Cytochrome b - Drosophila melanogaster (Fruit fly)

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P18935 (CYB_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome b

Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

Name:	mt:Cyt-b
Synonyms:	Cob, cytb

Encoded on

Mitochondrion

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subunit structure	The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.
Sequence similarities	Belongs to the cytochrome b family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro spermatogenesis Inferred from mutant phenotype PubMed 21407254. Source: FlyBase
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 378

378

Cytochrome b

PRO_0000060893

Regions

Transmembrane

34 – 54

Helical; Potential

Transmembrane

77 – 97

Helical; Potential

Transmembrane

114 – 134

Helical; Potential

Transmembrane

141 – 159

Helical; Potential

Transmembrane

179 – 199

Helical; Potential

Transmembrane

230 – 250

Helical; Potential

Transmembrane

262 – 282

Helical; Potential

Transmembrane

289 – 309

Helical; Potential

Transmembrane

321 – 341

Helical; Potential

Transmembrane

349 – 369

Helical; Potential

Sites

Metal binding

Iron 1 (heme b562 axial ligand)

Metal binding

Iron 2 (heme b566 axial ligand)

Metal binding

183

Iron 1 (heme b562 axial ligand)

Metal binding

197

Iron 2 (heme b566 axial ligand)

Sequences

Sequence

Length

Mass (Da)

Tools

P18935 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 6CB9067643ABCE83
Show »

FASTA

378

43,225

        10         20         30         40         50         60 
MNKPLRNSHP LFKIANNALV DLPAPINISS WWNFGSLLGL CLIIQILTGL FLAMHYTADI 

        70         80         90        100        110        120 
NLAFYSVNHI CRDVNYGWLL RTLHANGASF FFICIYLHVG RGIYYGSYKF TPTWLIGVII 

       130        140        150        160        170        180 
LFLVMGTAFM GYVLPWGQMS FWVATVITNL LYAIPYLGMD LVQWLWGGFA VDNATLTRFF 

       190        200        210        220        230        240 
TFHFILPFIV LAMTMIHLLF LHQTGSNNPI GLNSNIDKIP FHPYFTFKDI VGFIVMIFIL 

       250        260        270        280        290        300 
ISLVLISPNL LGDPDNFIPA TPLVTPAHIQ PEWYFLFAYA ILRSIPNKLG GVIALVLSIA 

       310        320        330        340        350        360 
ILMILPFYNL SKFRGIQFYP INQVMFWSML VTVILLTWIG ARPVEEPYVL IGQILTVVYF 

       370 
LYYLVNPLIT KWWDNLLN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations." Garesse R. Genetics 118:649-663(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Bretagne.
[2]	"Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons." Lewis D.L., Farr C.L., Kaguni L.S. Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37275 Genomic DNA. Translation: AAA69714.1. U37541 Genomic DNA. Translation: AAC47822.1.
PIR	S01190.
RefSeq	NP_008288.1. NC_001709.1.
3D structure databases
ProteinModelPortal	P18935.
SMR	P18935. Positions 16-365.
ModBase	Search...
Proteomic databases
PRIDE	P18935.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0100884; FBpp0100186; FBgn0013678.
GeneID	192472.
KEGG	dme:CYTB.
Organism-specific databases
CTD	4519.
FlyBase	FBgn0013678. mt:Cyt-b.
Phylogenomic databases
eggNOG	COG1290.
GeneTree	ENSGT00390000017948.
InParanoid	P18935.
KO	K00412.
OMA	WVNARAP.
OrthoDB	EOG48KPT9.
ProtClustDB	MTH00156.
Gene expression databases
Bgee	P18935.
Family and domain databases
InterPro	IPR016175. Cyt_b/b6. IPR005798. Cyt_b/b6_C. IPR005797. Cyt_b/b6_N. IPR016174. Di-haem_cyt_TM. [Graphical view]
PANTHER	PTHR19271. PTHR19271. 1 hit.
Pfam	PF00032. Cytochrom_B_C. 1 hit. PF13631. Cytochrom_B_N_2. 1 hit. [Graphical view]
SUPFAM	SSF81648. Cytochrome_b/b6_C. 1 hit. SSF81342. Transmembr_di-haem_cytochrome. 1 hit.
PROSITE	PS51003. CYTB_CTER. 1 hit. PS51002. CYTB_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Cyt-b5-r. drosophila.
GenomeRNAi	192472.
NextBio	842189.

Entry information

Entry name

CYB_DROME

Accession

Primary (citable) accession number: P18935

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents