P18926 (SCX1_CENTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Beta-toxin Clt1 Alternative name(s): Neurotoxin 1 Toxin II.20.3.4
Organism	Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Taxonomic identifier	1028682 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides

Protein attributes

Sequence length	66 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Sodium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sodium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 66	66	Beta-toxin Clt1		PRO_0000066761
Amino acid modifications
	Disulfide bond	12 ↔ 65		By similarity
	Disulfide bond	16 ↔ 41		By similarity
	Disulfide bond	25 ↔ 46		By similarity
	Disulfide bond	29 ↔ 48		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P18926 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: CEF5462C6047D4F2	FASTA	66	7,558
	10 20 30 40 50 60 KEGYLVNHST GCKYECFKLG DNDYCLRECR QQYGKGAGGY CYAFGCWCTH LYEQAVVWPL PNKTCS

References

[1]

"Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann." Martin B.M., Carbone E., Yatani A., Brown A.M., Ramirez A.N., Gurrola G.B., Possani L.D. Toxicon 26:785-794(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	A31188.
3D structure databases
ProteinModelPortal	P18926.
SMR	P18926. Positions 1-66.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR018218. Scorpion_toxinL. IPR002061. Scorpion_toxinL/defesin. [Graphical view]
Pfam	PF00537. Toxin_3. 1 hit. [Graphical view]
PRINTS	PR00285. SCORPNTOXIN.
SMART	SM00505. Knot1. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SCX1_CENTE

Accession

Primary (citable) accession number: P18926

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program