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Protein

Cytochrome b

Gene

MT-CYB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Iron 1 (heme b562 axial ligand)
Metal bindingi98 – 981Iron 2 (heme b566 axial ligand)
Metal bindingi183 – 1831Iron 1 (heme b562 axial ligand)
Metal bindingi197 – 1971Iron 2 (heme b566 axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene namesi
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded oniMitochondrion
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Cytochrome bPRO_0000060776Add
BLAST

Proteomic databases

PaxDbiP18946.

Expressioni

Gene expression databases

ExpressionAtlasiP18946. baseline.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034623.

Structurei

Secondary structure

1
380
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 73Combined sources
Helixi12 – 198Combined sources
Beta strandi23 – 253Combined sources
Helixi30 – 323Combined sources
Helixi34 – 5320Combined sources
Turni60 – 623Combined sources
Helixi63 – 7311Combined sources
Helixi77 – 10428Combined sources
Helixi107 – 1093Combined sources
Helixi111 – 13323Combined sources
Helixi138 – 14811Combined sources
Helixi149 – 1535Combined sources
Beta strandi154 – 1563Combined sources
Helixi157 – 16610Combined sources
Beta strandi168 – 1714Combined sources
Helixi173 – 20432Combined sources
Helixi215 – 2173Combined sources
Beta strandi218 – 2203Combined sources
Helixi221 – 24626Combined sources
Beta strandi250 – 2523Combined sources
Helixi254 – 2574Combined sources
Helixi273 – 2753Combined sources
Helixi276 – 2849Combined sources
Beta strandi285 – 2873Combined sources
Helixi288 – 30013Combined sources
Helixi301 – 3033Combined sources
Helixi305 – 3073Combined sources
Beta strandi312 – 3165Combined sources
Helixi320 – 34122Combined sources
Helixi348 – 36417Combined sources
Helixi366 – 37712Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16C1-380[»]
1LLYmodel-A1-380[»]
2BCCX-ray3.50C1-380[»]
3BCCX-ray3.70C1-380[»]
3CWBX-ray3.51C/P1-380[»]
3H1HX-ray3.16C/P1-380[»]
3H1IX-ray3.53C/P1-380[»]
3H1JX-ray3.00C/P1-380[»]
3H1KX-ray3.48C/P1-380[»]
3H1LX-ray3.21C/P1-380[»]
3L70X-ray2.75C/P1-380[»]
3L71X-ray2.84C/P1-380[»]
3L72X-ray3.06C/P1-380[»]
3L73X-ray3.04C/P1-380[»]
3L74X-ray2.76C/P1-380[»]
3L75X-ray2.79C/P1-380[»]
3TGUX-ray2.70C/P1-380[»]
4U3FX-ray3.23C/P2-380[»]
ProteinModelPortaliP18946.
SMRiP18946. Positions 1-380.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18946.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4663. Eukaryota.
COG1290. LUCA.
HOGENOMiHOG000255206.
HOVERGENiHBG017694.
InParanoidiP18946.
KOiK00412.
OMAiFFFVAVY.
OrthoDBiEOG7BGHKX.
PhylomeDBiP18946.
TreeFamiTF353088.

Family and domain databases

Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNIRKSHP LLKMINNSLI DLPAPSNISA WWNFGSLLAV CLMTQILTGL
60 70 80 90 100
LLAMHYTADT SLAFSSVAHT CRNVQYGWLI RNLHANGASF FFICIFLHIG
110 120 130 140 150
RGLYYGSYLY KETWNTGVIL LLTLMATAFV GYVLPWGQMS FWGATVITNL
160 170 180 190 200
FSAIPYIGHT LVEWAWGGFS VDNPTLTRFF ALHFLLPFAI AGITIIHLTF
210 220 230 240 250
LHESGSNNPL GISSDSDKIP FHPYYSFKDI LGLTLMLTPF LTLALFSPNL
260 270 280 290 300
LGDPENFTPA NPLVTPPHIK PEWYFLFAYA ILRSIPNKLG GVLALAASVL
310 320 330 340 350
ILFLIPFLHK SKQRTMTFRP LSQTLFWLLV ANLLILTWIG SQPVEHPFII
360 370 380
IGQMASLSYF TILLILFPTI GTLENKMLNY
Length:380
Mass (Da):42,592
Last modified:November 1, 1990 - v1
Checksum:iD2D4496EC294D77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52392 Genomic DNA. Translation: CAA36636.1.
L08376 Genomic DNA. Translation: AAA18844.1.
PIRiS10198.
RefSeqiNP_006926.1. NC_001323.1.

Genome annotation databases

EnsembliENSGALT00000029080; ENSGALP00000034623; ENSGALG00000018360.
GeneIDi807641.
KEGGigga:807641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52392 Genomic DNA. Translation: CAA36636.1.
L08376 Genomic DNA. Translation: AAA18844.1.
PIRiS10198.
RefSeqiNP_006926.1. NC_001323.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16C1-380[»]
1LLYmodel-A1-380[»]
2BCCX-ray3.50C1-380[»]
3BCCX-ray3.70C1-380[»]
3CWBX-ray3.51C/P1-380[»]
3H1HX-ray3.16C/P1-380[»]
3H1IX-ray3.53C/P1-380[»]
3H1JX-ray3.00C/P1-380[»]
3H1KX-ray3.48C/P1-380[»]
3H1LX-ray3.21C/P1-380[»]
3L70X-ray2.75C/P1-380[»]
3L71X-ray2.84C/P1-380[»]
3L72X-ray3.06C/P1-380[»]
3L73X-ray3.04C/P1-380[»]
3L74X-ray2.76C/P1-380[»]
3L75X-ray2.79C/P1-380[»]
3TGUX-ray2.70C/P1-380[»]
4U3FX-ray3.23C/P2-380[»]
ProteinModelPortaliP18946.
SMRiP18946. Positions 1-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034623.

Proteomic databases

PaxDbiP18946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000029080; ENSGALP00000034623; ENSGALG00000018360.
GeneIDi807641.
KEGGigga:807641.

Organism-specific databases

CTDi4519.

Phylogenomic databases

eggNOGiKOG4663. Eukaryota.
COG1290. LUCA.
HOGENOMiHOG000255206.
HOVERGENiHBG017694.
InParanoidiP18946.
KOiK00412.
OMAiFFFVAVY.
OrthoDBiEOG7BGHKX.
PhylomeDBiP18946.
TreeFamiTF353088.

Enzyme and pathway databases

ReactomeiR-GGA-611105. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTraceiP18946.
PROiP18946.

Gene expression databases

ExpressionAtlasiP18946. baseline.

Family and domain databases

Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
    Desjardins P., Morais R.
    J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. "Pathways of lysozyme evolution inferred from the sequences of cytochrome b in birds."
    Kornegay J.R., Kocher T.D., Williams L.A., Wilson A.C.
    J. Mol. Evol. 37:367-379(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiCYB_CHICK
AccessioniPrimary (citable) accession number: P18946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.