P18915 (CAH6_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase 6
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name=CA-VI
Salivary carbonic anhydrase
Secreted carbonic anhydrase

Gene names

Name:

CA6

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide. Its role in saliva is unknown.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Secreted.
Tissue specificity	Major constituent of saliva.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 14	14	Ref.2
	Chain	15 – 319	305	Carbonic anhydrase 6		PRO_0000004239
Regions
	Region	215 – 216	2	Substrate binding By similarity
Sites
	Active site	80	1	Proton acceptor By similarity
	Active site	141	1	By similarity
	Metal binding	106	1	Zinc; catalytic By similarity
	Metal binding	108	1	Zinc; catalytic By similarity
	Metal binding	133	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...)
	Glycosylation	251	1	N-linked (GlcNAc...)
	Disulfide bond	37 ↔ 219		Potential
Experimental info
	Sequence conflict	16	1	H → S AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P18915 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 179884A7A9083AED	FASTA	319	37,007
	10 20 30 40 50 60 MITLLFLLVV GAQAQHEWTY SEGVLDEKHW RLQYPDCGGT RQSPIDLKMK KVRYNPSLRA 70 80 90 100 110 120 LNLTGYGLRQ GEFPMTNNGH TVQISLPSSM RMTTSDGSQY LAKQMHFHWG GDSSEISGSE 130 140 150 160 170 180 HTVDGMRYII EIHVVHYHSK YGSYEEAQNE PDGLAVLAAL VEVKDYAENT YYSNFISHLE 190 200 210 220 230 240 DIRYAGQSTV LRDLDIQDML PGDLRYYYSY LGSLTTPSCT ENVHWFVVAD TVKLSKTQIE 250 260 270 280 290 300 KLENSLLNHQ NETIQNNYRS TQPLNHRVVE ANFVSHPHQE YTLGSKLHFY LNNIDQNLEY 310 LRRFIEQKIT KRKKEKYWP

References

[1]	"Sequence of bovine carbonic anhydrase VI: potential recognition sites for N-acetylgalactosaminyltransferase." Jiang W., Woitach J.T., Gupta D. Biochem. J. 318:291-296(1996) [PubMed: 8761494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Submandibular gland.
[2]	"Tissue and species distribution of the secreted carbonic anhydrase isoenzyme." Fernley R.T., Darling P., Aldred P., Wright R.D., Coghlan J.P. Biochem. J. 259:91-96(1989) [PubMed: 2497732] [Abstract] Cited for: PROTEIN SEQUENCE OF 15-39.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X96503 mRNA. Translation: CAA65357.1.
IPI	IPI00688247.
PIR	S71877.
RefSeq	NP_776323.1. NM_173898.2.
UniGene	Bt.47.
3D structure databases
ProteinModelPortal	P18915.
ModBase	Search...
Protein-protein interaction databases
STRING	P18915.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	280742.
KEGG	bta:280742.
Organism-specific databases
CTD	765.
Phylogenomic databases
eggNOG	maNOG16006.
GeneTree	ENSGT00570000078862.
HOVERGEN	HBG002837.
InParanoid	P18915.
OrthoDB	EOG43FGWZ.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018428. Carbonic_anhydrase_CA6. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KO	K01672.
PANTHER	PTHR18952:SF17. Carbonic_anhydrase_CA6. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH6_BOVIN

Accession

Primary (citable) accession number: P18915
Secondary accession number(s): Q95322

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	July 15, 1999
Last modified:	January 25, 2012
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program