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P18945 (COX3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded onMitochondrion
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183757

Regions

Transmembrane15 – 3521Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane233 – 25321Helical; Potential

Secondary structure

.................... 261
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18945 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: E326CB937B123BC8

FASTA26129,625
        10         20         30         40         50         60 
MAHQAHSYHM VDPSPWPIFG AAAALLTTSG LIMWFHYSST TLLTMGLLSM LLVMLQWWRD 

        70         80         90        100        110        120 
VVRESTFQGH HTPTVQKGLR YGMILFITSE AFFFLGFFWA FFHSSLAPTP ELGGQWPPTG 

       130        140        150        160        170        180 
VKPLNPLEVP LLNTAILLAS GVTVTWAHHS ITEGNRKQAI HALTLTILLG FYFTALQAME 

       190        200        210        220        230        240 
YHEASFSIAD SVYGSTFFVA TGFHGLHVII GSSFLTVCLL RLIKFHFTPN HHFGFEAAAW 

       250        260 
YWHFVDIIWL FLYMSMYWWG S 

« Hide

References

[1]"Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
Desjardins P., Morais R.
J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: White leghorn.
[2]"Mitochondrial DNA replication and transcription are dissociated during embryonic cardiac hypertrophy."
Kennedy J.M., Lobacz S.R., Kelley S.W.
Am. J. Physiol. 261:C1091-C1098(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52392 Genomic DNA. Translation: CAA36631.1.
PIRS10193.
RefSeqNP_006921.2. NC_001323.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LLKmodel-A1-261[»]
ProteinModelPortalP18945.
SMRP18945. Positions 1-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000029087; ENSGALP00000034618; ENSGALG00000018367.
GeneID807637.
KEGGgga:807637.

Organism-specific databases

CTD4514.

Phylogenomic databases

eggNOGCOG1845.
HOVERGENHBG016686.
InParanoidP18945.
KOK02262.
OMAFFWAFYH.
ProtClustDBMTH00118.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20934096.
PROP18945.

Entry information

Entry nameCOX3_CHICK
AccessionPrimary (citable) accession number: P18945
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references