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P18943 (COX1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded onMitochondrion
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Cytochrome c oxidase subunit 1
PRO_0000183306

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane268 – 28821Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane338 – 35821Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane414 – 43421Helical; Potential
Transmembrane456 – 47621Helical; Potential

Sites

Metal binding621Iron (heme A axial ligand) Probable
Metal binding2401Copper B Probable
Metal binding2441Copper B Probable
Metal binding2901Copper B Probable
Metal binding2911Copper B Probable
Metal binding3761Iron (heme A3 axial ligand) Probable
Metal binding3781Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P18943 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 29EF4E3DB9B9CDA9

FASTA51557,051
        10         20         30         40         50         60 
MTFINRWLFS TNHKDIGTLY LIFGTWAGMA GTALSLLIRA ELGQPGTLLG DDQIYNVIVT 

        70         80         90        100        110        120 
AHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSTVE 

       130        140        150        160        170        180 
AGAGTGWTVY PPLAGNLAHA GASVDLAIFH YLAGVSSILG AINFITTIIN MKPPALSQYQ 

       190        200        210        220        230        240 
TPLFVWSVLI TAILLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 

       250        260        270        280        290        300 
PEVYILILPG FGMISHVVAY YAGKKEPFGY MGMVWAMLSI GFLGFIVWAH HMFTVRMDVD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGIKV FSWLATLHGG TIKWDPPMLW ALGFIFLFTI GGLTGIVLAN 

       370        380        390        400        410        420 
SSLDIALHDT YYVVAHFHYV LSMGAVFAIL AGFTHWFPLF TGFTLHPSWT KAHFGVMFTG 

       430        440        450        460        470        480 
VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW NTLSSIGSLI SMTAVIMLMF IVWEAFSAKR 

       490        500        510 
KVLQPELTAT NIEWIHGCPP PYHTFEEPAF VQVQE 

« Hide

References

[1]"Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates."
Desjardins P., Morais R.
J. Mol. Biol. 212:599-634(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: White leghorn.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52392 Genomic DNA. Translation: CAA36627.1.
PIRS10189.
RefSeqNP_006917.1. NC_001323.1.

3D structure databases

ProteinModelPortalP18943.
SMRP18943. Positions 3-514.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP18943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000029093; ENSGALP00000034614; ENSGALG00000018373.
GeneID807639.
KEGGgga:807639.

Organism-specific databases

CTD4512.

Phylogenomic databases

eggNOGCOG0843.
GeneTreeENSGT00390000001518.
HOVERGENHBG003841.
InParanoidP18943.
KOK02256.
ProtClustDBMTH00116.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20934098.
PROP18943.

Entry information

Entry nameCOX1_CHICK
AccessionPrimary (citable) accession number: P18943
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways