Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P18944

- COX2_CHICK

UniProt

P18944 - COX2_CHICK

Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi160 – 1601Copper ACurated
    Metal bindingi195 – 1951Copper ACurated
    Metal bindingi199 – 1991Copper ACurated
    Metal bindingi203 – 2031Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:MT-CO2
    Synonyms:COII, COXII, MTCO2
    Encoded oniMitochondrion
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Cytochrome c oxidase subunit 2PRO_0000183547Add
    BLAST

    Proteomic databases

    PaxDbiP18944.
    PRIDEiP18944.

    Structurei

    3D structure databases

    ProteinModelPortaliP18944.
    SMRiP18944. Positions 1-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6114Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini82 – 227146Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8120HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000264988.
    HOVERGENiHBG012727.
    InParanoidiP18944.
    KOiK02261.
    OMAiMDEVNEP.
    OrthoDBiEOG7TJ3JX.
    PhylomeDBiP18944.
    TreeFamiTF344269.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18944-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANHSQLGFQ DASSPIMEEL VEFHDHALMV ALAICSLVLY LLTLMLMEKL    50
    SSNTVDAQEV ELIWTILPAI VLVLLALPSL QILYMMDEID EPDLTLKAIG 100
    HQWYWTYEYT DFKDLSFDSY MTPTTDLPLG HFRLLEVDHR IVIPMESPIR 150
    VIITADDVLH SWAVPALGVK TDAIPGRLNQ TSFITTRPGV FYGQCSEICG 200
    ANHSYMPIVV ESTPLKHFEA WSSLLSS 227
    Length:227
    Mass (Da):25,569
    Last modified:November 1, 1990 - v1
    Checksum:i7B0C1CEBCCD72AED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52392 Genomic DNA. Translation: CAA36628.1.
    PIRiS10190.
    RefSeqiNP_006918.1. NC_001323.1.

    Genome annotation databases

    EnsembliENSGALT00000029090; ENSGALP00000034615; ENSGALG00000018370.
    GeneIDi807635.
    KEGGigga:807635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52392 Genomic DNA. Translation: CAA36628.1 .
    PIRi S10190.
    RefSeqi NP_006918.1. NC_001323.1.

    3D structure databases

    ProteinModelPortali P18944.
    SMRi P18944. Positions 1-223.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P18944.
    PRIDEi P18944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000029090 ; ENSGALP00000034615 ; ENSGALG00000018370 .
    GeneIDi 807635.
    KEGGi gga:807635.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000264988.
    HOVERGENi HBG012727.
    InParanoidi P18944.
    KOi K02261.
    OMAi MDEVNEP.
    OrthoDBi EOG7TJ3JX.
    PhylomeDBi P18944.
    TreeFami TF344269.

    Miscellaneous databases

    NextBioi 20934094.
    PROi P18944.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
      Desjardins P., Morais R.
      J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: White leghorn.

    Entry informationi

    Entry nameiCOX2_CHICK
    AccessioniPrimary (citable) accession number: P18944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3