P18945 (COX3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	MT-CO3
Synonyms:	COIII, COXIII, MTCO3

Encoded on

Mitochondrion

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 261

261

Cytochrome c oxidase subunit 3

PRO_0000183757

Regions

Transmembrane

15 – 35

21

Helical; Potential

Transmembrane

38 – 58

21

Helical; Potential

Transmembrane

82 – 102

21

Helical; Potential

Transmembrane

127 – 147

21

Helical; Potential

Transmembrane

159 – 179

21

Helical; Potential

Transmembrane

197 – 217

21

Helical; Potential

Transmembrane

233 – 253

21

Helical; Potential

Secondary structure

1

.

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.

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.

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.

.

.

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261

Helix Strand Turn

Details...

Helix

16 – 37

22

Helix

41 – 65

25

Helix

73 – 106

34

Helix

110 – 112

3

Beta strand

114 – 117

4

Helix

129 – 153

25

Helix

156 – 183

28

Helix

192 – 223

32

Helix

233 – 255

23

Turn

256 – 260

5

Sequences

	Sequence		Length	Mass (Da)
	P18945 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: E326CB937B123BC8	FASTA	261	29,625
	10 20 30 40 50 60 MAHQAHSYHM VDPSPWPIFG AAAALLTTSG LIMWFHYSST TLLTMGLLSM LLVMLQWWRD 70 80 90 100 110 120 VVRESTFQGH HTPTVQKGLR YGMILFITSE AFFFLGFFWA FFHSSLAPTP ELGGQWPPTG 130 140 150 160 170 180 VKPLNPLEVP LLNTAILLAS GVTVTWAHHS ITEGNRKQAI HALTLTILLG FYFTALQAME 190 200 210 220 230 240 YHEASFSIAD SVYGSTFFVA TGFHGLHVII GSSFLTVCLL RLIKFHFTPN HHFGFEAAAW 250 260 YWHFVDIIWL FLYMSMYWWG S

References

[1]	"Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates." Desjardins P., Morais R. J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: White leghorn.
[2]	"Mitochondrial DNA replication and transcription are dissociated during embryonic cardiac hypertrophy." Kennedy J.M., Lobacz S.R., Kelley S.W. Am. J. Physiol. 261:C1091-C1098(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X52392 Genomic DNA. Translation: CAA36631.1.

IPI

IPI00579527.

PIR

S10193.

RefSeq

NP_006921.2. NC_001323.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1LLK	model	-	A	1-261	[»]

ProteinModelPortal

P18945.

SMR

P18945. Positions 1-261.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

807637.

KEGG

gga:807637.

Organism-specific databases

CTD

4514.

Phylogenomic databases

eggNOG

COG1845.

HOVERGEN

HBG016686.

InParanoid

P18945.

KO

K02262.

OrthoDB

EOG437RFN.

ProtClustDB

MTH00118.

Family and domain databases

Gene3D

1.20.120.80. 1 hit.

InterPro

IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]

PANTHER

PTHR11403. PTHR11403. 1 hit.

Pfam

PF00510. COX3. 1 hit.
[Graphical view]

SUPFAM

SSF81452. CytC_oxdse_III. 1 hit.

PROSITE

PS50253. COX3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

20934096.

Entry information

Entry name

COX3_CHICK

Accession

Primary (citable) accession number: P18945

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program