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Protein

Acetylcholine receptor subunit gamma

Gene

Chrng

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: RGD
  • ligand-gated ion channel activity Source: RGD

GO - Biological processi

  • cation transmembrane transport Source: GOC
  • cation transport Source: RGD
  • ion transmembrane transport Source: GOC
  • skeletal muscle contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit gamma
Gene namesi
Name:Chrng
Synonyms:Achrg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2354. Chrng.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 240218ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 26525HelicalSequence analysisAdd
BLAST
Transmembranei274 – 29219HelicalSequence analysisAdd
BLAST
Transmembranei308 – 32922HelicalSequence analysisAdd
BLAST
Topological domaini330 – 476147CytoplasmicSequence analysisAdd
BLAST
Transmembranei477 – 49721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: RGD
  • cell junction Source: UniProtKB-KW
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 519497Acetylcholine receptor subunit gammaPRO_0000000336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi150 ↔ 164By similarity
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18916.
PRIDEiP18916.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026529.

Structurei

3D structure databases

ProteinModelPortaliP18916.
SMRiP18916. Positions 24-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP18916.
KOiK04818.
PhylomeDBiP18916.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGGQGPQLL LLLLATCLGA QSRNQEERLL ADLMRNYDPH LRPAERDSDV
60 70 80 90 100
VNVSLKLTLT NLISLNEREE ALTTNVWIEM QWCDYRLRWD PKDYEGLWIL
110 120 130 140 150
RVPSTMVWQP DIVLGNNVDG VFEVALYCNV LVSPDGCIYW LPPAIFRSSC
160 170 180 190 200
SISVTYFPFD WQNCSLVFQS QTYSTSEINL QLSQEDGQAI EWIFIDPEAF
210 220 230 240 250
TENGEWAIRH RPAKMLLDPV TPAEEAGHQK VVFYLLIQRK PLFYVINIIV
260 270 280 290 300
PCVLISSVAI LIYFLPAKAG GQKCTVATNV LLAQTVFLFL VAKKVPETSQ
310 320 330 340 350
AVPLISKYLT FLMVVTILIV VNSVVVLNVS LRSPHTHSMA RGVRKVFLRL
360 370 380 390 400
LPQLLRMHVH PRAPAAVQDA RLRLQNGSSS GWPIMTREEG DLCLPRSELL
410 420 430 440 450
FRQRQRNGLV QAVLEKLENG PEMRQSQEFC GSLKQASPAI QACVDACNLM
460 470 480 490 500
ARARHQQSHF DSGNEEWLLV GRVLDRVCFL AMLSLFICGT AGIFLMAHYN
510
QVPDLPFPGD PRPYLPLPD
Length:519
Mass (Da):58,621
Last modified:May 1, 1992 - v2
Checksum:i1C97A83DE42A0D09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74834 mRNA. Translation: CAA52828.1.
X06364 Genomic DNA. Translation: CAA29662.1.
PIRiS13874.
RefSeqiNP_062018.1. NM_019145.1.
UniGeneiRn.44634.

Genome annotation databases

GeneIDi25753.
KEGGirno:25753.
UCSCiRGD:2354. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74834 mRNA. Translation: CAA52828.1.
X06364 Genomic DNA. Translation: CAA29662.1.
PIRiS13874.
RefSeqiNP_062018.1. NM_019145.1.
UniGeneiRn.44634.

3D structure databases

ProteinModelPortaliP18916.
SMRiP18916. Positions 24-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026529.

Proteomic databases

PaxDbiP18916.
PRIDEiP18916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25753.
KEGGirno:25753.
UCSCiRGD:2354. rat.

Organism-specific databases

CTDi1146.
RGDi2354. Chrng.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP18916.
KOiK04818.
PhylomeDBiP18916.

Miscellaneous databases

PROiP18916.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure and functional expression of the alpha-, beta-, gamma-, delta- and epsilon-subunits of the acetylcholine receptor from rat muscle."
    Witzemann V., Stein E., Barg B., Konno T., Koenen M., Kues W., Criado M., Hofmann M., Sakmann B.
    Eur. J. Biochem. 194:437-448(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.
  2. "Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs."
    Witzemann V., Barg B., Nishikawa Y., Sakmann B., Numa S.
    FEBS Lett. 223:104-112(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 203-306.

Entry informationi

Entry nameiACHG_RAT
AccessioniPrimary (citable) accession number: P18916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 1, 1992
Last modified: June 8, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.