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P18944

- COX2_CHICK

UniProt

P18944 - COX2_CHICK

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Protein
Cytochrome c oxidase subunit 2
Gene
MT-CO2, COII, COXII, MTCO2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi160 – 1601Copper A Inferred
Metal bindingi195 – 1951Copper A Inferred
Metal bindingi199 – 1991Copper A Inferred
Metal bindingi203 – 2031Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei27 – 4721Helical; Reviewed prediction
Add
BLAST
Topological domaini48 – 6114Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei62 – 8120Helical; Reviewed prediction
Add
BLAST
Topological domaini82 – 227146Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Cytochrome c oxidase subunit 2
PRO_0000183547Add
BLAST

Proteomic databases

PaxDbiP18944.
PRIDEiP18944.

Structurei

3D structure databases

ProteinModelPortaliP18944.
SMRiP18944. Positions 1-223.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000264988.
HOVERGENiHBG012727.
InParanoidiP18944.
KOiK02261.
OMAiMDEVNEP.
OrthoDBiEOG7TJ3JX.
PhylomeDBiP18944.
TreeFamiTF344269.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18944-1 [UniParc]FASTAAdd to Basket

« Hide

MANHSQLGFQ DASSPIMEEL VEFHDHALMV ALAICSLVLY LLTLMLMEKL    50
SSNTVDAQEV ELIWTILPAI VLVLLALPSL QILYMMDEID EPDLTLKAIG 100
HQWYWTYEYT DFKDLSFDSY MTPTTDLPLG HFRLLEVDHR IVIPMESPIR 150
VIITADDVLH SWAVPALGVK TDAIPGRLNQ TSFITTRPGV FYGQCSEICG 200
ANHSYMPIVV ESTPLKHFEA WSSLLSS 227
Length:227
Mass (Da):25,569
Last modified:November 1, 1990 - v1
Checksum:i7B0C1CEBCCD72AED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52392 Genomic DNA. Translation: CAA36628.1.
PIRiS10190.
RefSeqiNP_006918.1. NC_001323.1.

Genome annotation databases

EnsembliENSGALT00000029090; ENSGALP00000034615; ENSGALG00000018370.
GeneIDi807635.
KEGGigga:807635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52392 Genomic DNA. Translation: CAA36628.1 .
PIRi S10190.
RefSeqi NP_006918.1. NC_001323.1.

3D structure databases

ProteinModelPortali P18944.
SMRi P18944. Positions 1-223.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P18944.
PRIDEi P18944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000029090 ; ENSGALP00000034615 ; ENSGALG00000018370 .
GeneIDi 807635.
KEGGi gga:807635.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000264988.
HOVERGENi HBG012727.
InParanoidi P18944.
KOi K02261.
OMAi MDEVNEP.
OrthoDBi EOG7TJ3JX.
PhylomeDBi P18944.
TreeFami TF344269.

Miscellaneous databases

NextBioi 20934094.
PROi P18944.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
    Desjardins P., Morais R.
    J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White leghorn.

Entry informationi

Entry nameiCOX2_CHICK
AccessioniPrimary (citable) accession number: P18944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 14, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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