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Protein

Retinol-binding protein 4

Gene

RBP4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.1 Publication2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98SubstrateCombined sources1 Publication1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: UniProtKB
  • transporter activity Source: InterPro

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP1 Publication
Gene namesi
Name:RBP4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010281 – 183Retinol-binding protein 4Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 160Combined sources2 Publications
Disulfide bondi70 ↔ 174Combined sources2 Publications
Disulfide bondi120 ↔ 129Combined sources2 Publications
Modified residuei121Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

PaxDbiP18902.
PeptideAtlasiP18902.
PRIDEiP18902.

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with TTR (PubMed:2209607). Interaction with TTR prevents its loss by filtration through the kidney glomeruli (Probable). Interacts with STRA6 (PubMed:17255476, PubMed:18419130).Curated3 Publications

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000566.

Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi17 – 20Combined sources4
Beta strandi22 – 30Combined sources9
Beta strandi33 – 35Combined sources3
Beta strandi39 – 47Combined sources9
Beta strandi53 – 62Combined sources10
Beta strandi68 – 79Combined sources12
Beta strandi85 – 94Combined sources10
Beta strandi100 – 109Combined sources10
Beta strandi111 – 123Combined sources13
Beta strandi127 – 142Combined sources16
Helixi146 – 158Combined sources13
Turni173 – 175Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ERBX-ray1.90A1-183[»]
1FELX-ray1.80A1-183[»]
1FEMX-ray1.90A1-183[»]
1FENX-ray1.90A1-183[»]
1HBPX-ray1.90A1-183[»]
1HBQX-ray1.70A1-183[»]
1KT3X-ray1.40A1-183[»]
1KT4X-ray1.46A1-183[»]
1KT5X-ray1.46A1-175[»]
1KT6X-ray1.10A1-183[»]
1KT7X-ray1.27A1-183[»]
ProteinModelPortaliP18902.
SMRiP18902.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18902.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
HOVERGENiHBG004493.
InParanoidiP18902.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00213. LIPOCALIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P18902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ERDCRVSSFR VKENFDKARF AGTWYAMAKK DPEGLFLQDN IVAEFSVDEN
60 70 80 90 100
GHMSATAKGR VRLLNNWDVC ADMVGTFTDT EDPAKFKMKY WGVASFLQKG
110 120 130 140 150
NDDHWIIDTD YETFAVQYSC RLLNLDGTCA DSYSFVFARD PSGFSPEVQK
160 170 180
IVRQRQEELC LARQYRLIPH NGYCDGKSER NIL
Length:183
Mass (Da):21,069
Last modified:November 1, 1990 - v1
Checksum:iD6BA064CB9E67C09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65585 mRNA. Translation: AAB28336.1.
PIRiI46955.
S13186.
UniGeneiBt.5318.

Similar proteinsi

Entry informationi

Entry nameiRET4_BOVIN
AccessioniPrimary (citable) accession number: P18902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: December 20, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families