SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P18945

- COX3_CHICK

UniProt

P18945 - COX3_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 3
Gene
MT-CO3, COIII, COXIII, MTCO3
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. respiratory chain complex IV assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed prediction
Add
BLAST
Transmembranei38 – 5821Helical; Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183757Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 3722
Helixi41 – 6525
Helixi73 – 10634
Helixi110 – 1123
Beta strandi114 – 1174
Helixi129 – 15325
Helixi156 – 18328
Helixi192 – 22332
Helixi233 – 25523
Turni256 – 2605

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LLKmodel-A1-261[»]
ProteinModelPortaliP18945.
SMRiP18945. Positions 1-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOVERGENiHBG016686.
InParanoidiP18945.
KOiK02262.
OMAiYFVPGPS.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18945-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQAHSYHM VDPSPWPIFG AAAALLTTSG LIMWFHYSST TLLTMGLLSM    50
LLVMLQWWRD VVRESTFQGH HTPTVQKGLR YGMILFITSE AFFFLGFFWA 100
FFHSSLAPTP ELGGQWPPTG VKPLNPLEVP LLNTAILLAS GVTVTWAHHS 150
ITEGNRKQAI HALTLTILLG FYFTALQAME YHEASFSIAD SVYGSTFFVA 200
TGFHGLHVII GSSFLTVCLL RLIKFHFTPN HHFGFEAAAW YWHFVDIIWL 250
FLYMSMYWWG S 261
Length:261
Mass (Da):29,625
Last modified:November 1, 1990 - v1
Checksum:iE326CB937B123BC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52392 Genomic DNA. Translation: CAA36631.1.
PIRiS10193.
RefSeqiNP_006921.2. NC_001323.1.

Genome annotation databases

EnsembliENSGALT00000029087; ENSGALP00000034618; ENSGALG00000018367.
GeneIDi807637.
KEGGigga:807637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52392 Genomic DNA. Translation: CAA36631.1 .
PIRi S10193.
RefSeqi NP_006921.2. NC_001323.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LLK model - A 1-261 [» ]
ProteinModelPortali P18945.
SMRi P18945. Positions 1-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000029087 ; ENSGALP00000034618 ; ENSGALG00000018367 .
GeneIDi 807637.
KEGGi gga:807637.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

eggNOGi COG1845.
HOVERGENi HBG016686.
InParanoidi P18945.
KOi K02262.
OMAi YFVPGPS.

Miscellaneous databases

NextBioi 20934096.
PROi P18945.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
    Desjardins P., Morais R.
    J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White leghorn.
  2. "Mitochondrial DNA replication and transcription are dissociated during embryonic cardiac hypertrophy."
    Kennedy J.M., Lobacz S.R., Kelley S.W.
    Am. J. Physiol. 261:C1091-C1098(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_CHICK
AccessioniPrimary (citable) accession number: P18945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi