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Protein

Retinol-binding protein 4

Gene

RBP4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98SubstrateCombined sources1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP
Gene namesi
Name:RBP4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Secreted 2 Publications

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010281 – 183Retinol-binding protein 4Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 160Combined sources1 Publication
Disulfide bondi70 ↔ 174Combined sources1 Publication
Disulfide bondi120 ↔ 129Combined sources1 Publication
Modified residuei121Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

PaxDbiP18902.
PeptideAtlasiP18902.
PRIDEiP18902.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000442.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000566.

Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi17 – 20Combined sources4
Beta strandi22 – 30Combined sources9
Beta strandi33 – 35Combined sources3
Beta strandi39 – 47Combined sources9
Beta strandi53 – 62Combined sources10
Beta strandi68 – 79Combined sources12
Beta strandi85 – 94Combined sources10
Beta strandi100 – 109Combined sources10
Beta strandi111 – 123Combined sources13
Beta strandi127 – 142Combined sources16
Helixi146 – 158Combined sources13
Turni173 – 175Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ERBX-ray1.90A1-183[»]
1FELX-ray1.80A1-183[»]
1FEMX-ray1.90A1-183[»]
1FENX-ray1.90A1-183[»]
1HBPX-ray1.90A1-183[»]
1HBQX-ray1.70A1-183[»]
1KT3X-ray1.40A1-183[»]
1KT4X-ray1.46A1-183[»]
1KT5X-ray1.46A1-175[»]
1KT6X-ray1.10A1-183[»]
1KT7X-ray1.27A1-183[»]
ProteinModelPortaliP18902.
SMRiP18902.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18902.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
HOVERGENiHBG004493.
InParanoidiP18902.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
[Graphical view]
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ERDCRVSSFR VKENFDKARF AGTWYAMAKK DPEGLFLQDN IVAEFSVDEN
60 70 80 90 100
GHMSATAKGR VRLLNNWDVC ADMVGTFTDT EDPAKFKMKY WGVASFLQKG
110 120 130 140 150
NDDHWIIDTD YETFAVQYSC RLLNLDGTCA DSYSFVFARD PSGFSPEVQK
160 170 180
IVRQRQEELC LARQYRLIPH NGYCDGKSER NIL
Length:183
Mass (Da):21,069
Last modified:November 1, 1990 - v1
Checksum:iD6BA064CB9E67C09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65585 mRNA. Translation: AAB28336.1.
PIRiI46955.
S13186.
UniGeneiBt.5318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65585 mRNA. Translation: AAB28336.1.
PIRiI46955.
S13186.
UniGeneiBt.5318.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ERBX-ray1.90A1-183[»]
1FELX-ray1.80A1-183[»]
1FEMX-ray1.90A1-183[»]
1FENX-ray1.90A1-183[»]
1HBPX-ray1.90A1-183[»]
1HBQX-ray1.70A1-183[»]
1KT3X-ray1.40A1-183[»]
1KT4X-ray1.46A1-183[»]
1KT5X-ray1.46A1-175[»]
1KT6X-ray1.10A1-183[»]
1KT7X-ray1.27A1-183[»]
ProteinModelPortaliP18902.
SMRiP18902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000566.

Proteomic databases

PaxDbiP18902.
PeptideAtlasiP18902.
PRIDEiP18902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
HOVERGENiHBG004493.
InParanoidiP18902.

Miscellaneous databases

EvolutionaryTraceiP18902.

Gene expression databases

BgeeiENSBTAG00000000442.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
[Graphical view]
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRET4_BOVIN
AccessioniPrimary (citable) accession number: P18902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.