PaxDbiP18947.
PRIDEiP18947.

Expressioni

Tissue specificityi

Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

Gene expression databases

BgeeiWBGene00006928.

Interactioni

Protein-protein interaction databases

STRINGi6239.F59D8.2.

Structurei

3D structure databases

ProteinModelPortaliP18947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 685662VitellogeninPROSITE-ProRule annotationAdd
BLAST
Domaini1306 – 1507202VWFDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
GeneTreeiENSGT00530000064273.
HOGENOMiHOG000004768.
InParanoidiP18947.
OMAiVECEVEN.
OrthoDBiEOG091G00HR.
PhylomeDBiP18947.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSIIIASLV ALAIAASPAL DRTFSPKSEY VYKFDGLLLS GLPTTFSDAS
60 70 80 90 100
QTLISCRTRL QAVDDRYIHL QLIDIQYSAS HIPQSEQWPK IESLEQRELS
110 120 130 140 150
DELKELLELP FRAQIRNGLV SEIQFSSEDA EWSKNAKRSI LNLFSLRKSA
160 170 180 190 200
PVDEMSQDQK DMESDKDSLF FNVHEKTMEG DCEVAYTIVQ EGGKTIYTKS
210 220 230 240 250
VNFDKCITRP ETAYGLRFGS ECKECEKEGQ FVQPQTVYTY TFKNEKLQES
260 270 280 290 300
EVNSIYTLNV NGQEVVKSET RAKVTFVEES KINREIKKVS GPKEEIVYSM
310 320 330 340 350
ENEKLIEQFY KQGDKAEVNP FKAIEIEQKV EQLEEIFRQI QEHEQNTPET
360 370 380 390 400
VHLIARAVRM FRMCTIEELK KVHTTIYTKA EKKVQLVIET TLAVAGTKNT
410 420 430 440 450
IQHLIHHFEK KSITPLRAAE LLKSVQETLY PSEHIADLLI QLAQSPLSEK
460 470 480 490 500
YEPLRQSAWL AAGSVVRGFA SKTQDLPLIR PASRQTKEKY VRVFMQHFRN
510 520 530 540 550
ADSTYEKVLA LKTLGNAGID LSVYELVQLI QDPRQPLSIR TEAVDALRLL
560 570 580 590 600
KDVMPRKIQK VLLPVYKNRQ NKPELRMAAL WRMMHTIPEE PVLAHIVSQM
610 620 630 640 650
ENESNQHVAA FTYNVLRQFS KSTNPCYQQL AVRCSKVLLF TRYQPQEQML
660 670 680 690 700
STYSQLPLFN SEWLSGVQFD FATIFEKNAF LPKEVQASFE TVFGGNWNKY
710 720 730 740 750
FAQVGFSQQN FEQVILKTLE KLSLYGKQSD ELRSRRVQSG IQMLQEIVKK
760 770 780 790 800
MNIRPRVQQT DSQNAHAVFY LRYKEMDYIV LPIDMETIDN VVEKYVRNGE
810 820 830 840 850
FDIKSLLTFL TNDSKFELHR ALFFYEAERR IPTTIGMPLT ISGKMPTILS
860 870 880 890 900
INGKVSIELE KLGARLVLDI VPTVATTHVT EMRFWYPVIE QGVKSLQSAR
910 920 930 940 950
LHTPLRFEST VELKKNTLEI THKFVVPENK KTTVSVHTRP VAFIRVPKNQ
960 970 980 990 1000
DSEYVEAEEK TISHSQYQMS TEEIDRQYET FGLRINAQGN VLSQWTLPMV
1010 1020 1030 1040 1050
LMTEQDFEFT LENKNRPVEF TARVTIGNLE KTDLSEIKFD KIFEKEFDLE
1060 1070 1080 1090 1100
NNESENRRQY FHKMIREIQS EQGFKNLITL KLEAPQQMYW NTELRTVCDK
1110 1120 1130 1140 1150
WIRMCKVEMD ARRSPIEHEN KEWTLRTELL AARPQMPSSL RQLREQPHRE
1160 1170 1180 1190 1200
VQLALNAKWG SSKKSEITFN AQLEQSTEQK KFLRNIEREY KGIPEYELLI
1210 1220 1230 1240 1250
KAARLNQVNV VSEYKLTPES EYTFSRIFDL IKAYNFWTVS EKRVQNEDRR
1260 1270 1280 1290 1300
VVLQLSVEPL SRQYMNMTIQ TPEQEVELKN VRIPRVVLPT IARRAMFQQT
1310 1320 1330 1340 1350
WEKTGATCKV DQSEVSTFDN VIYRAPLTTC YSLVAKDCSE QPRFAVLAKK
1360 1370 1380 1390 1400
INKNSEELLV KVVRREEEIV VKKSDDKFLV KVDGKKVNPT ELEQYNIEIL
1410 1420 1430 1440 1450
GDNLIVIRLP HGEVRFDGYT VKTNMPSVAS QNQLCGLCGN NDGERDNEFM
1460 1470 1480 1490 1500
TADNYETEDV EEFHRSYLLK NEECEVEKDR ISEKKNYKNK WNREEKKSDY
1510 1520 1530 1540 1550
ESSSDYESNY DEKETEKELV KKTLIKEFSN RVCFSIEPVS ECRRGLESEK
1560 1570 1580 1590 1600
TSNKKIRFTC MPRHSKNARR FLKEAREQTV ADLVDFPVSF VESVKIPTAC

VAY
Length:1,603
Mass (Da):186,309
Last modified:March 28, 2003 - v3
Checksum:iE303170325BC99BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1691L → V in AAA28163 (Ref. 2) Curated
Sequence conflicti183 – 1875EVAYT → RSRLH in AAA28163 (Ref. 2) Curated
Sequence conflicti275 – 2751T → S in AAA28163 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081486 Genomic DNA. Translation: CCD71958.1.
M11498 Genomic DNA. Translation: AAA28163.1.
X02754 Genomic DNA. Translation: CAA26531.1.
PIRiA43084.
RefSeqiNP_508612.1. NM_076211.5.
UniGeneiCel.21335.

Genome annotation databases

EnsemblMetazoaiF59D8.2; F59D8.2; WBGene00006928.
GeneIDi180646.
KEGGicel:CELE_F59D8.2.
UCSCiF59D8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081486 Genomic DNA. Translation: CCD71958.1.
M11498 Genomic DNA. Translation: AAA28163.1.
X02754 Genomic DNA. Translation: CAA26531.1.
PIRiA43084.
RefSeqiNP_508612.1. NM_076211.5.
UniGeneiCel.21335.

3D structure databases

ProteinModelPortaliP18947.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F59D8.2.

Proteomic databases

EPDiP18947.
PaxDbiP18947.
PRIDEiP18947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59D8.2; F59D8.2; WBGene00006928.
GeneIDi180646.
KEGGicel:CELE_F59D8.2.
UCSCiF59D8.2. c. elegans.

Organism-specific databases

CTDi180646.
WormBaseiF59D8.2; CE26817; WBGene00006928; vit-4.

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
GeneTreeiENSGT00530000064273.
HOGENOMiHOG000004768.
InParanoidiP18947.
OMAiVECEVEN.
OrthoDBiEOG091G00HR.
PhylomeDBiP18947.

Miscellaneous databases

PROiP18947.

Gene expression databases

BgeeiWBGene00006928.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIT4_CAEEL
AccessioniPrimary (citable) accession number: P18947
Secondary accession number(s): Q9BPP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 28, 2003
Last modified: September 7, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.