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Protein

Cytochrome b

Gene

MT-CYB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.By similarity

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Caution

The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.4 Publications

Cofactori

heme4 PublicationsNote: Binds 2 heme groups non-covalently.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Iron 1 (heme b562 axial ligand)PROSITE-ProRule annotationCombined sources4 Publications1
Metal bindingi98Iron 2 (heme b566 axial ligand)Combined sources4 Publications1
Metal bindingi183Iron 1 (heme b562 axial ligand)Combined sources4 Publications1
Metal bindingi197Iron 2 (heme b566 axial ligand)Combined sources4 Publications1
Binding sitei202UbiquinoneCombined sources3 Publications1

GO - Molecular functioni

  • heme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • ubiquinol-cytochrome-c reductase activity Source: InterPro

GO - Biological processi

  • mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
  • respiratory electron transport chain Source: AgBase
  • response to oxidative stress Source: AgBase

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding, Ubiquinone

Enzyme and pathway databases

ReactomeiR-GGA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene namesi
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded oniMitochondrion
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalCombined sources4 PublicationsAdd BLAST21
Transmembranei78 – 99HelicalCombined sources4 PublicationsAdd BLAST22
Transmembranei114 – 134HelicalCombined sources4 PublicationsAdd BLAST21
Transmembranei179 – 199HelicalCombined sources4 PublicationsAdd BLAST21
Transmembranei227 – 247HelicalCombined sources4 PublicationsAdd BLAST21
Transmembranei289 – 309HelicalCombined sources4 PublicationsAdd BLAST21
Transmembranei321 – 341HelicalCombined sources4 PublicationsAdd BLAST21
Transmembranei348 – 368HelicalCombined sources4 PublicationsAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000607761 – 380Cytochrome bAdd BLAST380

Proteomic databases

PaxDbiP18946

Expressioni

Gene expression databases

BgeeiENSGALG00000018360
ExpressionAtlasiP18946 baseline and differential

Interactioni

Subunit structurei

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.4 Publications

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034623

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni5 – 7Combined sources3
Helixi12 – 19Combined sources8
Beta strandi23 – 25Combined sources3
Helixi30 – 32Combined sources3
Helixi34 – 53Combined sources20
Turni60 – 62Combined sources3
Helixi63 – 73Combined sources11
Helixi77 – 104Combined sources28
Helixi107 – 109Combined sources3
Helixi111 – 133Combined sources23
Helixi138 – 148Combined sources11
Helixi149 – 153Combined sources5
Beta strandi154 – 156Combined sources3
Helixi157 – 166Combined sources10
Beta strandi168 – 171Combined sources4
Helixi173 – 204Combined sources32
Helixi215 – 217Combined sources3
Beta strandi218 – 220Combined sources3
Helixi221 – 246Combined sources26
Beta strandi250 – 252Combined sources3
Helixi254 – 257Combined sources4
Helixi273 – 275Combined sources3
Helixi276 – 284Combined sources9
Beta strandi285 – 287Combined sources3
Helixi288 – 300Combined sources13
Helixi301 – 303Combined sources3
Helixi305 – 307Combined sources3
Beta strandi312 – 316Combined sources5
Helixi320 – 341Combined sources22
Helixi348 – 364Combined sources17
Helixi366 – 377Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16C1-380[»]
1LLYmodel-A1-380[»]
2BCCX-ray3.50C1-380[»]
3BCCX-ray3.70C1-380[»]
3CWBX-ray3.51C/P1-380[»]
3H1HX-ray3.16C/P1-380[»]
3H1IX-ray3.53C/P1-380[»]
3H1JX-ray3.00C/P1-380[»]
3H1KX-ray3.48C/P1-380[»]
3H1LX-ray3.21C/P1-380[»]
3L70X-ray2.75C/P1-380[»]
3L71X-ray2.84C/P1-380[»]
3L72X-ray3.06C/P1-380[»]
3L73X-ray3.04C/P1-380[»]
3L74X-ray2.76C/P1-380[»]
3L75X-ray2.79C/P1-380[»]
3TGUX-ray2.70C/P1-380[»]
4U3FX-ray3.23C/P2-380[»]
ProteinModelPortaliP18946
SMRiP18946
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18946

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4663 Eukaryota
COG1290 LUCA
GeneTreeiENSGT00390000017948
HOGENOMiHOG000255206
HOVERGENiHBG017694
InParanoidiP18946
KOiK00412
OMAiHETGSNN
OrthoDBiEOG091G0DW4
PhylomeDBiP18946
TreeFamiTF353088

Family and domain databases

CDDicd00290 cytochrome_b_C, 1 hit
cd00284 Cytochrome_b_N, 1 hit
Gene3Di1.20.810.10, 1 hit
InterProiView protein in InterPro
IPR005798 Cyt_b/b6_C
IPR036150 Cyt_b/b6_C_sf
IPR005797 Cyt_b/b6_N
IPR027387 Cytb/b6-like_sf
IPR030689 Cytochrome_b
IPR016174 Di-haem_cyt_TM
PfamiView protein in Pfam
PF00032 Cytochrom_B_C, 1 hit
PF00033 Cytochrome_B, 1 hit
PIRSFiPIRSF038885 COB, 1 hit
SUPFAMiSSF81342 SSF81342, 1 hit
SSF81648 SSF81648, 1 hit
PROSITEiView protein in PROSITE
PS51003 CYTB_CTER, 1 hit
PS51002 CYTB_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P18946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNIRKSHP LLKMINNSLI DLPAPSNISA WWNFGSLLAV CLMTQILTGL
60 70 80 90 100
LLAMHYTADT SLAFSSVAHT CRNVQYGWLI RNLHANGASF FFICIFLHIG
110 120 130 140 150
RGLYYGSYLY KETWNTGVIL LLTLMATAFV GYVLPWGQMS FWGATVITNL
160 170 180 190 200
FSAIPYIGHT LVEWAWGGFS VDNPTLTRFF ALHFLLPFAI AGITIIHLTF
210 220 230 240 250
LHESGSNNPL GISSDSDKIP FHPYYSFKDI LGLTLMLTPF LTLALFSPNL
260 270 280 290 300
LGDPENFTPA NPLVTPPHIK PEWYFLFAYA ILRSIPNKLG GVLALAASVL
310 320 330 340 350
ILFLIPFLHK SKQRTMTFRP LSQTLFWLLV ANLLILTWIG SQPVEHPFII
360 370 380
IGQMASLSYF TILLILFPTI GTLENKMLNY
Length:380
Mass (Da):42,592
Last modified:November 1, 1990 - v1
Checksum:iD2D4496EC294D77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52392 Genomic DNA Translation: CAA36636.1
L08376 Genomic DNA Translation: AAA18844.1
PIRiS10198
RefSeqiNP_006926.1, NC_001323.1

Genome annotation databases

EnsembliENSGALT00000053400; ENSGALP00000049893; ENSGALG00000032079
GeneIDi807641
KEGGigga:807641

Similar proteinsi

Entry informationi

Entry nameiCYB_CHICK
AccessioniPrimary (citable) accession number: P18946
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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