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P18945

- COX3_CHICK

UniProt

P18945 - COX3_CHICK

Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro
    2. respiratory chain complex IV assembly Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:MT-CO3
    Synonyms:COIII, COXIII, MTCO3
    Encoded oniMitochondrion
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183757Add
    BLAST

    Structurei

    Secondary structure

    1
    261
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 3722
    Helixi41 – 6525
    Helixi73 – 10634
    Helixi110 – 1123
    Beta strandi114 – 1174
    Helixi129 – 15325
    Helixi156 – 18328
    Helixi192 – 22332
    Helixi233 – 25523
    Turni256 – 2605

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LLKmodel-A1-261[»]
    ProteinModelPortaliP18945.
    SMRiP18945. Positions 1-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    HOVERGENiHBG016686.
    InParanoidiP18945.
    KOiK02262.
    OMAiYFVPGPS.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHQAHSYHM VDPSPWPIFG AAAALLTTSG LIMWFHYSST TLLTMGLLSM    50
    LLVMLQWWRD VVRESTFQGH HTPTVQKGLR YGMILFITSE AFFFLGFFWA 100
    FFHSSLAPTP ELGGQWPPTG VKPLNPLEVP LLNTAILLAS GVTVTWAHHS 150
    ITEGNRKQAI HALTLTILLG FYFTALQAME YHEASFSIAD SVYGSTFFVA 200
    TGFHGLHVII GSSFLTVCLL RLIKFHFTPN HHFGFEAAAW YWHFVDIIWL 250
    FLYMSMYWWG S 261
    Length:261
    Mass (Da):29,625
    Last modified:November 1, 1990 - v1
    Checksum:iE326CB937B123BC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52392 Genomic DNA. Translation: CAA36631.1.
    PIRiS10193.
    RefSeqiNP_006921.2. NC_001323.1.

    Genome annotation databases

    EnsembliENSGALT00000029087; ENSGALP00000034618; ENSGALG00000018367.
    GeneIDi807637.
    KEGGigga:807637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52392 Genomic DNA. Translation: CAA36631.1 .
    PIRi S10193.
    RefSeqi NP_006921.2. NC_001323.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LLK model - A 1-261 [» ]
    ProteinModelPortali P18945.
    SMRi P18945. Positions 1-261.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000029087 ; ENSGALP00000034618 ; ENSGALG00000018367 .
    GeneIDi 807637.
    KEGGi gga:807637.

    Organism-specific databases

    CTDi 4514.

    Phylogenomic databases

    eggNOGi COG1845.
    HOVERGENi HBG016686.
    InParanoidi P18945.
    KOi K02262.
    OMAi YFVPGPS.

    Miscellaneous databases

    NextBioi 20934096.
    PROi P18945.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
      Desjardins P., Morais R.
      J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: White leghorn.
    2. "Mitochondrial DNA replication and transcription are dissociated during embryonic cardiac hypertrophy."
      Kennedy J.M., Lobacz S.R., Kelley S.W.
      Am. J. Physiol. 261:C1091-C1098(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX3_CHICK
    AccessioniPrimary (citable) accession number: P18945
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3