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P18907 (AT1A1_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit alpha-1
Short name=Sodium pump subunit alpha-1
EC=3.6.3.9
Alternative name(s):
Na(+)/K(+) ATPase alpha-1 subunit
Gene names
Name:ATP1A1
OrganismEquus caballus (Horse) [Complete proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus

Protein attributes

Sequence length1021 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activity

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Subunit structure

Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with SIK1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Melanosome By similarity.

Post-translational modification

Phosphorylation on Tyr-10 modulates pumping activity. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 55 By similarity
PRO_0000002481
Chain6 – 10211016Sodium/potassium-transporting ATPase subunit alpha-1
PRO_0000002482

Regions

Topological domain6 – 8580Cytoplasmic Potential
Transmembrane86 – 10621Helical; Potential
Topological domain107 – 12923Extracellular Potential
Transmembrane130 – 15021Helical; Potential
Topological domain151 – 286136Cytoplasmic Potential
Transmembrane287 – 30620Helical; Potential
Topological domain307 – 31812Extracellular Potential
Transmembrane319 – 33618Helical; Potential
Topological domain337 – 770434Cytoplasmic Potential
Transmembrane771 – 79020Helical; Potential
Topological domain791 – 80010Extracellular Potential
Transmembrane801 – 82121Helical; Potential
Topological domain822 – 84120Cytoplasmic Potential
Transmembrane842 – 86423Helical; Potential
Topological domain865 – 91652Extracellular Potential
Transmembrane917 – 93620Helical; Potential
Topological domain937 – 94913Cytoplasmic Potential
Transmembrane950 – 96819Helical; Potential
Topological domain969 – 98315Extracellular Potential
Transmembrane984 – 100421Helical; Potential
Topological domain1005 – 102117Cytoplasmic Potential
Region80 – 823Phosphoinositide-3 kinase binding By similarity

Sites

Active site37414-aspartylphosphate intermediate By similarity
Metal binding7151Magnesium By similarity
Metal binding7191Magnesium By similarity

Amino acid modifications

Modified residue101Phosphotyrosine By similarity
Modified residue161Phosphoserine; by PKC By similarity
Modified residue451Phosphoserine By similarity
Modified residue531Phosphotyrosine By similarity
Modified residue2151Phosphoserine By similarity
Modified residue2171Phosphothreonine By similarity
Modified residue2261Phosphoserine By similarity
Modified residue2581Phosphotyrosine By similarity
Modified residue4501Phosphoserine By similarity
Modified residue9411Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
P18907 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 4FEB03FFB04E0216

FASTA1,021112,697
        10         20         30         40         50         60 
MGKGGGRDKY EPAAISEHGN KKKAKKERDM DELKKEVSMD DHKLSLDELQ RKYGTDLSRG 

        70         80         90        100        110        120 
LTTARAAEIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSM LLWIGAILCF LAYGIQAATE 

       130        140        150        160        170        180 
EEPQNDNLYL GVVLSAVVII TGCFSYYQEA KSSKIMESFK NMVPQQALVV RNGEKMSINA 

       190        200        210        220        230        240 
EEVVVGDLVE VKGGDRIPAD LRIISANGCK VDNSSLTGES EPQTRSPDFT NENPLETRNI 

       250        260        270        280        290        300 
AFFSTNCVEG TARGIVVYTG DRTVMGRIAT LASGLEGGQT PIAAEIEHFI HIITGVAVFL 

       310        320        330        340        350        360 
GVTFFILSLI LEYTWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA RKNCLVKNLE 

       370        380        390        400        410        420 
AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT TENQSGVSFD KTSATWLSLS 

       430        440        450        460        470        480 
RIAGLCNRAV FQANQENIPI LKRAVAGDAS ESALLKCIEL CCGSVKEMRD RYPKIVEIPF 

       490        500        510        520        530        540 
NSTNKYQLSI HKNPNTSEPQ HLLVMKGAPE RILDRCSSIL LNGKEQPLDE ELKDAFQNAY 

       550        560        570        580        590        600 
LELGGLGERV LGFCHLFLPD EQFPEGFQFD TDDVNFPLEN LCFVGLISMI DPPRAAVPDA 

       610        620        630        640        650        660 
VGKCRSAGIK VIMVTGDHPI TAKAIAKGVG IISEGNETVE DIAARLNIPV SQVNPRDAKA 

       670        680        690        700        710        720 
CVVHGSDLKD MTPEQLDDIL RHHTEIVFAR TSPQQKLIIV EGCQRQGAIV AVTGDGVNDS 

       730        740        750        760        770        780 
PALKKADIGV AMGIAGSDVS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS 

       790        800        810        820        830        840 
NIPEITPFLI FIIANIPLPL GTVTILCIDL GTDMVPAISL AYEQAESDIM KRQPRNPQTD 

       850        860        870        880        890        900 
KLVNERLISM AYGQIGMIQA LGGFFTYFVI LAENGFLPIH LLGLRVDWDD RWVNDVEDSY 

       910        920        930        940        950        960 
GQQWTYEQRK IVEFTCHTAF FVSIVVVQWA DLVICKTRRN SVFQQGMKNK ILIFGLFEET 

       970        980        990       1000       1010       1020 
ALAAFLSYCP GMGVALRMYP LKPTWWFCAF PYSLLIFVYD EVRKLIIRRR PGGWVEKETY 


Y

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References

[1]"Structure of the alpha 1 subunit of horse Na,K-ATPase gene."
Kano I., Nagai F., Satoh K., Ushiyama K., Nakao T., Kano K.
FEBS Lett. 250:91-98(1989) [PubMed: 2544461] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X16773 expand/collapse EMBL AC list , X16774, X16775, X16776, X16777, X16778, X16779, X16780, X16781, X16782, X16783, X16784, X16785, X16786, X16787, X16788, X16789, X16790, X16791, X16792, X16793, X16794, X16795 Genomic DNA. Translation: CAA34716.1.
PIRS04630.
UniGeneEca.17012.

3D structure databases

ProteinModelPortalP18907.
SMRP18907. Positions 24-1021.
ModBaseSearch...

Protein family/group databases

MEROPSI04.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004298.
InParanoidP18907.
OrthoDBEOG46MBHS.

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR005775. ATPase_P-typ_cation-ex_asu_euk.
IPR006069. ATPase_P-typ_cation-exchng_asu.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00121. NAKATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAT1A1_HORSE
AccessionPrimary (citable) accession number: P18907
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 16, 2011
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents