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Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi160Copper ACurated1
Metal bindingi195Copper ACurated1
Metal bindingi199Copper ACurated1
Metal bindingi203Copper ACurated1

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled electron transport Source: GO_Central
  • respiratory electron transport chain Source: AgBase
  • response to oxidative stress Source: AgBase

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 61Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei62 – 81HelicalSequence analysisAdd BLAST20
Topological domaini82 – 227Mitochondrial intermembraneSequence analysisAdd BLAST146

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835471 – 227Cytochrome c oxidase subunit 2Add BLAST227

Proteomic databases

PaxDbiP18944
PRIDEiP18944

Expressioni

Gene expression databases

BgeeiENSGALG00000018370

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034615

Structurei

3D structure databases

ProteinModelPortaliP18944
SMRiP18944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4767 Eukaryota
COG1622 LUCA
GeneTreeiENSGT00390000017410
HOGENOMiHOG000264988
HOVERGENiHBG012727
InParanoidiP18944
KOiK02261
OMAiWSYEYTD
OrthoDBiEOG091G0IO9
PhylomeDBiP18944
TreeFamiTF344269

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P18944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANHSQLGFQ DASSPIMEEL VEFHDHALMV ALAICSLVLY LLTLMLMEKL
60 70 80 90 100
SSNTVDAQEV ELIWTILPAI VLVLLALPSL QILYMMDEID EPDLTLKAIG
110 120 130 140 150
HQWYWTYEYT DFKDLSFDSY MTPTTDLPLG HFRLLEVDHR IVIPMESPIR
160 170 180 190 200
VIITADDVLH SWAVPALGVK TDAIPGRLNQ TSFITTRPGV FYGQCSEICG
210 220
ANHSYMPIVV ESTPLKHFEA WSSLLSS
Length:227
Mass (Da):25,569
Last modified:November 1, 1990 - v1
Checksum:i7B0C1CEBCCD72AED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52392 Genomic DNA Translation: CAA36628.1
PIRiS10190
RefSeqiNP_006918.1, NC_001323.1

Genome annotation databases

EnsembliENSGALT00000054328; ENSGALP00000058371; ENSGALG00000032456
GeneIDi807635
KEGGigga:807635

Similar proteinsi

Entry informationi

Entry nameiCOX2_CHICK
AccessioniPrimary (citable) accession number: P18944
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health