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Protein

Acetylcholine receptor subunit gamma

Gene

Chrng

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine-gated cation-selective channel activity Source: RGD
  • ligand-gated ion channel activity Source: RGD
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  • cation transport Source: RGD
  • neuromuscular synaptic transmission Source: GO_Central
  • response to nicotine Source: GO_Central
  • skeletal muscle contraction Source: RGD
  • synaptic transmission, cholinergic Source: GO_Central

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit gamma
Gene namesi
Name:Chrng
Synonyms:Achrg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2354 Chrng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 240ExtracellularSequence analysisAdd BLAST218
Transmembranei241 – 265HelicalSequence analysisAdd BLAST25
Transmembranei274 – 292HelicalSequence analysisAdd BLAST19
Transmembranei308 – 329HelicalSequence analysisAdd BLAST22
Topological domaini330 – 476CytoplasmicSequence analysisAdd BLAST147
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000033623 – 519Acetylcholine receptor subunit gammaAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 164By similarity
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18916
PRIDEiP18916

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026529

Structurei

3D structure databases

ProteinModelPortaliP18916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP18916
KOiK04818
PhylomeDBiP18916

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGGQGPQLL LLLLATCLGA QSRNQEERLL ADLMRNYDPH LRPAERDSDV
60 70 80 90 100
VNVSLKLTLT NLISLNEREE ALTTNVWIEM QWCDYRLRWD PKDYEGLWIL
110 120 130 140 150
RVPSTMVWQP DIVLGNNVDG VFEVALYCNV LVSPDGCIYW LPPAIFRSSC
160 170 180 190 200
SISVTYFPFD WQNCSLVFQS QTYSTSEINL QLSQEDGQAI EWIFIDPEAF
210 220 230 240 250
TENGEWAIRH RPAKMLLDPV TPAEEAGHQK VVFYLLIQRK PLFYVINIIV
260 270 280 290 300
PCVLISSVAI LIYFLPAKAG GQKCTVATNV LLAQTVFLFL VAKKVPETSQ
310 320 330 340 350
AVPLISKYLT FLMVVTILIV VNSVVVLNVS LRSPHTHSMA RGVRKVFLRL
360 370 380 390 400
LPQLLRMHVH PRAPAAVQDA RLRLQNGSSS GWPIMTREEG DLCLPRSELL
410 420 430 440 450
FRQRQRNGLV QAVLEKLENG PEMRQSQEFC GSLKQASPAI QACVDACNLM
460 470 480 490 500
ARARHQQSHF DSGNEEWLLV GRVLDRVCFL AMLSLFICGT AGIFLMAHYN
510
QVPDLPFPGD PRPYLPLPD
Length:519
Mass (Da):58,621
Last modified:May 1, 1992 - v2
Checksum:i1C97A83DE42A0D09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74834 mRNA Translation: CAA52828.1
X06364 Genomic DNA Translation: CAA29662.1
PIRiS13874
RefSeqiNP_062018.1, NM_019145.1
UniGeneiRn.44634

Genome annotation databases

GeneIDi25753
KEGGirno:25753
UCSCiRGD:2354 rat

Similar proteinsi

Entry informationi

Entry nameiACHG_RAT
AccessioniPrimary (citable) accession number: P18916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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