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P18946 (CYB_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene names
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded onMitochondrion
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Sequence similarities

Belongs to the cytochrome b family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Cytochrome b
PRO_0000060776

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane324 – 34421Helical; Potential
Transmembrane347 – 36721Helical; Potential

Sites

Metal binding841Iron 1 (heme b562 axial ligand)
Metal binding981Iron 2 (heme b566 axial ligand)
Metal binding1831Iron 1 (heme b562 axial ligand)
Metal binding1971Iron 2 (heme b566 axial ligand)

Secondary structure

1 .................................................... 380
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18946 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: D2D4496EC294D77A

FASTA38042,592
        10         20         30         40         50         60 
MAPNIRKSHP LLKMINNSLI DLPAPSNISA WWNFGSLLAV CLMTQILTGL LLAMHYTADT 

        70         80         90        100        110        120 
SLAFSSVAHT CRNVQYGWLI RNLHANGASF FFICIFLHIG RGLYYGSYLY KETWNTGVIL 

       130        140        150        160        170        180 
LLTLMATAFV GYVLPWGQMS FWGATVITNL FSAIPYIGHT LVEWAWGGFS VDNPTLTRFF 

       190        200        210        220        230        240 
ALHFLLPFAI AGITIIHLTF LHESGSNNPL GISSDSDKIP FHPYYSFKDI LGLTLMLTPF 

       250        260        270        280        290        300 
LTLALFSPNL LGDPENFTPA NPLVTPPHIK PEWYFLFAYA ILRSIPNKLG GVLALAASVL 

       310        320        330        340        350        360 
ILFLIPFLHK SKQRTMTFRP LSQTLFWLLV ANLLILTWIG SQPVEHPFII IGQMASLSYF 

       370        380 
TILLILFPTI GTLENKMLNY

« Hide

References

[1]"Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
Desjardins P., Morais R.
J. Mol. Biol. 212:599-634(1990) [PubMed: 2329578] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Pathways of lysozyme evolution inferred from the sequences of cytochrome b in birds."
Kornegay J.R., Kocher T.D., Williams L.A., Wilson A.C.
J. Mol. Evol. 37:367-379(1993) [PubMed: 8308906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X52392 Genomic DNA. Translation: CAA36636.1.
L08376 Genomic DNA. Translation: AAA18844.1.
IPIIPI00593043.
PIRS10198.
RefSeqNP_006926.1. NC_001323.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16C1-380[»]
1LLYmodel-A1-380[»]
2BCCX-ray3.50C1-380[»]
3BCCX-ray3.70C1-380[»]
3CWBX-ray3.51C/P1-380[»]
3H1HX-ray3.16C/P1-380[»]
3H1IX-ray3.53C/P1-380[»]
3H1JX-ray3.00C/P1-380[»]
3H1KX-ray3.48C/P1-380[»]
3H1LX-ray3.21C/P1-380[»]
3L70X-ray2.75C/P1-380[»]
3L71X-ray2.84C/P1-380[»]
3L72X-ray3.06C/P1-380[»]
3L73X-ray3.04C/P1-380[»]
3L74X-ray2.76C/P1-380[»]
3L75X-ray2.79C/P1-380[»]
ProteinModelPortalP18946.
SMRP18946. Positions 1-380.
ModBaseSearch...

Protein-protein interaction databases

STRINGP18946.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000029080; ENSGALP00000034623; ENSGALG00000018360.
GeneID807641.
KEGGgga:807641.

Organism-specific databases

CTD4519.

Phylogenomic databases

HOGENOMHBG487932.
HOVERGENHBG017694.
InParanoidP18946.
OrthoDBEOG4Q84XW.
PhylomeDBP18946.
ProtClustDBMTH00119.

Family and domain databases

InterProIPR016175. Cyt_b/b6.
IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
Gene3DG3DSA:1.20.810.10. Cytochrome_b/b6. 1 hit.
KOK00412.
PANTHERPTHR19271. Cytochrome_b/b6. 1 hit.
PfamPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrom_B_N. 1 hit.
[Graphical view]
SUPFAMSSF81648. Cytochrome_b/b6_C. 1 hit.
SSF81342. Transmembr_di-haem_cytochrome. 1 hit.
PROSITEPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYB_CHICK
AccessionPrimary (citable) accession number: P18946
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 16, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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